Inhibition of tumor invasion and metastasis by peptidic mimetics of Arg- Gly Asp (RGD) derived from the cell recognition site of fibronectin

Oncology Research

Volumn 8, Issue 9, 1996, Pages 333-342

  Fujii, Hideki ^a,b   Nishikawa, Naoyuki ^c   Komazawa, Hiroyuki ^c   Orikasa, Atsushi ^c   Ono, Mitsunori ^c   Itoh, Isamu ^c   Murata, Jun ^a   Azuma, Ichiro ^b   Saiki, Ikuo ^a  

^a UNIVERSITY OF TOYAMA   (Japan)

^b HOKKAIDO UNIVERSITY   (Japan)

^c FUJIFILM CORPORATION   (Japan)

Author keywords

Arg Gly Asp Ser; fibronectin; invasion; metastasis; retro inverso peptide; retro peptide

Indexed keywords

ARGINYLGLYCYLASPARTIC ACID; FIBRONECTIN; PEPTIDE DERIVATIVE;

AMINO ACID SEQUENCE; ANIMAL CELL; ANTINEOPLASTIC ACTIVITY; ARTICLE; CANCER GROWTH; CANCER INVASION; CANCER MORTALITY; CANCER PREVENTION; FEMALE; LUNG METASTASIS; MOUSE; NONHUMAN; PRIORITY JOURNAL;

EID: 0030478172     PISSN: 09650407     EISSN: None     Source Type: Journal    
DOI: None     Document Type: Article

References (36)

1. 1. Hart, I. R. "Seed and soil" revisited: mechanisms of site-specific metastasis. Cancer Metastasis Rev. 1:5-16; 1982.
2. 2. Liotta, L. A.; Rao, C. V.; Barsky, S. H. Tumor invasion and the extracellular matrix. Lab. Invest. 49:636-649; 1983.
3. 3. Fidler, I. J. The Ernst W. Bertner Memorial Award Lecture: The evolution of biological heterogeneity in metastatic neoplasms. In: Nicolson, G. L.; Milas, L., eds. Cancer invasion and metastasis: biologic and therapeutic Aspects. New York: Raven Press; 1984:pp. 5-26.
4. 4. Nicolson, G. L. Tumor cell instability, diversification, and progression to the metastatic phenotype: from oncogene to oncofetal expression. Cancer Res. 47: 1473-1487; 1987.
5. 5. Karpathlan, S.; Pearlstein, E. Heterogeneous mechanism of tumor cell-induced platelet aggregation with possible strategy toward prevention of metastasis. In: Honn, K. V.; Sloane, B. F., eds. Hemostasis mechanisms and metastasis. Boston: Martinus Nijhoff; 1984:pp. 139-169.
6. 6. McCarthy, J. B.; Furcht, L. T. Laminin and fibronectin promote the haptotactic migration of B16-BL6 mouse melanoma cells in vitro. J. Cell Biol. 98:1474-1480; 1984.
7. 7. Terranova, V. P.; Hujanen, E. S.; Martin, G. R. Basement membrane and the invasive activity of metastatic tumor cells. J. Natl. Cancer Inst. 77:311-316; 1986.
8. 8. Pierschbacher, M. D.; Ruoslahti, E. Cell attachment activity of fibronectin can be duplicated by small synthetic fragments of the molecule. Nature 309:30-33; 1984.
9. 9. Ruoslahti, E.; Pierschbacher, M. D. Arg-Gly Asp: a versatile cell recognition signal. Cell 44:517-518; 1986.
10. 10. Pierschbacher, M. D.; Ruoslahti, E. Variants of the cell recognition site of fibronectin that retain attachment-promoting activity. Proc. Natl. Acad. Sci. USA 81: 5985-5988; 1984.
11. 11. Pierschbacher, M. D.; Ruoslahti, E. Influence of stereo-chemistry of the sequence Arg-Gly Asp-Xaa on binding specificity in cell adhesion. J. Biol. Chem. 262: 17294-17298; 1987.
12. 12. Gehlsen, K. R.; Argraves, W. S.; Piershbacher, M. D.; Ruoslahti, E. Inhibition of in vitro tumor cell invasion by Arg-Gly Asp-containing synthetic peptide. J. Cell Biol. 106:925-930; 1988.
13. 13. Hautanen, A.; Gailit, J.; Mann, D. M.; Ruoslahti, E. Effects of modifications of RGD sequence and its context on recognition by the fibronectin receptor. J. Biol. Chem. 264:1437-1442; 1989.
14. 14. Graf, J.; Iwamoto, Y.; Sasaki, M.; Martin, G. R.; Kleinman, H. K.; Robey, F. A.; Yamada, Y. Identification of an amino acid sequence in laminin mediating cell attachment, chemotaxis, and receptor binding. Cell 48:989-996; 1987.
15. 15. Humphries, M. J.; Olden, K.; Yamada, K. M. A synthetic peptide from fibronectin inhibits experimental metastasis of murine melanoma cells. Science 233:467-470; 1986.
16. 16. Humphries, M. J.; Yamada, K. M.; Olden, K. Investigation of the biological effects of anti-cell adhesive synthetic peptides that inhibit experimental metastasis of B16-F10 murine melanoma cells. J. Clin. Invest. 81:782-790; 1986.
17. 17. Saiki, I.; Murata, J.; Makabe, T.; Nishi, N.; Tokura, S.; Azuma, I. Inhibition of tumor angiogenesis by a synthetic cell-adhesive polypeptide containing the Arg-Gly Asp (RGD) sequence of fibronectin, poly(RGD). Jpn. J. Cancer Res. 81:668-675; 1990.
18. 18. Ugen, K. E.; Mahalingan, M.; Klein, P. A.; Kao, K. J. Inhibition of tumor cell-induced platelet aggregation and experimental tumor metastasis by synthetic GIy Arg-Gly Asp-Ser peptide. J. Natl. Cancer Inst. 80:1461-1466; 1988.
19. 19. Saiki, I.; Murata, J.; Iida, J.; Sakurai, T.; Nishi, N.; Matsuno, K.; Azuma, I. Antimetastatic effects of synthetic polypeptides containing repeated structures of the cell adhesive Arg-Gly Asp (RGD) and Tyr-Ile-Gly Ser-Arg (YIGSR) sequences. Br. J. Cancer 60:722-728; 1989.
20. 20. Saiki, I.; Iida, J.; Murata, J.; Ogawa, R.; Nishi, N.; Sugimura, K.; Tokura, S. ; Azuma, I. Inhibition of the metastasis of murine malignant melanoma by synthetic polymeric peptides containing core sequence of cell adhesive molecules. Cancer Res. 49:3815-3822; 1989.
21. 21. Saiki, I.; Murata, J.; Nishi, N.; Sugimura, K.; Azuma, I. The inhibition of murine lung metastasis by synthetic polypeptides [poly(Arg-Gly Asp) and poly(Tyr-Ile-Gly Ser-Arg)] with a core sequence of cell adhesion molecules. Br. J. Cancer 59:194-197; 1989.
22. 22. Kumagai, H.; Tajima, M.; Ueno, Y.; Kama, Y. G.; Ohba, M. Effect of cyclic RGD peptide on cell adhesion and tumor metastasis. Biochem. Biophys. Res. Commun. 177:74-82; 1991.
23. 23. Iwamoto, Y.; Robey, F. A.; Graf, J.; Sasaki, M.; Kleinman, H. K.; Yamada, Y. ; Martin, G.R. YIGSR, a synthetic laminin pentapeptide, inhibits experimental metastasis formation. Science 2378:1132-1134; 1987.
24. 24. Humphries, M. J.; Komoriya, A.; Akiyama, S. K.; Olden, K.; Yamada, K. M. Identification of two distinct regions of the type III connecting segment of human plasma fibronectin that promote cell type-specific adhesion. J. Biol. Chem. 262:6886-6892; 1987.
25. 25. Saiki, I.; Murata, J.; Makabe, T.; Matsumoto, Y.; Ohdate, Y.; Kawase, Y.; Taguchi, Y.; Shimojo, T.; Kimizuka, F.; Kato, I.; Azuma, I. Inhibition of lung metastasis by synthetic and recombinant fragment of human fibronectin with functional domains. Jpn. J. Cancer Res. 81: 1003-1011; 1990.
26. 26. Fujii, H.; Komazawa, H.; Mori, H.; Kojima, M.; Itoh, I.; Murata, J.; Azuma, I.; Saiki, I. Antimetastatic activities of synthetic Arg-Gly Asp-Ser (RGDS) and Arg-Leu-Asp-Ser (RLDS) peptide analogues and their inhibitory mechanism. Biol. Pharm. Bull. 18:1681-1688; 1995.
27. 27. Pierschbacher, M. D.; Ruoslahti, E. Influence of stereo-chemistry of the sequence Arg-Gly Asp-Xaa on binding specificity in cell adhesion. J. Biol. Chem. 262: 17294-17298; 1987.
28. 28. Komazawa, H.; Saiki, I.; Igarashi, Y.; Azuma, I.; Kojima, M.; Orikasa, A.; Ono, M.; Itoh, I. Inhibition of tumor metastasis by synthetic vinyl polymer containing cell-adhesive RGDS peptide. J. Bioactive and Compatible Polym. 8:258-274; 1993.
29. 29. Komazawa, H.; Saiki, I.; Igarashi, Y.; Azuma, I.; Tokura, S.; Kojima, M.; Orikasa, A.; Ono, M.; Itoh, I. The conjugation of RGDS peptide with CM-chitin augments the peptide mediated inhibition of tumor metastasis. Carbohydr. Polym. 21:299-307; 1993.
30. 30. Komazawa, H.; Saiki, I.; Nishikawa, N.; Yoneda, J.; Yoo, Y. C.; Kojima, M.; Ono, M.; Itoh, I.; Nishi, N.; Tokura, S.; Azuma, I. Inhibition of tumor metastasis by Arg-Gly Asp-Ser (RGDS) peptide conjugated with sulfated chitin derivative, SCM-chitin-RGDS. Clin. Exp. Metastasis 11:482-491; 1993.
31. 31. Chorev, M.; Shavitz, R.; Goodman, M.; Minick, S.; Guillemin, R. Partially modified retro-inverso enkephalinamides: topochemical long acting analogs in vitro and in vivo. Science 204:1210-1212; 1979.
32. 32. Shioiri, T.; Ninomiya, K.; Yamada, S. Diphenylphosphoryl azide. A new convenient reagent for a modified Curtus reaction and for the peptide synthesis. J. Am. Chem. Soc. 94:6203-6205; 1972.
33. 33. Hart, I. R. The selection and characterization of an invasive variant of the B16 melanoma. Am. J. Pathol. 97: 587-592; 1979.
34. 34. Saiki, I.; Matsumoto, Y.; Murata, J. Makabe, T.; Yoneda, J.; Okuyama, H.; Kimizuka, F.; Ishizaki, Y.; Kato, I.; Azuma, I. Recombinant fusion polypeptide with cell-and heparin-binding domains of fibronectin inhibits liver metastasis of L5178Y-ML25 lymphoma cells. Jpn. J. Cancer Res. 82:1120-1129; 1991.
35. 35. Fidler, I. J. Selection of successive tumor lines for metastasis. Nature 242:148-149; 1973.
36. 36. Saiki, I.; Murata, J.; Nakajima, M.; Tokura, S.; Azuma, I. Inhibition of sulfated chitin derivatives of invasion through extracellular matrix and enzymatic degradation by metastatic melanoma cells. Cancer Res. 50: 3631-3637; 1990.