Effect of a tobacco-related nitrosamine on intercellular communication in human urothelial cells: A possible factor in smoking-related bladder carcinogenesis

Oncology Research

Volumn 8, Issue 9, 1996, Pages 371-378

  Lyng, Fiona M ^a,b   De Feijter Rupp, Heather L ^c   Hayashi, Tomonori ^c   O'Malley, Kieran ^d   Murphy, Dennis M ^d   Cottell, David C ^b   Trosko, James E ^c   Seymour, Colin B ^a   Mothersill, Carmel ^a  

^a DUBLIN INSTITUTE OF TECHNOLOGY   (Ireland)

^b UNIVERSITY COLLEGE DUBLIN   (Ireland)

^c MICHIGAN STATE UNIVERSITY   (United States)

^d BEAUMONT HOSPITAL   (Ireland)

Author keywords

bladder carcinogenesis; connexins; gap junction intercellular communication; nitrosamines; tissue culture

Indexed keywords

NITROSAMINE;

ARTICLE; BLADDER CARCINOGENESIS; BLADDER CARCINOMA; CANCER RISK; CELL COMMUNICATION; CHEMICAL CARCINOGENESIS; HUMAN; HUMAN CELL; PRIORITY JOURNAL; SMOKING; UROTHELIUM;

EID: 0030477897     PISSN: 09650407     EISSN: None     Source Type: Journal    
DOI: None     Document Type: Article

References (39)

1. 1. Preussmann, R.; Eisenbrand, M. N-Nitroso carcinogens in the environment. In: Searle, C. E., ed. Chemical carcinogens. Am. Chem. Soc. Monograph 182:829; 1984.
2. 2. Hecht, S.; Hoffmann, D. The relevance of tobacco-specific nitrosamines to human cancer. Cancer Surv. 8:273-294; 1989.
3. 3. Bartsch, H.; Montesano, R. Relevance of nitrosamines to human cancer. Carcinogenesis 5:1381-1393; 1984.
4. 4. Druckrey, H.; Preussmann, R.; Ivancovic, S.; Schmahl, D. Organtrope carcinogene Wirkung bei 65 verschiendenen N-Nitroso-Verbindungen an BD-Ratten. Z. Krebsforsch. 69:103-201; 1967.
5. 5. Hilfrich, J.; Schmeltz, I.; Hoffmann, D. Tobacco carcinogenesis. 17. Effects of N-nitrosodiethanolamine and 1,1-diethanolhydrazine in Syrian golden hamsters. Cancer Lett. 4:55-60; 1977.
6. 6. Lijinsky, W.; Reuber, M. D.; Manning, W. B. Potent carcinogenicity of nitrosodiethanolamine in rats. Nature 288:589-590; 1980.
7. 7. Preussmann, P.; Habs, M.; Habs, S.; Schmahl, H. Carcinogenicity of N-nitrosodiethanolamine in rats at 5 different dose levels. Cancer Res. 42:5167-5171; 1982.
8. 8. Denkel, E.; Pool, B. L.; Schlehofer, J. R.; Eisenbrand, G. Biological activity of N-nitrosodiethanolamine and potential metabolites which may arise after activation by alcohol dehydrogenase in Salmonella typhimurium, in mammalian cells and in vivo. J. Cancer Res. Clin. Oncol. 111:149-153; 1986.
9. 9. Hecht, S. S.; Carmella, S. G.; Murphy, S. E.; Akerkar, S.; Brunnemann, K. D.; Hoffmann, D. A tobacco specific lung carcinogen in the urine of men exposed to cigarette smoke. New Engl. J. Med. 329:1543-1546; 1993.
10. 10. Ross, R. K.; Paganini-Hill, A.; Henderson, B. E. Epidemiology of bladder cancer. In: Skinner, D. G.; Lieskovsky, G., eds. Diagnosis and management of genitourinary cancer. Philadelphia: W. B. Saunders Co.; 1988:pp. 23-31.
11. 11. Burns, P. B.; Swanson, G. M. Risk of urinary bladder cancer among Blacks and Whites: the role of cigarette use and occupation. Cancer Causes Control 2:371-379; 1991.
12. 12. Carmella, S. G.; Akerkar, S.; Hecht, S. S. Metabolites of the tobacco specific nitrosamine 4-(methylnitrosamino)-1-(3-pyridyl)-1-butanone in smokers' urine. Cancer Res. 53:721-724; 1993.
13. 13. Castonguay, A.; Lin, D.; Stoner, G. D. Comparative carcinogenicity in A/J mice and metabolism by cultured mouse peripheral lung of N′-nitrosonornicotine, 4-(methylnitrosamino)-1-(3-pyridyl)-1-butanone and their analogues. Cancer Res. 43:1223-1229; 1983.
14. 14. Rivenson, A.; Hoffmann, D.; Prokopezyk, B.; Amin, S.; Hecht, S. S. Induction of lung and exocrine pancreas tumours in F344 rats by tobacco specific and Areca-derived N-nitrosamines. Cancer Res. 48:6912-6917; 1988.
15. 15. Tricker, A. R.; Mostafa, M. H.; Spiegelhalder B.; Preussmann, R. Urinary excretion of nitrate, nitrite and N-nitroso compounds in schistosomiasis and bilharzia bladder cancer patients. Carcinogenesis 10:547-552; 1989.
16. 16. Mostafa, M. H.; Helmi, S.; Badawi, A. F.; Tricker, A. R.; Spiegelhalder, B.; Preussmann, R. Nitrate, nitrite and volatile N-nitroso compounds in the urine of Schistosoma haematobium and Schistosoma mansoni infected patients. Carcinogenesis 15:619-625; 1994.
17. 17. Beyer, E. C.; Goodenough, D. A.; Paul, D. L. The connexins, a family of related gap junction proteins. In: Hertzberg, E. L.; Johnson, R. G., eds. Gap junctions: proceedings of the International Conference on Gap Junctions held at Pacific Grove, California, July 6-10, 1987. New York: Alan R. Liss, Inc.; 1988: pp. 165-175.
18. 18. Beyer, E. C.; Paul, D. L.; Goodenough, D. A. Connexin 43: a protein from rat heart homologous to a gap junction protein from liver. J. Cell Biol. 105:2621-2629; 1987.
19. 19. Fishman, G. I.; Eddy, R. L.; Shows, T. B.; Rosenthal, L.; Leinwand, L. A. The human connexin gene family of gap junction proteins: distinct chromosomal locations but similar structure. Genomics 10:250-256; 1991.
20. 20. Kumar, N. M.; Gilula, N. B. Cloning and characterisation of human and rat liver cDNAs coding for a gap junction protein. J. Cell Biol. 103:767-776; 1986.
21. 21. Loewenstein, W. R. Junctional intercellular communication and the control of growth. Biochim. Biophys. Acta 560:1-65; 1979.
22. 22. Trosko, J. E.; Chang, C. C. Non-genotoxic mechanisms in Carcinogenesis. Role of inhibited intercellular communication.In: Hart, R. W.; Hoergen, F. G., eds. Carcinogen risk assessment: new directions in the qualitative and quantitative aspects. Cold Spring Harbour: Cold Spring Harbour Laboratory Press; 1988: pp. 139-170.
23. 23. Unwin, P. N. T.; Zampighi, G. Structure of junctions between communicating cells. Nature 283:545-549; 1980.
24. 24. Willecke, K.; Hennemann, H.; Dahl, E.; Jungbluth, S.; Heynkes, R. The diversity of connexin genes encoding gap junctional proteins. Eur. J. Cell Biol. 56:1-7; 1991.
25. 25. Wilgenbus, K. K.; Kirkpatrick, C. J.; Knuechel, R.; Willecke, K.; Traub, O. Expression of Cx26, Cx32, Cx43 gap junction proteins in normal and neoplastic human tissue. Int. J. Cancer 51: 522-529; 1991.
26. 26. Yamasaki, H. Role of gap junctional intercellular communication in malignant cell transformation. In: Hertzberg, E. L.; Johnson, R. G., eds. Gap junctions: proceedings of the International Conference on Gap Junctions held at Pacific Grove, California, July 6-10, 1987. New York: Alan R. Liss, Inc.; 1988: pp. 449-465.
27. 27. Grossman, H. B.; Liebert, M.; Lee, I. W.; Lee, S. W. Decreased connexin expression and intercellular communication in human-bladder cancer cells. Cancer Res. 54:3062-3065; 1994.
28. 28. Mothersill, C.; Cusack, A.; Seymour, C. B.; Hennessy, T. P. Optimisation of conditions for the culture of human oesophageal mucosa. Cell Biol. Int. Rep. 13:625-633; 1989.
29. 29. Mothersill, C.; Harney, J.; Seymour, C.B. Induction of stable p53 oncoprotein and of c-myc overexpression in cultured normal human urothelium by radiation and N-nitrosodiethanolamine. Radiat. Res. 138:93-98; 1994.
30. 30. El-Fouly, M. H.; Trosko, J. E.; Chang, C. C. Scrape loading and dye transfer: a rapid and simple technique to study gap junctional intercellular communication. Exp. Cell Res. 168:422-430; 1987.
31. 31. Chomczynski, P.; Sacchi, N. Single-step method of RNA isolation by acid guanidinium thiocyanate-phenol-chloroform extraction. Anal. Biochem. 162:156-159; 1987.
32. 32. Puissant, C.; Houdebine, L. M. An improvement of the single step method of RNA isolation by acid guanidinium thiocyanate-phenol-chloroform extraction. Biotechniques 8:148-149; 1990.
33. 33. O' Connell, J. F.; Nesnow, S.; Slaga, T. J. Initiation, promotion and complete carcinogenesis by N-methyl-N′-nitro-N-nitrosoguanidine or ethylnitrosourea in the Sencar mouse skin tumourigenesis model. Cancer Lett. 37:301-310; 1987.
34. 34. Tiedink, H. G. M.; De Haan, L. H.; Jongen, W. M. F.; Koeman, J. H. In vitro testing and the carcinogenic potential of several nitrosated indole compounds. Cell Biol. Toxicol. 7:371-386; 1991.
35. 35. Cha, R. S.; Thilly, W. G.; Zarb, H. N-Nitroso-N-methyl-urea induced rat mammary tumours arise from cells with pre-existing oncogenic HrasI gene mutation. Proc. Natl. Acad. Sci. USA 91:3749-3753; 1994.
36. 36. Trosko, J. E.; Chang, C. C.; Madhukar, B. V.; Oh, S. Y.; Bombick, D.; El-Fouly, M. H. Modulation of gap junction intercellular communication by tumour promoting chemicals, oncogenes and growth factors during carcinogenesis. In: Hertzberg, E. L.; Johnson, R. G., eds. Gap junctions: Proceedings of the International Conference of Gap Junctions held at Pacific Grove, California, July 6-10, 1987. New York: Alan R. Liss, Inc.; 1988:pp. 435-448.
37. 37. Holder, J. W.; Elmore, E.; Barrett, J. C. Gap junction function and cancer. Cancer Res. 53:3475-3485; 1993.
38. 38. Cheng, S. J.; Sala, M.; Li, M. H.; Courtois, I.; Chouroulinkov, I. Promoting effect of Roussin's red identified in pickled vegetables from Linxian China. Carcinogenesis2:313-319; 1981.
39. 39. Althausen, A. F.; Prout, G. R.; Daly, J. J. Non-invasive papillary carcinoma of the bladder associated with carcinoma in situ. J. Urol. 116:575-580; 1976.