The prospects for xenotransplantation

QJM: An International Journal of Medicine

Volumn 89, Issue 12, 1996, Pages 885-891

  Warrens, A N ^a   Dorling, A ^a   Lechler, R I ^a  

^a HAMMERSMITH HOSPITAL   (United Kingdom)

Author keywords

[No Author keywords available]

Indexed keywords

ANTIBODY; COMPLEMENT;

CELLULAR IMMUNITY; GENETICS; GRAFT REJECTION; HEART FAILURE; HISTOCOMPATIBILITY; HUMAN; LIVER FAILURE; ORGAN DONOR; PRIORITY JOURNAL; RESPIRATORY FAILURE; SHORT SURVEY; SWINE; XENOTRANSPLANTATION; ZOONOSIS;

EID: 0030477234     PISSN: 00335622     EISSN: None     Source Type: Journal    
DOI: 10.1093/qjmed/89.12.885     Document Type: Short Survey

References (28)

1. Valderrábano F, Jones E, Mallick N. Report on the management of renal failure in Europe, XXIV, 1993. Nephrol Dial Transplant 1995; 10 (suppl 5):1-25.
2. Cokal R. Quality of life in patients undergoing renal replacement therapy. Kidney Int 1993; 40 (suppl):S23-7.
3. Aranzabal J, Pérdigo L, Mijares J, Villar F. Renal transplantation costs: an economic analysis and comparison with dialysis costs. Transplant Proc 1991; 23:2574.
4. Karlberg I. Cost analysis of alternative treatments in endstage renal disease. Transplant Proc 1992; 24:335.
5. Report of the British Transplantation Society Working Party on Organ Donation. 1995.
6. United Kingdom Transplant Support Service Authority (UKTSSA). Renal Transplant Audit. 1995.
7. Dorling A, Lechler R. Prospects for xenografting. Curr Opin Immunol 1994; 6:765.
8. Sandrin M, Vaughan H, Dabkowski P, McKenzie I. Anti-pig IgM antibodies in human serum react predominantly with gal(α1-3)gal epitopes. Proc Natl Acad Sci USA 1993; 90:11391-5.
9. Inverardi L, Samaja M, Motterini R, Mangili F, Bender J, Pardi R. Early recognition of a discordant xenogeneic organ by circulating lymphocytes. J Immunol 1992; 149:1416-23.
10. Fischel R, Platt J, Matas A, Perry E, Dalmasso A, Muriel C, Najarian J, Bach F, Bolman R. Prolonged survival of a discordant cardiac xenograft in a rhesus monkey. Transplant Proc 1991; 23:589-90.
11. Hasan R, Van den Bogaerde J, Forty J, Wright L, Wallwork J, White D. Xenograft adaptation is dependent on the presence of antispecies antibody, not prolonged residence in the recipient. Transplant Proc 1992; 24:531-2.
12. Sandrin M, Fodor W, Mouhtouris E, Osman N, Cohney S, Rollins S, Cuilmette E, Setter E, Squinto S, McKenzie I. Enzymatic remodelling of the carbohydrate surface of a xenogeneic cell substantially reduces human antibody binding and complement-mediated cytolysis. Nature Med 1995; 1:1261-7.
13. Leventhal J, Dalmasso A, Cranwell J, Platt J, Manivel C, Bolman R, Matas A. Prolongation of cardiac xenograft survival by depletion of complement. Transplantation 1993; 55:857-66.
14. Bach F, Robson S, Hinkler H, Ferran C, Stuhmeier K, Wrighton C, Hancock W. Barriers to xenotransplantation. Nature Medicine 1995; 1:869-73.
15. McCurry K, Kooyman D, Alvarado C, Cotterell A, Martin M, Logan J, Platt J. Human complement regulatory proteins protect swine-to-primate cardiac xenografts from humoral injury. Nature Med 1995; 1:423-7.
16. Robson S, Young V, Cook N, Metternich R, Kasper-Konig W, Lesnikoski B, Pierson R, III, Hancock W, Candinas D, White D, Bach F. Thrombin inhibition in an ex vivo model of porcine heart xenograft hyperacute rejection. Transplantation 1996; 61:862-8.
17. Warrens A, Lombardi G, Lechler R. Presentation and recognition of alloantigens. In: Thomson A, Catto G, eds. Immunology of Renal Transplantation. London, Edward Arnold, 1993:27.
18. Murray A, Khodadoust M, Pober J, Bothwell A. Porcine aortic endothelial cells activate human T cells: direct presentation of MHC antigens and costimulation by ligands for human CD2 and CD28. Immunity 1994; 1:57-63.
19. Dorling A, Binns R, Lechler R. Cellular xenoresponses: Although vigorous, direct human T cell anti-pig primary Xenoresponses are significantly weaker than equivalent alloresponses. Xenotransplantation 1996; 3:149-57.
20. Dorling A, Lombardi G, Bins R, Lechler R. Detection of primary direct and indirect human anti-porcine T cell responses using a porcine dendritic cell population. Eur J Immunol 1996; 26:1378-87.
21. Kirk A, Li R, Kirsch M, Abernethy K, Doyle C, Bollinger R. The human antiporcine cellular repertoire. Transplantation 1993; 55:924-31.
22. Sachs D, Sykes M, Greenstein J, Cosimi A. Tolerance and xenograft survival. Nature Med 1995; 1:969.
23. Elsen M, Scares M, Latinne D, Cornet A, Bazin H. Role of associated natural killer and CD4+, CD8+ cells in the cellular rejection of a discordant xenograft. Transplant Proc 1993; 25:447-9.
24. Blakely M, Van der Werf W, Berndt M, Dalmasso A, Bach F, Hancock W. Activation of intragraft endothelial and mononuclear cells during discordant xenograft rejection. Transplantation 1994; 58:1059-66.
25. Allan J. Xenotransplantation at a crossroads: prevention versus progress. Nature Med 1996; 2:18-21.
26. Report of the Working Party on Xenografts, Nuffield Council on Bioethics. Animal-to-human transplants: the ethics of Xenotransplantation. 1996.
27. Stoye J, Coffin J. The dangers of Xenotransplantation. Nature Medicine 1995; 1:1100.
28. Holmes G, Chapman L, Stewart J, Straus S, Hilliard J, Davenport D. Guidelines for the prevention and treatment of B-virus infections in exposed persons. Clin Infect Dis 1995; 20:421-39.