Genetic regulation and therapeutic modulation of apoptosis in human malignant glioma

Cellular Physiology and Biochemistry

Volumn 6, Issue 6, 1996, Pages 376-380

  Weller, Michael ^a  

^a UNIVERSITY HOSPITAL TÜBINGEN   (Germany)

Author keywords

Apoptosis; Bcl 2; CD95(Fas APO l); Malignant glioma; p53

Indexed keywords

FAS ANTIGEN; PROTEIN P53; SOMATOMEDIN C;

APOPTOSIS; CARCINOGENESIS; GLIOMA; HUMAN; IMMUNE RESPONSE; MUTATION; PRIORITY JOURNAL; PROTEIN EXPRESSION; REVIEW; SIGNAL TRANSDUCTION;

EID: 0030477085     PISSN: 10158987     EISSN: 14219778     Source Type: Journal    
DOI: 10.1159/000154840     Document Type: Article

References (29)

1. Kerr JFR. Winterford CM. Harmon BV: Apoptosis: Its significance in cancer and cancer therapy. Cancer 1994;73:2013-2026.
2. HolTmann B, Licberman DA: Molecular controls of apoptosis: Differ-entiation/growth arrest primary response genes, proto-oncogenes, and tumor suppressor genes as positive and negative regulators. Oncogene 1994:9:1807-1812.
3. Ellison DW. Stcart PV. Gatter KC. Weller RO: Apoptosis in cerebral astrocytic tumours and its relationship to expression of the 6D-2 and p53 proteins. Neuropathol Appl Neuro-biol 1995:21:352-361.
4. Nakagawa S. Shiraishi T. Kihara SI. Tabuchi K: Detection of DNA strand breaks associated with apoptosis in human brain tumors. Virchows Arch 1995:427:175-179.
5. Kordek R. Hironishi M. Liberski PP. Yanagihara R. Gajdusek DC: Apoptosis in glial tumors as determined by in situ nonradioactive labeling of DNA breaks. Acta Neuropathol 1996:91:112-116.
6. Iwaki T. Miyazono M, Hitotsumal-su T. Tateishi J: An immunohistochemical study of tissue transglutaminase in gliomas with reference to their cell dying processes. Am .1 Pathol 1994:145:776-781.
7. Weller M. Malipiero U, Aguzzi A. Reed JC. Fontana A: Protooncogene bcl-2 gene transfer abrogates Fas/ APO-I antibody-mediated apoptosis of human malignant glioma cells and confers resistance to chemotherapeutic drugs and therapeutic irradiation. J Clin Invest 1995;95: 2633-2643.
8. Weller M. Fontana A: The failure of current immunotherapy for malignant glioma: Tumor-derived TGF-p, T cell apoptosis, and the immune privilege of the brain. Brain Res Rev 1995:21:128-151.
9. Weller M. Constam DB. Malipiero U, Fontana A: Transforming growth factor-Pj induces apoptosis of murine T cell clones wihout down-regu-lating 6D-2 mRNA expression. Eur J Immunol 1994;24:1293-1300.
10. Bogler O. Huang HJS. Kleihues P. Cavenee WK: The p53 gene and its role in brain tumors. Glia 1995:15: 308-327.
11. Eeles RA: Germlinc mutations in the 77*53 gene. Cancer Surv 1995; 25:101-124.
12. Gomcz-Manzano C. Fueyo J, Kvrit-sis AP. Stock PA. Roth JA. McDonnell TJ, Stccj KD. Lewin VA, Yung WKA: Adenovirus-mediated transfer of the p53 gene produces rapid and generalized death of human glioma cells via apoptosis. Cancer Res 1996:56:694-699.
13. Alderson EM. Castlebcrg RL, Harsh GR IV, Louis DN, Henson JW: Human gliomas with wild-type p53 express bcl-2. Cancer Res 1995:55:99-101.
14. Nakasu S. Nakasu Y. Nioka H. Na-kajima M. Handa J: bcl-2 protein expression in tumors of the central nervous system. Actaa Neuropathol 1994:88:520-526.
15. Krishna M. Smith TW. Recht LD: Expression of bcl-2 in reactive and neoplastic astrocytes: Lack of correlation with presence or degree of malignancy. J Neurosurg 1995:83: 1017-1022.
16. Resnicoff M. Abraham D. Yutana-wiboonchai W. Rotman HL. Kajstu-ra J. Rubin R. Zoltick P. Baserga R: The insulin-like growth factor I receptor protects tumor cells from apoptosis in vivo. Cancer Res 1995; 55:2463-2469.
17. Trojan J. Blosscy BK, Johnson TR. Rudin SD, Tykocinski M. Man J. Ban J: Loss of tumorigenicity of rat glioblastoma directed by episome-based antisense cDNA transcription of insulin-like growth factor 1. Proc Natl Acad Sci USA 1992:89:4874-4878.
18. Trojan J. Johnson TR. Rudin SD. ilan J. Tykocinski ML. Ilan J: Treatment and prevention of rat glioblastoma by immunogenic C6 cells expressing antisense insulin-like growth factor I RNA. Science 1993; 259:94-97.
19. Resnicotlf M. Sell C. Rubini M, Coppola D. Ambrose D. Baserga R. Rubin R: Rat glioblastoma cells expressing an antisense RNA to the insulin-like growth factor-1 (IGF-1) receptor arc nontumorigenicand induce regression of wild-tvpe tumors. Cancer Res 1994:54:2218-2222.
20. Roth W. Fontana A. Trepel M. Reed JC. Dichgans J. Weller M: Synergistic cytotoxicity of malignant glioma cells induced by CD95 ligand and cytotoxic drugs (abstract). J Neuro-Oncol 1996:30:32.
21. Reed JC: BC1-2: Prevention of apoptosis as a mechanism of drug resistance. Hematol/Oncol Clin North Am 1995:9:451-473.
22. Couldwell WT. Hinton DR. He S. Chen TC, Scbat L, Weiss MH. Law RE: Protein kinase C inhibitors induce apoptosis in human malignant glioma cell lines. FEBS Lett 1994; 345:43-46.
23. Weller M. Trepel M. Schabet M. Krajewski S, Reed JC: Hypericin-based phototoxic proapoptotic pharmacotherapy of human malignant glioma (abstract). J Ncuro-Oncol 1996:30:48.
24. Jones KD. Couldwell WT. Hinton DR. Su Y. He S. Anker L. Law RE: Lovastatin induces growth inhibition and apoptosis in human malignant glioma cells. Biochem Biophys Res Commun 1994:205:1681-1687.
25. Nagata S. Golstein P: The Fas death factor. Science 1995:267:1449-1456.
26. Weller M. Frei K, Groscurth P, Krammer PH, Yonckawa Y, Fontana A: Anti-Fas/APO-l antibody-mediated apoptosis of cultured human malignant glioma cells: Induction and modulation of sensitivity by cytokines. J Clin Invest 1994;94:954-964.
27. Tachibana O. Nakazawa H. Lampe J. Watanabc K. Kleihues P. Ohgaki H: Expression of Fas/APO-l during the progression of astrocytomas. Cancer Res 1995;5528-5530.
28. Weller M. Malipiero U. Rensing-Ehl A, Barr PJ, Fontana A: Fas/APO-l gene transfer for human malignant glioma. Cancer Res 1995:55:2936-2944.
29. Ogasawara J. Watanabe-Fukunaga R, Adachi M. Matsuzawa A. Kasu-gai T. Kitamura Y. Itoh N, Suda T. Nagata S: Lethal effect of the anli-Fas antibody in mice. Nature 1993; 364:806-809.