Cytotoxic effect of Ca++ released from intracellular stores during cerebral energy deprivation

Neurological Research

Volumn 18, Issue 6, 1996, Pages 499-504

  Grøndahl, Tor Ø ^a   Langmoen, Iver A ^a  

^a OSLO UNIVERSITY HOSPITAL   (Norway)

Author keywords

Calcium; Cerebral ischemia anoxia; Endoplasmatic reticulum; Hippocampus; Rat; Thapsigargin

Indexed keywords

ANIMAL TISSUE; ARTICLE; BRAIN HYPOXIA; BRAIN ISCHEMIA; CALCIUM CELL LEVEL; CALCIUM TRANSPORT; CYTOTOXICITY; ENDOPLASMIC RETICULUM; HIPPOCAMPUS; NONHUMAN; PATHOPHYSIOLOGY; RAT;

EID: 0030475873     PISSN: 01616412     EISSN: None     Source Type: Journal    
DOI: 10.1080/01616412.1996.11740461     Document Type: Article

References (34)

1. Ferris CD, Snyder SH. Inositol 1,4,5-trisphosphate-activated calcium channels. Annu Rev Physiol 1992; 54: 469-488
2. Siesjö BK, Bengtsson F, . Calcium fluxes, calcium antagonists, and calcium-related pathology in brain ischemia, hypoglycemia, and spreading depression: A unifying hypothesis. J Cereb Blood Flow Metab 1989; 9: 127-140
3. Hansen AJ, Zeuthen T. Extracellular ion concentrations in rat brain cortex. Acta Physiol Scand 1981; 113: 437-445
4. +] in the hippocampus during recovery from short-term, transient ischemia. J Cereb Blood Flow Metab 1992; 12 759-772
5. 2+] in hypoxia and ischemia in rat brain in vivo. J Gen Physiol 1990; 95: 837-866
6. Kass IS, Lipton P. Mechanisms involved in irreversible anoxic damage to the in vitro rat hippocampal slice. J Physiol 1982; 332: 459-472
7. Kass IS, Lipton P. Calcium and long-term transmission damage following anoxia in dentate gyrus and CA 1 regions of the rat hippocampal slice. J Physiol 1986; 378: 313-334
8. Harvey J, Collingridge GL. Thapsigargin blocks the induction of long-term potentiation in rat hippocampal slices. Neurosci Left 1992; 139: 197-200
9. 2+-ATPase. Proc Natl Acad Sci USA 1990; 87: 2466-2470
10. Lee KM, Toscas K, Villereal ML. Inhibition of bradykinin- and thapsigargin-induced entry by tyrosine kinase inhibitors. J Biol Chem 1993; 268: 9945-9948
11. 2+ ATPase inhibitors 2,5 di-(t-butyl)-1,4-benzohydraquinone and thapsigargin in bovine adrenal chromaffin cells. Biochem J 1992; 288: 457-463
12. Rotnes JS, Iversen JG. Thapsigargin reveals evidence for fMLP-insensitive calcium pools in human leukocytes. Cell Calcium 1992; 13: 487-500
13. Verma A, Hirsch DJ, Hanley MR, Thastrup O, Christensen SB, Snyder SH. Inositol trisphosphate and thapsigargin discriminate endoplasmic reticulum stores of calcium in rat brain. Biochem Biophys Res Commun 1990; 172: 811-816
14. Ghosh TK, Bian JH, Short AD, Rybak SL, Gill DL Persistent intracellular calcium pool depletion by thapsigargin and its influence on cell growth. J Biol Chem 1991; 266: 24690-24697
15. Skrede KK, Westgård RH. The transverse hippocampal slice: A well-defined cortical structure maintained in vitro. Brain Res 1971; 35: 589-593
16. Langmoen IA, Andersen P. The hippcocampal slice in vitro. A description of the technique and some examples of the opportunities it offers. In: Kerkut GA, Wheat HV, eds. Electrophysiology of Isolated Mammalian CNS Preparations, London: Academic Press; 1981: pp.51-105
17. Haas HL, Schaerer B, Vosmansky M. A simple perfusion chamber for the study of nervous tissue slices in vitro. J Neuosci Met 1979; 1: 323-325
18. Andersen P, Bluss TVP, Skrede KK. Unit analysis of hippocampal population spikes. Exp Brain Res 1971; 13: 208-221
19. 2+ prevents neurotoxicity. Brain Res 1992; 598: 196-202
20. Harris RJ, Symon L, Branston NM, Bayhan M. Changes in extracellular calcium activity in cerebral ischemia. J Cereb Blood Flow Metab 1981; 1: 203-209
21. Regehr WG, Connor JA., Tank DW. Optical imaging of calcium accumulation in pyramidal cells during synaptic activation. Nature 1989; 341: 533-536
22. 2+ changes in hippocampal neurons. Neuron 1991; 6. 901-905
23. Choi DW. Glutamate neurotoxicity in cortical cell culture is calcium dependent. Neurosci Lett 1985; 58: 293-297
24. 2+ solutions. J Neurosci 1986; 6: 3144-3151
25. Roberts ELJ, Sick TJ. Calcium-sensitive recovery of extracellular potassium and synaptic transmission in rat hippocampal slices exposed to brief anoxia. Brain Res 1988; 456: 113-119
26. Lipton P, Lobner D. Mechanisms of intracellular calcium accumulation in the CAT region of rat hippocampus during anoxia in vitro. Stoke 1990; 21:11160-64
27. Thastrup O, Linnebjerg H, Bjerrum PJ, Knudsen JB, Christensen SB. The inflammatory and tumor-promoting sesquiterpene lactone, thapsigargin, activates platelets by selective mobilization of calcium as shown by protein phosphorylations. Biochim Biophys Acta 1987, 927: 65-73
28. 2+ without generation of inositol phosphates in NG115-401L neuronal cells. Biochem J 1988; 253: 81-86
29. Takemura H, Huigghes AR, Thastrup O, Putney JJ. Activation of calcium entry by the tumor promoter thapsigargin in parotid acinar cells. Evidence that an intracellular calcium pool and not an inositol phosphate regulates calcium fluxes at the plasma membrane. J Biol Chem 1989; 264: 12266-12271
30. Lynch G, Larson J, Kelso S, Barrionuevo G, Schottler F. Intracellular injections of EGTA biock induction of hippocampal long-term potentiation. Nature 1983; 305: 719-721
31. 2+ in mammalian neurons. Trends Pharmacol Sci 1990; 11: 254-260
32. Schoepp D, Bockaert J, Sladeczek F. Pharmacological and functional characteristics of metabotropic excitatory amino acid receptors. Trends Pharmacol Sci 1990; 11: 508-515
33. Opitz T, Reymann KG. Blockade of metabotropic glutamate receptors protects rat CA1 neurons from hypoxic injury. Neuroreport 1991; 2: 455-457
34. Frandsen A, Schousboe A. Mobilization of dantrolene-sensitive intracellular calcium pools is involved in the cytotoxicity induced by quisqualate and N-methyl-D-aspartate but not by 2-amino-3-(3-hydroxy-5-methylisoxazot-4-yl) propionate and kainate in cultured cerebral cortical neurons. Proc Natl Acad Sci USA 1992; 89: 2590-2594