Involvement of transforming growth factor α (TGFα) and epidermal growth factor receptor (EGFR) in sex hormone-induced prostatic dysplasia and the growth of an androgen-independent transplantable carcinoma of the prostate

Carcinogenesis

Volumn 17, Issue 12, 1996, Pages 2571-2579

  Kaplan, Paula J ^a   Leav, Irwin ^a   Greenwood, Jessica ^a   Kwan, Paul W L ^a   Ho, Shuk Mei ^a  

^a TUFTS UNIVERSITY   (United States)

Author keywords

[No Author keywords available]

Indexed keywords

EPIDERMAL GROWTH FACTOR; EPIDERMAL GROWTH FACTOR RECEPTOR; TRANSFORMING GROWTH FACTOR ALPHA;

ANIMAL EXPERIMENT; ARTICLE; CONTROLLED STUDY; DYSPLASIA; IMMUNOHISTOCHEMISTRY; MALE; NONHUMAN; NORTHERN BLOTTING; PRIORITY JOURNAL; PROSTATE; PROSTATE CARCINOMA; RADIOASSAY; RADIOIMMUNOASSAY; RAT;

ANIMALS; GONADAL STEROID HORMONES; MALE; PRECANCEROUS CONDITIONS; PROSTATIC NEOPLASMS; RATS; RECEPTOR, EPIDERMAL GROWTH FACTOR; RNA, MESSENGER; TRANSFORMING GROWTH FACTOR ALPHA;

EID: 0030475514     PISSN: 01433334     EISSN: None     Source Type: Journal    
DOI: 10.1093/carcin/17.12.2571     Document Type: Article

References (57)

1. Steiner, M.S. (1995) Review of peptide growth factors in benign prostatic hyperplasia and urological malignancy. J. Urol., 153, 1085-1096.
2. Habib, F.K. (1990) Peptide growth factors: A new frontier in prostate cancer. EORTC Genitourinary Group monograph 7: Prostate cancer and testicular cancer, Wiley-Liss, New York, pp. 107-115.
3. Burgess, A.W. (1989) Epidermal growth factor and transforming growth factor α. Br. Med. Bull., 45, 401-424.
4. Davis, C.G. (1990) The many faces of epidermal growth factor repeats. New Biol., 2, 410-419.
5. Carpenter, G. (1993) EGF: New tricks for an old growth factor. Current Opin. Cell Biol., 5, 261-264.
6. Maygarden, S.J., Strom, S. and Ware, J.L. (1992) Localization of epidermal growth factor receptor by immunohistochemical methods in human prostatic carcinoma, prostatic intraepithelial neoplasia, and benign hyperplasia. Arch. Pathol. Lab. Med., 116, 269-274.
7. Maddy, S.Q., Chisholm, G.D., Hawkins, R.A. and Habib, F.K. (1987) Localization of epidermal growth factor receptors in the human prostate by biochemical and immunocytochemical methods. J. Endocrinol., 113, 147-153.
8. Ibrahim, G.K., Kerns, B.M., MacDonald, J.A., Ibrahim, S.N., Kinney, R.B., Humphrey, P.A. and Robertson, C.N. (1993) Differential immunoreactivity of epidermal growth factor receptor in benign, dysplastic and malignant prostatic tissues. J Urol., 149, 170-173.
9. Cohen, D.W., Simak, R., Fair, W.R., Melamed, J., Scher, H.I. and Cordon-Cardo, C. (1994) Expression of transforming growth factor-α and the epidermal growth factor receptor in human prostate tissues. J. Urol., 152, 2120-2124.
10. Davies, P. and Eaton, C.L. (1989) Binding of epidermal growth factor by human normal, hypertrophic and carcinomatous prostate. Prostate, 14, 123-132.
11. Mellon, K., Thompson, S., Charlton, R.G., Marsh, C., Robinson, M., Lane, D.P., Harris, A.L., Horne, C.H.W. and Neal, D.E. (1992) p53, c-erbB-2 and the epidermal growth factor receptor in the benign and malignant prostate. J. Urol., 147, 496-499.
12. Harper, M.E., Goddard, L., Glynne-Jones, E., Wilson, D.W., Price-Thomas, M., Peeling, W.B. and Griffiths, K. (1993) An immunocytochemical analysis of TGFα expression in benign and malignant prostatic tumors. Prostate, 23, 9-23.
13. Giri, D.K., Pal, R., Wadhwa, S.N. and Talwar, G.P. (1995) Immunohistochemical localization of transforming growth factor-α, epidermal growth factor receptor and C-erb B-2 protein in hyperplastic human prostates. Carcinogenesis, 16, 729-733.
14. Gregory, H., Willshire, I.R., Kavanagh, J.P., Blacklock, N.J., Chowdury, S. and Richards, R.C. (1986) Urogastrone-epidermal growth factor concentrations in prostatic fluid of normal individuals and patients with benign prostatic hypertrophy. Clin. Sci., 70, 359-363.
15. Habib, F.K. and Chisholm, G.D. (1991) The role of growth factors in the human prostate. Scand. J. Urol. Nephrol., 126(Suppl.), 53-58.
16. Elson, S.D., Browne, C.A. and Thorburn, G.D. (1984) Identification of epidermal growth factor-like activity in human male reproductive tissues and fluids. J. Clin. Endocrinol. Metab., 58, 589-594.
17. Traish, A.M. and Wotiz, H.H. (1987) Prostatic epidermal growth factor receptors and their regulation by androgens. Endocrinology, 121, 1461-1467.
18. Hiramatsu, M., Kashimata, M., Minami, N., Sato, A., Murayama, M. and Minami, N. (1988) Androgenic regulation of epidermal growth factor in the mouse ventral prostate. Biochem. Int., 17, 311-317.
19. St-Arnaud, R., Poyet, P., Walker, P. and Labrie, F. (1988) Androgens modulate epidermal growth factor receptor levels in the rat ventral prostate. Mol. Cell. Endocrinol., 56, 21-27.
20. Gupta, C. and Jaumotte, J. (1993) Epidermal growth factor binding in the developing male reproductive duct and its regulation by testosterone. Endocrinology, 133, 1778-1782.
21. Wu, H.H., Kawamata, H., Kawai, K., Lee, C. and Oyasu, R. (1993) Immunohistochemical localization of epidermal growth factor and transforming growth factor α in the male rat accessory sex organs. J. Urol., 150, 990-993.
22. Mroczkowski, B. and Reich, M. (1993) Identification of biologically active epidermal growth factor precursor in human fluids and secretions. Endocrinology, 132, 417-425.
23. Taylor, T. and Ramsdell, J. (1993) Transforming growth factor-α and its receptor are expressed in the epithelium of the rat prostate gland. Endocrinology, 133, 1306-1311.
24. Fiorelli, G., DeBellis, A., Longo, A., Natali, A., Constantini, A. and Serio, M. (1989) Epidermal growth factor receptors in human hyperplastic prostate tissue and their modulation by chronic treatment with a gonadotropin-releasing hormone analog. J. Clin. Endocrinol. Metab., 68, 740-743.
25. Serio, M. and Fiorelli, G. (1991) Dual control by androgens and peptide growth factors of prostatic growth in human benign prostatic hyperplasia. Mol. Cell. Endrocrinol., 78, C77-C81.
26. McKeehan, W.L., Adams, P.S. and Rosser, M.P. (1984) Direct mitogenic effects of insulin, epidermal growth factor, glucocorticoid, cholera toxin, unknown pituitary factors and possibly prolactin but not androgen on normal rat prostate epithelial cells in serum-free, primary cell culture. Cancer Res., 44, 1998-2010.
27. Nishi, N., Matuo, Y., Nakamoto, T. and Wada, F. (1988) Proliferation of epithelial cells derived from rat dorsolateral prostate in serum-free primary cell culture and their response to androgen. In Vitro Cell. Dev. Biol., 24, 778-786.
28. Sutkowski, D.M., Fong, C.J., Sensibar, J.A., Rademaker, A.W., Sherwood, E.R., Kozlowski, J.M. and Lee, C. (1992) Interaction of epidermal growth factor and transforming growth factor beta in human prostatic epithelial cells in culture. Prostate, 21, 133-143.
29. Schuurmans, A.L.G., Bolt, J., Veldscholte, J. and Mulder, E. (1991) Regulation of growth of LNCaP human prostate tumor cells by growth factors and steroid hormones. J. Steroid Biochem. Mol. Biol., 40, 193-197.
30. Morris, G.L. and Dodd, J.G. (1990) Epidermal growth factor receptor mRNA levels in human prostatic tumors and cell lines. J. Urol., 143, 1272-1274.
31. Tillotson, J.K. and Rose, D.P., (1991) Density-dependent regulation of epidermal growth factor receptor expression in DU145 human prostate cancer cells. Prostate, 19, 53-61.
32. Ching, K.Z., Ramsey, E., Pettigrew, N., D'Cunha, R., Jason, M. and Dodd, J.G. (1993) Expression of mRNA for epidermal growth factor, transforming growth factor-alpha and their receptor in human prostate tissue and cell lines. Mol. Cell. Biochem., 126, 151-158.
33. Hofer, D.R., Sherwood, E.R., Bromberg, W.D., Mendelsohn, L.C. and Kozlowski, J.M. (1991) Autonomous growth of androgen-independent human prostatic carcinoma cells: role of transforming growth factor α. Cancer Res., 51, 2780-2785.
34. Leav, I., Ho, S.-M., Ofner, P., Merk, F.B., Kwan, P.W.L. and Damassa, D. (1988) Biochemical alterations in sex hormone-induced hyperplasia and dysplasia of the dorsolateral prostates of Noble rats. J. Natl Cancer Inst., 80, 1045-1053.
35. Bostwick, D.G. (1995) High grade prostatic intraepithelial neoplasia: The most likely precursor of prostate cancer. Cancer, 75, 1823-1836.
36. Bosland, M.C., Ford, H. and Horton, L. (1995) Induction at high incidence of ductal prostate adenocarcinomas in Noble/Cr and Sprague-Dawley Hsd:SD rats treated with a combination of testosterone and estradiol 17β or diethylstilbestrol. Carcinogenesis, 16, 1311-1317.
37. Ho, S.-M., Leav, I., Damassa, D., Kwan, P.W.L., Merk, F.B. and Seto, H.S.K. (1988) Testosterone-mediated increase in 5α-dihydrotestosterone content, nuclear androgen receptor levels, and cell division in an androgen-independent prostate carcinoma of Noble rats. Cancer Res., 48, 609-614.
38. Noble, R.L. (1980) Development of androgen-stimulated transplants of Nb rat carcinoma of the dorsal prostate and their response to sex hormones and tamoxifen. Cancer Res., 40, 3551-3554.
39. Leav, I., Kwan, P.W.L., Merk, F.B., Chang, C. and Ho, S.-M. (1992) Immunohistochemical and in situ hybridization studies of androgen receptor expression in a transplantable androgen-independent prostatic carcinoma line (AIT) of Noble rats. Lab. Invest., 67, 788-795.
40. Chomczynski, P. and Sacchi, N. (1987) Single-step method of RNA isolation by acid guanidinium thiocyanate-phenol-chloroform extraction. Anal. Biochem., 162, 156-159.
41. Chomczynski, P. (1992) Solubilization in formamide protects RNA from degradation. Nucl. Acids Res., 20, 3791-3792.
42. Chomczynski, P. (1992) One-hour downward alkaline capillary transfer for blotting of DNA and RNA. Anal. Biochem., 201, 134-139.
43. Clements, J.A., Matheson, B.A., Wines, D.R., Brady, J.M., MacDonald, R.J. and Funder, J.W. (1988) Androgen dependence of specific kallikrein gene family members expressed in rat prostate. J. Biol. Chem., 263, 16132-16137.
44. Ausubel, F., Brent, R., Kingston, R., Moore, D., Seidman, J., Smith, J. and Struhl, K. (1988) Current protocols in molecular biology, John Wiley and Sons, New York.
45. Lingham, R.B., Stancel, G.M. and Loose-Mitchell, D. (1988) Estrogen regulation of epidermal growth factor receptor messenger ribonucleic acid. Mol. Endocrinol., 2, 230-235.
46. Lee, D.C. and Rose, T.M. (1985) Cloning and sequence analysis of a cDNA for rat transforming growth factor-α. Nature, 313, 489-491.
47. Dorow, D.S. and Simpson, R.J. (1988) Cloning and sequence analysis of a cDNA for rat epidermal growth factor. Nuc. Acids Res., 16, 9338.
48. Ilio, K.Y., Sensibar, J.A. and Lee, C. (1995) Effect of TGFβ1, TGFα, and EGF on cell proliferation and cell death in rat ventral prostatic epithelial cells in culture. J. Androl., 16, 482-490.
49. Gan, B.S., Hollenberg, M.D., MacCannell, K.L., Lederis, K., Winkler, M.E. and Derynck, R. (1987) Distinct vascular actions of epidermal growth factor-urogastrone and transforming growth factor-α. J. Pharmacol. Exp. Ther., 242, 331-337.
50. Ebner, R. and Derynck, R. (1991) Epidermal growth factor and transforming growth factor-α: differential intracellular routing and processing of ligand-receptor complexes. Cell Regulat., 2, 599-612.
51. Fish, E.M. and Molitoris, B.A. (1994) Alterations in epithelial polarity and the pathogenesis of disease states. New Engl. J. Med., 330, 1580-1588.
52. Leav, I., Merk, F.B., Kwan, P.W.L. and Ho, S.-M. (1989) Androgen-supported estrogen-enhanced epithelial proliferation in the prostates of intact Noble rats. Prostate, 15, 23-40.
53. Nelson, K.G., Takahashi, T., Lee, D.C., Luetteke, N.C., Bossert, N.L., Ross, K., Eitzman, B.E. and McLachlan, J.A. (1992) Transforming growth factor-α is a potential mediator of estrogen action in the mouse uterus. Endocrinology, 131, 1657-1664.
54. Bates, S.E., Davidson, N.E., Valverius, E.M., Freter, C.E., Dickson, R.B., Tam, J.P., Kudlow, J.E., Lippman, M.E. and Salomon, D.S. (1988) Expression of transforming growth factor α and its messenger ribonucleic acid in human breast cancer: its regulation by estrogen and its possible functional significance. Mol. Endocrinol., 2, 543-555.
55. Saeki, T., Cristiano, A., Lynch, M.J., Brattain, M., Kim, N., Normanno, N., Kenney, N., Ciardiello, F. and Salomon, D.S. (1991) Regulation of estrogen through the 5′-flanking region of the transforming growth factor α gene. Mol. Endocrinol., 5, 1955-1963.
56. Ho, S.-M. and Yu, M. (1993) Selective increase in type II estrogen-binding sites in the dysplastic dorsolateral prostates of Noble rats. Cancer Res., 53, 528-532.
57. Ho, S.-M. and Yu, M. (1995) Hormonal regulation of nuclear type II estrogen binding sites in the dorsolateral prostate of Noble rats. J. Steroid Biochem. Molec. Biol., 52, 233-238.