Behavioural pharmacology of α2-adrenoceptors

Journal of Psychopharmacology

Volumn 10, Issue SUPPL. 3, 1996, Pages 19-25

  Middleton, Hugh C ^a  

^a UNIVERSITY OF NOTTINGHAM   (United Kingdom)

Author keywords

Attention; Behaviour; Locus coeruleus; Noradrenaline; Somatic marker; 2 adrenoceptors

Indexed keywords

ALPHA 2 ADRENERGIC RECEPTOR; ALPHA ADRENERGIC RECEPTOR BLOCKING AGENT; ALPHA ADRENERGIC RECEPTOR STIMULATING AGENT;

ATTENTION; BEHAVIOR; CONFERENCE PAPER; ELECTROSTIMULATION; LOCUS CERULEUS; NORADRENERGIC SYSTEM; PHARMACOLOGY; PRIORITY JOURNAL;

EID: 0030475055     PISSN: 02698811     EISSN: None     Source Type: Journal    
DOI: None     Document Type: Conference Paper

References (91)

1. Acheson A, Zigmond M J, Stricker E M (1980) Compensatory increases in tyrosine bydroxyialse activity in rat brain after intraventricular injection of 6-hydroxydopamine. Science 207: 537-5 40
2. 2-Adrenoceptormediated hyperpolarization of locus coeruleus neurons: intracellular studies in vivo. Science 215:1394-1396
3. Arnsten AFT, Contant TA (1992) Alpha-2 adrenergic agonists decrease distractibility in aged monkeys performing the delayed response task. Psychopharmacology 108:159-169
4. 2-Adrenergic mechanisms in prefrontal cortex associated with cognitive decline in aged nonhuman primates. Science 230:1273-1276
5. Arnsten AFT, Goldman-Rakic PS (1990) Analysis of alpha-2 adrenergic agonist effects on the delayed nonmatch-to-sample performance of aged rhesus monkeys. Neurobiol Aging 11: 583-590
6. Aston-Jones G, Chiang C, Alexinsky T (1991) Discharge of noradrenergic neurons in behaving rats and monkeys suggests a role in vigilance. Prog Brain Res 88: 501-519
7. Aston-Jones G, Rajkowski J, Kubiak P, Alexinsky T (1994) Locus coeruleus neurons are selectively activated by attended cues in a vigilance task. J Neurosci 14: 4467-4480
8. Aston-Jones G, Ennis M, Pieribone VA, Nickell W T, Shipley M T (1986) The brain nucleus locus coeruleus: restricted afferent control of a broad efferent network. Science 234: 734-737
9. Bartus RT, Dean RL (1979) Recent memory in aged non-human primates: hypersensitivity to visual interference during retention. Exp Aging Res 5: 385-400
10. Bowes M P, Peters R H, Kernan W J, Hopper D L (1992) Effects of yohimbine and idazoxan on motor behaviours in male rats. Pharmacol Biochem Behav 41: 707-713
11. 3H] idazoxan in rat brain, J Pharmacol Exp Therap 241: 1092-1098
12. 3H] idazoxan in rat brain. J Pharmacol Exp Therap 241: 1079-1091
13. Cederbaum J M, Aghajanian G K (1976) Noradrenergic neurons of the locus coeruleus: Inhibition by epinephrine and activation by the alpha-antagonist piperoxane. Brain Res 112: 413-419
14. Charney D S, Bremner J D, Redmond D E Jr (1995) Noradrenergic neural substrates for anxiety and fear. In Bloom F E, Kupfer D J (eds) Psychopharmacology: the fourth generation of progress. Raven Press, New York, pp. 387-395
15. Charney D S, Woods S W, Krystal J H, Nagy L M, Heninger G R (1992) Noradrenergic dysregulation in panic disorder: the effects of intravenous yonimbine and clonidine in panic disorder patients. Acta Psychiatr Scand 86: 273-282
16. Clark C R, Geffen G M, Geffen L B (1989) Catecholamines and the covert orientation of attention in humans. Neuropsychologia 27: 131-139
17. Clark D M, Ehlers A (1993) Empirical status of the cognitive theory and treatment of panic disorder. Appl Prevent Psychol 2: 151-159
18. Cole B J, Robbins TW (1987) Dissociable effects of lesions to the dorsal or ventral noradrenergic bundle on acquisition, performance and extinction of aversive conditioning. Behaviour Neurosci 101: 478-488
19. Cole B J, Robbins T W (1992) Forebrain norepinephrine: role in controlled information processing in the rat. Neuropsychopharmacology 7: 129-142
20. Cole B J, Robbins T W, Everitt B J (1988) Lesions of the dorsal noradrenergic bundle simultaneously enhance and reduce responsitivity to novelty in a food preference test. Brain Res Rev 13: 325-349
21. 2-noradrenergic system. Effects on cognition. Drugs Aging 5:116-126
22. Coull J T, Middleton H C, Robbins T W, Sahakian B J (1995a) Clonidine and diazepam have differential effects on tests of memory and learning. Psychopharmacology 120: 322-332
23. Coull J T, Middleton H C, Robbins T W, Sahakian B J (1995b) Contrasting effects of donidine and diazepam on tests of working memory and planning. Psychopharmacology 120: 311-321
24. Coull J T, Sahakian B J, Middleton H C, Young A H, Park S B, McShane R H, Cowen P J, Robbins TW (1995c( Differential effects of donidine, haloperidol, diazepam and tryptophan depletion on focused attention and attentional search. Psychopharmacology 121: 222-230
25. Craig A D (1992) Spinal and trigeminal lamina 1 input to the locus coeruleus anterogradely labeled with Phaseolus vulgaris leueoagglutinin (PHA-L) in the cat and monkey. Brain Res 584: 325-328
26. 2-adrenoeeptor agonists, medetomide, donidine and UK 14,304 on extraneuronal levels of noradrenaline in the rat frontal cortex: evaluation using in vivo microdialysis and synaptosomal uptake studies. Br J Pharmacol 114: 1717-1723
27. Damasio A R (1995) Descartes' error. Emotion, reason and the human brain. Picador Press, London
28. Davis M (1992) A neural systems approach to the study of the amygdala, fear and anxiety. In Elliott J M, Heal D J, Marsden C A (eds) Experimental approaches to anxiety and depression. John Wiley, Chichester, pp. 45-71
29. Deakin J F W, Graeff F G (1991) 5-HT and mechanisms of defence. J Psychopharmacol 5: 305-315
30. Delbarre B, Schmitt H (1973) A further attempt to characterize sedative receptors activated by donidine in chicks and mice. Eur J Pharmaeol 22:355-359
31. 2B-adrenoceptor subtypes in postmortem human brain. J Neurochem 58: 1555-1560
32. 2-adrenoceptor antagonists differentially influence locomotor and stereotyped behaviour induced by d-amphetamine and apomorphine in rat. Psychopharmacology 96: 521-527
33. 1-adrenoceptor binding in dorsal noradrenergic bundle-lesioned rats. Brain Res 420: 152-156
34. 2-Adrenoceptors mediate clonidine-induced sedation in the rat. Br J Pharmacol 133: 133-138
35. Dunn L T, Everitt B J (1987) The effects of lesions to the noradrenergic projections from the locus ceruleus and lateral tegmental groups on conditioned taste aversion in the rat. Behaviour Neurosci 101: 409-422
36. Evenden J L, Marston H M, Jones G H, Giardini V, Lenard L, Everitt B J, Robbins T W (1989) Effects of excitotoxic lesions of the substantia innominata, ventral and dorsal globus pallidus on visual discrimination acquisition, performance and reversal in the rat. Behaviour Brain Res 32: 129-149
37. Everitt B J, Robbins T W, Selden N R W (1990) Functions of the locus coeruleus noradrenergic system: a neurobiological and behavioural synthesis. In Marsden C A, Heal D J (eds) Pharmacology of noradrenaline in the central nervous system. Oxford University Press, Oxford, pp. 349-378
38. Eysenck M W (1982) Attention and arousal. Springer, Berlin
39. File S E (1987) The contribution of behavioural studies to the neuropharmacology of anxiety. Neuropharmacology 26: 877-886
40. Foote S L, Morrison J H (1987) Extrathalamic modulation of neocortical function. Ann Rev Neurosci 10: 67-95
41. Foote S L, Bloom F E, Aston-Jones G (1983) The nucleus locus coeruleus: new evidence for anatomical and physiological specificity. Physiol Rev 63: 844-914
42. Frith C D, Dowdy J, Ferner I N, CrowT J (1985) Selective impairment of paired associate learning after administration of centrallyacting adrenergic agonist (clonidine). Psychophannacology 87: 490-493
43. Haefely W (1992) The role of GABA in anxiolytic/antidepressant drug action. In Elliott J M, Heal D J, Marsden C A (eds) Experimental approaches to anxiety and depression. John Wiley, Chichester, pp. 151-168
44. Handley S L, Mithani S (1984) Effects of alpha-adrenoceptors agonists and antagonists in a maze-exploration model of "fear"-motivated behaviour. Naunyn-Schmiedeberg's Arch Pharmacol 327: 1-5
45. Harley C, Milway J S, LaChaille J-C (1989) Locus coeruleus potentiation of dentate gyrus responses: evidence for two systems. Brain Res Bull 22: 643-650
46. 2-adrenoceptors in the brain. Europ J Pharmacol 170: 19-28
47. Hopkins WF, Johnston D (1985) Electrophysiology of human selective attention. Trends Neurosci 8: 400-405
48. Johnston A L, Koening-Berard E, Cooper TA, File S E (1988) A comparison of the effects of clonidine, rilmenidine and guanfacine in the holeboard and elevated plus-maze. Drug Dev Res 15: 405-414
49. Jouvet M, Delorme F (1965) Locus coeruleus et sommeil paradoxal. C R Séanc Soc Biol 159: 895-899
50. Kaitin K I, Bliwise D L, Gleason C, Nino-Murcia G, Dement W C, Libet B (1986) Sleep disturbance produced by electrical stimulation of the locus coeruleus in a human subject. Biol Psychiatr 27: 710-716
51. Koob G F, Thatcher-Britton K, Britton D R, Roberts D C S (1984) Destruction of the locus coeruleus or the dorsal NE bundle does not alter the release of punished responding by ethanol and chlordiazepoxide. Physiol Behav 33: 479-485
52. Langer S Z (1974) Presynaptic regulation of catecholamine release. Biochem Pharmacol 23: 1793-1800
53. Langlais P J, Connor D J, Thal L (1993) Comparison of the effects of single and combined lesions of the nucleus basalis magnocellularis and dorsal noradrenergic bundle on learning and memory in the rat. Behav Brain Res 54: 81-90
54. Madison DV, Nicholl RA (1982) Noradrenaline blocks accommodation of pyramidal cell discharge in the hippocampus. J Neurophysiol 59: 667-687
55. Mason S T, Iversen S D (1979) Theories of dorsal bundle extinction effect. Brain Res Rev 1: 107-137
56. McCormick DA, Prince DA (1988) Noradrenergic modulation of firing pattern in guinea pig and cat thalamic neurons, in vitro. J Neurophysiol 59: 978-996
57. McCormick D A, Wang Z (1988) Serotonin and noradrenaline excite GABAergic neurones of the guinea-pig and cat nucleus reticularis thalami. J Physiol 442: 235-255
58. 2-adrenoceptors in the central nervous system. J Physiol Pharmacol 46: 241-258
59. MacKinnon A C, Spedding M, Brown C M (1994) Alpha-2-adrenoceptors: more subtypes but fewer functional differences. Trend Pharmacol Sci 15: 119-123
60. McMahon S B, Wall P D (1985) Electrophysiological mapping of brain stem projections of spinal cord lamina 1 cells in the rat. Brain Res 333: 19-26
61. 3H]UK 14304. J Neurochem 52: 1210-1217
62. Middleton H C (1996) Non-random associations between fears, beliefs and behaviours amongst panic patients. Anxiety, in press
63. Mochetti I, De Bernardi M A, Szekely A M, Alho H, Brooker G, Costa E (1989) Regulation of nerve growth factor biosynthesis by β-adrenergic receptor activation in astrcytoma cells: a potential role of c-Fos protein. Proc Nat Acad Sci, USA 86: 3891-3895
64. Morgan J I, CurranT (1991) Stimulus-transcription coupling in the nervous system. Ann Rev Neurosci 14: 421-452
65. Moruzzi G, Magoun H W (1949) Brain stem reticular formation and activation of the E E G. Electroencephalogr Clin Neurophysiol 1: 455-473
66. Nestler E J, Greengard P (1994) Protein phosphorylation and the regulation of neuronal function. In Siegel G, Agranoff B, Albers R W, Molinoff P (eds) Basic neurochemistry, 5th edn. Raven Press, New York, pp. 449-474
67. Nutt D J (1989) Altered alpha-2-adrenoceptor sensitivity in panic disorder. Arch Gen Psychiatr 46: 165-169
68. Ordway G A, Jaconetta S M, Halaris A E (1993) Characterization of subtypes of alpha-2 adrenoceptors in the human brain. J Pharmacol Exp Therap 264: 967-976
69. Fellow S, Chopin P, File S E (1985) Are the anxiogenic effects yobimbine in the social interaction test mediated benzodiazepine receptors? Neurosci Lett 55: 5-9
70. Posner M I (1980) Orienting of attention. Q J Exp Psychol 32: 3-25
71. Redmond D E Jr (1987) Studies of the nucleus locus coeruleus in monkeys and hypotheses for neuropsychopharmacology. In Meltzer H Y (ed.) Psychopharmacology: the third generation of progress. Raven Press, New York, pp. 467-474
72. Robbins T W (1994) Cortical noradrenaline, attention and arousal. Psychol Med 14: 13-21
73. Robbins T W, Everitt B J, Cole B J, Archer T, Mohammed A (1985) Functional hypotheses of the coeruleo-cortical noradrenergic projection: a review of recent experimentation and theory. Physiol Psychol 13: 127-150
74. Sahakian B J, Winn P, Robbins T W, Dooley R J, Everitt B J, Dunn L T, Wallace M, James W P T (1983) Changes in body weight and food-related behaviour induced by destruction of the ventral dorsal noradrenergic bundle. Neuroscience 10: 1405-1420
75. Sara S J, Vaakov A, Hervé A (1994) Locus coeruleus-evoked responses in behaving rats: a clue to the role of noradrenaline in memory. Brain Res Bull 35: 457-465
76. 2-adrenergic receptor subtype gene expression in rat brain. Mol Brain Res 21: 133-149
77. Seiden N R W, Bobbins T W, Everitt B J (1990) Enhanced behavioural conditioning to context and impaired behavioural and neuroendocrine responses to conditioning stimuli following cerulec-cortical noradrenergic lesions: support for an attentional hypothesis of central noreadrenergic function. J Neurosci 10: 531-539
78. Selden N R W, Cole B J, Everitt B J, Robbins T W (1990) Damage to ceruleo-cortieal noradrenergic projections impairs locally cued but enhances spatially cued water maze acquisition. Behav Brain Res 35: 29-52
79. Serviö J, Mazurkiewicz M, Haapalinna A, Riekkinen P Jr, Lahtinen H, Riekkinen P J Sr (1994) The effects of selective alpha-2 adrenergic agents on the performance of rats in a 5-choice serial reaction time task. Brain Res Bull 35: 451-455
80. Smeets W J A J, Reiner A (1994( Phylogeny and development of catecholamine systems in the CNS of vertebrates. Cambridge University Press, Cambridge
81. 2-adrenoceptor antagonist idazoxan on mood, memory and attention in normal volunteers. J Psychopharmacol 6: 376-381
82. Steketee J D, Silverman P B, Swann A C (1992) Nor-adrenergic mechanisms in neophobia. Psychopharmacology 106: 136-142
83. Tsaltas E, Preston G C, Gray J A (1983) The effects of dorsal bundle lesions on serial and trace conditioning. Behav Brain Res 10: 361-374
84. Van Bockstaele E J, Aston-Jones G (1995) Integration in the ventral medulla and coordination of sympathetic and arousal functions. Clin Exp Hypertension 17: 153-165
85. Vankov A, Hervé-Minivielle A, Sara S J (1995) Response to novelty and its rapid habituation in locus coeruleus neurons of the freely exploring rat. Europ J Neurosci 7: 1180-1187
86. 2-adrenoceptor agonists and antagonists measured by cumulative concentration-response curves. Br J Pharmacol 109: 655-660
87. Verleye M, Bernet F (1983) Behavioural effects of lesions of the central noradrenergic bundles in the rat. Pharmacology, Biochemistry and Behaviour 19: 407-414
88. 2-adrenergic receptor subtypes in brain. Pharmacology Biochemistry and Behaviour 41: 267-273
89. Waterhouse B D, Sessler F M, Cheng J, Woodward D J, Arizi A, Moises H C (1988) New evidence for a gating action of norepinephrine in central neuronal circuits of mammalian brain. Brain Research Bulletin 22: 425-432
90. Wright I K, Heaton M, Upton N, Marsden C A (1992) Comparison of acute and chronic treatment of various serotonergic agents with those of diazepan and idazoxan in the rat elevated X-maze. Psychopharmacology 107: 405-414
91. Woodward D J, Moises H C, Waterhouse B D, Hoffer B J, Freedman R (1979) Modulatory actions of norepinephrine in the central nervous system. Federation Proceedings 38: 2109-2116