Why isn't warfarin prescribed to patients with nonrheumatic atrial fibrillation?

Journal of General Internal Medicine

Volumn 11, Issue 12, 1996, Pages 721-728

  Beyth, Rebecca J ^a,h   Antani, Meghal R ^d,e   Covinsky, Kenneth E ^a,i   Miller, David G ^b,f   Chren, Mary Margaret ^c   Quinn, Linda M ^a   Landefeld, C Seth ^a,c,g  

^a UNIVERSITY HOSPITALS OF CLEVELAND   (United States)

^b Cleveland Neighborhood Hlth C   (United States)

^c LOUIS STOKES CLEVELAND VA MEDICAL CENTER   (United States)

^d CASE WESTERN RESERVE UNIVERSITY SCHOOL OF MEDICINE   (United States)

^e UNIVERSITY OF MINNESOTA   (United States)

^f MetroHealth Medical Center   (United States)

^g DEPARTMENT OF VETERANS AFFAIRS   (United States)

^h Merck/Amer Fed Aging Res F   (United States)

ⁱ CASE WESTERN RESERVE UNIVERSITY   (United States)

Author keywords

atrial fibriliation, nonrheumatic; medical decision making; physician opinions; prescription practices; Warfarin

Indexed keywords

ACETYLSALICYLIC ACID; WARFARIN;

ADULT; AGED; ANTICOAGULATION; ARTICLE; BLEEDING; CLINICAL TRIAL; CONTROLLED CLINICAL TRIAL; CONTROLLED STUDY; DRUG EFFICACY; DRUG SAFETY; FEMALE; HEALTH SURVEY; HEART ATRIUM FIBRILLATION; HUMAN; MAJOR CLINICAL STUDY; MALE; MEDICAL DECISION MAKING; MEDICAL PRACTICE; PRESCRIPTION; RANDOMIZED CONTROLLED TRIAL; RISK BENEFIT ANALYSIS; RISK FACTOR; SINGLE BLIND PROCEDURE; STROKE;

EID: 0030474964     PISSN: 08848734     EISSN: None     Source Type: Journal    
DOI: 10.1007/BF02598985     Document Type: Article

References (35)

1. Petersen P, Boysen G, Godtfredsen J, Andersen ED, Andersen B. Placebo-controlled, randomised trial of warfarin and aspirin for prevention of thromboembolic complications in chronic atrial fibrillation. Lancet. 1989;1:175-9.
2. Boston Area Anticoagulation Trial for Atrial Fibrillation Investigators. The effect of low-dose warfarin on the risk of stroke in patients with nonrheumatic atrial fibrillation. N Engl J Med. 1990;323:1505-11.
3. Stroke Prevention in Atrial Fibrillation Study Group Investigators. Preliminary report of the stroke prevention in atrial fibrillation study. N Engl J Med. 1990;322:863-8.
4. Connolly SJ, Laupacis A, Gent M, Roberts RS, Cairns JA, Joyner C. Canadian atrial fibrillation anticoagulation (CAFA) study. J Am Coll Cardiol. 1991;18:349-55.
5. Ezekowitz MD, Bridgers SL, James KE, et al. Warfarin in the prevention of stroke associated with nonrheumatic atrial fibrillation. N Engl J Med. 1992;327:1406-12.
6. Singer DE. Randomized trials of warfarin for atrial fibrillation. N Engl J Med. 1992;327:1451-3.
7. Albers GW, Atwood JE, Hirsh J, Sherman DG, Hughes RA, Connolly SJ. Stroke prevention in nonvalvular atrial fibrillation. Ann Intern Med. 1991;115:727-36.
8. Laupacis A. Anticoagulants for atrial fibrillation. Lancet. 1993; 342:1251-2.
9. Laupacis A, Albers G, Dunn M, Feinberg W. Antithrombotic therapy in atrial fibrillation. Chest. 1992;102:4268-333.
10. Laupacis A, Albers G, Dunn M, Feinberg W. Antithrombotic therapy in atrial fibrillation. Chest. 1995;108:352S-9S.
11. Gage BF, Cardinalli AB, Albers GW, Owens DK. Cost-effectiveness of warfarin and aspirin for prophylaxis of stroke in patients with nonvalvular atrial fibrillation. JAMA. 1995;274:1839-45.
12. Feinberg WM, Blackshear JL, Laupacis A, Kronmal R, Hart RG. Prevalence, age distribution, and gender of patients with atrial fibrillation. Analysis and implications. Arch Intern Med. 1995;155: 469-73.
13. Antani MR, Beyth RJ, Covinsky KE, et al. Failure to prescribe warfarin to patients with nonrheumatic atrial fibrillation. J Gen Intern Med. 1996;11:713-20.
14. Wolf PA, Abbott RD, Kannel WB. Atrial fibrillation: a major contributor to stroke in the elderly. The Framingham Study. Arch Intern Med. 1987;147:1561-4.
15. Atrial Fibrillation Investigators. Risk factors for stroke and efficacy of antithrombotic therapy in atrial fibrillation. Analysis of pooled data from five randomized controlled trials. Arch Intern Med. 1994;154:1449-57.
16. Bailar JC, Louis TA, Lavori PW, Polansky M. A classification for biomedical research reports. N Engl J Med. 1984;311:1482-7.
17. Bath PMW, Prasad A, Brown MM, MacGregor GA. Survey of use of anticoagulation in patients with atrial fibrillation. BMJ. 1993;307: 1045.
18. Chang HJ, Bell JR, Deroo DB, Kirk JW, Wasson JH, Dartmouth Primary Care COOP Project. Physician variation in anticoagulating patients with atrial fibrillation. Arch Intern Med. 1990;150:81-4.
19. Kutner M, Nixon G, Silverstone F. Physicians' attitudes toward oral anticoagulants and antiplatelet agents for stroke prevention in elderly patients with atrial fibrillation. Arch Intern Med. 1991;151:1950-3.
20. McCrory DC, Matchar DB, Samsa G, Sanders LL, Pritchett ELC. Physician attitudes about anticoagulatton for nonvalvular atrial fibrillation. Arch Intern Med. 1995;155:277-81.
21. Flegel KM, Hutchinson TA, Groome PA, Tousignant P. Factors relevant to preventing embolic stroke in patients with non-rheumatic atrial fibrillation. J Clin Epidemiol. 1991;44:551-60.
22. Landefeld CS, Beyth RJ. Anticoagulant-related bleeding: clinical epidemiology, prediction and prevention. Am J Med. 1993;95:315-28.
23. Albers GW. Atrial fibrillation and stroke. Three new studies, three remaining questions. Arch Intern Med. 1994;154:1443-8.
24. Gurwitz JH, Avorn J, Ross-Degnan D. Aging and the anticoagulant response to warfarin therapy. Ann Intern Med. 1992;116: 901-4.
25. Landefeld CS, Goldman L. Major bleeding in outpatients treated with warfarin: incidence and prediction by factors known at the start of outpatient therapy. Am J Med. 1989;87:144-52.
26. Stroke Prevention in Atrial Fibrillation Study Group Investigators. Warfarin versus aspirin for prevention of thromboembolism in atrial fibrillation: stroke prevention in atrial fibrillation II study. Lancet. 1994;343:687-91.
27. Fihn SD, Callahan CM, Martin DC, McDonnell MB, Henikoff JG, White RH. The risk for and severity of bleeding complications in elderly patients treated with warfarin. Ann Intern Med. 1996;124: 970-9.
28. Tversky A, Kahneman D. Judgment under uncertainty: heuristics and biases. Science. 1974;185:1124-31.
29. Eraker SA, Politser P. How decisions are reached: physician and patient. Ann Intern Med. 1982;97:262-8.
30. Spranca M, Minsk E, Baron J. Omission and commission in judgment and choice. J Exp Soc Psychol. 1991;27:76-105.
31. Asch DA, Baron J, Hershey JC, et al. Omission bias and pertussis vaccination. Med Decis Making. 1994;14:118-23.
32. Wetle T. Age as a risk factor for inadequate treatment. JAMA. 1987;258:516.
33. Greco PJ, Eisenberg JM. Changing physicians' practices. N Engl J Med. 1993;329:1271-4.
34. Lomas J, Enkin M, Anderson GM, Hannah WJ, Vayda E, Singer J. Opinion leaders versus audit and feedback to implement practice guidelines: delivery after previous cesarean section. JAMA. 1991; 265:2202-7.
35. Landefeld CS, Anderson PA. Guideline-based consultation, to prevent anticoagulant-related bleeding: a randomized, controlled trial in a teaching hospital. Ann Intern Med. 1992;116:829-37.