Myocardial viability: Methods of assessment and clinical relevance

American Heart Journal

Volumn 132, Issue 6, 1996, Pages 1226-1235

  Iskandrian, Abdulmassih S ^a   Heo, Jaekyeong ^a   Schelbert, Heinrich R ^b  

^a PENN PRESBYTERIAN MEDICAL CENTER   (United States)

^b UNIVERSITY OF CALIFORNIA   (United States)

Author keywords

[No Author keywords available]

Indexed keywords

CARBON 11; DOBUTAMINE; FLUORODEOXYGLUCOSE F 18; IODINE 123; METHOXY ISOBUTYL ISONITRILE TECHNETIUM TC 99M; RUBIDIUM 82; THALLIUM 201;

CONGESTIVE HEART FAILURE; CORONARY ARTERY DILATATION; CORONARY ARTERY DISEASE; DIAGNOSTIC ACCURACY; DIAGNOSTIC IMAGING; GRAFT PATENCY; HEART CATHETERIZATION; HEART EJECTION FRACTION; HEART INFARCTION; HEART MUSCLE PERFUSION; HEART MUSCLE REVASCULARIZATION; MYOCARDIAL DISEASE; NUCLEAR MAGNETIC RESONANCE IMAGING; POSITRON EMISSION TOMOGRAPHY; PRIORITY JOURNAL; PROGNOSIS; REVIEW; TWO DIMENSIONAL ECHOCARDIOGRAPHY;

EID: 0030474893     PISSN: 00028703     EISSN: None     Source Type: Journal    
DOI: 10.1016/S0002-8703(96)90467-6     Document Type: Article

References (81)

1. Schelbert HR. Merits and limitations of radionuclide approaches to viability and future developments. J Nucl Cardiol 1994;1:S86-96.
2. Rahimtoola SH. The hibernating myocardium. Am Heart J 1989;117:211-21.
3. Braunwald E, Kloner RA. The stunned myocardium: prolonged, post-ischemic ventricular dysfunction. Circulation 1982;66:1146-9.
4. Schwaiger M, Brunken R, Grover-McKay M, Krivokapich J, Child J, Tillisch JH, et al. Regional myocardial metabolism in patients with acute myocardial infarction assessed by positron emission tomography. J Am Coll Cardiol 1986;8:800-8.
5. Maddahi J, Schelbert HR, Brunken R, Di Carli M. Roles of thallium-201 and PET imaging in evaluation of myocardial viability and management of patients with coronary artery disease and left ventricular dysfunction. J Nucl Med 1994;35:707-15.
6. Bonow RO. The hibernating myocardium: implications for management of congestive heart failure. Am J Cardiol 1995;75:17A-25A.
7. Diamond GA, Forrester JS, DeLuz PL, Wyatt HL, Swan HJC. Post-extrasystolic potentiation of ischemic myocardium by atrial stimulation. Am Heart J 1978;95:204-9.
8. Schelbert HR, Buxton D. Insights into coronary artery disease gained from metabolic imaging. Circulation 1988;78:496-505.
9. Iskandrian AS, Heo J, Helfant EH, Segal BL. Chronic myocardial ischemia and left ventricular function. Ann Intern Med 1987;107:925-7.
10. Vom Dahl J, Eitzman D, Al-Aouar A, Kanter HL, Hicks RJ, Deeb M, et al. Relation of regional function, perfusion and metabolism in patients with advanced coronary artery disease undergoing surgical revascularization. Circulation 1994;90:2356-66.
11. Gropler R, Siegel B, Sampathkumaran K, Perez JE, Sobel BE, Bergmann SR, et al. Dependence of recovery of contractile function on maintenance of oxidative metabolism after myocardial infarction. J Am Coll Cardiol 1992;19:989-97.
12. Bolli R, Zhu WX, Moyers ML, Hartley CJ, Roberts R. Beta-adrenergic stimulation reverses postischemic myocardial dysfunction without producing subsequent functional deterioration. Am J Cardiol 1985;56:946-8.
13. Becker LC, Levine JH, Di Paula AF, Guamieri T, Aversano T. Reversal of dysfunction in postischemic stunned myocardium by epinephrine and postextrasystolic potentiation. J Am Coll Cardiol 1986;7:580-9.
14. Kloner R, Allen J, Cox T, Zheng Y, Ruiz C. Stunned left ventricular myocardium after exercise treadmill testing in coronary artery disease. Am J Cardiol 1991;68:329-34.
15. Matsuzaki M, Gallagher KP, Kemper WS, White F, Ross J Jr. Sustained regional dysfunction produced by prolonged coronary stenosis: gradual recovery after reperfusion. Circulation 1983;68:170-80.
16. Vanoverschelde JJ, Wijins W, Depre C, Essamri B, Heyndrick GR, Borgers M, et al. Mechanisms of chronic regional ischemic dysfunction in humans: new insight from the study of noninfarcted collateral dependent myocardium. Circulation 1993;87:1513-23.
17. Vanoverschelde JL. Chronic myocardial hibernation [letter]. Circulation 1994;89:1907-8.
18. Iskandrian AS, Heo J, Stanberry C. When is myocardial viability an important clinical issue? J Nucl Med 1994;35:4S-7S.
19. Liedtke AJ. Alterations of carbohydrate and lipid metabolism in the acutely ischemic heart. Prog Cardiovasc Dis 1981;23:321-36.
20. Opie LH. Effects of regional ischemia on metabolism of glucose and fatty acids. Circ Res 1976;38:152-74.
21. Tamaki N, Kawamoto M, Takahashi N, Yonekura Y, Magata Y, Nohara R, et al. Prognostic value of an increase in fluorine-18 deoxyglucose up-take in patients with myocardial infarction: comparison with stress thallium imaging. J Am Coll Cardiol 1993;22:1621-7.
22. Buxton D, Vaghaiwalla-Mody F, Krivokapich J, Phelps M, Schelbert H. Quantitative assessment of prolonged metabolic abnormalities in reperfused canine myocardium. Circulation 1992;85:1842-56.
23. Czernin J, Porenta G, Brunken R, Krivokapich J, Chen K, Bennett R, et al. Regional blood flow, oxidative metabolism and glucose utilization in patients with acute myocardial infarction. Circulation 1993;88:884-95.
24. Feigl E, Neat G, Huang A. Interrelations between coronary artery pressure, myocardial metabolism and coronary blood flow. J Mol Cell Cardiol 1990;22:375-90.
25. Flameng W, Suy R, Schwarz F, Borgers M, Piessens J, Thone F, et al. Ultrastructural correlates of left ventricular contraction abnormalities in patients with ischemic heart disease: determinants of reversible segmental post-revascularization surgery. Am Heart J 1981;102:846-57.
26. Brunken R, Tillisch J, Schwaiger M, Child JS, Marshall R, Mandelkern M, et al. Regional perfusion, glucose metabolism and wall motion in patients with chronic electrocardiographic Q-wave infarction: evidence for persistence of viable tissue in some infarct regions by positron emission tomography. Circulation 1986;73:951-63.
27. Tillisch J, Brunken R, Marshall R, Schwaiger M, Mandelkern M, Phelps M, et al. Reversibility of cardiac wall motion abnormalities predicted by positron tomography. N Engl J Med 1986;314:884-8.
28. Carrel T, Jenni R, Haubold-Reuter S, Von Schultess G, Pasic M, Turina M. Improvement of severely reduced left ventricular function after surgical revascularization in patients with preoperative myocardial infarction. Eur J Cardiothorac Surg 1992;6:479-84.
29. Lucignani G, Paolini G, Landoni C, Zuccari M, Paganelli G, Galli L, et al. Presurgical identification of hibernating myocardium by combined use of technetium-99m hexakis 2-methoxyisobutyl isonitrile single photon emission tomography and fluorine-18 fluoro-2-deoxyglucose positron emission tomography in patients with coronary artery disease. Eur J Nucl Med 1992;19:874-81.
30. Camici P, Ferrannini E, Opie LH. Myocardial metabolism in ischemic heart disease: basic principles and application to imaging by positron emission tomography. Prog Cardiovasc Dis 1989;32:217-38.
31. Lee K, Marwick T, Cook S, Go RT, Fix JS, James KB, et al. Prognosis of patients with left ventricular dysfunction with and without viable myocardium after myocardial infarction. Circulation 1994;90:2687-94.
32. Tamaki N, Kawamoto M, Tadamura E, Magata Y, Yonekura Y, Nohara R, et al. Prediction of reversible ischemia after revascularization: perfusion and metabolic studies with positron emission tomography. Circulation 1995;91:1697-705.
33. Maes A, Flameng W, Nuyts J, Borgers M, Shivalkar B, Ausma J, et al. Histological alterations in chronically hypoperfused myocardium: correlation with PET findings. Circulation 1994;90:735-45.
34. Gropler R, Geltman E, Sampathkumaran K, Perez JE, Moerlein SM, Sobel BE, et al. Functional recovery after coronary revascularization for chronic coronary artery disease is dependent on maintenance of oxidative metabolism. J Am Coll Cardiol 1992;20:569-77.
35. Gropler RJ, Geltman EM, Sampathiumaran K, Perez JE, Schectman KB, Conversano A. Comparison of carbon-11-acetate with fluorine-18-fluorodeoxyglucose for delineating viable myocardium by positron emission tomography. J Am Coll Cardiol 1993;22:1587-97.
36. 15O-water and dynamic positron emission tomography. Circulation 1992;86:167-78.
37. Gould KL, Yoshida K, Hess MJ, Haynie M, Mullani N, Smalling RW. Myocardial metabolism of fluorodeoxyglucose compared to cell membrane integrity for the potassium analogue rubidium-82 for assessing infarct size in man. J Nucl Med 1991;32:1-9.
38. 11C-palmitate. Circulation 1981;64:689-99.
39. 11C-labeled palmitate. Circulation 1980;61:242-55.
40. Schelbert HR, Henze E, Keen R, Schon HR, Hansen H, Selin C, et al. C-11 palmitic acid for the noninvasive evaluation of regional myocardial fatty acid metabolism with positron computed tomography: IV. in vivo demonstration of impaired fatty acid oxidation in acute myocardial ischemia. Am Heart J 1983;106:736-50.
41. Tamaki N, Fujibayashi Y, Magata Y, Yonekura Y, Konishi J. Radionuclide assessment of myocardial fatty acid metabolism by PET and SPECT. J Nucl Cardiol 1995;2:256-66.
42. Burt RW, Perkins OW, Oppenheim BE, Schwanwecker DS, Stein L, Wellman HN, et al. Direct comparison of fluorine-18 FDG SPECT, fluorine-18 FDG PET and rest thallium-201 SPECT for detection of myocardial viability. J Nucl Med 1995;36:176-81.
43. Pohost GM, Zir LM, Moore RH, McKusick KA, Guiney TE, Beller GA. Differentiation of transiently ischemic myocardium from infarcted myocardium by serial imaging after a single dose of thallium-201. Circulation 1977;55:294-302.
44. Kayden DS, Sigal S, Soufer R, Mattera J, Zaret B, Wackers FJT. Thallium-201 for assessment of myocardial viability: quantitative comparison of 24-hour redistribution imaging with imaging after reinjection at rest. J Am Coll Cardiol 1991;18:1480-6.
45. Iskandrian AS. Thallium reinjection imaging: The search for an optimal protocol [editorial]. J Nucl Med 1993;34:743-6.
46. 18F-fluorodeoxyglucose. Circulation 1991;83:26-37.
47. Dilsizian V, Rocco TP, Freeman NMT, Leon MB, Bonow RO. Enhanced detection of ischemic but viable myocardium by the reinjection of thallium after stress-redistribution imaging. N Engl J Med 1990;323:141-6.
48. Iskandrian AS, Hakki A-H, Kane SA, Goel IP, Mundth ED, Segal BL. Rest and redistribution thallium-201 myocardial scintigraphy to predict improvement in left ventricular function after coronary arterial bypass grafting. Am J Cardiol 1983;51:1312-6.
49. Dilsizian V, Freedman NMT, Bacharach SL, Perrone-Filardi P, Bonow RO. Regional thallium uptake in irreversible defects: magnitude of change in thallium activity after reinjection distinguishes viable from nonviable myocardium. Circulation 1992;85:627-34.
50. Dilsizian V, Perrone-Filardi P, Arrighi JA, Bacharach SL, Quyyumi AA, Freedman NMT, et al. Concordance and discordance between stress-redistribution-reinjection thallium imaging for assessing viable myocardium: comparison with metabolic activity by PET. Circulation 1993;88:941-52.
51. Udelson JE, Coleman PS, Metherall J, Pandian NG, Gomez AR, Griffith JL, et al. Predicting recovery of severe regional ventricular dysfunction: comparison of resting scintigraphy with thallium-201 and Tc-99m sestamibi. Circulation 1994;89:2552-61.
52. Dilsizian V, Arrighi JA, Diodati JG, Quyyumi AA, Alavi K, Bacharach SL, et al. Myocardial viability in patients with chronic coronary artery disease: comparison of Tc-99m sestamibi with thallium reinjection and F-18 fluorodeoxyglucose. Circulation 1994;89:578-87.
53. Beanlands RSB, Dawood F, Wen WH, McLaughlin PR, Butany J, D'Amati G, et al. Are the kinetics of technetium-99m methoxyisobutyl-isonitrile affected by cell metabolism and viability? Circulation 1990;82:1802-14.
54. Zimmerman R, Mall G, Roach B, Zimmer G, Gabel M, Zehelein J, et al. Residual thallium activity in irreversible defects as a marker of myocardial viability: a clinicopathological study. Circulation 1995;91:1016-21.
55. Ragosta M, Beller GA, Watson DD, Kaul S, Gimple LW. Quantitative planar rest-redistribution thallium imaging in detection of myocardial viability and prediction of improvement in left ventricular function after coronary artery bypass surgery in patients with severely depressed left ventricular function. Circulation 1993;87:1630-41.
56. Mori T, Minamiji K, Kurogane H, Ogawa K, Yoshida Y. Rest-injected thallium-201 imaging for assessing viability of severe asynergic regions. J Nucl Med 1991;32:1718-24.
57. Besozzi MC, Brown MD, Hubner KF, Smith GT, Bond HW, Goodman MM, et al. Retrospective post-therapy of cardiac function in 208 coronary artery disease patients evaluated by positron emission tomography [Abstract]. J Nucl Med 1992;33:885.
58. Hansen CL, Corbett JR, Pippin JJ, Jansen DE, Kulkarni PV, Ugolini V, et al. Iodine-123-phenylpentadecanoic acid and single photon emission computed tomography in identifying left ventricular regional metabolic abnormalities in patients with coronary artery disease: comparison with thallium-201 myocardial tomography. J Am Coll Cardiol 1988;12:78-87.
59. Iskandrian AS, Powers J, Cave V, Wasserleben V, Cassel D, Heo J. Assessment of myocardial viability by dynamic tomographic I-123 iodophenylpentadecanoic acid imaging: comparison to rest-redistribution thallium-201 imaging. J Nucl Cardiol 1995;2:101-9.
60. Knapp FF, Goodman MM, Callahan AP, Kirsch G. Radioiodinated 15-CP-iodophenyl-33-dimethyl-pentadecanoic acid: a useful new agent to evaluate myocardial fatty acid uptake. J Nucl Med 1986;27:521-31.
61. Tamaki N, Kawamoto M, Yonekura Y, Fujibayashi Y, Takahashi N, Konisi J, et al. Regional metabolic abnormality in relation to perfusion and wall motion in patients with myocardial infarction: assessment with emission tomography using an iodinated branched fatty acid analog. J Nucl Med 1992;33:659-67.
62. Cigarroa CG, DeFillippi CR, Brickner ME, Alvarez LG, Wait MA, Grayburn PA. Inotropic contractile reserve during dobutamine stress echocardiography predicts recovery of regional left ventricular function after coronary revascularization. Circulation 1993;88:430-6.
63. Baer FM, Voth E, Deutsch HJ, Schneider CA, Schicha H, Sechtem U. Assessment of viable myocardium by dobutamine transesophageal echocardiography and comparison with fhiorine-18 fluorodeoxy-glucose positron emission tomography. J Am Coll Cardiol 1994;24:343-53.
64. La Canna G, Alfieri O, Giubbini R, Gargano M, Ferrari R, Visioli O. Echocardiography during infusion of dobutamine for identification of reversible dysfunction in patients with chronic coronary artery disease. J Am Coll Cardiol 1994;23:617-26.
65. Barilla F, Gheorghiade M, Alam M, Khaja F, Goldstein S. Low-dose dobutamine in patients with acute myocardial infarction identifies viable but not contractile myocardium and predicts the magnitude of improvement in wall motion abnormalities in response to coronary revascularization. Am Heart J 1991;122:1522-31.
66. Sabia P, Powers ER, Ragosta M, Sarenbock IJ, Burwell LR, Kaul S. An association between collateral blood flow and myocardial viability in patients with recent myocardial infarction. N Engl J Med 1992;327:1825-31.
67. Afridi I, Kleiman NS, Raizner AE, Zoghbi WA. Dobutamine echocardiography in myocardial hibernation: optimal dose and accuracy in predicting recovery of ventricular function after coronary angioplasty. Circulation 1995;91:663-70.
68. Panza JA, Dilsizian V, Laurienzo JM, Curiel RV, Katsiyiannis PT. Relation between thallium uptake and contractile response to dobutamine: implications regarding myocardial viability in patients with chronic coronary artery disease and left ventricular dysfunction. Circulation 1995;91:990-8.
69. Ratner AV, Okada RD, Newell JE, Pohost GM. The relationship between proton nuclear magnetic resonance relaxation parameters and myocardial perfusion with acute coronary arterial occlusion and reperfusion. Circulation 1985;71:823-8.
70. Baer FM, Voth E, Schneider CA, Theissen P, Schicha H, Sechtem U. Comparison of low dose dobutamine-gradient-echomagnetic imaging and positron emission tomography with F-18 fluorodeoxyglucose in patients with chronic coronary artery disease: a functional and morphological approach of residual myocardial viability. Circulation 1995;91:1006-15.
71. Popio KA, Gorlin R, Bechtel D, Levine JA. Postextrasystolic potentiation as a predictor of potential myocardial viability: preoperative anal-yses compared with studies after coronary bypass surgery. Am J Cardiol 1977;39:944-51.
72. Horn HR, Teichholz LE, Cohn PF, Herman MV, Gorlin R. Augmentation of left ventricular contraction pattern in coronary artery disease by an inotropic catecholamine: the epinephrine ventriculogram. Circulation 1974;49:1063-71.
73. Rahimtoola SH. A perspective on the three large multicenter randomized clinical trials of coronary bypass surgery for chronic stable angina. Circulation 1985;72(V Suppl):123-35.
74. Alderman EL, Fischer LD, Litwin P, Kaiser GC, Myers WO, Maynard C, et al. Results of coronary artery surgery in patients with poor left ventricular function. Circulation 1983;68:785-95.
75. Eitzman D, Al-Aouar Z, Kanter H, Vom Dahl J, Kirsh M, Deeb GM, et al. Clinical outcome of patients with advanced coronary artery disease after viability studies with positron emission tomography. J Am Coll Cardiol 1992;20:559-65.
76. Di Carli MF, Davidson M, Little R, Khanna S, Mody FV, Brunken RC, et al. Value of metabolic imaging with positron emission tomography for evaluating prognosis in patients with coronary artery disease and left ventricular dysfunction. Am J Cardiol 1994;73:527-33.
77. Gioia G, Powers J, Russell J, Cassel D, Heo J, Iskandrian AS. Prognostic value of rest-redistribution SPECT thallium imaging in ischemic cardiomyopathy. Am J Cardiol 1995;75:759-62.
78. Lemlek J, Heo J, Iskandrian AS. The clinical relevance of myocardial viability in patient management. Am Heart J 1992;124:1327-31.
79. Iskandrian AS, Heo J, Nguyen T. Current and emerging scintigraphic methods to assess myocardial viability and their clinical importance. Am J Cardiac Imaging 1992;6:16-27.
80. Galli M, Marcassa C, Bolli E, Giannuzzi P, Temporelli PL, Imparato A, et al. Spontaneous delayed recovery of perfusion and contraction after the first five weeks following anterior infarction: evidence for the presence of hibernating myocardium in the infarcted area. Circulation 1994;90:1386-97.
81. Maes A, Vande Werf F, Nuyts J, Bormans G, Desmet W, Mortelmans L. Impaired myocardial tissue perfusion early after successful thrombolysis: impact on myocardial flow, metabolism and function at late follow-up. Circulation 1995;92:2072-8.