메뉴 건너뛰기




Volumn 28, Issue 6, 1996, Pages 511-522

Towards genomic drug therapy with antisense oligonucleotides

Author keywords

Antisense; DNA; Oligonucleotide; RNA

Indexed keywords

ANTISENSE OLIGONUCLEOTIDE; MESSENGER RNA; PEPTIDE NUCLEIC ACID;

EID: 0030474866     PISSN: 07853890     EISSN: None     Source Type: Journal    
DOI: 10.3109/07853899608999115     Document Type: Review
Times cited : (20)

References (88)
  • 1
    • 0041582974 scopus 로고
    • Inhibition of Rous sarcoma virus replication and cell transformation by a specific oligodeoxynucleotide
    • Zamecnik PC, Stephenson ML. Inhibition of Rous sarcoma virus replication and cell transformation by a specific oligodeoxynucleotide. Proc Natl Acad Sci USA 1978; 75: 280-4.
    • (1978) Proc Natl Acad Sci USA , vol.75 , pp. 280-284
    • Zamecnik, P.C.1    Stephenson, M.L.2
  • 2
    • 0022555863 scopus 로고
    • The role of antisense RNA and gene regulation
    • Green PJ, Pines O, Inouye M. The role of antisense RNA and gene regulation. Annu Rev Biochem 1986; 55: 569-97.
    • (1986) Annu Rev Biochem , vol.55 , pp. 569-597
    • Green, P.J.1    Pines, O.2    Inouye, M.3
  • 3
    • 0025948490 scopus 로고
    • Towards gene-inhibition therapy: A review of progress and prospects in the field of antiviral antisense nucleic acids and ribozymes
    • James W. Towards gene-inhibition therapy: a review of progress and prospects in the field of antiviral antisense nucleic acids and ribozymes. Antiviral Chem 1991; 2: 191-214.
    • (1991) Antiviral Chem , vol.2 , pp. 191-214
    • James, W.1
  • 4
    • 11944267365 scopus 로고
    • Antisense oligonucleotides: A new therapeutic principle
    • Uhlmann E, Peyman A. Antisense oligonucleotides: a new therapeutic principle. Chem Rev 1990; 90: 543-84.
    • (1990) Chem Rev , vol.90 , pp. 543-584
    • Uhlmann, E.1    Peyman, A.2
  • 5
    • 33748577758 scopus 로고
    • Sequence-specific recognition and modification of double-helical DNA by oligonucleotides
    • Thuong NT, Helene C. Sequence-specific recognition and modification of double-helical DNA by oligonucleotides. Angew Chem Int Edn Engl 1993; 32: 666-90.
    • (1993) Angew Chem Int Edn Engl , vol.32 , pp. 666-690
    • Thuong, N.T.1    Helene, C.2
  • 6
    • 0025339373 scopus 로고
    • Regulation of gene expression by antisense, sense and antigene nucleic acids
    • Helene C, Toulme J. Regulation of gene expression by antisense, sense and antigene nucleic acids. Biochim Biophys Acta 1990; 1049: 99-125.
    • (1990) Biochim Biophys Acta , vol.1049 , pp. 99-125
    • Helene, C.1    Toulme, J.2
  • 7
    • 0011886091 scopus 로고
    • Thermodynamics of antisense oligonucleotide hybridization
    • Erickson RP, Izant JG, eds. New York: Raven Press Ltd
    • Freier SM, Lima WF, Sanghvi YS, et al. Thermodynamics of antisense oligonucleotide hybridization. In: Erickson RP, Izant JG, eds. Gene Regulation: Biology of Antisense RNA and DNA. New York: Raven Press Ltd, 1992: 95-107.
    • (1992) Gene Regulation: Biology of Antisense RNA and DNA , pp. 95-107
    • Freier, S.M.1    Lima, W.F.2    Sanghvi, Y.S.3
  • 8
    • 0025433271 scopus 로고
    • Conjugates of oligonucleotides and modified oligonucleotides: A review of their synthesis and properties
    • Goodchild J. Conjugates of oligonucleotides and modified oligonucleotides: a review of their synthesis and properties. Bioconjug Chem 1990; 1: 165-87.
    • (1990) Bioconjug Chem , vol.1 , pp. 165-187
    • Goodchild, J.1
  • 9
    • 0025806824 scopus 로고
    • Chemically modified oligonucleotides as probes and inhibitors
    • English U, Gauss D. Chemically modified oligonucleotides as probes and inhibitors. Angew Chem Int Edn Engl 1991; 30: 613-29.
    • (1991) Angew Chem Int Edn Engl , vol.30 , pp. 613-629
    • English, U.1    Gauss, D.2
  • 11
    • 0021891882 scopus 로고
    • Nucleoside phosphorothioates
    • Eckstein F. Nucleoside phosphorothioates. Annu Rev Biochem 1985; 54: 367-402.
    • (1985) Annu Rev Biochem , vol.54 , pp. 367-402
    • Eckstein, F.1
  • 12
    • 0024293252 scopus 로고
    • Oligonucleotide N-alkylphosphoramidates: Synthesis and binding to polynucleotides
    • Jager A, Levy MJ, Hecht SM. Oligonucleotide N-alkylphosphoramidates: synthesis and binding to polynucleotides. Biochemistry 1988; 27: 7237-46.
    • (1988) Biochemistry , vol.27 , pp. 7237-7246
    • Jager, A.1    Levy, M.J.2    Hecht, S.M.3
  • 13
    • 0018789683 scopus 로고
    • Nonionic nucleic acid analogues. Synthesis and characterization of dideoxyribonucleoside methylphosphonates
    • Miller PS, Yano J, Yano E, Carroll C, Jayaraman K, Ts'O POP. Nonionic nucleic acid analogues. Synthesis and characterization of dideoxyribonucleoside methylphosphonates. Biochemistry 1979; 18: 5134-43.
    • (1979) Biochemistry , vol.18 , pp. 5134-5143
    • Miller, P.S.1    Yano, J.2    Yano, E.3    Carroll, C.4    Jayaraman, K.5    Ts'O, P.O.P.6
  • 14
    • 0015168319 scopus 로고
    • Synthesis and properties of adenine and thymine nucleoside alkyl phosphotriesters, the neutral analogs of dinucleoside monophosphates
    • Miller PS, Fang KN, Kondo NS, Ts'O POP. Synthesis and properties of adenine and thymine nucleoside alkyl phosphotriesters, the neutral analogs of dinucleoside monophosphates. J Am Chem Soc 1971; 93: 6657-65.
    • (1971) J Am Chem Soc , vol.93 , pp. 6657-6665
    • Miller, P.S.1    Fang, K.N.2    Kondo, N.S.3    Ts'O, P.O.P.4
  • 15
    • 0028177581 scopus 로고
    • Oligodeoxyribonucleotide N3′-P5′ phosphoramidates: Synthesis and hybridization properties
    • Gryaznov S, Chen JK. Oligodeoxyribonucleotide N3′-P5′ phosphoramidates: synthesis and hybridization properties. J Am Chem Soc 1994; 116: 3143-4.
    • (1994) J Am Chem Soc , vol.116 , pp. 3143-3144
    • Gryaznov, S.1    Chen, J.K.2
  • 16
    • 0029664865 scopus 로고    scopus 로고
    • Oligonucleotide N3′-P5′ phosphoroamidates as antisense agents
    • Gryaznov S, Skorski T, Cucco C, et al. Oligonucleotide N3′-P5′ phosphoroamidates as antisense agents. Nucleic Acids Res 1996; 24: 1508-14.
    • (1996) Nucleic Acids Res , vol.24 , pp. 1508-1514
    • Gryaznov, S.1    Skorski, T.2    Cucco, C.3
  • 17
    • 15144346068 scopus 로고
    • Synthesis of nonionic oligonucleotide analogues
    • Sanghvi YS, Cook PD, eds. ACS Symposium Series 580. Washington DC: American Chemical Society
    • Maddry JA, Reynolds RC, Montgomery JA, Secrist JA III. Synthesis of nonionic oligonucleotide analogues. In: Sanghvi YS, Cook PD, eds. Carbohydrate Modifications in Antisense Research. ACS Symposium Series 580. Washington DC: American Chemical Society, 1994: 40-51.
    • (1994) Carbohydrate Modifications in Antisense Research , pp. 40-51
    • Maddry, J.A.1    Reynolds, R.C.2    Montgomery, J.A.3    Secrist III, J.A.4
  • 18
    • 16044362048 scopus 로고
    • Synthesis and hybridization properties of DNA oligomers containing sulfide-linked dinucleosides
    • Sanghvi YS, Cook PD, eds. ACS Symposium Series 580. Washington DC: American Chemical Society
    • Just G, Kawai SH. Synthesis and hybridization properties of DNA oligomers containing sulfide-linked dinucleosides. In: Sanghvi YS, Cook PD, eds. Carbohydrate Modifications In Antisense Research. ACS Symposium Series 580. Washington DC: American Chemical Society, 1994: 52-65.
    • (1994) Carbohydrate Modifications in Antisense Research , pp. 52-65
    • Just, G.1    Kawai, S.H.2
  • 19
    • 0026683445 scopus 로고
    • Synthesis of a novel methylhydroxylamine-linked nucleoside dinner and its incorporation into antisense sequences
    • Vasseur JJ, Debart F, Sanghvi YS, Cook PD. Synthesis of a novel methylhydroxylamine-linked nucleoside dinner and its incorporation into antisense sequences. J Am Chem Soc 1992; 114: 4006-7.
    • (1992) J Am Chem Soc , vol.114 , pp. 4006-4007
    • Vasseur, J.J.1    Debart, F.2    Sanghvi, Y.S.3    Cook, P.D.4
  • 20
    • 0027304997 scopus 로고
    • Synthesis and binding properties of pyrimidine oligodeoxynucleoside analogs containing neutral phosphodiester replacements: The formacetal and 3′-thioformacetal internucleoside linkages
    • Jones RJ, Lin KY, Milligan, JF, Wadwani S, Matteucci MD. Synthesis and binding properties of pyrimidine oligodeoxynucleoside analogs containing neutral phosphodiester replacements: the formacetal and 3′-thioformacetal internucleoside linkages. J Org Chem 1993; 58: 2983-91.
    • (1993) J Org Chem , vol.58 , pp. 2983-2991
    • Jones, R.J.1    Lin, K.Y.2    Milligan, J.F.3    Wadwani, S.4    Matteucci, M.D.5
  • 21
    • 0002326455 scopus 로고
    • Hybridization: Consideration affecting antisense drugs
    • Crooke ST, Lebleu B, eds. Boca Raton: CRC Press Inc.
    • Freier SM. Hybridization: consideration affecting antisense drugs. In: Crooke ST, Lebleu B, eds. Antisense Research and Applications. Boca Raton: CRC Press Inc., 1991: 67-82.
    • (1991) Antisense Research and Applications , pp. 67-82
    • Freier, S.M.1
  • 22
    • 0027204049 scopus 로고
    • Oligodeoxynucleotides containing 2′-O-modified adenosine: Synthesis and effects on stability of DNA duplexes
    • Lesnik EA, Guinosso CJ, Kawasaki AM, et al. Oligodeoxynucleotides containing 2′-O-modified adenosine: synthesis and effects on stability of DNA duplexes. Biochemistry 1993; 32: 7832-8.
    • (1993) Biochemistry , vol.32 , pp. 7832-7838
    • Lesnik, E.A.1    Guinosso, C.J.2    Kawasaki, A.M.3
  • 23
    • 0027181381 scopus 로고
    • Intracellular disposition and metabolism of fluorescently labelled unmodified and modified oligonucleotides microinjected into mammalian cells
    • Fisher TL, Terhorst T, Cao X, Wagner RW. Intracellular disposition and metabolism of fluorescently labelled unmodified and modified oligonucleotides microinjected into mammalian cells. Nucleic Acid Res 1993; 21: 3857-65.
    • (1993) Nucleic Acid Res , vol.21 , pp. 3857-3865
    • Fisher, T.L.1    Terhorst, T.2    Cao, X.3    Wagner, R.W.4
  • 24
    • 0026332351 scopus 로고
    • Medicinal chemistry of antisense oligonucleotides: Future opportunities
    • Cook PD. Medicinal chemistry of antisense oligonucleotides: future opportunities. Anticancer Drug Des 1991; 6: 585-607.
    • (1991) Anticancer Drug des , vol.6 , pp. 585-607
    • Cook, P.D.1
  • 25
    • 0024362965 scopus 로고
    • Sugar-modified oligonucleotides: Synthesis, physicochemical and biological properties
    • Imbach JL, Rayner B, Morvan F. Sugar-modified oligonucleotides: synthesis, physicochemical and biological properties. Nucleosides Nucleotides 1989; 8: 627-48.
    • (1989) Nucleosides Nucleotides , vol.8 , pp. 627-648
    • Imbach, J.L.1    Rayner, B.2    Morvan, F.3
  • 26
    • 0003434347 scopus 로고
    • Hexopyranosyl-like oligonucleotides
    • Sanghvi YS, Cook PD, eds. ACS Symposium series 580. Washington DC: American Chemical Society
    • Herdewijn P, De Winter H, Doboszewski B, et al. Hexopyranosyl-like oligonucleotides. In: Sanghvi YS, Cook PD, eds. Carbohydrate Modifications in Antisense Research. ACS Symposium series 580. Washington DC: American Chemical Society, 1994: 80-99.
    • (1994) Carbohydrate Modifications in Antisense Research , pp. 80-99
    • Herdewijn, P.1    De Winter, H.2    Doboszewski, B.3
  • 27
    • 0042798373 scopus 로고
    • 4′-thio-RNA: A novel class of sugar modified β-RNA
    • Sanghvi YS, Cook PD, eds. ACS Symposium series 580. Washington DC: American Chemical Society
    • Bellon L, Leudier C, Barascut JL, Maury G, Imbach JL. 4′-thio-RNA: a novel class of sugar modified β-RNA. In: Sanghvi YS, Cook PD, eds. Carbohydrate Modifications in Antisense Research. ACS Symposium series 580. Washington DC: American Chemical Society, 1994: 68-79.
    • (1994) Carbohydrate Modifications in Antisense Research , pp. 68-79
    • Bellon, L.1    Leudier, C.2    Barascut, J.L.3    Maury, G.4    Imbach, J.L.5
  • 30
    • 0028908575 scopus 로고
    • Tricyclic 2′-deoxycytidine analogs: Synthesis and incorporation into oligonucleotides which have enhanced binding to complementary RNA
    • Lin KY, Jones RJ, Matteucci M. Tricyclic 2′-deoxycytidine analogs: synthesis and incorporation into oligonucleotides which have enhanced binding to complementary RNA. J Am Chem Soc 1995; 117: 3873-4.
    • (1995) J Am Chem Soc , vol.117 , pp. 3873-3874
    • Lin, K.Y.1    Jones, R.J.2    Matteucci, M.3
  • 31
    • 0027023642 scopus 로고
    • GEM 91 - An antisense oligonucleotide phosphorothioate as a therapeutic agent for AIDS
    • Agrawal S, Tang Y-C. GEM 91 - an antisense oligonucleotide phosphorothioate as a therapeutic agent for AIDS. Antisense Res Dev 1992; 2: 261-6.
    • (1992) Antisense Res Dev , vol.2 , pp. 261-266
    • Agrawal, S.1    Tang, Y.-C.2
  • 32
    • 0028019410 scopus 로고
    • Gene inhibition using antisense oligodeoxynucleotides
    • Wagner RW. Gene inhibition using antisense oligodeoxynucleotides. Nature 1994; 372: 333-5.
    • (1994) Nature , vol.372 , pp. 333-335
    • Wagner, R.W.1
  • 33
    • 0027730294 scopus 로고
    • Evaluation of some properties of phosphorodithioate oligodeoxyribonucleotide for antisense application
    • Gosh MK, Gosh K, Dahl O, Cohen JS. Evaluation of some properties of phosphorodithioate oligodeoxyribonucleotide for antisense application. Nucleic Acids Res 1993; 21: 5761-6.
    • (1993) Nucleic Acids Res , vol.21 , pp. 5761-5766
    • Gosh, M.K.1    Gosh, K.2    Dahl, O.3    Cohen, J.S.4
  • 34
    • 0026577868 scopus 로고
    • Synthesis and base-pairing properties of the nuclease resistant α-anomeric deoxyribonucleotide α-[r(UCUUAACCCACA)]
    • Debart F, Rayner B, Degols G, Imbach JL. Synthesis and base-pairing properties of the nuclease resistant α-anomeric deoxyribonucleotide α-[r(UCUUAACCCACA)]. Nucleic Acids Res 1992; 20: 1193-200.
    • (1992) Nucleic Acids Res , vol.20 , pp. 1193-1200
    • Debart, F.1    Rayner, B.2    Degols, G.3    Imbach, J.L.4
  • 36
    • 0028800708 scopus 로고
    • Antisense 2′-O-alkyl oligoribonucleotides are efficient inhitors of reverse transcription
    • Boiziau C, Larrouy B, Sproat BS, Toulme JJ. Antisense 2′-O-alkyl oligoribonucleotides are efficient inhitors of reverse transcription. Nucleic Acids Res 1995; 23: 164-71.
    • (1995) Nucleic Acids Res , vol.23 , pp. 164-171
    • Boiziau, C.1    Larrouy, B.2    Sproat, B.S.3    Toulme, J.J.4
  • 37
    • 0028038592 scopus 로고
    • Peptide nucleic acid (PNA). A DNA mimic with a peptide backbone
    • Nielsen PE, Egholm M, Buchardt O. Peptide nucleic acid (PNA). A DNA mimic with a peptide backbone. Bioconjug Chem 1994; 5: 3-7.
    • (1994) Bioconjug Chem , vol.5 , pp. 3-7
    • Nielsen, P.E.1    Egholm, M.2    Buchardt, O.3
  • 38
    • 0027104702 scopus 로고
    • Antisense and antigene properties of peptide nucleic acids
    • Hanvey JC, Peffer NC, Bisi JE, et al. Antisense and antigene properties of peptide nucleic acids. Science 1992; 258: 1481-5.
    • (1992) Science , vol.258 , pp. 1481-1485
    • Hanvey, J.C.1    Peffer, N.C.2    Bisi, J.E.3
  • 39
    • 0029980721 scopus 로고    scopus 로고
    • Antisense properties of duplex-and triplex-forming PNAs
    • Knudsen M, Nielsen PE. Antisense properties of duplex-and triplex-forming PNAs. Nucleic Acids Res 1996; 24: 494-500.
    • (1996) Nucleic Acids Res , vol.24 , pp. 494-500
    • Knudsen, M.1    Nielsen, P.E.2
  • 40
    • 84988099601 scopus 로고
    • Synthetic modifications of antisense oligonucleotides: Novel backbone replacements with improved properties
    • De Mesmaeker A, Waldner A, Fritsch V, Lebreton J, Wolf RM. Synthetic modifications of antisense oligonucleotides: novel backbone replacements with improved properties. Bull Soc Chim Belg 1994; 103: 705-17.
    • (1994) Bull Soc Chim Belg , vol.103 , pp. 705-717
    • De Mesmaeker, A.1    Waldner, A.2    Fritsch, V.3    Lebreton, J.4    Wolf, R.M.5
  • 41
    • 0026621339 scopus 로고
    • Implication of RNA structure on antisense oligonucleotide hybridization kinetics
    • Lima WF, Monia BP, Ecker DJ, Freier SM. Implication of RNA structure on antisense oligonucleotide hybridization kinetics. Biochemistry 1992; 31: 12055-61.
    • (1992) Biochemistry , vol.31 , pp. 12055-12061
    • Lima, W.F.1    Monia, B.P.2    Ecker, D.J.3    Freier, S.M.4
  • 42
    • 0025834035 scopus 로고
    • Inhibition of HIV-LTR gene expression by oligonucleotides targeted to the TAR element
    • Vickers T, Baker BF, Cook PD, et al. Inhibition of HIV-LTR gene expression by oligonucleotides targeted to the TAR element. Nucleic Acids Res 1991; 19: 3359-68.
    • (1991) Nucleic Acids Res , vol.19 , pp. 3359-3368
    • Vickers, T.1    Baker, B.F.2    Cook, P.D.3
  • 43
    • 0026770701 scopus 로고
    • Predicting antisense oligonucleotide inhibitory efficacy: A computational approach using histograms and thermodynamic indices
    • Stull RA, Taylor LA, Szoka FC Jr. Predicting antisense oligonucleotide inhibitory efficacy: a computational approach using histograms and thermodynamic indices. Nucleic Acids Res 1992; 20: 3501-8.
    • (1992) Nucleic Acids Res , vol.20 , pp. 3501-3508
    • Stull, R.A.1    Taylor, L.A.2    Szoka Jr., F.C.3
  • 44
    • 0028041615 scopus 로고
    • Recognition and cleavage of hairpin structures in nucleic acids by oligodeoxynucleotides
    • Francois JC, Thuong NT, Helene C. Recognition and cleavage of hairpin structures in nucleic acids by oligodeoxynucleotides. Nucleic Acids Res 1994; 22: 3943-50.
    • (1994) Nucleic Acids Res , vol.22 , pp. 3943-3950
    • Francois, J.C.1    Thuong, N.T.2    Helene, C.3
  • 45
    • 0028296622 scopus 로고
    • Selection of structure-specific inhibitors of the HIV rev-rev response element complex
    • Cload ST, Schepartz A. Selection of structure-specific inhibitors of the HIV rev-rev response element complex. J Am Chem Soc 1994; 116: 437-42.
    • (1994) J Am Chem Soc , vol.116 , pp. 437-442
    • Cload, S.T.1    Schepartz, A.2
  • 46
    • 0027425105 scopus 로고
    • Oligonucleotide clamps arrest DNA synthesis on a single stranded DNA target
    • Giovannangeli C, Thuong NT, Helene C. Oligonucleotide clamps arrest DNA synthesis on a single stranded DNA target. Proc Natl Acad Sci USA 1993; 90: 10013-7.
    • (1993) Proc Natl Acad Sci USA , vol.90 , pp. 10013-10017
    • Giovannangeli, C.1    Thuong, N.T.2    Helene, C.3
  • 47
    • 0027749313 scopus 로고
    • The binding of an antisense oligonucleotide to a hairpin structure via triplex formation inhibits chemical and biological reactions
    • Brossalina E, Pascolo E, Toulme JJ. The binding of an antisense oligonucleotide to a hairpin structure via triplex formation inhibits chemical and biological reactions. Nucleic Acids Res 1993; 21: 5616-22.
    • (1993) Nucleic Acids Res , vol.21 , pp. 5616-5622
    • Brossalina, E.1    Pascolo, E.2    Toulme, J.J.3
  • 48
    • 0028938489 scopus 로고
    • Recognition and cleavage of single-stranded DNA containing hairpin structures by oligonucleotides forming both Watson-Crick and Hoogsteen hydrogen bonds
    • Francois JC, Helene C. Recognition and cleavage of single-stranded DNA containing hairpin structures by oligonucleotides forming both Watson-Crick and Hoogsteen hydrogen bonds. Biochemistry 1995; 34: 65-72.
    • (1995) Biochemistry , vol.34 , pp. 65-72
    • Francois, J.C.1    Helene, C.2
  • 49
    • 0000876330 scopus 로고
    • Use of hydrophobic substituents in controlling self assembly of oligonucleotides
    • Letsinger RL, Chatuvedi SK, Farooqui F, Salunkhe M. Use of hydrophobic substituents in controlling self assembly of oligonucleotides. J Am Chem Soc 1993; 115: 7535-6.
    • (1993) J Am Chem Soc , vol.115 , pp. 7535-7536
    • Letsinger, R.L.1    Chatuvedi, S.K.2    Farooqui, F.3    Salunkhe, M.4
  • 50
    • 0027469581 scopus 로고
    • The functionalization of oligonucleotides via phosphoramidite derivatives
    • Beaucage SL, Iyer RP. The functionalization of oligonucleotides via phosphoramidite derivatives. Tetrahedron 1993; 49: 1925-63.
    • (1993) Tetrahedron , vol.49 , pp. 1925-1963
    • Beaucage, S.L.1    Iyer, R.P.2
  • 51
    • 0025492461 scopus 로고
    • Synthesis and interactive properties of an oligonucleotide with anthraquinone at the sugar fragment
    • Yamana K, Nishijima Y, Ikeda T, et al. Synthesis and interactive properties of an oligonucleotide with anthraquinone at the sugar fragment. Bioconjug Chem 1990; 1: 319-24.
    • (1990) Bioconjug Chem , vol.1 , pp. 319-324
    • Yamana, K.1    Nishijima, Y.2    Ikeda, T.3
  • 52
    • 0029340735 scopus 로고
    • Oligodeoxyribonucleotides with conjugated dihydropyrroloindole oligopeptides: Preparation and hybridization properties
    • Lukhtanov EA, Kutyavin IV, Gamper HB, Meyer RB Jr. Oligodeoxyribonucleotides with conjugated dihydropyrroloindole oligopeptides: preparation and hybridization properties. Bioconjug Chem 1995; 6: 418-26.
    • (1995) Bioconjug Chem , vol.6 , pp. 418-426
    • Lukhtanov, E.A.1    Kutyavin, I.V.2    Gamper, H.B.3    Meyer Jr., R.B.4
  • 53
    • 0027153587 scopus 로고
    • Large scale, liquid phase synthesis of oligonucleotides by the phosphoramidate approach
    • Bonora GM, Biancotto G, Maffini M, Scremin CL. Large scale, liquid phase synthesis of oligonucleotides by the phosphoramidate approach. Nucleic Acids Res 1993; 21: 1213-21.
    • (1993) Nucleic Acids Res , vol.21 , pp. 1213-1221
    • Bonora, G.M.1    Biancotto, G.2    Maffini, M.3    Scremin, C.L.4
  • 54
    • 0026651984 scopus 로고
    • Inhibition of leukemia cell proliferation by receptor-mediated uptake of c-myb antisense oligodeoxynucleotides
    • Citro G, Perrotti D, Cucco C, et al. Inhibition of leukemia cell proliferation by receptor-mediated uptake of c-myb antisense oligodeoxynucleotides. Proc Natl Acad Sci USA 1992; 89: 7031-5.
    • (1992) Proc Natl Acad Sci USA , vol.89 , pp. 7031-7035
    • Citro, G.1    Perrotti, D.2    Cucco, C.3
  • 56
    • 0025758178 scopus 로고
    • Mode of action of 5′-linked cholesterol phosphorothioate oligonucleotides in inhibiting syncytia formation and infection by HIV-1 and HIV-2 in vitro
    • Stein CA, Ranajit P, DeVico AI, et al. Mode of action of 5′-linked cholesterol phosphorothioate oligonucleotides in inhibiting syncytia formation and infection by HIV-1 and HIV-2 in vitro. Biochemistry 1991; 30: 2439-44.
    • (1991) Biochemistry , vol.30 , pp. 2439-2444
    • Stein, C.A.1    Ranajit, P.2    DeVico, A.I.3
  • 57
    • 0027034899 scopus 로고
    • Poly (L-lysine)-conjugated oligonucleotides promote sequence-specific inhibition of acute HIV-1 infection
    • Degols G, Leonetti JP, Benkirane M, Devaux C, LeBleu B. Poly (L-lysine)-conjugated oligonucleotides promote sequence-specific inhibition of acute HIV-1 infection. Antisense Res Dev 1992; 2: 293-301.
    • (1992) Antisense Res Dev , vol.2 , pp. 293-301
    • Degols, G.1    Leonetti, J.P.2    Benkirane, M.3    Devaux, C.4    LeBleu, B.5
  • 58
    • 0026601792 scopus 로고
    • Effective incorporation of 2′-O-methyl-oligoribonucleotides into liposomes and enhanced cell association through modification with thiocholesterol
    • Oberhauser B, Wagner E. Effective incorporation of 2′-O-methyl-oligoribonucleotides into liposomes and enhanced cell association through modification with thiocholesterol. Nucleic Acids Res 1992; 20: 533-8.
    • (1992) Nucleic Acids Res , vol.20 , pp. 533-538
    • Oberhauser, B.1    Wagner, E.2
  • 59
    • 0027156131 scopus 로고
    • Inhibition of HIV proliferation in MT-4 cells by antisense oligonucleotide conjugated to lipophilic groups
    • Svinarchuk FP, Konevetz DA, Pliasunova OA, Pokrovsky AG, Vlassov VV. Inhibition of HIV proliferation in MT-4 cells by antisense oligonucleotide conjugated to lipophilic groups. Biochimie 1993; 75: 49-54.
    • (1993) Biochimie , vol.75 , pp. 49-54
    • Svinarchuk, F.P.1    Konevetz, D.A.2    Pliasunova, O.A.3    Pokrovsky, A.G.4    Vlassov, V.V.5
  • 60
    • 0028915965 scopus 로고
    • Prodrugs of oligonucleotides: The acyloxy esters of oligodeoxyribonucleoside phosphorothioates
    • Iyer RP, Yu D, Agrawal S. Prodrugs of oligonucleotides: the acyloxy esters of oligodeoxyribonucleoside phosphorothioates. Bioorg Chem 1995; 23: 1-21.
    • (1995) Bioorg Chem , vol.23 , pp. 1-21
    • Iyer, R.P.1    Yu, D.2    Agrawal, S.3
  • 61
    • 0028970203 scopus 로고
    • The prooligonucleotide approach. I. Esterase-mediated reversibility of dithymidine S-alkyl-phosphorothiolates to dithymidine phosphorothioates
    • Barber I, Rayner B, Imbach JL. The prooligonucleotide approach. I. Esterase-mediated reversibility of dithymidine S-alkyl-phosphorothiolates to dithymidine phosphorothioates. Bioorg Med Chem Lett 1995; 5: 563-8.
    • (1995) Bioorg Med Chem Lett , vol.5 , pp. 563-568
    • Barber, I.1    Rayner, B.2    Imbach, J.L.3
  • 63
    • 0028915281 scopus 로고
    • An assessment of the antisense properties of RNase H-competent and steric-blocking oligomers
    • Bonham MA, Brown S, Boyd AL, et al. An assessment of the antisense properties of RNase H-competent and steric-blocking oligomers. Nucleic Acids Res 1995; 23: 1197-203.
    • (1995) Nucleic Acids Res , vol.23 , pp. 1197-1203
    • Bonham, M.A.1    Brown, S.2    Boyd, A.L.3
  • 64
    • 0028598284 scopus 로고
    • Study of antisense oligonucleotide phosphorothioates containing segments of oligodeoxynucleotides and 2′-O-methyloligoribonucleotides
    • Metelev V, Liszienicz J, Agrawal S. Study of antisense oligonucleotide phosphorothioates containing segments of oligodeoxynucleotides and 2′-O-methyloligoribonucleotides. Bioorg Med Chem Lett 1994; 4: 2929-34.
    • (1994) Bioorg Med Chem Lett , vol.4 , pp. 2929-2934
    • Metelev, V.1    Liszienicz, J.2    Agrawal, S.3
  • 65
    • 0026048056 scopus 로고
    • Effects of phosphorothioate capping on antisense oligonucleotide stability, hybridization and antiviral efficacy versus herpes simplex virus infection
    • Hoke GD, Draper K, Freier SM, et al. Effects of phosphorothioate capping on antisense oligonucleotide stability, hybridization and antiviral efficacy versus herpes simplex virus infection. Nucleic Acids Res 1991; 19: 5743-8.
    • (1991) Nucleic Acids Res , vol.19 , pp. 5743-5748
    • Hoke, G.D.1    Draper, K.2    Freier, S.M.3
  • 66
    • 0029042615 scopus 로고
    • Ribozymes as human therapeutic agents
    • Christoffersen RE, Marr JJ. Ribozymes as human therapeutic agents. J Med Chem 1995; 38; 2023-37.
    • (1995) J Med Chem , vol.38 , pp. 2023-2037
    • Christoffersen, R.E.1    Marr, J.J.2
  • 67
    • 0026648446 scopus 로고
    • Effects of the terminal phosphate derivatization of β- and α-oligodeoxynucleotides on their antisense activity in protein biosynthesis, stability and uptake by eukaryotic cells
    • Butorin AS, Boiziau C, Le Doan T, Toulme JJ, Helene C. Effects of the terminal phosphate derivatization of β- and α-oligodeoxynucleotides on their antisense activity in protein biosynthesis, stability and uptake by eukaryotic cells. Biochimie 1992; 74: 485-9.
    • (1992) Biochimie , vol.74 , pp. 485-489
    • Butorin, A.S.1    Boiziau, C.2    Le Doan, T.3    Toulme, J.J.4    Helene, C.5
  • 68
    • 0029103994 scopus 로고
    • Carbon-hydrogen bonds of DNA sugar units as targets for chemical nucleases and drugs
    • Pratviel G, Bernadou J, Meunier B. Carbon-hydrogen bonds of DNA sugar units as targets for chemical nucleases and drugs. Angew Chem Int Edn Engl 1995; 34: 746-69.
    • (1995) Angew Chem Int Edn Engl , vol.34 , pp. 746-769
    • Pratviel, G.1    Bernadou, J.2    Meunier, B.3
  • 69
    • 0028533862 scopus 로고
    • Efficient sequence-specific cleavage of RNA using novel europium complexes conjugated to oligonucleotides
    • Hall J, Hüsken D, Pieles U, Moser HE, Häner R. Efficient sequence-specific cleavage of RNA using novel europium complexes conjugated to oligonucleotides. Chem Biol 1994; 1: 185-90.
    • (1994) Chem Biol , vol.1 , pp. 185-190
    • Hall, J.1    Hüsken, D.2    Pieles, U.3    Moser, H.E.4    Häner, R.5
  • 70
    • 0028467451 scopus 로고
    • DNA-linked RNase H for site-selective cleavage of RNA
    • Uchiyama Y, Inoue H, Ohtsuka E, et al. DNA-linked RNase H for site-selective cleavage of RNA. Bioconjug Chem 1994; 5: 327-32.
    • (1994) Bioconjug Chem , vol.5 , pp. 327-332
    • Uchiyama, Y.1    Inoue, H.2    Ohtsuka, E.3
  • 71
    • 0000842047 scopus 로고
    • Formation of two- and three-stranded polyribonucleotides
    • Felsenfeld G, Rich A. Formation of two- and three-stranded polyribonucleotides. Biochim Biophys Acta 1957; 26: 457-68.
    • (1957) Biochim Biophys Acta , vol.26 , pp. 457-468
    • Felsenfeld, G.1    Rich, A.2
  • 72
    • 0023619361 scopus 로고
    • Sequence-specific cleavage of double helical DNA by triplet helix formation
    • Moser HE, Dervan PB. Sequence-specific cleavage of double helical DNA by triplet helix formation. Science 1987; 238: 645-50.
    • (1987) Science , vol.238 , pp. 645-650
    • Moser, H.E.1    Dervan, P.B.2
  • 74
    • 0028997796 scopus 로고
    • Sequence composition effects on the energetics of triple helix formation by oligonucleotides containing a designed mimic of protonated cytosine
    • Priestley ES, Dervan PB. Sequence composition effects on the energetics of triple helix formation by oligonucleotides containing a designed mimic of protonated cytosine. J Am Chem Soc 1995; 117: 4761 -5.
    • (1995) J Am Chem Soc , vol.117 , pp. 4761-4765
    • Priestley, E.S.1    Dervan, P.B.2
  • 76
    • 0025817256 scopus 로고
    • Second structural motif for recognition of DNA by oligonucleotide directed triple-helix formation
    • Beal PA, Dervan PB. Second structural motif for recognition of DNA by oligonucleotide directed triple-helix formation. Science 1991; 251: 1360-3.
    • (1991) Science , vol.251 , pp. 1360-1363
    • Beal, P.A.1    Dervan, P.B.2
  • 77
    • 0028352070 scopus 로고
    • Linkage structures strongly influence the binding cooperativity of DNA intercalators conjugated to triplex forming oligonucleotides
    • Orson FM, Kinsey BM, McShan WM. Linkage structures strongly influence the binding cooperativity of DNA intercalators conjugated to triplex forming oligonucleotides. Nucleic Acids Res 1994; 22: 479-84.
    • (1994) Nucleic Acids Res , vol.22 , pp. 479-484
    • Orson, F.M.1    Kinsey, B.M.2    McShan, W.M.3
  • 78
    • 0027723230 scopus 로고
    • Modulation of oligonucleotide duplex and triplex stablity via hydrophobic interactions
    • Gryaznov SM, Lloyd DH. Modulation of oligonucleotide duplex and triplex stablity via hydrophobic interactions. Nucleic Acids Res 1993; 21: 5909-15.
    • (1993) Nucleic Acids Res , vol.21 , pp. 5909-5915
    • Gryaznov, S.M.1    Lloyd, D.H.2
  • 79
    • 0345038605 scopus 로고
    • Triple-helix formation of oligonucleotides containing [(3′S,5′R)-2′-deoxy-3′,5′-ethano-β-D- ribofuranosyl]nucleosides ('bicyclodeoxynucleosides')
    • Bolli M, Leumann C. Triple-helix formation of oligonucleotides containing [(3′S,5′R)-2′-deoxy-3′,5′-ethano-β-D- ribofuranosyl]nucleosides ('bicyclodeoxynucleosides'). Angew Chem Int Edn Engl 1995; 34: 694-6.
    • (1995) Angew Chem Int Edn Engl , vol.34 , pp. 694-696
    • Bolli, M.1    Leumann, C.2
  • 80
    • 0028143428 scopus 로고
    • Triple-helices targeted to the polypurine tract of a murine retrovirus
    • Porumb H, Dagneaux C, Letellier R, Malvy C, Taillandier E. Triple-helices targeted to the polypurine tract of a murine retrovirus. Gene 1994; 149: 101-7.
    • (1994) Gene , vol.149 , pp. 101-107
    • Porumb, H.1    Dagneaux, C.2    Letellier, R.3    Malvy, C.4    Taillandier, E.5
  • 81
    • 0028913724 scopus 로고
    • Recognition of duplex DNA by RNA polynucleotides
    • McDonald CD, Mahler LJ III. Recognition of duplex DNA by RNA polynucleotides. Nucleic Acids Res 1995; 23: 500-6.
    • (1995) Nucleic Acids Res , vol.23 , pp. 500-506
    • McDonald, C.D.1    Mahler III, L.J.2
  • 82
    • 0028908157 scopus 로고
    • Relative stabilities of triple helices composed of combinations of DNA, RNA and 2′-O-methyl-RNA backbones: Chimeric circular oligonucleotides as probes
    • Wang S, Kool ET. Relative stabilities of triple helices composed of combinations of DNA, RNA and 2′-O-methyl-RNA backbones: chimeric circular oligonucleotides as probes. Nucleic Acids Res 1995; 23; 1157-64.
    • (1995) Nucleic Acids Res , vol.23 , pp. 1157-1164
    • Wang, S.1    Kool, E.T.2
  • 83
    • 0028061228 scopus 로고
    • Pyrimidine phosphorothioate oligonucleotides form triple-stranded helices and promote transcription inhibition
    • Xodo L, Alunni-Fabbroni M, Manzini G, Quadrifoglio F. Pyrimidine phosphorothioate oligonucleotides form triple-stranded helices and promote transcription inhibition. Nucleic Acids Res 1994; 22: 3322-30.
    • (1994) Nucleic Acids Res , vol.22 , pp. 3322-3330
    • Xodo, L.1    Alunni-Fabbroni, M.2    Manzini, G.3    Quadrifoglio, F.4
  • 84
    • 0028557343 scopus 로고
    • Triple-strand-forming methylphosphonate oligodeoxynucleotides targeted to mRNA efficiently block protein synthesis
    • Reynolds MA, Arnold LJ Jr, Almazan MT, et al. Triple-strand-forming methylphosphonate oligodeoxynucleotides targeted to mRNA efficiently block protein synthesis. Proc Natl Acad Sci USA 1994; 91: 12433-7.
    • (1994) Proc Natl Acad Sci USA , vol.91 , pp. 12433-12437
    • Reynolds, M.A.1    Arnold Jr., L.J.2    Almazan, M.T.3
  • 85
    • 0027233528 scopus 로고
    • Sequence-specific inhibition of DNA restriction enzyme cleavage by PNA
    • Nielsen PE, Engholm M, Berg RM, Buchardt O. Sequence-specific inhibition of DNA restriction enzyme cleavage by PNA. Nucleic Acids Res 1993; 21: 197-200.
    • (1993) Nucleic Acids Res , vol.21 , pp. 197-200
    • Nielsen, P.E.1    Engholm, M.2    Berg, R.M.3    Buchardt, O.4
  • 86
    • 0028075767 scopus 로고
    • Sequence-specific transcription arrest by peptide nucleic acid bound to the DNA template strand
    • Nielsen PE, Engholm M, Buchardt O. Sequence-specific transcription arrest by peptide nucleic acid bound to the DNA template strand. Gene 1994; 149: 139-45.
    • (1994) Gene , vol.149 , pp. 139-145
    • Nielsen, P.E.1    Engholm, M.2    Buchardt, O.3
  • 87
    • 9044228030 scopus 로고    scopus 로고
    • Transcription-mediated binding of peptide nucleic acid (PNA) to double-stranded DNA: Sequence-specific suicide transcription
    • Laren HJ, Nielsen PE. Transcription-mediated binding of peptide nucleic acid (PNA) to double-stranded DNA: sequence-specific suicide transcription. Nucleic Acids Res 1996; 24: 458-63.
    • (1996) Nucleic Acids Res , vol.24 , pp. 458-463
    • Laren, H.J.1    Nielsen, P.E.2
  • 88
    • 0028961229 scopus 로고
    • Single-strand targeted triplex formation. Destabilization of guanine quadruplex structures by foldback triplex-forming oligonucleotides
    • Kandimalla ER, Agrawal S. Single-strand targeted triplex formation. Destabilization of guanine quadruplex structures by foldback triplex-forming oligonucleotides. Nucleic Acids Res 1995; 23: 1068-74.
    • (1995) Nucleic Acids Res , vol.23 , pp. 1068-1074
    • Kandimalla, E.R.1    Agrawal, S.2


* 이 정보는 Elsevier사의 SCOPUS DB에서 KISTI가 분석하여 추출한 것입니다.