Immediate-early gene expression in ovine brain after cardiopulmonary bypass and hypothermic circulatory arrest

Anesthesiology

Volumn 85, Issue 6, 1996, Pages 1439-1446

  Bokesch, Paula M ^a,b   Marchand, James ^a   Seirafi, Peter A ^a   Deiss, Judith M ^a   Warner, Kenneth G ^a   Bronson, Roderick T ^a   Kream, Richard M ^a  

^a Dept of Cardiothoracic Anesthesia ^*

^b LERNER RESEARCH INSTITUTE   (United States)

Author keywords

Animals: lambs; Brain: excitatory neurotransmitters; c fos; immediate early gene expression; ischemia; Experimental techniques: immunohistochemistry; in situ hybridization; Surgery: cardiopulmonary bypass; hypothermic circulatory arrest

Indexed keywords

MESSENGER RNA; PROTEIN C FOS;

ANIMAL EXPERIMENT; ANIMAL MODEL; ANIMAL TISSUE; ARTICLE; BRAIN HYPOXIA; BRAIN ISCHEMIA; CARDIOPULMONARY BYPASS; CONTROLLED STUDY; GENE EXPRESSION; HEART ARREST; HIPPOCAMPUS; IMMEDIATE EARLY GENE; INDUCED HYPOTHERMIA; LAMB; NERVE CELL NECROSIS; NEWBORN; NONHUMAN; ONCOGENE C FOS; PRIORITY JOURNAL;

ANIMALS; CARDIOPULMONARY BYPASS; CELL DEATH; GENE EXPRESSION; GENES, FOS; HIPPOCAMPUS; HYPOTHERMIA, INDUCED; IN SITU HYBRIDIZATION; INTERNEURONS; MODELS, BIOLOGICAL; PROTEIN BIOSYNTHESIS; SHEEP;

EID: 0030474657     PISSN: 00033022     EISSN: None     Source Type: Journal    
DOI: 10.1097/00000542-199612000-00026     Document Type: Article

References (24)

1. Redman JM, Gillinov AM, Zehr KJ, Blue ME, Troncoso JC, Reitz BA, Cameron DE, Johnston MV, Baumgartner WA: Glutamate excitotoxicity: A mechanism of neurologic injury associated with hypothermic circulatory arrest. J Thorac Cardiovasc Surg 1994; 107:776-87
2. Redman JM, Gillinov AM, Blue M, Zehr KJ, Troncoso JC, Cameron DE, Johnston MV, Baumgartner WA: The monosialoganglioside, GM1, reduces neurologic injury associated with hypothermie circulatory arrest. Surgery 1993; 114:324-33
3. Rothman SM, Olney JW: Glutamate and the pathophysiology of hypoxic-ischemic brain damage. Ann Neuro) 1986; 19:105-11
4. Lipton SA, Rosenberg PA: Excitatory amino acids as a final common pathway for neurologic disorders. N Engl J Med 1994; 330:613-22
5. Hughes P, Dragunow M: Induction of immediate-early genes and the control of neurotransmitter-regulated gene expression within the nervous system. Pharmacol Rev 1995; 47:133-78
6. Smeyne RJ, Vendrell M, Hayward M, Baker SJ, Miao GC, Schilling K, Robertson LM, Curran T, Morgan JI: Continuous c-fos expression precedes programmed cell death in vivo. Nature 1993; 363:166-9
7. Kiessling M, Gass P: Stimulus-transcription coupling in focal cerebral ischemia. Brain Pathol 1994; 4:77-83
8. Morgan JI, Cohen DR, Hempstead JL, Curran T: Mapping patterns of c-fos expression in the central nervous system after seizures. Science 1987; 236:192-7
9. Bullitt E: Expression of C-fos-like protein as a marker for neuronal activity following noxious stimulation in the rat. J Comp Neurol 1990; 296:517-30
10. Sheng M, Greenberg ME: The regulation and function of c-fos and other immediate early genes in the nervous system. Neuron 1990; 4:477-85
11. Ikeda J, Nakajima T, Gerfen C, Nowak TS: In situ hybridization analysis of c-fos and prodynorphin mRNA levels and distribution in gerbil hippocampus after transient ischemia. Stroke 1990; 21:1-16
12. Sonnenberg JL, MacGregor-Leon PF, Curran T, Morgan J: Dynamic alterations occur in the levels and composition of transcription factor AP-1 complexes after seizure. Neuron 1989a; 3:359-65
13. Bokesch PM, Marchand JE, Connelly CS, Wurm WH, Kream RM: Dextromethorphan inhibits ischemia-induced c-fos expression and delayed neuronal death in hippocampal neurons. ANESTHESIOLOGY 1994; 81:470-7
14. Gil R, Foster AC, Woodruff GN: Systemic administration of MK-801 protects against ischemia-induced hippocampal neurodegeneration in the gerbil. J Neurosci 1987; 7:3343-49
15. Shaw PJ, Bates D, Cartlidge NEF, French JM, Heaviside D, Julian DG, Shaw DA: Neurologic and neuropsychological morbidity following major surgery: Comparison of coronary artery bypass and peripheral vascular surgery. Stroke 1987; 18:700-7
16. Feerick AE, Johnston WE, Jenkins LW, Lin CY, Mackay JH, Prough DS: Hyperglycemia during hypothermic canine cardiopulmonary bypass increases cerebral lactate. ANESTHESIOLOGY 1995; 82:512-20
17. Sonnenberg JL, Rauscher FJ, Morgan JI, Curran T: Regulation of proenkephalin by Fos andjun. Science 1989; 246:1622-5
18. Marchand JE, Zaccheo TS, Connelly CS, Kream RM: Selective in situ hybridization histochemical analyses of alternatively spliced mRNAs encoding preprotachykinins in rat central nervous system. Mol Brain Res 1993; 17:83-94
19. Shimonaka H, Marchand JE, Connelly CS, Kream RM: Development of an antiserum to the midportion of substance P: Applications for biochemical and anatomical studies of substance P-related peptide species in CNS tissues. J Neurochem 1992; 59:81-92
20. Zaccheo TS, Gonsalves RA, Kream RM: Detection and estimation of mRNA levels using a non-linear model in neurona labeled by in situ hybridization histochemistry. Neurolmage 1993; 1:151-61
21. Gasic GP, Hollman M: Molecular neurobiology of glutamate receptors. Annu Rev Physiol 1992; 54:507-36
22. Crittenden MD, Roberts CS, Rosa L, Vatsia SK, Katz D, Clark RE, Swain JA: Brain protection during circulatory arrest. Ann Thorac Surg 1991; 51:942-7
23. McConnell JR, Fleming WH, Chu WK, Hahn FJ, Sarafian LB, Hofschire PJ, Kugler JD: Magnetic resonance imaging of the brain in infants and children before and after cardiac surgery. Am J Dis Child 1990; 144:374-8
24. Stow PJ, Burrows FA, McLeod ME, Coles JG: The effects of cardiopulmonary bypass and profound hypothermic circulatory arrest on anterior fontanel pressure in infants. Can J Anaesth 1987; 34:450-4