Effects of the synthetic vitamin D analogue EB 1089 and tamoxifen on the growth of experimental rat mammary tumours

Endocrine-Related Cancer

Volumn 3, Issue 4, 1996, Pages 327-335

  Mackay, A G ^a   Ofori Kuragu, E A ^a   Lansdown, A ^b   Coombes, R C ^c   Binderup, L ^d   Colston, K W ^a  

^a ST GEORGE S HOSPITAL   (United Kingdom)

^b IMPERIAL COLLEGE SCHOOL OF MEDICINE   (United Kingdom)

^c CHARING CROSS HOSPITAL   (United Kingdom)

^d LEO PHARMA A S   (Denmark)

Author keywords

[No Author keywords available]

Indexed keywords

CALCIUM; METHYLNITROSOUREA; SEOCALCITOL; TAMOXIFEN; VITAMIN D DERIVATIVE;

ANIMAL EXPERIMENT; ANIMAL MODEL; ANIMAL TISSUE; ARTICLE; BREAST TUMOR; CONTROLLED STUDY; FEMALE; NONHUMAN; ORAL DRUG ADMINISTRATION; RAT;

EID: 0030474546     PISSN: 13510088     EISSN: None     Source Type: Journal    
DOI: 10.1677/erc.0.0030327     Document Type: Article

References (37)

1. 3. Proceedings of the National Academy of Sciences of the USA 78 4990-4994.
2. 3 with an oxygen atom in the side chain skeleton. A trial of the development of vitamin D compounds which exhibit potent differentiation-inducing activity without inducing hypercalcaemia. FEBS Letters 226 58-62.
3. 3, inhibits the growth of human breast cancer in vitro and in vivo without causing hypercalcemia. Endocrinology 129 832-837.
4. Berger U, Wilson P, McClelland RA, Colston K, Haussler MR, Pike JW & Coombes RC 1988 Immunocytochemical detection of 1,25-dihydroxyvitamin D receptors in normal human tissues. Journal of Clinical Endocrinology and Metabolism 67 607-613.
5. Binderup L & Bramm E 1988 Effects of a novel vitamin D analogue MC903 on cell proliferation and differentiation in vitro and on calcium metabolism in vivo. Biochemical Pharmacology 37 887-895.
6. 3 analogues: a novel class of potent regulators of cell growth and immune responses. Biochemical Pharmacology 42 1569-1575.
7. Binderup E, Calverley MJ & Binderup L 1991b Synthesis and biological activity of 1a-hydroxylated vitamin D analogues with polyunsaturated side chains. In Vitamin D. Gene Regulation, Structure-Function Analysis and Clinical Application, pp 192-193. Eds AW Norman, R Bouillon & M Thomasset. Berlin: Walter de Gruyter.
8. Bower M, Colston KW, Stein RC, Hedley A, Gazet JC, Ford HT & Coombes RC 1991 Topical calcipotriol treatment in advanced breast cancer. Lance 1337 701-702.
9. 3 and malignant melanoma: the presence of receptors and inhibition of cell growth in culture. Endocrinology 108 1082-1086.
10. 3 receptors in human epithelial cancer cell lines. Cancer Research 42 856-859.
11. 3 binding in estrogen-responsive rat breast tumor. Endocrinology 119 397-403.
12. Colston KW, Berger U & Coombes RC 1989 Possible role for vitamin D in controlling breast cancer cell proliferation. Lancet i 188-191.
13. Colston KW, Chander SK, Mackay AG & Coombes RC 1992a Effects of synthetic vitamin D analogues on breast cancer cell proliferation in vivo and in vitro. Biochemical Pharmacology 44 693-702.
14. Colston KW, Mackay AG, James SY, Binderup L, Chander S & Coombes RC 19926 EB 1089: a new vitamin D analogue that inhibits the growth of breast cancer cells in vivo and in vitro. Biochemical Pharmacology 44 2273-2280.
15. Early Breast Cancer Trial Collaborative Group 1992 Systemic treatment of early breast cancer by hormonal, cytotoxic or immune therapy. 133 randomised trials involving 31 000 recurrences and 24 000 deaths among 75 000 women. Lancet 339 1-5, 71-85.
16. 3. Cancer Research 47 21-25.
17. 3 metabolites. Cancer Research 43 4443-4447.
18. Furr BJA & Jordan VC 1984 The pharmacology and clinical uses of tamoxifen. Pharmacology and Therapeutics 25 127-205.
19. Garnett TJ, Studd JWW, Savvas M & Watson NR 1992 Effects of plasma estradiol levels on increases in vertebral and femoral bone density following therapy with estradiol and estradiol with testosterone implants. Obstetrics and Gynecology 79 968-972.
20. 3) in rats with intact ovarian function consuming low calcium diet. Bone and Mineral 8 185-193.
21. 3 prolong the survival time of mice inoculated with myeloid leukemia cells. Proceedings of the National Academy of Sciences of the USA 80 201-206.
22. James SY, Mackay AG & Colston KW 1994 Effects of a new synthetic vitamin D analogue, EB 1089, on the oestrogen-responsive growth of human breast cancer cells. Journal of Endocrinology 141 555-563.
23. Kragballe K 1989 Treatment of psoriasis by the topical application of the novel cholecalciferol analogue calcipotriol (MC903). Archives of Dermatology 125 1647-1652.
24. Lahti E, Blanco G, Kauppila ZA, Apaja-Sarkkinen M, Taskinen PJ & Laatikainen T 1993 Endometrial changes in postmenopausal breast cancer patients receiving tamoxifen. Obstetrics and Gynecology 81 660-664.
25. Love RR, Mazess RB, Barden HS, Epstein S, Newcomb PA & Jordan VC 1992 Effects of bone mineral density in postmenopausal women with breast cancer. New England Journal of Medicine 326 852-856.
26. Mangelsdorf DJ, Koeffler HP, Donaldson CA, Pike JW & Haussler MR 1984 1,25-Dihydroxyvitamin D3-induced differentiation in a human promyelocytic cell line (HL60); receptor-mediated maturation to macrophagelike cells. Journal of Cellular Biology 98 391-398.
27. Mathiasen IS, Colston KW & Binderup L 1993 EB 1089, a novel vitamin D analogue, has strong antiproliferative and differentiation inducing effects on cancer cells. Journal of Steroid Biochemistry and Molecular Biology 46 365-371.
28. Ostrem VK, Tanaka Y, Prahl J, Deluca HF & Ikekawa N 1987 24- and 26-homo-1,25-dihydroxyvitamin D3: preferential activity in inducing diffeentiation of human leukemia cells HL-60 in vitro. Proceedings of the National Academy of Sciences of the USA 84 2610-2614.
29. Reichel H, Koeffler HP & Norman AW 1989 The role of the vitamin D endocrine system in health and disease. New England Journal of Medicine 320 980-991.
30. Stevenson JC, Cust MP, Gangar KF, Hillard TC, Lees B & Whitehead MI 1990 Effects of transdermal versus oral hormone replacement therapy on bone density in spine and proximal femur in postmenopausal women. Lancet 355 265-269.
31. Stewart PJ & Stem PH 1986 Effects of the antiestrogens tamoxifen and clomiphene on bone resorption in vitro. Endocrinology 118 125-131.
32. 31P Spectroscopy and histological studies of the response of rat mammary tumours to endocrine therapy. British Journal of Cancer 61 258-262.
33. Turken S, Siris E, Seldin D, Flaster E, Hyman G & Lindsay R 1989 Effects of tamoxifen on spinal bone density in women with breast cancer. Cancer 81 1086-1088.
34. Turner RT, Wakely GK, Hannon KS & Bell NH 1987 Tamoxifen prevents the skeletal effects of ovarian hormone deficiency in rats. Journal of Bone and Mineral Research 2 449-456.
35. Wakeling A E 1988 Cellular mechanisms in tamoxifen action on tumours. Reviews on Endocrine-Related Cancer 30 27-33.
36. Williams JC, Gusterson B, Humphreys J, Monagan P, Coombes RC, Rudland P & Neville AM 1981 N-Methyl-N-nitrosourea-induced rat mammary tumours. Hormone responsiveness but lack of spontaneous metastasis. Journal of the National Cancer Institute 66 147-155.
37. Wronski TJ, Cintron M, Doherty AL & Dann LM 1988 Estrogen treatment prevents osteopenia and depresses bone turnover in ovariectomized rats. Endocrinology 123 681-686.