Effect of the insecticidal Galanthus nivalis agglutinin on metabolism and the activities of brush border enzymes in the rat small intestine

Journal of Nutritional Biochemistry

Volumn 7, Issue 12, 1996, Pages 677-682

  Pusztai, Arpad ^a   Koninkx, Jos ^b   Hendriks, Henno ^b   Kok, Wouter ^b   Hulscher, Saskia ^b   Van Damme, Els J M ^c   Peumans, Willy J ^c   Grant, George ^a   Bardocz, Susan ^a  

^a ROWETT RESEARCH INSTITUTE   (United Kingdom)

^b UTRECHT UNIVERSITY   (Netherlands)

^c UNIVERSITY OF LEUVEN   (Belgium)

Author keywords

digestion; GNA; gut maturation; PHA phytohaemagglutinin; transgenic plants

Indexed keywords

AGGLUTININ; LECTIN;

ANIMAL EXPERIMENT; ARTICLE; BRUSH BORDER; CONTROLLED STUDY; MALE; NONHUMAN; RAT; SMALL INTESTINE; TOXICITY;

GALANTHUS NIVALIS;

EID: 0030474254     PISSN: 09552863     EISSN: None     Source Type: Journal    
DOI: 10.1016/S0955-2863(96)00131-3     Document Type: Article

References (18)

1. 1 Peumans, W.J. and Van Damme, E.J.M. (1996). Prevalence, biological activity and genetic manipulation of lectins in foods. Trends Food Sci. Technol. 7, 132-138
2. 2 Pusztai, A. (1993). Dietary lectins are metabolic signals for the gut and modulate immune and hormone functions. Eur. J. Clin. Nutr. 47, 691-699
3. 3 Pusztai, A., Grant, G., Spencer, R.J., Duguid, T.J., Brown, D.S., Ewen, S.W.B., Peumans, W.J., Van Damme, E.J.M., and Bardocz, S. (1993). Kidney bean lectin-induced Escherichia coli overgrowth in the small intestine is blocked by GNA, a mannose-specific lectin. J. Appl. Bacteriol. 75, 360-368
4. 4 Bardocz, S., Grant, G., Ewen, S.W.B., Duguid, T.J., Brown, D.S., Englyst, K., and Pusztai, A. (1995). Reversible effect of phytohaemagglutinin on the growth and metabolism of rat gastrointestinal tract. Gut 37, 353-360
5. 5 Banwell, J.G., Howard, R., Kabir, I., Adrian, T.E., Diamond, R.H., and Abramowsky, C. (1993). Small intestinal growth caused by feeding red kidney bean phytohaemagglutinin lectin to rats. Gastroenterology 104, 1669-1677
6. 6 Pusztai, A., Ewen, S.W.B., Grant, G., Peumans, W.J., Van Damme, E.J.M., Coates, M.E., and Bardocz, S. (1995). Lectins and also bacteria modify the glycosylation of gut surface receptors in the rat. Glycoconjugate J. 12, 22-35
7. 7 Gatehouse, A.M.R., Powell, K.S., Peumans, W.J., Van Damme, E.J.M., and Gatehouse, J.A. (1995). Insecticidal properties of plant lectins: their potential in plant protection. In Lectins: Biomedical Perspectives (A. Pusztai and S. Bardocz, ed.), p. 35-57, Taylor & Francis, London, UK
8. 8 Pusztai, A., Ewen, S.W.B., Grant, G., Peumans, W.J., Van Damme, E.J.M., Rubio, L., and Bardocz, S. (1990). The relationship between survival and binding of plant lectins during small intestinal passage and their effectiveness as growth factors. Digestion 46 (suppl. 2), 308-316
9. 9 Erikson, R.H., Kim, J., Sleisenger, M.H., and Kim, Y.S. (1985). Effects of lectins on the activity of brush border membrane-bound enzymes of rat small intestine. J. Pediatr. Gastroenterol. Nutr. 4, 984-991
10. 10 Van Damme, E.J.M., Allen, A.K., and Peumans, W.J. (1987). Isolation and characterization of a lectin with exclusive specificity towards mannose from snowdrop (Galanthus nivalis) bulbs. FEBS Lett. 215, 140-144
11. 11 Pusztai, A. and Palmer, R.M. (1977). Nutritional evaluation of kidney beans (Phaseolus vulgaris): the toxic principle. J. Sci. Food Agric. 28, 620-623
12. 12 Lowry, O.H., Rosebrough, N.J., Farr, A.L., and Randall, R.J. (1951). Protein measurements with the Folin phenol reagent. J. Biol. Chem. 193, 265-275
13. 13 Labarca, C. and Paigen, K. (1980). A simple, rapid and sensitive DNA assay procedure. Anal. Biochem. 102, 344-352
14. 14 Messer, M. and Dahlqvist, A. (1966). A one step ultramicromethod for the assay of intestinal disaccharidases. Anal. Biochem. 14, 376-392
15. 15 Bessey, O.A., Lowry, O.H., and Brock, M.J. (1946). A method for the rapid determination of alkaline phosphatase with five cubic millimetres of serum. J. Biol. Chem. 164, 321-329
16. 16 Marouz, S., Louvard, D., and Barratti, J. (1973). The aminopeptidase of hog intestinal brush border. Biochim. Biophys. Acta 321, 282-295
17. 17 Banwell, J.G., Boldt, D.H., Meyers, J., Weber, F.L., Miller, B., and Howard, R. (1983). Phytohaemagglutinin derived from red kidney bean (Phaseolus vulgaris): a cause for intestinal malabsorption associated with bacterial overgrowth in the rat. Gastroenterology 84, 506-515
18. 18 Donatucci, D.A., Liener, I.E., and Gross, C.J. (1987). Binding of navy bean (Phaseolus vulgaris) lectin to the intestinal cells of the rat and its effect on the absorption of glucose. J. Nutr. 117, 2156-2160