CR 2249: A new putative memory enhancer. Behavioural studies on learning and memory in rats and mice

Journal of Pharmacy and Pharmacology

Volumn 48, Issue 12, 1996, Pages 1290-1297

  Garofalo, Paolo ^a   Colombo, Silvia ^a   Lanza, Marco ^a   Revel, Laura ^a   Makovec, Francesco ^a  

^a Rotta Research Laboratorium   (Italy)

Author keywords

[No Author keywords available]

Indexed keywords

3,4 DIHYDROXYPHENYLETHYLENE GLYCOL; 4 AMINO 5 (4,4 DIMETHYLCYCLOHEXYL)AMINO 5 OXOPENTANOIC ACID; GLUTAMIC ACID DERIVATIVE; NEBOGLAMINE; NOOTROPIC AGENT; NORADRENALIN; SCOPOLAMINE; UNCLASSIFIED DRUG;

ANIMAL EXPERIMENT; ANIMAL MODEL; ARTICLE; BEHAVIOR; CHOLINERGIC ACTIVITY; COGNITIVE DEFECT; CONTROLLED STUDY; DRUG SCREENING; ELECTRIC SHOCK; HIPPOCAMPUS; LEARNING; MALE; MEMORY; MEMORY CONSOLIDATION; MICRODIALYSIS; MOTOR ACTIVITY; MOUSE; NONHUMAN; NORADRENALIN RELEASE; NORADRENERGIC SYSTEM; PASSIVE AVOIDANCE; RAT; TRAINING;

EID: 0030474030     PISSN: 00223573     EISSN: None     Source Type: Journal    
DOI: 10.1111/j.2042-7158.1996.tb03938.x     Document Type: Article

References (43)

1. Altman, H. J., Nordy, D. A., Ögren, S. O. (1984) Role of serotonin in memory: facilitation by aloproclate and zimeldine. Psychopharmacol. 84: 496-502
2. 3H]5,7-Dichlorokynurenic acid, a novel radioligand labels NMDA receptor-associated glycine binding sites. Eur. J. Pharmacol. 206: 149-154
3. Bhattacharya, S. K., Upadhyay, S. N., Jaiswal, A. K. (1993) Effect of piracetam on electroshock induced amnesia and decrease in brain acetylcholine in rats. Indian J. Exp. Biol. 31: 822-824
4. 2-Adrenoceptor subtypes and imidazoline-like binding sites in the rat brain. Br. J. Pharmacol. 99: 803-809
5. Davies, J. A., Jackson, B., Redfern, P. H. (1974) The effect of amantadine, L-dopa, (plus)-amphetamine and apomorphine on the acquisition of the conditioned avoidance response. Neuropharmacol. 13: 199-204
6. 3H]Norepinephrine release in rat hippocampal slices. Neuropharmacology 34: 141-147
7. Dismukes, R. K., Rake, A. V. (1972) Involvement of biogenic amines in memory formation. Psychopharmacology (Berlin) 23: 17-25
8. 3H]SNF 8702. Mol. Pharmacol. 41: 1089-1095
9. Eisenhofer, G., Goldstein, D. S., Ropchak, T. G., Nguyen, H. Q., Keiser, H. R., Kopin, I. J. (1988) Source and physiological significance of plasma 3,4-dihydroxyphenylglycol and 3-methoxy-4-hydroxyphenylglycol. J. Aut. Nervous System 24: 1-14
10. Fedele, E., Foster, A. C. (1993) An evaluation of the role of extra-cellular amino acids in the delayed neurodegeneration induced by quinolinic acid in the rat striatum. Neuroscience 52: 911-917
11. Foster, A. C., Wong, E. H. F. (1987) The novel anticonvulsant MK-801 binds to the activated state of N-methyl-D-aspartate receptor in rat brain. Br. J. Pharmacol. 91: 403-409
12. 3H]8-Hydroxy-2-(di-n-propylamino)tetralin binding to pre- and postsynaptic 5-hydroxytryptamine sites in various regions of the rat brain. J. Neurochem. 44: 1685-1696
13. Hutson, P. H., Sama, G. S., Kantamaneni, B. D., Curzon, G. (1985) Monitoring the effects of a tryptophan load on brain indole metabolism in freely moving rats by simultaneous cerebrospinal fluid sampling and brain dialysis. J. Neurochem. 44: 1266-1273
14. Itoh, Y., Oishi, R., Nishibori, M., Saeki, K. (1990) In vivo measurement of noradrenaline and 3,4-dihydroxyphenylethylenglycol in the rat hypothalamus by microdialysis: effects of various drugs affecting noradrenaline metabolism. J. Pharmacol. Exp. Ther. 255: 1090-1097
15. B autoreceptor antagonist in rat cerebral cortex. Eur. J. Pharmacol. 237: 191-195
16. Lazarova-Bakarova, M. B., Petkova, B. P., Todorov, I. K., Petkov, V. D. (1991) Memory impairment induced by combined disturbance of noradrenergic and dopaminergic neurotransmission: effects of nootropic drugs. Acta Physiol. Pharmacol. Bulg. 17: 29-34
17. 2 receptor binding sites. Mol. Pharmacol. 21: 301-314
18. 3H]Kainic acid to receptor sites in rat brain. Mol. Pharmacol. 15: 492-505
19. Makovec, F., Peris, W., Rovati, L. C., Rovati, L. A. (1995) Preparation of derivatives of glutamic and aspartic acids, as drugs for enhancing memory and learning. Chem. Abstr. 122: 291526q
20. Marino, A., Florio, T., Meucci, O., Landilfi, E., Grimaldi, M., Ventra, C., Schettini, G. (1990) Fipexide improvement of cognitive functions in rat: behavioral and neurochemical studies. Pharmacol. Res. 22: 179-187
21. Matsumoto, Y., Iwasaki, K., Fujiwara, M. (1991) Effect of nebracetam on experimental disruption of spatial cognition using radial maze task in rats. Jpn J. Pharmacol. Suppl. 55: 183P
22. 1adrenoceptors in rat brain. Naunyn Schmie-debergs Arch. Pharmacol. 312: 23-26
23. Mohammed, A. H. (1993) Effects of cholinesterase inhibitors on learning and memory in rats: a brief review with special reference to THA. Acta Neurol. Scand. Suppl. 149: 13-15
24. Mohs, R. C., Davis, B. M., Greenwald, B. S., Marné, A. A., Johns, C. A., Horvath, T. B., Davis, K. L. (1985) Clinical studies of the cholinergic deficit in Alzheimer's disease. II. Psychopharmacologic studies. J. Am. Geriatr. Soc. 33: 749-757
25. Mondadori, C., Etienne, P. (1990) Nootropic effects of ACE inhibitors in mice. Psychopharmacology 100: 301-307
26. Mondadori, C., Classen, W., Borkowski, J., Ducret, T., Buerki, H., Schadè, A. (1986) Effects of oxiracetam on learning and memory in animals: comparison with piracetam. Clin. Neuropharmacol. 9 (Suppl. 3): S27
27. 3H]αamino-3-hydroxy-5-methylisoxazole-4-propionic acid (AMPA) and filtration assay. Neurochem. Res. 12: 775-782
28. 3H]-CGS 19755: a novel N-methyl-D-aspartate antagonist with nanomolar affinity in rat brain. Br. J. Pharmacol. 95: 932-938
29. Nybäck, H., Wiesel, F. A., Skett, P. (1979) Effects of piracetam on brain monoamine metabolism and serum prolactin levels in the rat. Psychopharmacology 61: 235-238
30. Oishi, R., Itoh, Y., Adachi, N., Saeki, K. (1991) Effect of MCI-225, a new psychoactive compound, on monoamine metabolism in the rat brain. Jpn J. Pharmacol. S1: 294
31. Paxinos, G., Watson, C. (1982) The rat brain in stereotaxic coordinates, Academic Press, Sidney
32. Pittaluga, A., Pattarini, R., Raiteri, M. (1995) Putative cognition enhancers reverse kynurenic acid antagonism at hippocampal NMDA receptors. Eur. J. Pharmacol. 272: 203-209
33. Pugliese, A. M., Corradetti, R., Ballerini, L., Pepeu, G. (1990) Effect of the nootropic drug oxiracetam on field potentials of the rat hippocampal slices. Br. J. Pharmacol. 99: 189-193
34. Rayevsky, K. S., Kharlamov, A. N. (1983) GABAergic drugs: effects on conditioning, memory and learning. Pharmacol. Res. Commun. 15: 85-96
35. Sahakian, B. J., Sarna, G. S., Kantamaneni, B. D., Jackson, A., Hutson, P. H., Curzon, G. (1985) Association between learning and cortical catecholamines in non-drug-treated rats. Psychopharmacology 86: 339-343
36. Sansone, M., Castellano, C., Battaglia, M., Ammassari-Teule, M. (1990) Oxiracetam prevents mecamylamine induced impairment of active, but not passive, avoidance learning in mice. Pharmacol. Biochem. Behav. 36: 389-392
37. Schmidt, J. (1990) Influence of nootropic drugs on apomorphine induced stereotyped behavior in rats. Biomed. Biochem. Acta 49: 133-136
38. Serra, G., Collu, M., Cartellotta, M. C., Forgione, A., Fratta, W. (1989) Effect of fipexide on passive avoidance behaviour in rats. Pharmacol. Res. 21: 603-4508
39. Summers, W. K., Majovski, L. V., Marsh, G. M., Tachiki, K., Kling, A. (1986) Oral letrahydroaminoacridine in long-term treatment of senile dementia, Alzheimer type. New Engl. J. Med. 315: 1241-1245
40. Vanderwolf, C. H., Cain, D. P. (1994) The behavioral neurobiology of learning and memory: a conceptual reorientation. Brain Res. Rev. 19: 264-297
41. Venault, P., Chapouthier, G., Prado de Carvalho, L., Simiand, J., Morre, M., Dodd, R. H., Rossier, J. (1986) Benzodiazepine impairs and β-carboline enhances performance in learning and memory tasks. Nature 321: 864-866
42. 3H]Norepinephrine release from hippocampal slices is an in vitro biochemical tool for investigating the pharmacological properties of excitatory amino acid receptors. J. Neurochem. 49: 1438-1442
43. 2 muscarinic receptor subtypes. Life Sci. 32: 3001-3011