Physiopathology of ascites in portal hypertension

Acta Gastro-Enterologica Belgica

Volumn 59, Issue 3, 1996, Pages 191-197

  Michielsen, P P ^a,b  

^a UNIVERSITY OF ANTWERP   (Belgium)

^b ANTWERP UNIVERSITY HOSPITAL   (Belgium)

Author keywords

ascites; physiopathology; portal hypertension

Indexed keywords

ASCITES; CONFERENCE PAPER; HUMAN; PATHOPHYSIOLOGY; PERIPHERAL CIRCULATION; PORTAL HYPERTENSION; VASODILATATION;

ASCITES; EDEMA; HUMANS; HYPERTENSION, PORTAL; KIDNEY; LIVER CIRRHOSIS; PERITONEAL CAVITY; RENIN-ANGIOTENSIN SYSTEM; SODIUM; SPLANCHNIC CIRCULATION; SYMPATHETIC NERVOUS SYSTEM; VASODILATION;

EID: 0030473932     PISSN: 00015644     EISSN: None     Source Type: Journal    
DOI: None     Document Type: Conference Paper

References (43)

1. MICHIELSEN P.P., PELCKMANS P.A. Haemodynamic changes in portal hypertension : new insights in the pathogenesis and clinical implications. Acta Gastroenterol. Belg., 1994, 57 : 194-205.
2. GROSZMANN R J., ATTERBURY C.E The pathophysiology of portal hypertension : a basis for classification. Semin Liver Dis., 1982, 2 : 177-86.
3. GARCIA-TSAO G. Cirrhotic ascites : pathogenesis and management. Gastroenterologist, 1995, 3 : 41-54.
4. GIBSON J B , SMITH J.C. The origin of ascites in experimental cirrhosis in the rat. Am J Pathol, 1962, 41 : 535-47.
5. MORALI G.A., SNIDERMAN K.W., DEITEL K.M., TOBE S., WITTSULLIVAN H., SIMON M., HEATHCOTE J, BLENDIS L.M. Is sinusoidal portal hypertension a necessary factor for the development of hepatic ascites ? J. Hepatol., 1992, 16 . 249-50.
6. SHEAR L.S., CHING S., GABUZDA G.I. Compartimentatization of ascites and edema in patients with hepatic cirrhosis. N. Eng. J. med., 1970, 282 : 1391-5.
7. ARROYO V., GINÈS P., JIMÉNEZ W., RODÉS J. Ascites, renal failure and electrolyte disorders in cirrhosis. Pathogenesis, diagnosis, and treatment. In : MC INTYRE N., BENHAMOU J.-P., BIRCHER J., RIZZETTO M, RODÉS J. (eds.), Oxford Textbook of Clinical Hepatology. Oxford University Press, 1991, 429-70.
8. ROSOFF L.JR., ZIA P., REYNOLDS T., HORTON R. Studies of renin and aldosterone in cirrhotic patients with ascites, Gastroenterology, 1975, 69 . 698-705.
9. 2 in cirrhosis. Relationship to functional renal failure and sodium and water retention. Eur. J. Clin. Invest., 1983, 13 : 271-8
10. BICHET D, SZATALOWICZ V , CHAIRMOWICZ C., SCHRIER R W. Role of vasopressin in abnormal water excretion in cirrhotic patients. Ann. Int. Med., 1982, 96 : 413-7.
11. EPSTEIN M., PINS D.S., ARRINGTON R., DENUNZIO A.G., ENGSTROM R. Comparison of the effects of water immersion and saline infusion are a means of inducing volume expansion in man. J. Appl. Physiol , 1975, 39 . 66-70
12. LIEBERMAN F.L., REYNOLDS T.B. Plasma volume in cirrhosis of the liver : its relation to portal hypertension, ascites and renal failure. J. Clin. Invest., 1967, 46 1297-1308.
13. LÓPEZ-NOVOA J M., RENGEL M A , HERNANDO L. Dynamics of ascites formation in rats with experimental cirrhosis. Am. J. Physiol., 1980, 238 . F353-7.
14. LIEBERMAN F.L., DENISON E.K , REYNOLDS T.B. The relationship of plasma volume, portal hypertension, ascites. and renal sodium retention in cirrhosis : the overflow theory of ascites formation. Ann. N. Y. Acad. Sci., 1970, 170 : 202-6.
15. KOSTREVA D.R., CASTANER A., KAMPINE J.P. Reflex effects of hepatic baroreceptors on renal and cardiac sympathetic nerve activity. Am. J Physiol., 1980, 238 : R390-4.
16. LEVY M., ALLOTEY J.B.K. Temporal relationships between urinary salt retention and altered systemic hemodynamics in dogs with experimental cirrhosis. J Lab Clin. Med., 1978, 92 . 560-9.
17. SCHRIER R.W , ARROYO V., BERNARDI M , EPSTEIN M., HENRIKSEN J H., RODÉS J. Peripheral arterial vasodilation hypothesis. A proposal for the initiation of renal sodium and water retention in cirrhosis. Hepatology, 1988, 8 . 1151-7
18. MURRAY J.F , DAWSON A M., SHERLOCK S. Circulatory changes in chronic liver disease. Am J. Med. 1958, 24 . 358-67
19. COLOMBATO L.A , AIBILLOS A., GROSZMANN R.J. Temporal relationship of peripheral vasodilation, plasma volume expansion and the hyperdynamic circulatory state in portal-hypertensive rats. Hepatology. 1992, 15 : 323-8.
20. ALBILLOS A., COLOMBATO L A., GROSZMANN R.J Vasodilation and sodium retention in prehepatic portal hypertension. Gastroenterology, 1992, 102 : 931-5.
21. LOPEZ C., JIMENEZ W., ARROYO V. Temporal relationship between the decrease m mean arterial pressure and sodium retention in conscious spontaneous hypertensive rats with carbon tetrachloride-induced cirrhosis Hepatology. 1991, 13 . 585-9.
22. SHAPIRO M.D., NICHOLLS K.M., GROVES B.M., KLUGE R., CHUNG H.M., BICHET D.G., SCHRIER R.W Interrelationship between cardiac output and vascular resistance as determinants of effective arterial blood volume in cirrhotic patients. Kidney Int., 1985, 28 : 206-11.
23. LENZ K., HORTNAGL H., DRUML W., REITHER H , SCHMID R., SCHNEEWEISS B., LAGGNER A , GRIMM G., GERBES A.L. Ornipressin in the treatment of functional renal failure in decompensated liver cirrhosis. Effects on renal hemodynamics and atrial natriuretic factor. Gastroenterology, 1991, 101 : 1060-7.
24. - retention in portal hypertensive rats. Gastroenterology, 1993, 104 : 575-9.
25. ω-mtro-L-arginine administration corrects peripheral vasodilation and systemic capillary hypotension and ameliorates plasma volume expansion and sodium retention in portal hypertensive rats. Hepatology, 1993, 17 : 84-90.
26. WILKINSON S.P., SMITH L.K., WILLIAMS R Changes in plasma renin activity in cirrhosis : a reappraisal based on studies in 67 patients and "low-renin" cirrhosis. Hypertension, 1979, 1 125-9.
27. HENRIKSEN J.H., BENDTSEN F., SORENSEN T.I.A., STADEAGER C., RING-LARSEN H. Reduced central blood volume in cirrhosis. Gastroenterology, 1989, 97 : 1506-13.
28. WONG F., LIU P., TOBE S., MORALI G., BLENDIS L. Central blood volume in cirrhosis : measurement with radionuclide angiography. Hepatology, 1994, 19 : 312-21.
29. DUDLEY F.J. Pathophysiology of sodium retention in cirrhosis In : BOSCH J., GROSZMANN R.J. (eds), Portal hypertension. Pathophysiology and treatment. Blackwell, Oxford, 1994, 54-71
30. BENOIT J.N., ZIMMERMAN B., PREMEN A J , GO V.L., GRANGER D.N. Role of glucagon in splanchnic hyperemia of chronic portal hypertension. Am. J. Physiol, 1986, 251 . G674-7.
31. VALLANCE P., MONCADA S. Hyperdynamic circulation in cirrhosis : a role for nitric oxide ? Lancet, 1991, 337 : 776-8
32. PIZCUETA M.P., PIQUÉ J M., BOSCH J., WHITTLE B.J., MONCADA S. Effects of inhibiting nitric oxide biosynthesis on the systemic and splanchnic circulation of rats with portal hypertension. Br. J. Pharmacol., 1992, 105 : 184-90.
33. PIZCUETA P., PIQUÉ J.M., FERNÁNDEZ M., BOSCH J., RODÉS J., WHITTLE B.J., MONCADA S. Modulation of the hyperdynamic circulation of cirrhotic rats by nitric oxide inhibition. Gastroenterology, 1992, 103 : 1909-15.
34. SIEBER C.C., GROSZMANN R J. Nitric oxide mediates hyporeactivity to vasopressors in mesenteric vessels of portal hypertensive rats. Gastroenterology, 1992, 103 : 235-9.
35. SIEBER C.C., LOPEZ-TALAVERA J.C., GROSZMANN R.J. Role of nitric oxide in the in vitro splanchnic vascular reactivity in ascitic cirrhotic rats. Gastroenterology. 1993, 104 : 1750-4.
36. MICHIELSEN P P., BOECKXSTAENS G.E., SYS S U., HERMAN A G., PELCKMANS P.A. Role of nitric oxide in hyporeactivity to noradrenaline of isolated aortic rings in portal hypertensive rats. Eur. J Pharmacol., 1995, 273 : 167-74.
37. MICHIELSEN P.P., BOECKXSTAENS O.E., SYS S.U., HERMAN A.G., PELCKMANS P A. The role of increased nitric oxide in the vascular hyporeactivity to noradrenaline in long-term portal hypertensive rats. J. Hepatol., 1995, 23 341-7.
38. MICHIELSEN P.P. In vitro study on the involvement of nitric oxide in the pathophysiology of vascular hyporeactivity in portal hypertension. Doctoral Thesis Antwerp, 1995.
39. SOGNI P., MOREAU R., OHSUGA M., CAILMAIL S., OBERTI F., HADENGUE A., PUSSARD E., LEBREC D. Evidence for normal nitric oxide-mediated vasodilator tone in conscious rats with cirrhosis. Hepatology, 1992, 16 : 980-3.
40. IWATA F., JOH T , KAWAI T, ITOH M. Role of EDRF in splanchnic blood flow of normal and chronic portal hypertensive rats. Am. J. Physiol., 1992, 263 : G149-54.
41. CAWLEY T., GERAHGTY J., OSBORNE H., DOCHERTY J.R. Effects of portal hypertension on responsiveness of rat mesenteric artery and aorta, Br. J. Pharmacol., 1995, 114 : 791-5.
42. WU Z.Y., BENOIT J.N. Nonreceptor-mediated intestinal vasoconstriction in portal hypertensive rats. Am. J Physiol., 1994, 267 : H370-5.
43. CAHILL P.A , YU W., SITZMANN J.V. Altered adenylyl cyclase activities and G-protein abnormalities in portal hypertensive rabbits. J. Clin. Invest., 1994, 93, 2691-700.