2-Hydroxydesipramine and desipramine plasma levels: How are they related to antidepressant response?

International Clinical Psychopharmacology

Volumn 11, Issue 4, 1996, Pages 219-227

  Stern, S L ^a   Cooper, T B ^b,c,d   Nelson, L D ^e   Johnson, M H ^f   Suckow, R F ^c  

^a OHIO STATE UNIVERSITY   (United States)

^b NATHAN S KLINE INSTITUTE FOR PSYCHIATRIC RESEARCH   (United States)

^c NEW YORK STATE PSYCHIATRIC INSTITUTE   (United States)

^d College of Physicians and Surgeons ^*  (United States)

^e UNIVERSITY OF CALIFORNIA   (United States)

^f Golden Triangle Mental Health Center   (United States)

Author keywords

2 hydroxydesipramine; antidepressants; depression; desipramine; tricyclic plasma levels

Indexed keywords

2 HYDROXYDESIPRAMINE; DESIPRAMINE; DRUG METABOLITE;

ADULT; ARTICLE; CLINICAL ARTICLE; CLINICAL TRIAL; CONTROLLED CLINICAL TRIAL; CONTROLLED STUDY; DEPRESSION; DRUG BLOOD LEVEL; DRUG METABOLISM; FEMALE; HIGH PERFORMANCE LIQUID CHROMATOGRAPHY; HUMAN; MALE; OUTPATIENT; PRIORITY JOURNAL;

EID: 0030473931     PISSN: 02681315     EISSN: None     Source Type: Journal    
DOI: 10.1097/00004850-199612000-00002     Document Type: Article

References (26)

1. Amsterdam JD, Brunswick DJ, Potter L, Winokur A and Rickels K (1985) Desipramine and 2-hydroxydesipramine plasma levels in endogenous depressed patients. Archives of General Psychiatry, 42, 361-364.
2. Asberg M, Cronholm B, Sjoqvist F and Tuck D (1971) Relationship between plasma level and therapeutic effect of nortriptyline. British Medical Journal, 3, 331-334.
3. Baldessarini RJ, Teicher MH, Cassidy JW and Stein MH (1988) Anticonvulsant cotreatment may increase toxic metabolites of antidepressants and other psychotropic drugs. Journal of Clinical Psychopharmacology, 8, 381-382.
4. Breyer-Pfaff U, Gaertner HJ, Kreuter F, Scharek G, Brinkschulte M and Wiatr R (1982) Antidepressive effect and pharmacokinetics of amitriptyline with consideration of unbound drug and 10-hydroxynortriptyline levels. Psychopharmacology, 76, 240-244.
5. Coryell WH, Turner RD and Sherman A (1987) Desipramine plasma levels and clinical response: evidence for a curvilinear relationship. Journal of Clinical Psychopharmacology, 7, 138-142.
6. Golden RN, DeVane CL, Laizure SC, Rudorfer MV, Sherer MA and Potter WZ (1988) Bupropion in depression: II. the role of metabolites in clinical outcome. Archives of General Psychiatry, 45, 145-149.
7. Hamilton M (1960) A rating scale for depression. Journal of Neurology, Neurosurgery and Psychiatry, 23, 56-62.
8. Kutcher SP, Reid K, Dubbin JD and Shulman KI (1986a) Electrocardiogram changes and therapeutic desipramine and 2-hydroxy-desipramine concentrations in elderly depressives. British Journal of Psychiatry, 148, 676-679.
9. Kutcher SP, Shulman KI and Reid K (1986b) Desipramine plasma concentration and therapeutic response in elderly depressives: a naturalistic pilot study. Canadian Journal of Psychiatry, 31, 752-754.
10. Nelson JC, Jatlow P, Quinlan DM and Bowers MB Jr (1982) Desipramine plasma concentrations and antidepressant response. Archives of General Psychiatry, 39, 1419-1422.
11. Nelson JC, Bock JL and Jatlow PI (1983) Clinical implications of 2-hydroxydesipramine plasma concentrations. Clinical Pharmacology and Therapeutics, 33, 183-189.
12. Nelson JC, Mazure C and Jatlow PI (1988) Antidepressant activity of 2-hydroxydesipramine. Clinical Pharmacology and Therapeutics, 44, 283-288.
13. Nelson JC, Mazure CM, Bowers MB Jr and Jatlow PI (1991) A preliminary, open study of the combination of fluoxetine and desipramine for rapid treatment of major depression. Archives of General Psychiatry, 48, 303-307.
14. Nordin C, Bertilsson L and Siwers B (1987) Clinical and biochemical effects during treatment with nortriptyline: the role of 10-OH-nortirptyline. Clinical Pharmacology and Therapeutics, 42, 10-19.
15. Nordin C, Bertilsson L, Dahl M-L, Resul B, Toresson G and Sjoqvist F (1991) Treatment of depression with E-10-hydroxynortriptyline - a pilot study on biochemical effects and pharmacokinetics. Psychopharmacology, 103, 287-290.
16. Perry PJ, Zeilmann C and Arndt S (1994) Tricyclic antidepressant concentrations in plasma: an estimate of their sensitivity and specificity as a predictor of response. Journal of Clinical Psychopharmacology, 14, 230-240.
17. Roose SP, Glassman AH, Attia E and Woodring S (1994) Comparative efficacy of selective serotonin reuptake inhibitors and tricyclics in the treatment of melancholia. American Journal of Psychiatry, 151, 1735-1739.
18. Simpson GM, Pi EH, Abdelmalek E. Boyd DL, Carroll RS, Cooper TB and Miller A (1983) Relationship between plasma desipramine levels and clinical outcome for RDC major depressive inpatients. Psychopharmacology, 80, 240-242.
19. Spitzer RL, Endicott J and Robins E (1978) Research Diagnostic Criteria (RDC) for a Selected Group of Functional Disorders, 3rd edn. Biometrics Research, New York.
20. Stern SL, Cooper TB, Johnson MH, Jones BA, Nelson LD and Smeltzer DJ (1987) Lack of weight gain under desipramine. Biological Psychiatry, 22, 796-797.
21. Stern SL, Ribner HS, Cooper TB, Nelson LD, Johnson MH and Suckow RF (1991) 2-Hydroxydesipramine and desipramine plasma levels and electrocardiographic effects in depressed younger adults. Journal of Clinical Psychopharmacology, 11, 93-98.
22. Suckow RF and Cooper TB (1984) Determination of trimipramine and metabolites in plasma by liquid chromatography with electrochemical detection. Journal of Pharmaceutical Sciences, 73, 1745-1748.
23. Task Force on the Use of Laboratory Tests in Psychiatry (1985) Tricyclic antidepressants - blood level measurements and clinical outcome: an APA Task Force report. American Journal of Psychiatry, 142, 155-162.
24. Weilburg JB, Rosenbaum JF, Meltzer-Brody S and Shustari J (1991) Tricyclic augmentation of fluoxetine. Annals of Clinical Psychiatry, 3, 209-213.
25. Young RC, Alexopoulos GS, Shindledecker R, Dhar AK and Kutt H (1988) Plasma 10-hydroxynortriptyline and therapeutic response in geriatric depression. Neuropsychopharmacology, 1, 213-215.
26. Ziegler VE, Biggs JT, Rosen JH, Meyer DA and Preskorn SH (1978) Imipramine and desipramine plasma levels: relationship to dosage schedule and sampling time. Journal of Clinical Psychiatry, 39, 36-39.