Therapeutic effect of the quinolone prodrug prulifloxacin against experimental urinary tract infections in mice

Arzneimittel-Forschung/Drug Research

Volumn 46, Issue 12, 1996, Pages 1169-1173

  Tomii, Yoshifumi ^a   Ozaki, Masakuni ^a   Matsuda, Masato ^a   Honmura, Takuya ^a   Nishimura, Ikumi ^a   Yamaguchi, Reiko ^a   Adachi, Toshiko ^a   Okawa, Yumi ^a   Nishino, Takeshi ^b  

^a NIPPON SHINYAKU CO LTD   (Japan)

^b KYOTO PHARMACEUTICAL UNIVERSITY   (Japan)

Author keywords

CAS 123447 62 1; NM394, in vitro antibacterial activity; NM441, pharmacokinetics; prulifloxacin, active metabolite; quinolones; urinary tact infections, experimental

Indexed keywords

6 FLUORO 1 METHYL 4 OXO 7 (1 PIPERAZINYL) 4H 1,3 THIAZETO[3,2 A]QUINOLINE 3 CARBOXYLIC ACID; CIPROFLOXACIN; LEVOFLOXACIN; OFLOXACIN; PRODRUG; PRULIFLOXACIN; QUINOLINE DERIVED ANTIINFECTIVE AGENT; TOSUFLOXACIN;

ANIMAL EXPERIMENT; ANIMAL MODEL; ANTIBACTERIAL ACTIVITY; ARTICLE; BIOAVAILABILITY; CONTROLLED STUDY; DRUG BLOOD LEVEL; DRUG TISSUE LEVEL; ESCHERICHIA COLI; GRAM NEGATIVE BACTERIUM; GRAM POSITIVE BACTERIUM; IN VITRO STUDY; KIDNEY; LUNG; MALE; MOUSE; NONHUMAN; ORAL DRUG ADMINISTRATION; PSEUDOMONAS AERUGINOSA; URINARY TRACT INFECTION;

ANIMALS; ANTI-INFECTIVE AGENTS; ANTI-INFECTIVE AGENTS, URINARY; AREA UNDER CURVE; DIOXOLANES; ESCHERICHIA COLI INFECTIONS; FLUOROQUINOLONES; HALF-LIFE; MALE; MICE; MICE, INBRED STRAINS; MICROBIAL SENSITIVITY TESTS; PIPERAZINES; QUINOLONES; URINARY TRACT INFECTIONS;

EID: 0030473909     PISSN: 00044172     EISSN: None     Source Type: Journal    
DOI: None     Document Type: Article

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