Comparison of the antiviral efficacy of ribozymes and antisense RNA directed against bovine leukemia virus rex/tax

Antisense and Nucleic Acid Drug Development

Volumn 6, Issue 4, 1996, Pages 301-304

  Cantor, Glenn H ^a   Stone, Diana M ^a   McElwain, Terry F ^a   Palmer, Guy H ^a  

^a WASHINGTON STATE UNIVERSITY   (United States)

Author keywords

[No Author keywords available]

Indexed keywords

ANTIGEN P24; COMPLEMENTARY RNA; RIBOZYME;

ANIMAL CELL; ANTIVIRAL ACTIVITY; ARTICLE; BOVINE LEUKEMIA VIRUS; CONTROLLED STUDY; GENETIC TRANSFECTION; LUNG ALVEOLUS CELL; NONHUMAN; PLASMID; PRIORITY JOURNAL; PROMOTER REGION; REGULATOR GENE; ROUS SARCOMA ONCOVIRUS; START CODON; VIRUS GENE;

EID: 0030473548     PISSN: 10872906     EISSN: None     Source Type: Journal    
DOI: 10.1089/oli.1.1996.6.301     Document Type: Article

References (7)

1. CANTOR, G.H., MCELWAIN, T.F., BIRKEBAK, T.A., and PALMER, G.H. (1993). Ribozyme cleaves rex/tax mRNA and inhibits bovine leukemia virus expression. Proc. Natl. Acad. Sci. USA 90, 10932-10936.
2. CANTOR, G.H., and PALMER, G.H. (1992). Antisense oligonucleotide inhibition of bovine leukemia virus tax expression in a cell-free system. Antisense Res. Dev. 2, 147-152.
3. CRISELL, P., THOMPSON, S., and JAMES, W. (1993). Inhibition of HIV-1 replication by ribozymes that show poor activity in vitro. Nucleic Acids Res. 21, 5251-5255.
4. DERSE, D. (1988). Trans-acting regulation of bovine leukemia virus mRNA processing. J. Virol. 62, 1115-1119.
5. FEYTER, R.D., YOUNG, M., SCHROEDER, K., DENNIS, E.S., and GERLACH, W. (1996). A ribozyme gene and an antisense gene are equally effective in conferring resistance to tobacco mosaic virus on transgenic tobacco. Mol. Gen. Genet. 250, 329-338.
6. HOMANN, M., TZORTZAKAKI, S., RITTNER, K., SCZAKIEL, G., and TABLER, M. (1993). Incorporation of the catalytic domain of a hammerhead ribozyme into antisense RNA enhances its inhibitory effect on the replication of human immunodeficiency virus type 1. Nucleic Acids Res. 21, 2809-2814.
7. ZHOU, C., BAHNER, I.C., LARSON, G.P., ZAIA, J.A., ROSSI, J.J., and KOHN, D.B. (1994). Inhibition of HIV-1 in human T-lymphocytes by retrovirally transduced anti-tat and rev hammerhead ribozymes. Gene 149, 33-39.