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Volumn 795, Issue , 1996, Pages 168-180

Both IL-2 and IL-4 synergize with IL-12 to induce a CTL response, a response completely blocked by TGF-β

Author keywords

[No Author keywords available]

Indexed keywords

CYTOKINE; GAMMA INTERFERON; INTERLEUKIN 10; INTERLEUKIN 12; INTERLEUKIN 2; INTERLEUKIN 4; INTERLEUKIN 5; INTERLEUKIN 6; INTERLEUKIN 9; TRANSFORMING GROWTH FACTOR BETA;

EID: 0030472992     PISSN: 00778923     EISSN: None     Source Type: Book Series    
DOI: 10.1111/j.1749-6632.1996.tb52665.x     Document Type: Conference Paper
Times cited : (8)

References (52)
  • 1
    • 0022640843 scopus 로고
    • Two types of murine helper T cell clone. I. Definition according to profiles of lymphokine activities and secreted proteins
    • MOSMANN, T. R., H. CHERWINSKI, M. W. BOND, M. A. GIEDLIN & R. L. COFFMAN. 1986. Two types of murine helper T cell clone. I. Definition according to profiles of lymphokine activities and secreted proteins. J. Immunol. 136: 2348-2357.
    • (1986) J. Immunol. , vol.136 , pp. 2348-2357
    • Mosmann, T.R.1    Cherwinski, H.2    Bond, M.W.3    Giedlin, M.A.4    Coffman, R.L.5
  • 2
    • 0024353079 scopus 로고
    • Th1 and Th2 cells: Different patterns of lymphokine secretion lead to different functional properties
    • MOSMANN, T. R. & R. L. COFFMAN. 1989. Th1 and Th2 cells: Different patterns of lymphokine secretion lead to different functional properties. Ann. Rev. Immunol. 7: 145-173.
    • (1989) Ann. Rev. Immunol. , vol.7 , pp. 145-173
    • Mosmann, T.R.1    Coffman, R.L.2
  • 4
    • 0028288179 scopus 로고
    • Lymphokine production by human T cells in disease states
    • ROMAGNANI, S. 1994. Lymphokine production by human T cells in disease states. Ann. Rev. Immunol. 12: 227-257.
    • (1994) Ann. Rev. Immunol. , vol.12 , pp. 227-257
    • Romagnani, S.1
  • 5
    • 0028043326 scopus 로고
    • IL-12: A cytokine produced by antigen-presenting cells with immunoregulatory functions in the generation of T-helper cells type 1 and cytotoxic lymphocytes
    • TRINCHIERI, G. 1994. IL-12: A cytokine produced by antigen-presenting cells with immunoregulatory functions in the generation of T-helper cells type 1 and cytotoxic lymphocytes. Blood 84: 4008-4027.
    • (1994) Blood , vol.84 , pp. 4008-4027
    • Trinchieri, G.1
  • 6
  • 8
    • 0028349739 scopus 로고
    • Cellular and molecular mechanisms of the IL-12-induced increase in allospecific murine cytolytic T-cell activity
    • BLOOM, E. & J. HORVATH. 1994. Cellular and molecular mechanisms of the IL-12-induced increase in allospecific murine cytolytic T-cell activity. J. Immunol. 152: 4242-4253.
    • (1994) J. Immunol. , vol.152 , pp. 4242-4253
    • Bloom, E.1    Horvath, J.2
  • 9
    • 0029009835 scopus 로고
    • Costimulation with B7-1, IL-6, and IL-12 is sufficient for primary generation of murine antitumor cytolytic T lymphocytes in vitro
    • GAJEWSKI, T. F., J. RENAULD, A. VAN PEL & T. BOON. 1995. Costimulation with B7-1, IL-6, and IL-12 is sufficient for primary generation of murine antitumor cytolytic T lymphocytes in vitro. J. Immunol. 154: 5637-5648.
    • (1995) J. Immunol. , vol.154 , pp. 5637-5648
    • Gajewski, T.F.1    Renauld, J.2    Van Pel, A.3    Boon, T.4
  • 10
    • 0029069946 scopus 로고
    • Synergistic effects of IL-7 and IL-12 on human T cell activation
    • MEHROTRA, P. T., A. J. GRANT & J. P. SIEGEL. 1995. Synergistic effects of IL-7 and IL-12 on human T cell activation. J. Immunol. 154: 5093-5102.
    • (1995) J. Immunol. , vol.154 , pp. 5093-5102
    • Mehrotra, P.T.1    Grant, A.J.2    Siegel, J.P.3
  • 12
    • 0028944328 scopus 로고
    • Influence of IL-12 on p53 peptide vaccination against established Meth A sarcoma
    • NOGUCHI, Y., E. C. RICHARDS, Y-T. CHEN & L. J. OLD. 1995. Influence of IL-12 on p53 peptide vaccination against established Meth A sarcoma. Proc. Natl. Acad. Sci. USA 92: 2219-2223.
    • (1995) Proc. Natl. Acad. Sci. USA , vol.92 , pp. 2219-2223
    • Noguchi, Y.1    Richards, E.C.2    Chen, Y.-T.3    Old, L.J.4
  • 13
    • 0011791617 scopus 로고
    • Purification and some characteristics of human T-cell growth factor from phytohemagglutinin-stimulated lymphocyte-conditioned media
    • MIER, J. W. & R. C. GALLO. 1980. Purification and some characteristics of human T-cell growth factor from phytohemagglutinin-stimulated lymphocyte-conditioned media. Proc. Natl. Acad. Sci. USA 77: 6134-6138.
    • (1980) Proc. Natl. Acad. Sci. USA , vol.77 , pp. 6134-6138
    • Mier, J.W.1    Gallo, R.C.2
  • 14
    • 0022971159 scopus 로고
    • Requirement for three distinct lymphokines for the induction of cytotoxic T lymphocytes from thymocytes
    • TARAI, Y., S. H. HERRMANN, J. L. GREENSTEIN, G. L. SPITALNY & S. J. BURAKOFF. 1986. Requirement for three distinct lymphokines for the induction of cytotoxic T lymphocytes from thymocytes. J. Immunol. 137: 3494-3500.
    • (1986) J. Immunol. , vol.137 , pp. 3494-3500
    • Tarai, Y.1    Herrmann, S.H.2    Greenstein, J.L.3    Spitalny, G.L.4    Burakoff, S.J.5
  • 15
    • 0019501480 scopus 로고
    • The role of IL-2 in the differentiation of cytotoxic T cells: The effect of monoclonal anti-IL-2 antibody and absorption with IL-2-dependent T cell lines
    • KERN, D., S. GILLIS, M. OKADA & C. HENNEY. 1981. The role of IL-2 in the differentiation of cytotoxic T cells: The effect of monoclonal anti-IL-2 antibody and absorption with IL-2-dependent T cell lines. J. Immunol. 127: 1323.
    • (1981) J. Immunol. , vol.127 , pp. 1323
    • Kern, D.1    Gillis, S.2    Okada, M.3    Henney, C.4
  • 16
    • 0023847979 scopus 로고
    • B cell stimulatory factor-2 is involved in the differentiation of cytotoxic T lymphocytes
    • TAKAI, Y., G. G. WONG, S. C. CLARK, S. J. BURAKOFF & S. H. HERRMANN. 1988. B cell stimulatory factor-2 is involved in the differentiation of cytotoxic T lymphocytes. J. Immunol. 140: 508-512.
    • (1988) J. Immunol. , vol.140 , pp. 508-512
    • Takai, Y.1    Wong, G.G.2    Clark, S.C.3    Burakoff, S.J.4    Herrmann, S.H.5
  • 17
    • 0026467247 scopus 로고
    • Role of IL-6, IL-2, and IL-4 in the in vitro induction of cytotoxic T cells
    • QUENTMEIER, H., J. KLAUCKE, P. MUHLRADT & H. DREXLER. 1992. Role of IL-6, IL-2, and IL-4 in the in vitro induction of cytotoxic T cells. J. Immunol. 149: 3316-3320.
    • (1992) J. Immunol. , vol.149 , pp. 3316-3320
    • Quentmeier, H.1    Klaucke, J.2    Muhlradt, P.3    Drexler, H.4
  • 18
    • 0023140706 scopus 로고
    • Regulation of cytolytic T-lymphocyte generation by B-cell stimulatory factor
    • WIDMER, M. B. & K. H. GRABSTEIN. 1987. Regulation of cytolytic T-lymphocyte generation by B-cell stimulatory factor. Nature (London) 326: 795-798.
    • (1987) Nature (London) , vol.326 , pp. 795-798
    • Widmer, M.B.1    Grabstein, K.H.2
  • 19
    • 0026065837 scopus 로고
    • IL-4 supported induction of cytolytic T lymphocytes requires IL-2 and IL-6
    • BERTAGNOLLI, M., Y. TAKAI & S. H. HERRMANN. 1991. IL-4 supported induction of cytolytic T lymphocytes requires IL-2 and IL-6. Cell. Immunol. 133: 327-341.
    • (1991) Cell. Immunol. , vol.133 , pp. 327-341
    • Bertagnolli, M.1    Takai, Y.2    Herrmann, S.H.3
  • 20
    • 0023928315 scopus 로고
    • Identification of a 24-kDa cytokine that is required for development of cytolytic T lymphocytes
    • CERNETTI, C., R. M. STEINMAN & A. GRANELLI-PIPERNO. 1988. Identification of a 24-kDa cytokine that is required for development of cytolytic T lymphocytes. Proc. Natl. Acad. Sci. USA 85: 1605-1609.
    • (1988) Proc. Natl. Acad. Sci. USA , vol.85 , pp. 1605-1609
    • Cernetti, C.1    Steinman, R.M.2    Granelli-Piperno, A.3
  • 21
    • 0023852397 scopus 로고
    • B cell stimulatory factor 1 (IL-4) enhances the development of cytotoxic T cells from Lyt-2+ resting murine T lymphocytes
    • TRENN, G., H. TAKAYAMA, J. HU-LI, W. E. PAUL & M. V. SITKOVSKY. 1988. B cell stimulatory factor 1 (IL-4) enhances the development of cytotoxic T cells from Lyt-2+ resting murine T lymphocytes. J. Immunol. 140: 1101-1106.
    • (1988) J. Immunol. , vol.140 , pp. 1101-1106
    • Trenn, G.1    Takayama, H.2    Hu-Li, J.3    Paul, W.E.4    Sitkovsky, M.V.5
  • 22
    • 0023803252 scopus 로고
    • IL-6/BSF-2 functions as a killer helper factor in the in vitro induction of cytotoxic T cells
    • OKADA, M., M. KITAHARA, S. KISHIMOTO, T. MATSUDA, T. HIRANO & T. KISHIMOTO. 1988. IL-6/BSF-2 functions as a killer helper factor in the in vitro induction of cytotoxic T cells. J. Immunol. 141: 1543-1549.
    • (1988) J. Immunol. , vol.141 , pp. 1543-1549
    • Okada, M.1    Kitahara, M.2    Kishimoto, S.3    Matsuda, T.4    Hirano, T.5    Kishimoto, T.6
  • 23
    • 0023623496 scopus 로고
    • B cell stimulatory factor 1 (IL-4) is sufficient for the proliferation and differentiation of lectin-stimulated cytolytic T lymphocyte precursors
    • PFEIFER, J. D., D. T. MCKENZIE, S. L. SWAIN & R. W. DUTTON. 1987. B cell stimulatory factor 1 (IL-4) is sufficient for the proliferation and differentiation of lectin-stimulated cytolytic T lymphocyte precursors. J. Exp. Med. 166: 1464-1470.
    • (1987) J. Exp. Med. , vol.166 , pp. 1464-1470
    • Pfeifer, J.D.1    McKenzie, D.T.2    Swain, S.L.3    Dutton, R.W.4
  • 25
    • 0025820460 scopus 로고
    • IL-10: A novel cytotoxic T cell differentiation factor
    • CHEN, W. & A. ZLOTNIK. 1991. IL-10: A novel cytotoxic T cell differentiation factor. J. Immunol. 147: 528-534.
    • (1991) J. Immunol. , vol.147 , pp. 528-534
    • Chen, W.1    Zlotnik, A.2
  • 26
    • 0026619162 scopus 로고
    • IL-10 inhibits allogeneic proliferative and cytotoxic T cell responses generated in primary mixed lymphocyte cultures
    • BEJARANO, M. T., R. D. W. MALEFYT, J. S. ABRAMS, M. BIGLER, R. BACCHETTA, J. E. DE VRIES & M. G. RONCAROLO. 1992. IL-10 inhibits allogeneic proliferative and cytotoxic T cell responses generated in primary mixed lymphocyte cultures. Intl. Immunol. 4: 1389-1397.
    • (1992) Intl. Immunol. , vol.4 , pp. 1389-1397
    • Bejarano, M.T.1    Malefyt, R.D.W.2    Abrams, J.S.3    Bigler, M.4    Bacchetta, R.5    De Vries, J.E.6    Roncarolo, M.G.7
  • 27
    • 0027240219 scopus 로고
    • IL-10 inhibits human lymphocyte interferon γ-production by suppressing natural killer cell stimulatory factor/IL-12 synthesis in accessory cells
    • D'ANDREA, A., M. ASTE-AMEZAGA, N. M. VALIANTE, X. MA, M. KUBIN & G. TRINCHIERI. 1993. IL-10 inhibits human lymphocyte interferon γ-production by suppressing natural killer cell stimulatory factor/IL-12 synthesis in accessory cells. J. Exp. Med. 178: 1041-1048.
    • (1993) J. Exp. Med. , vol.178 , pp. 1041-1048
    • D'Andrea, A.1    Aste-Amezaga, M.2    Valiante, N.M.3    Ma, X.4    Kubin, M.5    Trinchieri, G.6
  • 28
    • 0025951644 scopus 로고
    • Transforming growth factor-β and IL-4 cause helper T cell precursors to develop into distinct effector helper cells that differ in lymphokine secretion pattern and cell surface phenotype
    • SWAIN, S. L., G. HUSTON, S. TONKONOGY, & A. WEINBERG. 1991. Transforming growth factor-β and IL-4 cause helper T cell precursors to develop into distinct effector helper cells that differ in lymphokine secretion pattern and cell surface phenotype. J. Immunol. 147: 2991-3000.
    • (1991) J. Immunol. , vol.147 , pp. 2991-3000
    • Swain, S.L.1    Huston, G.2    Tonkonogy, S.3    Weinberg, A.4
  • 29
    • 0026751479 scopus 로고
    • Differential effect of transforming growth factor β on the synthesis of Th1- and Th2-like lymphokines by human T lymphocytes
    • FARGEAS, C., C. Y. WU, T. NAKAJIMA, D. Cox, T. NUTMAN, & G. DELESPESSE. 1992. Differential effect of transforming growth factor β on the synthesis of Th1- and Th2-like lymphokines by human T lymphocytes. Eur. J. Immunol. 22: 2173-2176.
    • (1992) Eur. J. Immunol. , vol.22 , pp. 2173-2176
    • Fargeas, C.1    Wu, C.Y.2    Nakajima, T.3    Cox, D.4    Nutman, T.5    Delespesse, G.6
  • 30
    • 0027272821 scopus 로고
    • Role of transforming growth factor-β in the preferential induction of T helper cells of type 1 by staphylococcal enterotoxin B
    • NAGELKERKEN, K., K. J. GOLLOB, M. TIELEMANS & R. L. COFFMAN. 1993. Role of transforming growth factor-β in the preferential induction of T helper cells of type 1 by staphylococcal enterotoxin B. Eur. J. Immunol. 23: 2306-2310.
    • (1993) Eur. J. Immunol. , vol.23 , pp. 2306-2310
    • Nagelkerken, K.1    Gollob, K.J.2    Tielemans, M.3    Coffman, R.L.4
  • 31
    • 0028172533 scopus 로고
    • TGF-01 is a potent inducer of human effector T cells
    • CERWENKA, A., D. BEVEC, O. MAJDIC, W. KNAPP & W. HOLTER. 1994. TGF-01 is a potent inducer of human effector T cells. J. Immunol. 153: 4367-4377.
    • (1994) J. Immunol. , vol.153 , pp. 4367-4377
    • Cerwenka, A.1    Bevec, D.2    Majdic, O.3    Knapp, W.4    Holter, W.5
  • 33
    • 0028987734 scopus 로고
    • Transforming growth factor-β inhibits IL-12 induced production of interferon-γ by natural killer cells: A role for transforming growth factor-β in the regulation of T cell-independent resistance to Toxoplasma gondii
    • HUNTER, C. A., L. BERMUDEZ, H. BEERNINK, W. WAEGELL & J. S. REMINGTON. 1995. Transforming growth factor-β inhibits IL-12 induced production of interferon-γ by natural killer cells: A role for transforming growth factor-β in the regulation of T cell-independent resistance to Toxoplasma gondii. Eur. J. Immunol. 25: 994-1000.
    • (1995) Eur. J. Immunol. , vol.25 , pp. 994-1000
    • Hunter, C.A.1    Bermudez, L.2    Beernink, H.3    Waegell, W.4    Remington, J.S.5
  • 34
    • 0028048644 scopus 로고
    • Transforming growth factor-β (TGF-β1) inhibits DNA synthesis of PWM-stimulated PBMC via suppression of IL-2 and IL-6 production
    • REINHOLD, D., U. BANK, F. BUHLING, U. LENDECKEL, A. J. ULMER, H. D. FLAD & S. ANSORGE. 1994. Transforming growth factor-β (TGF-β1) inhibits DNA synthesis of PWM-stimulated PBMC via suppression of IL-2 and IL-6 production. Cytokine 4: 382-388.
    • (1994) Cytokine , vol.4 , pp. 382-388
    • Reinhold, D.1    Bank, U.2    Buhling, F.3    Lendeckel, U.4    Ulmer, A.J.5    Flad, H.D.6    Ansorge, S.7
  • 37
    • 0026636152 scopus 로고
    • Immunomodulatory effects of transforming growth factor-β on T lymphocytes
    • INGE, T. H., K. M. MCCOY, B. M. SUSSKIND, S. K. BARRETT, G. ZHAO & H. D. BEAR. 1992. Immunomodulatory effects of transforming growth factor-β on T lymphocytes. J. Immunol. 148: 3847-3856.
    • (1992) J. Immunol. , vol.148 , pp. 3847-3856
    • Inge, T.H.1    McCoy, K.M.2    Susskind, B.M.3    Barrett, S.K.4    Zhao, G.5    Bear, H.D.6
  • 38
    • 0027299565 scopus 로고
    • Transforming growth factor-β1 enhances the generation of allospecific cytotoxic T lymphocytes
    • KONDO, S., K. ISOBE, N. ISHIGURO, I. NAKASHIMA & T. MIURA. 1993. Transforming growth factor-β1 enhances the generation of allospecific cytotoxic T lymphocytes. Immunology 79: 459-464.
    • (1993) Immunology , vol.79 , pp. 459-464
    • Kondo, S.1    Isobe, K.2    Ishiguro, N.3    Nakashima, I.4    Miura, T.5
  • 39
    • 0028272528 scopus 로고
    • Production of gamma interferon by natural killer cells from Toxoplasma gondiiinfected SCID mice: Regulation by interleukin-10, interleukin-12, and tumor necrosis factor alpha
    • HUNTER, C. A., C. S. SUBAUSTE, V. H. VAN CLEAVE & J. S. REMINGTON. 1994. Production of gamma interferon by natural killer cells from Toxoplasma gondiiinfected SCID mice: Regulation by interleukin-10, interleukin-12, and tumor necrosis factor alpha. Infect. Immun. 62: 2818-2824.
    • (1994) Infect. Immun. , vol.62 , pp. 2818-2824
    • Hunter, C.A.1    Subauste, C.S.2    Van Cleave, V.H.3    Remington, J.S.4
  • 41
    • 0024467154 scopus 로고
    • Identification and purification of natural killer cell stimulatory factor (NKSF), a cytokine with multiple biologic effects on human lymphocytes
    • KOBAYASHI, M., L. FITZ, M. RYAN, R. M. HEWICK, S. C. CLARK, S. CHAN, R. LOUDON, F. SHERMAN, B. PERUSSIA & G. TRINCHIERI. 1989. Identification and purification of natural killer cell stimulatory factor (NKSF), a cytokine with multiple biologic effects on human lymphocytes. J. Exp. Med. 170: 827-845.
    • (1989) J. Exp. Med. , vol.170 , pp. 827-845
    • Kobayashi, M.1    Fitz, L.2    Ryan, M.3    Hewick, R.M.4    Clark, S.C.5    Chan, S.6    Loudon, R.7    Sherman, F.8    Perussia, B.9    Trinchieri, G.10
  • 42
    • 0028303170 scopus 로고
    • IL-12 synergizes with B7/CD28 interaction in inducing efficient proliferation and cytokine production of human T cells
    • KUBIN, M., M. KAMOUN & G. TRINCHIERI. 1994. IL-12 synergizes with B7/CD28 interaction in inducing efficient proliferation and cytokine production of human T cells. J. Exp. Med. 180: 211-222.
    • (1994) J. Exp. Med. , vol.180 , pp. 211-222
    • Kubin, M.1    Kamoun, M.2    Trinchieri, G.3
  • 43
    • 0029126574 scopus 로고
    • CD2 costimulation regulates responsiveness of activated T cells to interleukin-12
    • GOLLOB, J. A., J. Li, E. L. REINHERZ & J. RITZ. 1995. CD2 costimulation regulates responsiveness of activated T cells to interleukin-12. J. Exp. Med. 182: 721-731.
    • (1995) J. Exp. Med. , vol.182 , pp. 721-731
    • Gollob, J.A.1    Li, J.2    Reinherz, E.L.3    Ritz, J.4
  • 44
    • 0029071483 scopus 로고
    • Developmental commitment to the Th2 lineage by extinction of IL-12 signaling
    • SZABO, S. J., N. G. JACOBSON, A. S. DIGHE, U. GUBLER & K. M. MURPHY. 1995. Developmental commitment to the Th2 lineage by extinction of IL-12 signaling. Immunity 2: 665-675.
    • (1995) Immunity , vol.2 , pp. 665-675
    • Szabo, S.J.1    Jacobson, N.G.2    Dighe, A.S.3    Gubler, U.4    Murphy, K.M.5
  • 45
    • 0028979063 scopus 로고
    • The cytokines IL-4, IFN-y, and IL-12 regulate the development of subsets of memory effector helper T cells in vitro
    • BRADLEY, L. M., K. YOSHIMOTO & S. L. SWAIN. 1995. The cytokines IL-4, IFN-y, and IL-12 regulate the development of subsets of memory effector helper T cells in vitro. J. Immunol. 155: 1713-1724.
    • (1995) J. Immunol. , vol.155 , pp. 1713-1724
    • Bradley, L.M.1    Yoshimoto, K.2    Swain, S.L.3
  • 47
    • 0028911482 scopus 로고
    • Stimulatory and inhibitory effects of IL-4 and IL-13 on the production of cytokines by human peripheral blood mononuclear cells: Priming for IL-12 and tumor necrosis factor production
    • D'ANDREA, A., X. MA, M. ASTE-AMEZAGA, C. PAOANIN & G. TRINCHIERI. 1995. Stimulatory and inhibitory effects of IL-4 and IL-13 on the production of cytokines by human peripheral blood mononuclear cells: priming for IL-12 and tumor necrosis factor production. J. Exp. Med. 181: 537-546.
    • (1995) J. Exp. Med. , vol.181 , pp. 537-546
    • D'Andrea, A.1    Ma, X.2    Aste-Amezaga, M.3    Paoanin, C.4    Trinchieri, G.5
  • 49
    • 0027422313 scopus 로고
    • + T cells from αβ TCR transgenic mice: IL-12 substitution for macrophages to stimulate IFN-γ production is IFN-γ. dependent
    • + T cells from αβ TCR transgenic mice: IL-12 substitution for macrophages to stimulate IFN-γ production is IFN-γ. dependent. Int. Immunol. 5: 1119-1128.
    • (1993) Int. Immunol. , vol.5 , pp. 1119-1128
    • Macatonia, S.E.1    Hsieh, C.2    Murphy, K.M.3    O'Garra, A.4


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