Single or multiple dose ursodeoxycholic acid for cholestatic liver disease: Biliary enrichment and biochemical response

Journal of Hepatology

Volumn 25, Issue 6, 1996, Pages 887-894

  Van De Meeberg, Paul C ^a   Wolfhagen, Frank H J ^b   Van Berge Henegouwen, Gerard P ^a   Salemans, Jan M J I ^c   Tangerman, Albert ^c   Van Buuren, Henk R ^b   Van Hattum, Jan ^a   Van Erpecum, Karel J ^a  

^a UNIVERSITY MEDICAL CENTER UTRECHT   (Netherlands)

^b ERASMUS MEDICAL CENTER   (Netherlands)

^c RADBOUD UNIVERSITY MEDICAL CENTER   (Netherlands)

Author keywords

Cholestasis; Drug therapy; Primary biliary cirrhosis; Primary sclerosing cholangitis; Ursodeoxycholic acid

Indexed keywords

ALANINE AMINOTRANSFERASE; ASPARTATE AMINOTRANSFERASE; URSODEOXYCHOLIC ACID;

ARTICLE; BIOCHEMISTRY; CHOLESTASIS; CLINICAL ARTICLE; CLINICAL TRIAL; CONTROLLED CLINICAL TRIAL; CONTROLLED STUDY; HUMAN; PRIMARY BILIARY CIRRHOSIS; PRIMARY SCLEROSING CHOLANGITIS; PRIORITY JOURNAL; RANDOMIZED CONTROLLED TRIAL; TREATMENT OUTCOME;

EID: 0030472517     PISSN: 01688278     EISSN: None     Source Type: Journal    
DOI: 10.1016/S0168-8278(96)80293-5     Document Type: Article

References (43)

1. 1. Lindor KD, Dickson ER, Baldus WP, Jorgensen RA, Ludwig J, Murtaugh PA, Harrison JM, Wiesner RH, Anderson ML, Lange SM, LeSage G, Rossi SS, Hofmann, AF. Ursodeoxycholic acid in the treatment of primary biliary cirrhosis. Gastroenterology 1994; 106: 1284-90.
2. 2. Poupon RE, Poupon R, Balkau B, and the UDCA-PBC Study Group. Ursodiol for the long-term treatment of primary biliary cirrhosis. N Engl J Med 1994; 330: 1342-7.
3. 3. Heathcote EJ, Cauch-Dudek K, Walker V, Bailey RJ, Blendis LM, Ghent CN, Michieletti P, Minuk GY, Pappas SC, Scully LJ, Steinbrecher UP, Sutherland LR, Williams CN, Witt-Sullivan H, Worobetz LJ, Milner RA, Wanless IR. The Canadian multicenter double-blind randomized controlled trial of ursodeoxycholic acid in primary biliary cirrhosis. Hepatology 1994; 19: 1149-56.
4. 4. O'Brien CB, Senior JR, Arora-Mirchandani R, Batta AK, Salen G. Ursodeoxycholic acid for the treatment of primary sclerosing cholangitis: a 30-month pilot study. Hepatology 1991; 14: 838-47.
5. 5. Beuers U, Spengler U, Kruis W, Aydemir Ü, Wiebecke B, Heldwein W, Weinzierl M, Pape GR, Sauerbruch T, Paumgartner G. Ursodeoxycholic acid for treatment of primary sclerosing cholangitis: a placebo controlled trial. Hepatology 1992; 16: 707-14.
6. 6. Stiehl A, Walker S, Stiehl L, Rudolph G, Hofmann WJ, Theilmann L. Effect of ursodeoxycholic acid on liver and bile duct disease in primary sclerosing cholangitis. A 3-year pilot study with a placebo-controlled study period. J Hepatol 1994; 20: 57-64.
7. 7. Queneau PE, Montet JC. Hepatoprotection by hydrophilic bile salts. J Hepatol 1994; 21: 260-8.
8. 8. Calmus Y, Gane P, Rouger P, Poupon R. Hepatic expression of class I and class II major histocompatibility complex molecules in primary biliary cirrhosis: effect of ursodeoxycholic acid Hepatology 1990; 11: 12-5.
9. 9. Kürktschiev D, Subat S, Adler D, Schentke KU. Immunomodulating effect of ursodeoxycholic acid therapy in patients with primary biliary cirrhosis. J Hepatol 1993; 18: 373-7.
10. 10. Dumont M, Erlinger S, Uchman S. Hypercholeresis induced by ursodeoxycholic acid and 7-ketolithocholic acid in the rat: possible role of bicarbonate transport. Gastroenterology 1980; 79: 82-9.
11. 11. Fracchia M, Setchell KDR, Crosignani A, Podda M, Ferraris R, O'Connel N, Galatola G. Ursodeoxycholic acid induced hypercholeresis in a patient with primary biliary cirrhosis, Hepatology 1993; 18: 297A.
12. 12. Elsing C, Sägesser H, Reichen J. Ursodeoxycholate-induced hypercholeresis in cirrhotic rats: further evidence for cholehepatic shunting. Hepatology 1994; 20: 1048-54.
13. 13. Marteau P, Chazouilléres O, Myara A, Jian R, Rambaud J, Poupon R. Effect of chronic administration of ursodeoxycholic acid on the ileal absorption of endogenous bile acids in man. Hepatology 1990; 12: 1206-8.
14. 14. Eusufzai S, Ericsson S, Cederlund T, Einarsson K, Angelin B. Effect of ursodeoxycholic acid treatment on ileal absorption of bile acids in man as determined by the SeHCAT test. Gut 1991; 32: 1044-8.
15. 15. Stiehl A, Raedsch R, Rudolph G. Acute effects of ursodeoxycholic and chenodeoxycholic acid on the small intestinal absorption of bile acids. Gastroenterology 1990; 98: 424-8.
16. 16. Galatola G, Jazrawi RP, Northfield TC. Low dose ursodeoxycholic acid at bedtime and at mealtimes: effect on mass of lipids within the gallbladder and on gallstone dissolution. Eur J Gastroenterol Hepatol 1992; 4: 301-6.
17. 17. Igimi H, Carey MC. pH-solubility relations of chenodeoxycholic and ursodeoxycholic acids: physical-chemical basis for dissimilar solution and membrane phenomena. J Lipid Res 1980; 21: 72-90.
18. 18. Parquet M, Metman EH, Raizman A, Ramband JC, Berthaux N, Infante R. Bioavailability, gastrointestinal transit, solubilization and faecal excretion of ursodeoxycholic acid in man. Eur J Clin Invest 1985; 15: 171-8.
19. 19. Stiehl A, Raedsch R, Rudolph G. Ileal excretion of bile acids: comparison with biliary bile composition and effect of ursodeoxycholic acid treatment. Gastroenterology 1988; 94: 1201-6.
20. 20. Walker S, Rudolph G, Raedsch R, Stiehl A. Intestinal absorption of ursodeoxycholic acid in patients with extrahepatic biliary obstruction and bile drainage. Gastroenterology 1992; 102: 810-5.
21. 21. Hofmann AF. Pharmacology of ursodeoxycholic acid, an enterohepatic drug. Scand J Gastroenterol 1994; 29, Suppl 204: 1-15.
22. 22. Bateson MC, Ross PE, Murison J, Saunders JH, Bouchier IA. Ursodeoxycholic acid therapy and biliary lipids, a dose response study. Gut 1980; 21: 305-10.
23. 23. Thistle JL, Larusso NF, Hofmann AF, Turcotte J, Carlson GL, Ott BJ. Differing effects of ursodeoxycholic acid or chenodeoxycholic acid on biliary cholesterol saturation and bile acid metabolism in man. A dose response study. Dig Dis Sci 1982; 27: 161-8.
24. 24. Podda M, Ghezzi C, Battezzati PM, Bertolini E, Crosignani A, Petroni ML, Zuin M. Effect of different doses of ursodeoxycholic acid in chronic liver disease. Dig Dis Sci 1989; 34: 59S-65S.
25. 25. Marcus SM, Schteingart CD, Marquez ML, Hofmann AF, Xia Y, Steinbach JH, Ton-Nu H, Lillienau J, Angellotti MA, Schmassmann A. Active absorption of conjugated bile acids in vivo; kinetic parameters and molecular specificity of the ileal transport in the rat. Gastroenterology 1991; 100: 212-21.
26. 26. Stiehl A, Sauer P, Rudolph G, Klöters-Plachky P. Absorption of ursodeoxycholic acid in man: single dose versus multiple doses versus a microencapsulated, sodium carbonate containing formula. Gastroenterology 1993; 104: A999.
27. 27. Ludwig J, Dickson ER, McDonald GS. Staging of chronic nonsuppurative destructive cholangitis (syndrome of primary biliary cirrhosis). Virchow's Arch A 1978; 379: 103-12.
28. 28. Ludwig J, Larusso NF, Wiesner RH. The syndrome of primary sclerosing cholangitis. Prog Liver Dis 1990; 9: 555-66.
29. 29. Kuipers F, Spanjer HH, Havinga R, Scherphof GL, Vonk RJ. Lipoproteins and liposomes as in vivo cholesterol vehicles in the rat: preferential use of cholesterol carried by small unilamellar liposomes for the formation of muricholic acid. Biochim Biophys Acta 1986; 876: 559-66.
30. 30. Setchell KDR, Matsui A. Serum bile acid analysis. Clin Chim Acta 1983; 127: 1-17.
31. 31. Fracchia M, Ferraris R, Petrarulo M, Secreto P, Dunn T, Galatola G. Effect of ursodeoxycholic acid on the masses of biliary lipids and alkaline phosphatase within the gallbladder in chronic cholestatic liver disease. Eur J Gastroenterol Hepatol 1992; 4: 843-8.
32. 32. Lacerda MA, Lindor KD, Jorgensen RA, Rossi S, Hofmann A, Dickson ER. Ursodiol therapy in primary biliary cirrhosis (PBC): enrichment correlates with biochemical improvement. Gastroenterology 1993; 104: A933.
33. 33. Crosignani A, Podda M, Battezzati PM, Bertolini E, Zuin M, Watson D, Setchell KDR. Changes in bile acid composition in patients with primary biliary cirrhosis induced by ursodeoxycholic acid administration. Hepatology 1991; 14: 1000-7.
34. 34. Mazzella G, Parini P, Bazzoli F, Villanova N, Festi D, Aldini R, Roda A, Cipolla A, Polimeni C, Tonelli D, Roda E. Ursodeoxycholic acid administration on bile acid metabolism in patients with early stages of primary biliary cirrhosis. Dig Dis Sci 1993; 38: 896-902.
35. 35. Salemans JMJI, Nagengast FM, Tangerman A, Van Schaik A, Hopman WPM, De Haan AFJ, Jansen JBMJ. Effect of ageing on postprandial conjugated and unconjugated serum bile acid levels in healthy subjects. Eur J Clin Invest 1993; 23: 192-8.
36. 36. Tangerman A, Van Schaik A, Van Der Hoek EW. Analysis of conjugated and unconjugated bile acids in serum and jejunal fluid of normal subjects. Clin Chim Acta 1986; 159: 123-32.
37. 37. Federowski T, Salen G, Colalillo A, Tint GS, Mosbach EH, Hall JC. Metabolism of ursodeoxycholic acid in man. Gastroenterology 1977; 73: 1131-7.
38. 38. Jazrawi RP, de Caestecker JS, Goggin PM, Britten AJ, Joseph AEA, Maxwell JD, Northfield TC. Kinetics of hepatic bile acid handling in cholestatic liver disease: effect of ursodeoxycholic acid. Gastroenterology 1994; 106: 134-42.
39. 39. VanBerge Henegouwen GP, Hofmann AF. Clinical aspects of disturbances in the enterohepatic circulation of bile acids in man: the cholanopathies. Neth J Med 1978; 21: 257-69.
40. 40. VanBerge Henegouwen GP, Brandt KH, Eyssen H, Parmentier G. Sulphated and unsulphated bile acids in serum, bile, and urine of patients with cholestasis. Gut 1976; 17: 861-9.
41. 41. Colombo C, Crosignani A, Assaisso M, Battezzati PM, Podda M, Giunta A, Zimmer-Nechemias L, Setchell KDR. Ursodeoxycholic acid therapy in cystic fibrosis-associated liver disease: a dose-response study. Hepatology 1992; 16: 924-30.
42. 42. Jorgensen RA, Dickson ER, Hofmann AF, Rossi SS, Lindor KD. Characterisation of patients with a complete biochemical response to ursodeoxycholic acid. Gut 1995; 36: 935-8.
43. 43. Colombo C, Castellani MR, Balistreri WF, Seregni E, Assaisso ML, Giunta A. Scintigraphic documentation of an improvement in hepatobiliary excretory function after treatment with ursodeoxycholic acid in patients with cystic fibrosis and associated liver disease. Hepatology 1992; 15: 677-84.