Glycogen depletion contributes to ischemic preconditioning in the rat heart in vivo

American Journal of Physiology - Heart and Circulatory Physiology

Volumn 271, Issue 6 40-6, 1996, Pages

  McNulty, Patrick H ^a   Darling, Alisa ^b   Whiting, Jennifer M ^b  

^a VA CONNECTICUT HEALTHCARE SYSTEM   (United States)

^b NONE

Author keywords

acidosis; arrhythmias; lactic acid; myocardial infarction; myocardium

Indexed keywords

GLUCOSE; GLYCOGEN; INSULIN; LACTIC ACID;

ANIMAL MODEL; ANIMAL TISSUE; ARTICLE; CONTROLLED STUDY; GLYCOGEN METABOLISM; HEART ARRHYTHMIA; HEART INFARCTION; HEART MUSCLE ISCHEMIA; HEART PROTECTION; LACTIC ACIDOSIS; MALE; NONHUMAN; PRIORITY JOURNAL; RAT; REPERFUSION INJURY;

EID: 0030472418     PISSN: 03636135     EISSN: None     Source Type: Journal    
DOI: 10.1152/ajpheart.1996.271.6.h2283     Document Type: Article

References (25)

1. Apstein, C. S., F. N. Gravino, and C. C. Haudenschild. Determinants of a protective effect of glucose and insulin on the ischemic myocardium. Circ. Res. 52: 515-526, 1983.
2. ATP channels, and ischemic preconditioning in dogs. Am. J Physiol. 264 (Heart Circ. Physiol. 33): H1327-H1336, 1993.
3. Bailey, I. A., G. Radda, A.-M. Seymour, and S. Williams. The effects of insulin on myocardial metabolism and acidosis in normoxia and ischemia. Biochim. Biophys. Acta 720: 17-27, 1982.
4. --ATPase activity: savior of the ischemic heart (Abstract). Circulation 90: 3390, 1994.
5. Eberli, F. R., O. Weinberg, W. N. Grice, G. L. Horowitz, and C. S. Apstein. Protective effect of increased glycolytic substrate against systolic and diastolic dysfunction and increased coronary resistance from prolonged global underperfusion and reperfusion in isolated rabbit hearts perfused with erythrocyte suspensions. Circ. Res. 68: 466-481, 1991.
6. Garliek, P. B., G. K. Radda, and P. J. Seeley. Studies of acidosis in the ischemic heart by phosphorus nuclear magnetic resonance. Biochem. J. 184: 547-554, 1979.
7. Hagar, J. M., S. L. Hale, and R. A. Kloner. Effect of preconditioning ischemia on reperfusion arrhythmias after coronary artery occlusion and reperfusion in the rat. Circ. Res. 68: 61-68, 1991.
8. Janier, M., J.-L. Vanoverschelde, and S. R. Bergmann. Ischemic preconditioning stimulates anaerobic glycolysis in the isolated rabbit heart. Am. J. Physiol. 267 (Heart Circ. Physiol. 36): H1353-H1360, 1994.
9. Kida, M., H. Fujiwara, M. Ishida, C. Kawai, M. Ohura, I. Miura, and Y. Yabuuchi. Ischemic preconditioning preserves creatine phosphate and intracellular pH. Circulation 84: 2495-2503, 1991.
10. Langerstrom, C. F., W. E. Walker, and H. Taegtmeyer. Failure of glycogen depletion to improve left ventricular function of the rabbit heart after hypothermic ischemic arrest. Circ. Res. 63: 81-86, 1988.
11. Lawson, C. S., and J. M. Downey. Preconditioning: state of the art myocardial protection. Cardiovasc. Res. 27: 542-550, 1993.
12. Li, Y., and R. A. Kloner. Does protein kinase C play a role in ischemic preconditioning in rat hearts? Am. J. Physiol. 268 (Heart Circ. Physiol. 37): H426-H431, 1995.
13. McNulty, P. H., W. X. Liu, M. C. Luba, J. A. Valenti, G. V. Letsou, and J. C. Baldwin. Effect of nonworking heterotopic transplantation on rat heart glycogen metabolism. Am. J. Physiol. 268 (Endocrinol. Metab. 31): E48-E54, 1995.
14. McNulty, P. H., and M. C. Luba. Transient ischemia induces regional myocardial glycogen synthase activation and glycogen synthesis in vivo. Am. J. Physiol. 268 (Heart Circ. Physiol. 37): H364-H370, 1995.
15. Schaefer, S. L., J. Carr, E. Prussel, and R. Ramasamy. Effects of glycogen depletion on ischemic injury in isolated rat hearts: insights into preconditioning. Am. J. Physiol. 268 (Heart Circ. Physiol. 37): H935-H944, 1995.
16. Scheuer, J., and S. W. Stezoski. Protective effect of increased myocardial glycogen stores in cardiac anoxia in the rat. Circ. Res. 27: 835-849, 1970.
17. Segel, L. D., A. Chung, D. T. Mason, and E. A. Amsterdam. Cardiac glycogen in Long-Evans rats: diurnal pattern and response to exercise. Am. J. Physiol. 229: 398-401, 1975.
18. Shiki, K., and D. J. Hearse. Preconditioning of ischemic myocardium: reperfusion-induced arrhythmias. Am. J. Physiol. 253 (Heart Circ. Physiol. 22): H1470-H1476, 1987.
19. Speechly-Dick, M. E., M. M. Mocanu, and D. M. Yellon. Protein kinase C. Its role in ischemic preconditioning in the rat. Circ. Res. 75: 586-590, 1994.
20. Vanoverschelde, J.-L., M. Janier, J. Bakke, D. Marshall, and S. Bergmann. Rate of glycolysis during ischemia determines extent of ischemic injury and functional recovery after reperfusion. Am. J. Physiol. 267 (Heart Circ. Physiol. 36): H1785-H1794, 1994.
21. Van Wylen, D. Effect of ischemic preconditioning on interstitial purine metabolite and lactate accumulation during myocardial ischemia. Circulation 89: 2283-2289, 1994.
22. Vivaldi, M. T., R. A. Kloner, and F. J. Schoen. Triphenyltetrazolium staining of irreversible ischemic injury following coronary artery occlusion in rats. Am. J. Pathol. 121: 522-530, 1985.
23. Wolfe, C. L., H. F. Gilbert, K. M. Brindle, and G. K. Radda. Determination of the buffering capacity of rat myocardium during ischemia. Biochim. Biophys. Acta 971: 9-20, 1988.
24. Wolfe, C. L., R. E. Sievers, F. L. Visseren, and T. J. Donnelley. Loss of myocardial protection after preconditioning correlates with the time course of glycogen recovery within the preconditioned segment. Circulation 87: 881-892, 1993.
25. Ytrehus, K., Y. Liu, and J. Downey. Preconditioning protects ischemic rabbit heart by protein kinase C activation. Am. J. Physiol. 266 (Heart Circ. Physiol. 35): H1145-H1152, 1994.