Trypanosoma cruzi is a potent inducer of interleukin-12 production in macrophages

Medical Microbiology and Immunology

Volumn 185, Issue 3, 1996, Pages 189-193

  Frosch, Stefanie ^a   Kraus, Swantje ^a   Fleischer, Bernhard ^a  

^a BERNHARD NOCHT INSTITUTE FOR TROPICAL MEDICINE   (Germany)

Author keywords

Interleukin 12; Macrophages; Trypanosoma cruzi

Indexed keywords

CYTOKINE; GAMMA INTERFERON; INTERLEUKIN 12; LIPOPOLYSACCHARIDE; MESSENGER RNA;

ANIMAL CELL; ARTICLE; BONE MARROW CELL; CONTROLLED STUDY; CYTOKINE PRODUCTION; GENE INDUCTION; IMMUNOSTIMULATION; KINETICS; MACROPHAGE; MOUSE; NONHUMAN; PRIORITY JOURNAL; PROTEIN INDUCTION; REVERSE TRANSCRIPTION POLYMERASE CHAIN REACTION; SPLEEN CELL; TRYPANOSOMA CRUZI; TRYPOMASTIGOTE;

ANIMALS; INTERLEUKIN-12; MACROPHAGES; MICE; MICE, INBRED BALB C; RNA, MESSENGER; SPLEEN; TRYPANOSOMA CRUZI;

EID: 0030472258     PISSN: 03008584     EISSN: None     Source Type: Journal    
DOI: 10.1007/s004300050030     Document Type: Article

References (23)

1. Bilzer T, Stavrou D, Dahme E, Keiditsch E, Bürring KF, Anzil AP, Wechsler W (1991) Morphological, immunocytochemical and growth characteristics of three human glioblastomas established in vitro. Virchows Arch [A] 418:281-293
2. Biron CA, Gazzinelli, T (1995) Effects of IL-12 on immune responses to microbial infections: a key mediator in regulating disease outcome. Curr Opin Immunol 7:485-496
3. Bogdan C, Moll H, Solbach W, Röllinghoff M (1990) Tumor necrosis factor-α in combination with interferon-γ, but not with interleukin-4, activates murine macrophages for elimination of Leishmania major amastigotes. Eur J Immunol 20:1131-1135
4. Cardillo F, Voltarelli JC, Reed SG, Silva JS (1996) Regulation of Trypanosoma cruzi infection in mice by gamma-interferon and interleukin-10: the role of NK cells. Infect Immun 64: 128-134
5. Frosch S, Bonifas U, Eck HP, Bockstette M, Droege W, Rüde E, Reske-Kunz AB (1993) The efficient bovine insulin presentation capacity of bone marrow-derived macrophages activated by granulocyte-macrophage-colony-stimulating factor correlates with a high level of intracellular reducing thiols. Eur J Immunol 23:1430-1434
6. Gazzinelli RT, Oswald IP, Hieny S, James SL, Sher A (1992) The microbicidal activity of interferon-γ-treated macrophages against Trypanosoma cruzi involves an L-arginine-dependent, nitrogen oxide-mediated mechanism inhibitable by interleukin-10 and transforming growth factor-β. Eur J Immunol 22: 2501-2506
7. Hoft DF, Lynch RG, Kirchhoff LV (1993) Kinetic analysis of antigen-specific immune responses in resistant and susceptible mice during infection with Trypanosoma cruzi. J Immunol 151: 7038-7047
8. Hsieh C-S, Heimberger AB, Gold JS, O'Garra A, Murphy KM (1992) Differential regulation of T helper phenotype development by interleukins-4 and -10 in an αβ-1 cell-receptor transgenic system. Proc Natl Acad Sci USA 89:6065-6069
9. Munoz-Fernandez MA, Fernandez MA, Fresno M (1992) Synergism between tumor necrosis factor-α and interferon-γ on macrophage activation for the killing of intracellular Trypanosama cruzi through a nitric oxide-dependent mechanism. Eur J Immunol 22:301-307
10. Prat M, Gribando G, Comoglio PM, Cavallo G, Landolfo S. (1984) Monoclonal antibodies against murine gamma interferon. Proc Natl Acad Sci USA 81:4515-4519
11. Reed SG (1988) In vivo administration of recombinant IFN-γ induces macrophage activation, and prevents acute disease, immune suppression, and death in experimental Trypanosoma cruzi infections. J Immunol 140:4342-4347
12. Reed SG, Brownell CE, Russo DM, Silva JS, Grabstein KH, Morrissey PJ (1994) IL-10 mediates susceptibility to Trypanosoma cruzi infection. J Immunol 153:3135-3140
13. Rivera-Vanderpas MT, Rodriguez AM, Afchain D, Bazin H. and Capron A (1983) Trypanosoma cruzi: variation in susceptibility of inbred strains of rats. Acta Trop (Basel) 40:5-10
14. Schoenhaut DS, Chua AO, Wolitzky AG, Quinn PM, Dwyer CM. McComas W, Familletti PC, Gately MK, Gubler U (1992) Cloning and expression of murine IL-12. J Immunol 148:3433-3440
15. Silva JS, Twardzik DR, Reed SG (1991) Regulation of Trypanosoma cruzi infection in vitro and in vivo by transforming growth factor-β. J Exp Med 174:539-545
16. Silva JS, Morrissey PJ, Grabstein KH, Mohler KM, Anderson D, Reed SG (1992) Interleukin-10 and interferon-γ regulation of experimental Trypanosoma cruzi infection. J Exp Med 175: 169-174
17. Skeiky YAW, Guderian JA, Benson DR, Bacelar O, Carvalho EM, Kubin M, Badaro R, Trinchieri G, Reed SG (1995) A recombinant Leishmania antigen that stimulates human peripheral blood mononuclear cells to express a Th1-type cytokine profile and to produce interleukin-12. J Exp Med 181:1527-1537
18. Spitalny GL, Havell EA (1984) Monoclonal antibody to murine gamma-interferon inhibits lymphokine-induced antiviral and macrophage tumoricidal activities. J Exp Med 159:1560-1565
19. Torrico F, Heremans H, Rivera MT, Van Marck E, Billiau A, Carlier Y (1991) Endogenous IFN-γ is required for resistance to acute Trypanosoma cruzi infection in mice. J Immunol 146: 3626-3632
20. Trinchieri G (1994) Interleukin-12: a cytokine produced by antigen-presenting cells with immunoregulatory functions in the generation of T-helper cells type 1 and cytotoxic lymphocytes. Blood 84:4008-4027
21. Tushinski RJ, Oliver IT, Guilbert LJ, Tynan PW, Warner JR, Stanley ER (1982) Survival of mononuclear phagocytes depends on a lineage-specific growth factor that the differentiated cells selectively destroy. Cell 28:71-81
22. Wolf SF, Sieburth D, Sypek J (1994) Interleukin-12: a key modulatory of immune function. Stem cells 12:154-168
23. Zhang L, Tarleton RL (1996) Characterization of cytokine production in murine Trypanosoma cruzi infection by in situ immunocytochemistry: lack of association between susceptibility and type 2 cytokine production. Eur J Immunol 26:102-109