Determination of the chemical mechanism of neurotransmitter receptor-mediated reactions by rapid chemical kinetic methods

Archives of Physiology and Biochemistry

Volumn 104, Issue 6, 1996, Pages 752-761

  Hess, G P ^a  

^a Department of Obstetrics Gynecology   (United States)

Author keywords

conformational transitions; laser pulse; neurotransmitters; photolysis technique; signal transmission; transmembrane voltage

Indexed keywords

NEUROTRANSMITTER RECEPTOR;

CONFERENCE PAPER; HUMAN; KINETICS; LASER; MEMBRANE FLUIDITY; MUSCLE CELL; NERVE CELL; NEUROTRANSMISSION; NONHUMAN; PHOTOLYSIS; TECHNIQUE;

ANIMALS; CARBACHOL; KINETICS; LASERS; MODELS, BIOLOGICAL; PHOTOLYSIS; PROCAINE; PROTEIN CONFORMATION; RECEPTORS, NEUROTRANSMITTER; SIGNAL TRANSDUCTION;

MUS;

EID: 0030471979     PISSN: 13813455     EISSN: None     Source Type: Journal    
DOI: 10.1076/apab.104.6.752.12911     Document Type: Conference Paper

References (31)

1. AosHiMA, H., CASH, D.J. & HESS, O.P. (1981) Mechanism of inactivation (desensitization) of acetylcholine receptor. Investigations by fast reaction techniques with membrane vesicles. Biochemistry 20, 3467-3474.
2. CASH, D.J. & SUBBARAO, R. (1987) Desensitization of yaminobutyric acid receptor from rat brain: Two distinguishable receptors on the same membrane. Biochemistry 26, 7556-7562.
3. DE MAYO, P. (1960) Ultraviolet photochemistry of simple unsaturated systems. Adv. Org. Chem. 2, 367-425
4. GALZI, J.-L., REVAH, F., BESSIS, A. & CHANCEUX, J.-P. (1991) Functional architecture of the nicotinic acetylcholine receptor: From electric organ to brain. Annu. Rev. Pharmacol. 31, 37-72.
5. GEE, K.R., WIEBOLDT, R. & HESS, O.P. (1994) Synthesis and photochemistry of a new photolabile derivative of GABA. Neurotransmitter release and receptor activation in the microsecond time region. J. Am. Chem. Soc. 116, 8366-8367.
6. GEETHA, N. & HESS, G.P. (1992) On the mechanism of the y-aminobutyric acid (GABA) receptor in the mammalian (mouse) cerebral cortex. Chemical kinetic investigations with a 10 millisecond time resolution adapted to measurements of neuronal receptor function in single cells. Biochemistry 31, 5488-5499.
7. HAMILL, O.P., MARTY, A., NEHER, E., SAKMANN, B. & SIGWORTH, F.J. (1981) Improved patch clamp techniques for high-resolution current recording from cells and cellfree membrane patches. Pflügers Arch. 391, 85-100.
8. HESS, O.P., CASH, D.J. & AOSHIMA, H. (1979) Acetylcholine receptor-controlled ion fluxes in membrane vesicles investigated by fast reaction techniques. Nature 282,329-331.
9. HESS, G.P., CASH, D. J., & AOSHIMA, H. (1983) Acetylcholine receptor-controlled ion translocation: Chemical kinetic investigations of the mechanism. Annu. Rev. Biophys. Bioeng. 12, 443-473.
10. HESS, G.P., KOLB, H.A., LAUGER, P., SCHOFFENIELS, E. & SCHWARZE, W. (1984) Acetylcholine recqptor (from Electrophorus eleclricus): A comparison of single-channel current recordings and chemical kinetic measurements. Proc. Natl. Acad. Sei. USA 24, 5281-5285.
11. HESS, G.P., UDGAONKAR, J.B. & OLBRICHT, W.L. (1987) Chemical kinetic measurements of transmembrane processes using rapid reaction techniques: Acetylcholine receptor. Annu. Rev. Biophys. Chem. 16, 507-534.
12. KAPLAN, J.H., FORBUSH, B. & HOFFMANN, J.F. (1978) Rapid photolytic release of adenosine-5'-triphosphate from a protected analogue: utilization by the Na:K pump of human red blood cell ghosts. Biochemistry 17, 19291935.
13. KATZ, B. & THESLEFF, S. (1957) A study of the desensitization produced by acetylcholine at the motor endplate. J. Physiol. (London) 138, 63-80.
14. MADSEN, B.W. & EDESON, R.O. (1988) Nicotinic receptors and the elusive . Trends Pharmacol. Sei. 9, 315316.
15. MATSUBARA, N., BILLINGTON, A.P. & HESS, O.P. (1992) How fast does an acetylcholine receptor-channel open? Laser-pulse photolysis of a photolabile, inactive precursors of carbamoylcholine in kinetic investigations with BC3H1 cells in the \is time region? Biochemistry 31,5507-5514.
16. McCRAY, J.A., HERBETTE, L., KIHARA, T. & TRENTHAM, D.R. (1980) A new approach to time-resolved studies of ATP-requiring biological systems: Laser-flash photolysis of caged ATP. Proc. Natl. Acad. Sei. USA 77, 7237-7241.
17. MILBURN, T., MATSUBARA, N., BILLINGTON, A.P., UDGAONKAR, J.B., WALKER, J.W., CARPENTER, B.K., WEBB, WAV., MARQUE, J., DENK, W, MCCRAY, J.A. & HESS, O.P. (1989) Synthesis, photochemistry, and biological activity of a caged photolabile acetylcholine receptor ligand. Biochemistry 28, 49-55.
18. NEHER, E. & SAKMANN, B. (1976) Single-channel currents recorded from membrane of denervated frog muscle fibres. Nature 260, 861-863.
19. Niu, L. & HESS, O.P. (1993) An acetylcholine receptor regulatory site in BC3H1 cells: Characterized by laserpulse photolysis in the microsecond-to-millisecond time region. Biochemistry 32, 3831-3835.
20. Niu, L., ABOOD, L.G. & HESS, O.P. ( 1995) Cocaine: mechanism of inhibition of a muscle acetylcholine receptor studied by laser-pulse photolysis. Proc. Natl. Acad. Sei. USA 92 (in press)
21. OGDEN, D.C. & COLQUHOUN, D. (1985) Ion channel block by acetylcholine, carbachol and suberyldicholine at the frog neuromuscular junction. Proc. Roy. Soc. London, B 225, 329-355.
22. PASQUALE, E.B., TAKEYASU, K., UDGAONKAR, J.B., CASH, D.J., SEVERSKI, M.C. & HESS, O.P. (1983) Acetylcholine receptor: Evidence for a regulatory binding site in investigations of suberyldicholine-induced transmembrane ion flux in Elecirophoriis electrictts membrane vesicles. Biochemistry 22, 5967-5973.
23. PATCHORNIK, A. AMIT, B. & WOODWARD, R.B. (1970) Photosensitive protecting groups. J. Am. Chem. Soc. 92, 6333-6335.
24. PLANCK, M. (1890) Über die Potentialdifferenz zwischen verduennten Losungen binarer Electrolytes. Annalen Physik u. Chemie 40, 561-576.
25. RAMESH, D., WIEBOLDT, R., Niu, L., CARPENTER, B. K. & HESS, O.P. ( 1993) Photolysis of a new protecting group for the carboxyl function of neurotransmitters within 3 (is and with product quantum yield of 0.2. Proc. Natl. Acad. Sei. USA 90, 11074-11078.
26. TAKEYASU, K., SHIONA, S., UDGAONKAR, J.B., FUJITA, N. & HESS, G.P. (1986) Acetylcholine receptor: characterization of the voltage-dependent regulatory (inhibitory) site for acetylcholine in membrane vesicles from Torpedo califomica electroplax. Biochemistry 25,17701776.
27. UDGAONKAR, J.B. & HESS, G.P. (1987) Chemical kinetic measurements of a mammalian acetylcholine receptor using a fast reaction technique. Proc. Natl. Acad. Sei. USA 84, 8758-8762.
28. UNWIN, N. (1995) Acetylcholine receptor channel imaged in the open state. Nature 373, 37-43.
29. WALKER, J.W., McCRAY, J.A. & HESS, O.P. (1986) Photolabile protecting groups for an acetylcholine receptor ligand. Synthesis and photochemistry of a new class of o-nitrobenzyl derivatives and their effects on receptor function. Biochemistry 25, 1799-1805.
30. WALSTROM, K.M. & HESS, O.P. (1994) On the mechanism for the channel-opening reaction of strychnine-sensitive glycine receptors on cultured embryonic mouse spinal cord cells. Biochemistry 33, 7718-7730.
31. WIEBOLDT, R., GEE, K., Niu, L., RAMESH, D., CARPENTER, B.K. & HESS, O.P. (1994) Photolabile precursors of glutamate: synthesis, photochemical properties and activation of glutamate receptors on a microsecond timescale. Proc. Natl. Acad. Sei. USA 91, 8752-8756.