Changes in biliary lipid output after interruption of pravastatin treatment in humans

European Journal of Clinical Investigation

Volumn 26, Issue 12, 1996, Pages 1160-1165

  Hillebrant, C G ^a,b   Eriksson, M ^a   Nyberg, B ^a   Einarsson, K ^a  

^a KAROLINSKA INSTITUTE   (Sweden)

^b KAROLINSKA UNIVERSITY HOSPITAL   (Sweden)

Author keywords

3 Hydroxy 3 methylglutaryl coenzyme A; Bile acids; Cholesterol; Lathosterol; Low density lipoprotein,; Phospholipids

Indexed keywords

BILE ACID; CHOLESTEROL; HYDROXYMETHYLGLUTARYL COENZYME A REDUCTASE; LATHOSTEROL; LOW DENSITY LIPOPROTEIN; PHOSPHOLIPID; PRAVASTATIN;

ADULT; AGED; ARTICLE; BILE ACID SYNTHESIS; CHOLESTEROL SYNTHESIS; CLINICAL ARTICLE; CLINICAL TRIAL; CONTROLLED CLINICAL TRIAL; CONTROLLED STUDY; DRUG EFFECT; DRUG WITHDRAWAL; FEMALE; HUMAN; LIVER METABOLISM; MALE; PRIORITY JOURNAL; REBOUND;

EID: 0030471070     PISSN: 00142972     EISSN: None     Source Type: Journal    
DOI: 10.1046/j.1365-2362.1996.590608.x     Document Type: Article

References (32)

1. Kovanen PT, Bilheimer DW, Goldstein JL, Jaramillo JJ, Brown MS. Regulatory role for hepatic low density lipoprotein receptors in vivo in the dog. Proc Natl Acad Sci USA 1981;78:1194-8.
2. Ma PT, Gil G, Südhof TC, Bilheimer DW, Goldstein JL, Brown MS. Mevinolin, an inhibitor of cholesterol synthesis, induces mRNA for low density lipoprotein receptors in livers of hamsters and rabbits. Proc Natl Acad Sci USA 1986;83:8370-4.
3. Reihnér E, Rudling M, Ståhlberg D et al. Influences of pravastatin, a specific inhibitor of HMG-CoA reductase, on hepatic metabolism of cholesterol. N Engl J Med 1990;323:224-9.
4. Tobert JA, Bell GD, Birtwell J et al. Cholesterol-lowering effect of mevinolin, an inhibitor of 3-hydroxy-3-methylglutaryl-coenzyme A in healthy volunteers. J Clin Invest 1982;69:913-9.
5. Grundy SM. HMG CoA reductase inhibitors for treatment of hypercholesterolemia. N Engl J Med 1988;319:24-33.
6. Turley S, Dietschy JM. The metabolism and excretion of cholesterol by the liver. In: Arias IM, Popper H, Schachter D and Shafritz DA, eds. The Liver: Biology and Pathobiology. New York: Raven Press, 1988: 617-41.
7. Reihnér E, Björkhem I, Angelin B, Ewerth S, Einarsson K. Bile acid synthesis in humans: regulation of hepatic microsomal cholesterol 7α-hydroxylase activity. Gastroenterology 1989;97:1498-505.
8. Hofmann AF. The enterohepatic circulation of bile acids. In: Schultz SG, ed. Handbook of Physiology. Washington DC: American Physiological Association, 1989: 567-96.
9. Grundy SM, Bilheimer DW. Inhibition of 3-hydroxy-3-methylglutaryl-CoA reductase by mevinolin in familial hyperchlesterolemia heterozygotes: effects on cholesterol balance. Proc Natl Acad Sci USA 1984;81:2538-42.
10. Hoogerbrugge-van der Linden N, de Rooy FMW, Jansen H, van Blankenstein M. Effect of pravastatin on biliary lipid composition and bile acid synthesis in familial hypercholesterolaemia. Gut 1990;31:348-50.
11. Mitchell JC, Logan GM, Stone BG, Duane WC. Effects of lovastatin on biliary lipid secretion and bile acid metabolism in humans. J Lipid Res 1991;32:71-8.
12. Muraca M, Baggio G, Miconi L et al. Acute effects of HMG-CoA reductase inhibitors on biliary lipids in patients with interrupted enterohepatic circulation. Eur J Clin Invest 1991;21:204-8.
13. Mazella G, Parini P, Festi D et al. Effects of simvastatin, ursodeoxycholic acid and simvastatin plus ursodeoxycholic acid on biliary lipid secretion and cholic acid kinetics in nonfamilial hypercholesterolemia. Hepatology 1992;15:1072-8.
14. Duane WC. Effects of lovastatin and dietary cholesterol on sterol homeostasis in healthy human subjects. J Clin Invest 1993;92:911-8.
15. Duane WC. Effects of lovastatin and dietary cholesterol on bile acid kinetics and bile lipid composition in healthy male subjects. J Lipid Res 1994;35:501-9.
16. Loria P, Bertolotti M, Cassinadri MT et al. Short-term effects of simvastatin on bile acid synthesis and bile lipid secretion in human subjects. Hepatology 1994;19:882-8.
17. Mitchell JC, Stone BG, Logan GM, Duane WC. 1991. Role of cholesterol synthesis in regulation of bile acid synthesis and biliary cholesterol secretion in humans. J Lipid Res 1991;32:1143-9.
18. Bilhartz LE, Spady DK, Dietschy JM. Inappropriate hepatic cholesterol synthesis expands the cellular pool of sterol available for recruitment by bile acids in the rat. J Clin Invest 1989;84:1181-7.
19. Roda A, Festi D, Sama C, Mazella G, Aldini T, Roda E, Barbara L. Enzymatic determination of cholesterol in bile. Clin Chim Acta 1975;64:337-41.
20. Rouser G, Fleischer S, Yamamoto A. Two-dimensional thin-layer chromatographic separation of polar lipids and determination of phospholipids by phosphorus analysis of spots. Lipids 1970;5:494-6.
21. Fausa O, Skålhegg BA. Quantitative determination of bile acids and their conjugates using thin layer chromatography and a purified 3α-hydroxysteroid dehydrogenase. Scand J Gastroenterol 1974; 9:249-54.
22. Carey M. Critical tables for calculating the cholesterol saturation of native bile. J Lipid Res 1978;19:945-55.
23. Kempen JHM, Glatz JFC, Gevers Leuven JA, van der Voort HA, Katan MB. Serum lathosterol concentration is an indicator of whole-body cholesterol synthesis in humans. J Lipid Res 1988;29:1144-55.
24. Lund E, Sisfonte L, Reihnér E, Björkhem I. Determination of serum levels of unesterified lathosterol by isotope dilution-mass spectrometry. Scan J Clin Lab Invest 1989;49:165-71.
25. Carlson K. Lipoprotein fractionation. J Clin Pathol 1973;26(Suppl.5):32-7.
26. Lopez-Virella MF, Stone P, Ellis S, Colwell JA. Cholesterol determination in high-density lipoproteins separated by three different methods. Clin Chem 1977;23:882-4.
27. Magnusson I, Einarsson K, Angelin B, Nyberg B, Bergström K, Thulin L. Effects of somatostatin on hepatic bile formation. Gastroenterology 1989;96:206-12.
28. Bertolotti M, Abate N, Loria P et al. Regulation of bile acid synthesis in humans: Effect of treatment with bile acids, cholestyramine or simvastatin on cholesterol 7α-hydroxylation rates in vivo. Hepatology 1991;14:830-7.
29. Einarsson K, Reihnér E, Björkhem I. On the saturation of the cholesterol 7α-hydroxylase in human liver microsomes. J Lipid Res 1989;30:1477-81.
30. Björkhem I. Effects of mevinolin in rat liver: evidence for a lack of coupling between synthesis of hydroxymethylglutaryl-CoA-reductase and cholesterol 7α-hydroxylase activity. Biochim Biophys Acta 1986:, 877:43-9.
31. Pandak WM, Heuman DM, Hylemon PB, Vlahcevic ZR. Regulation of bile acid synthesis. IV. Interrelationship between cholesterol and bile acid biosynthesis pathways. J Lipid Res 1990;31:79-90.
32. Vlahcevic ZR, Heuman DM, Hylemon PB. Regulation of bile acid synthesis. Hepatology 1991;13:590-600.