Demonstration of the chiral inversion of ibuprofen by Verticillium lecanii in non-growing cultures

Letters in Applied Microbiology

Volumn 23, Issue 6, 1996, Pages 417-420

  Thomason, M J ^a   Rhys Williams, W ^a   Hutt, A J ^b   Lloyd, A W ^a   Hanlon, G W ^a  

^a UNIVERSITY OF BRIGHTON   (United Kingdom)

^b KING'S COLLEGE LONDON   (United Kingdom)

Author keywords

[No Author keywords available]

Indexed keywords

ENANTIOMERS; MAMMALS; PHYSIOLOGY; PROPIONIC ACID;

CHIRAL INVERSION; ENANTIOMERICS; S-ENANTIOMERS;

METABOLISM;

IBUPROFEN;

ARTICLE; BIOTRANSFORMATION; CONTROLLED STUDY; DRUG METABOLISM; DRUG STRUCTURE; ENANTIOMER; FUNGUS CULTURE; MODEL; NONHUMAN; RACEMIC MIXTURE;

FUNGI; MAMMALIA; TORRUBIELLA CONFRAGOSA;

EID: 0030470689     PISSN: 02668254     EISSN: None     Source Type: Journal    
DOI: 10.1111/j.1472-765X.1996.tb01349.x     Document Type: Article

References (7)

1. Hanlon, G.W., Kooloobandi, A. and Hutt, A.J. (1994) Microbial metabolism of 2-arylpropionic acids: effect of environmental parameters on the growth of Verticillium lecanii and its metabolism of ibuprofen. Journal of Applied Bacteriology 76, 442-447.
2. Hutt, A.J., Kooloobandi, A. and Hanlon, G.W. (1993) Microbial metabolism of 2-arylpropionic acids : chiral inversion of ibuprofen and 2-phenylpropionic acid. Chirality 5, 596-601
3. Mills, R.F.N., Adams, S.S., Liffe, E.E., Dickinson, A. and Nicholson, J.S. (1973) Metabolism of ibuprofen. Xenobiotica 3, 589-598.
4. Smith, R. and Rosazza, J. (1975), Microbial models of mammalian metabolism. Journal of Pharmaceutical Science 64, 1737-1759.
5. Thomason, M.J., Hanlon, G.W., Lloyd, A.W. and Hutt, A.J. (1994a) A reversed phase HPLC assay for the enantiomers of 2-phenylpropionic acid. 3rd Annual United Kingdom Association of Pharmaceutical Scientists Conference, Abstract 51.
6. Thomason, M.J., Hanlon, G.W., Lloyd, A.W. and Hutt, A.J. (1994b) Chiral inversion of 2-phenylpropionic acid in non-growing cultures of Verticillium lecanii. Journal of Pharmacy and Pharmacology 46, 1047P.
7. Thomason, M.J., Rhys-Williams, W., Hanlon, G.W. and Lloyd, A.W. (1995) Bidirectional chiral inversion of 2-phenylpropionic acid in non-growing cultures of Verticillium lecanii. Journal of Pharmacy and Pharmacology 47, 1059P.