Clinical experience with a porcine hepatocyte-based liver support system

International Journal of Artificial Organs

Volumn 19, Issue 11, 1996, Pages 664-669

  Chew, S C ^a   Hewitt, W R ^a   Watanabe, F D ^a   Eguchi, S ^a   Kahaku, E ^a   Middleton, Y ^a   Rozga, J ^a   Demetriou, Acuilles A ^a,b  

^a UNIVERSITY OF CALIFORNIA   (United States)

^b CEDARS SINAI MEDICAL CENTER   (United States)

Author keywords

bioartificial liver; encephalopathy; fulminant hepatic failure; liver failure

Indexed keywords

AMMONIA; DIALYSIS; LIVER; MERCURY COMPOUNDS; PATIENT TREATMENT;

BIOARTIFICIAL LIVER; CLINICAL EXPERIENCE; FULMINANT HEPATIC FAILURES; HEPATOCYTES; HOLLOW-FIBER CARTRIDGE; LIVER FAILURE; LIVER TRANSPLANT; MATRIX; ORTHOTOPIC; SUPPORT SYSTEMS;

ARTIFICIAL ORGANS;

ADOLESCENT; ADULT; ARTICLE; ARTIFICIAL LIVER; BRAIN DISEASE; CLINICAL ARTICLE; FEMALE; HUMAN; LIVER CELL; LIVER FAILURE; MALE; SCHOOL CHILD; SWINE;

EID: 0030469801     PISSN: 03913988     EISSN: None     Source Type: Journal    
DOI: 10.1177/039139889601901107     Document Type: Article

References (18)

1. Zieve L. Metabolic abnormalities in hepatic coma and potential toxins to be removed. Artificial Liver Support, Pitman, London 1975; 11-25.
2. Lee C, Tink A. Exchange transfusion in hepatic coma: report of a case. Med J Aust 1958; 1: 40-2.
3. Trey MB, Burns DG, Saunders SJ. Treatment of hepatic coma by exchange blood transfusion. N Engl J Med 1966; 274: 473-81.
4. Sabin S, Merritt JA, Treatment of hepatic coma in cirrhosis by plasmapheresis and plasma infusion (plasma exchange). Ann Intern Wed 1968: 68: 1-7.
5. Munoz SJ, Ballas SK, Moritz MJ, et al. Perioperative management of fulminant and subfulminant hepatic failure with therapeutic plasmapheresis. Transplant Proc 1989; 21: 3535-6.
6. Freeman JG, Matthewson K. Plasmapheresis in acute liver failure, Int J Artif Organs 1986; 9: 433-8.
7. Saunders SJ, Bosman SCW, Terblanche J, et al. Acute hepatic coma treated by cross-circulation with a baboon and by repeated exchange transfusions. Lancet 1968; 2: 585-8.
8. Hume D, Gayle W, Williams G. Cross-circulation of patients in hepatic coma with baboon partners having human blood. Surg Gynecol Obstet 1969; 128: 495-517.
9. Stange J, Mitzner S, Ramlow W, et al. A new procedure for the removal of protein-bound drugs and toxins. ASAIO J 1993; 39: 621-5.
10. Merrill JP, Smith S III, Callahan EJ III. The use of an artificial kidney: II. Clinical experience. J Clin Invest 1950; 29: 425-38.
11. Opolon P. High-permeability membrane hemodialysis and hemofiltration in acute hepatic coma: experimental and clinical results. Artif Organs 1979; 3: 354-60.
12. Gazzard BG, Weston MJ, Murray-Lyon IM, et al. Charcoal hemoperfusion in the treatment of fulminant hepatic failure. Lancet 1974; 1: 1301-7.
13. Denis J, Opolon P, Delorme ML. Long-term extra-corporeal assistance by continuous hemofiltration during fulminant hepatic failure. Gastroenterology and Clinical Biology 1979; 3: 337-48.
14. Eiseman B, Lien DS, Raffucci F. Heterologous liver perfusion in the treatment of hepatic failure. Ann Surg 1965; 162: 329-45.
15. Abouna GM, Serrou B, Boehming HG, et al. Long-term hepatic support by intermittent multi-species liver perfusion. Lancet 1970; 2: 391-6.
16. Parbhoo SP James IM, Ajdukiewicz A, et al. Extracorporeal pig-liver perfusion in treatment of hepatic coma due to fulminant hepatitis. Lancet 1971; 2: 659-65.
17. Rozga J, Williams F, Ro MS, et al. Development of a bioartificial liver: properties and function of a hollow-fiber module inoculated with liver cells. Hepatology 1993; 17: 258-65.
18. Rozga J, LePage E, Moscioni AD, et al. Clinical use of a bioartificial liver to treat fulminant hepatic failure. Ann Surg 1994; 219: 538-46.