Titration of gabapentin dose for optimal control of epileptic seizures

Advances in Therapy

Volumn 13, Issue 6, 1996, Pages 324-334

  Bruni, J ^a  

^a UNIVERSITY OF TORONTO   (Canada)

Author keywords

adjunctive therapy; antiepileptic drugs; dose titration; epilepsy; GABA; gabapentin

Indexed keywords

GABAPENTIN;

ANTICONVULSANT ACTIVITY; ARTICLE; BLOOD BRAIN BARRIER; CLINICAL TRIAL; DOSE CALCULATION; DOSE RESPONSE; DRUG ABSORPTION; DRUG EFFECT; DRUG EFFICACY; DRUG SAFETY; DRUG UPTAKE; EPILEPSY; HEADACHE; HUMAN; WEIGHT GAIN;

EID: 0030469633     PISSN: 0741238X     EISSN: None     Source Type: Journal    
DOI: None     Document Type: Article

References (4)

1. Mattson RH, Cramer JA, Collins JF, Department of Veterans Affairs Epilepsy Cooperative Study No. 264 Group. A comparison of valproate with carbamazepine for the treatment of complex partial seizures and secondarily generalized tonic-clonic seizures in adults. N Engl J Med. 1992;327:765-771.
2. Montouris GD. Practical insights and clinical experience with combinations of the new antiepileptic drugs. Neurology. 1995;45(suppl 2):S25-S28.
3. Taylor CP. Emerging perspectives on the mechanism of action of gabapentin. Neurology. 1994;44(suppl5):S10-S16.
4. Tasker JG, Dudek FE. Electrophysiology of GABA-mediated synaptic transmission and possible roles in epilepsy. Neurochem Res. 1991; 16:251-262.