Brain Ischemia and Gastric Mucosal Damage in Spontaneously Hypertensive Rats: The Role of Arterial Vagal Adrenoceptors

Digestive Diseases and Sciences

Volumn 41, Issue 12, 1996, Pages 2383-2391

  Kawakubo, Keishi ^a   Ibayashi, Setsuro ^a   Nagao, Tetsuhiko ^a   Doi, Kosei ^a   Aoyagi, Kunihiko ^a   Iida, Mitsuo ^a   Sadoshima, Seizo ^a   Fujishima, Masatoshi ^a  

^a KYUSHU UNIVERSITY   (Japan)

Author keywords

Brain ischemia; Gastric mucosal blood flow; Integrity of the gastric mucosa; Vagal adrenergic pathway

Indexed keywords

ADRENERGIC RECEPTOR; ALPHA 1 ADRENERGIC RECEPTOR; ATROPINE; GUANETHIDINE; PRAZOSIN;

ANIMAL EXPERIMENT; ANIMAL MODEL; ARTICLE; BRAIN BLOOD FLOW; BRAIN ISCHEMIA; CONTROLLED STUDY; FEMALE; HEMODYNAMICS; NONHUMAN; NORADRENERGIC SYSTEM; PRIORITY JOURNAL; RAT; SPONTANEOUSLY HYPERTENSIVE RAT; STOMACH MUCOSA BLOOD FLOW; STOMACH MUCOSA LESION;

ADRENERGIC AGENTS; ADRENERGIC ALPHA-ANTAGONISTS; ANALYSIS OF VARIANCE; ANIMALS; AORTIC BODIES; CEREBROVASCULAR CIRCULATION; FEMALE; GASTRIC ACID; GASTRIC MUCOSA; GUANETHIDINE; ISCHEMIC ATTACK, TRANSIENT; PRAZOSIN; RATS; RATS, INBRED SHR; RECEPTORS, ADRENERGIC; REGIONAL BLOOD FLOW; VAGOTOMY; VASCULAR RESISTANCE;

EID: 0030469338     PISSN: 01632116     EISSN: None     Source Type: Journal    
DOI: 10.1007/bf02100132     Document Type: Article

References (28)

1. Kitamura T, Ito K: Acute gastric changes in patients with acute stroke. 1: With reference to gastroendoscopic findings. Stroke 7:460-463, 1976
2. Kitamura T, Ito K: Acute gastric changes in patients with acute stroke. 2: Gastroendoscopic findings and biochemical observation of urinary noradrenalin, adrenalin, 17-OHCS and serum gastrin. Stroke 7:464-468, 1976
3. Hunt D, Gore I: Myocardial lesions following experimental intracranial hemorrhage. Am Heart J 83:232-236, 1972
4. Myers MG, Norris JW, Hachinski VC, Sole MJ: Plasma norepinephrine in stroke. Stroke 12:200-204, 1981
5. Neil-Dwyer G, Walter P, Cruickshank JM, Doshi B, O'Gorman P: Effect of propranolol and phentolamine on myocardial necrosis after subarachnoid hemorrhage. Br Med J 2:990-992, 1978
6. Malik AB: Mechanisms of neurogenic pulmonary edema. Circ Res 57:1-18, 1985
7. Guth PH: Gastric blood flow in restraint stress. Am J Dig Dis 17:807-813, 1972
8. Kitagawa H, Fujiwara M, Osumi Y: Effects of water immersion stress on gastric secretion and mucosal blood flow in rats. Gastroenterology 77:298-302, 1979
9. Hayase M, Takeuchi K: Gastric acid secretion and lesion formation in rats under water-immersion stress. Dig Dis Sci 31:166-171, 1986
10. Murakami M, Lam SK, Inasa M, Miyake T: Pathophysiology and pathogenesis of acute gastric mucosal lesions after hypothermic restraint stress in rats. Gastroenterology 88:660-665, 1985
11. Ross IN, Bahari HMM, Turnberg LA: The pH gradient across mucus adherent to rat fundic mucosa in vivo and the effects of potential damaging agents. Gastroenterology 81:713-718, 1981
12. Somasundarum K, Ganguly AK: Gastric mucosal protection during restraint stress in rats. Alteration in gastric adherent mucus and dissolved mucus in gastric secretion. Hepatogastroenterology 32:24-26, 1985
13. Auguste LJ, Argus L, Stein TA, Wise L: Arachidonic acid protection of rat mucosa against stress ulceration. J Surg Res 43:103-106, 1987
14. Konturek PK, Brzozowski T, Konturek SJ, Dembinski A: Role of epidermal growth factor, prostaglandin and sulfhydryls in stress-induced gastric lesions. Gastroenterology 99:1607-1615, 1990
15. Fujishima M, Ishitsuka T, Nakatomi Y, Tamaki K, Omae T: Changes in local cerebral blood flow following bilateral carotid occlusion in spontaneously hypertensive and normotensive rats. Stroke 12:874-876, 1981
16. Eklöf B, Siesjö BK: Cerebral blood flow in ischemia caused by carotid artery ligation in the rat. Acta Physiol Scand 87:69-77, 1973.
17. Choki J, Yamaguchi T, Takeya Y, Morotomi Y, Omae T: Effect of carotid artery ligation on regional cerebral blood flow in normotensive and spontaneously hypertensive rats. Stroke 8:374-379, 1977
18. Ogata J, Fujishima M, Morotomi Y, Omae T: Cerebral infarction following bilateral carotid artery ligation in normotensive and spontaneously hypertensive rats. A pathological study. Stroke 7:54-60, 1976
19. Aukland K, Bower BF, Berliner RW: Measurement of local blood flow with hydrogen gas. Circ Res 14:164-187, 1964
20. Yao H, Sadoshima S, Shiokawa O, Fujii K, Fujishima M: Renal blood flow in acute cerebral ischemia in spontaneously hypertensive rats: Effects of α- and β-adrenergic blockade. Stroke 18:629-633, 1987
21. Salim AS: Stress, the adrenergic hypothalamovagal pathway, and chronic gastric ulceration. J Psychosom Res 31:85-90, 1987
22. Salim AS: Reserpine, vagal adrenergic activity and stress-induced acute gastric mucosal injury in the rat. J Physiol 392:363-376, 1987
23. Izumiyama K, Kogure K: Experimental analysis of gastric mucosal blood flow after transient forebrain ischemia. Res Exp Med 190:301-303, 1990
24. Boura AL, Green AF: Adrenergic neuron blocking agents. Annu Rev Pharmacol 5:183-212, 1965
25. Furst CI: The biochemistry of guanethidine. Adv Drug Res 4:133-161, 1967
26. Lundberg J, Ahlman H, Dahlström A, Kewenter J: Catecholamine-containing nerve fibres in the human abdominal vagus. Gastroenterology 60:81-84, 1971
27. Dhital K, Lincoln J, Appenzeller O, Burnstock G: Adrenergic innervation of vasa and nervi nervorum of optic, sciatic, vagus and sympathetic nerve trunks in normal and streptozotocin-diabetic rats. Brain Res 367:39-44, 1986
28. Guth PH, Leung FW: Physiology of the gastric circulation. In Physiology of the gastrointestinal tract, 2nd ed, LR Johnson, J Christensen, MJ Jachson, ED Jacobson, JH Walsh (eds). New York, Raven Press, 1986, pp 1031-1053