메뉴 건너뛰기




Volumn 37, Issue 12, 1996, Pages 2021-2024

An improved method for rapid and efficient radioiodination of iodine-123-IQNB

Author keywords

Diastereomers; Iodine 123 IQNB; Muscarinic receptors; SPECT

Indexed keywords

3 QUINUCLIDINYL 4 IODOBENZILATE; 3 QUINUCLIDINYL 4 IODOBENZILATE I 123; IODINE 123; MUSCARINIC M2 RECEPTOR; RADIOLIGAND; UNCLASSIFIED DRUG;

EID: 0030469298     PISSN: 01615505     EISSN: None     Source Type: Journal    
DOI: None     Document Type: Article
Times cited : (23)

References (26)
  • 1
    • 0021288815 scopus 로고
    • Iodine-125 3-quinuclidinyl 4-iodobenzilate: A high affinity, high specific activity radioligand for the M1 and M2-acetylcholine receptors
    • Gibson RE, Rzeszotarski WJ, Jagoda EM, Francis BE, Reba RC, Eckelman WC. Iodine-125 3-quinuclidinyl 4-iodobenzilate: a high affinity, high specific activity radioligand for the M1 and M2-acetylcholine receptors. Life Sci 1984;34:2287-2296.
    • (1984) Life Sci , vol.34 , pp. 2287-2296
    • Gibson, R.E.1    Rzeszotarski, W.J.2    Jagoda, E.M.3    Francis, B.E.4    Reba, R.C.5    Eckelman, W.C.6
  • 4
    • 0024340310 scopus 로고
    • In vitro and in vivo characteristics of [iodine-125] 3-(R)-quinuclidinyl (S)-4-iodobenzilate
    • Gibson RE, Schneidau TA, Cohen VI, et al. In vitro and in vivo characteristics of [iodine-125] 3-(R)-quinuclidinyl (S)-4-iodobenzilate. J Nucl Med 1989;30:1079-1087.
    • (1989) J Nucl Med , vol.30 , pp. 1079-1087
    • Gibson, R.E.1    Schneidau, T.A.2    Cohen, V.I.3
  • 5
    • 0025132030 scopus 로고
    • 125I]iodobenzilate transport and specific binding to muscarinic acetylcholine receptor in rat brain in vivo: Implications for human studies
    • 125I]iodobenzilate transport and specific binding to muscarinic acetylcholine receptor in rat brain in vivo: implications for human studies [see comments]. J Cereb Blood Flow Metab 1990;10:781-807.
    • (1990) J Cereb Blood Flow Metab , vol.10 , pp. 781-807
    • Sawada, Y.1    Hiraga, S.2    Francis, B.3
  • 8
    • 0027420910 scopus 로고
    • A novel muscarinic receptor ligand which penetrates the blood brain barrier and displays in vivo selectivity for the m2 subtype
    • Gitler MS, Cohen VI, De la Cruz R, et al. A novel muscarinic receptor ligand which penetrates the blood brain barrier and displays in vivo selectivity for the m2 subtype. Life Sci 1993;53:1743-1751.
    • (1993) Life Sci , vol.53 , pp. 1743-1751
    • Gitler, M.S.1    Cohen, V.I.2    De La Cruz, R.3
  • 9
    • 0027406401 scopus 로고
    • Kinetic analysis of rat parotid gland muscarinic receptors in vivo: Comparison with brain and heart
    • Hiramatsu Y, Kawai R, Reba RC, Simon TR, Baum BJ, Blasberg RG. Kinetic analysis of rat parotid gland muscarinic receptors in vivo: comparison with brain and heart. Am J Physiol 1993;264:G541-G552.
    • (1993) Am J Physiol , vol.264
    • Hiramatsu, Y.1    Kawai, R.2    Reba, R.C.3    Simon, T.R.4    Baum, B.J.5    Blasberg, R.G.6
  • 10
    • 0028173250 scopus 로고
    • Tritiated QNB displays in vivo selectivity for the m2 subtype
    • Gitler MS, De la Cruz R, Zeeherg BR, Reba RC. Tritiated QNB displays in vivo selectivity for the m2 subtype. Life Sci 1994;55:1493-1508.
    • (1994) Life Sci , vol.55 , pp. 1493-1508
    • Gitler, M.S.1    De La Cruz, R.2    Zeeherg, B.R.3    Reba, R.C.4
  • 11
    • 0028276489 scopus 로고
    • Interaction of iodinated quinuclidinyl benzilate enantiomers with M3 muscarinic receptors
    • Hiramatsu Y, Eckelman WC, Baum BJ. Interaction of iodinated quinuclidinyl benzilate enantiomers with M3 muscarinic receptors. Life Sci 1994;54:1777-1783.
    • (1994) Life Sci , vol.54 , pp. 1777-1783
    • Hiramatsu, Y.1    Eckelman, W.C.2    Baum, B.J.3
  • 13
    • 0028877601 scopus 로고
    • Kinetic analysis of muscarinic receptors in human brain and salivary gland in vivo
    • Hiramatsu Y, Eckelman WC, Carrasquillo JA, et al. Kinetic analysis of muscarinic receptors in human brain and salivary gland in vivo. Am J Physiol 1995;268:R1491-R1499.
    • (1995) Am J Physiol , vol.268
    • Hiramatsu, Y.1    Eckelman, W.C.2    Carrasquillo, J.A.3
  • 14
    • 0021349693 scopus 로고
    • External imaging of cerebral muscarinic acetylcholine receptors
    • Eckelman WC, Reba RC, Rzeszotarski WJ, et al. External imaging of cerebral muscarinic acetylcholine receptors. Science 1984;223:291-293.
    • (1984) Science , vol.223 , pp. 291-293
    • Eckelman, W.C.1    Reba, R.C.2    Rzeszotarski, W.J.3
  • 15
    • 1842324335 scopus 로고
    • Muscarinic acetylcholine receptors in Alzheimer's disease. in vivo imaging with iodine- 123-labeled 3-quinuclidinyl-4-iodobenzilate and emission tomography
    • Holman BL, Gibson RE, Hill TC, Eckelman WC, Albert M, Reba RC. Muscarinic acetylcholine receptors in Alzheimer's disease. In vivo imaging with iodine- 123-labeled 3-quinuclidinyl-4-iodobenzilate and emission tomography. JAMA 1985;254: 3063-3066.
    • (1985) JAMA , vol.254 , pp. 3063-3066
    • Holman, B.L.1    Gibson, R.E.2    Hill, T.C.3    Eckelman, W.C.4    Albert, M.5    Reba, R.C.6
  • 16
    • 0024983297 scopus 로고
    • Cerebral muscarinic receptors in primary degenerative dementia as evaluated by SPECT with iodine-123-labeled QNB
    • Weinberger DR, Mann U, Gibson RE, et al. Cerebral muscarinic receptors in primary degenerative dementia as evaluated by SPECT with iodine-123-labeled QNB. Adv Neurol 1990;51:147-150.
    • (1990) Adv Neurol , vol.51 , pp. 147-150
    • Weinberger, D.R.1    Mann, U.2    Gibson, R.E.3
  • 18
    • 0026783202 scopus 로고
    • A comparison of FDG PET and IQNB SPECT in normal subjects and in patients with dementia
    • Weinberger DR, Jones D, Reba RC, et al. A comparison of FDG PET and IQNB SPECT in normal subjects and in patients with dementia. J Neuropsych Clin Neurosci 1992;4:239-248.
    • (1992) J Neuropsych Clin Neurosci , vol.4 , pp. 239-248
    • Weinberger, D.R.1    Jones, D.2    Reba, R.C.3
  • 19
    • 19244373614 scopus 로고
    • In vivo imaging of cerebral muscarinic receptors with iodine-123-QNB and SPECT: Studies in normal subjects and patients with dementia
    • Weinberger DR, Jones DW, Sunderland T, et al. In vivo imaging of cerebral muscarinic receptors with iodine-123-QNB and SPECT: studies in normal subjects and patients with dementia. Clin Neuropharmacol 1992;15:194A-195A.
    • (1992) Clin Neuropharmacol , vol.15
    • Weinberger, D.R.1    Jones, D.W.2    Sunderland, T.3
  • 20
    • 0027181285 scopus 로고
    • Deficits in iodine-labeled 3-quinuclidinyl benzilate binding in relation to cerebral blood flow in patients with Alzheimer's disease
    • Wyper DJ, Brown D, Patterson J, et al. Deficits in iodine-labeled 3-quinuclidinyl benzilate binding in relation to cerebral blood flow in patients with Alzheimer's disease. Eur J Nucl Med 1993;20:379-386.
    • (1993) Eur J Nucl Med , vol.20 , pp. 379-386
    • Wyper, D.J.1    Brown, D.2    Patterson, J.3
  • 21
    • 0029124771 scopus 로고
    • Differential cholinergic regulation in Alzhiemer's patients compared to controls following chronic blockade with scopolamine: A SPECT study
    • Sunderland T, Esposito G, Molchan SE, et al. Differential cholinergic regulation in Alzhiemer's patients compared to controls following chronic blockade with scopolamine: a SPECT study. Psychopharmacol 1995;121:231-241.
    • (1995) Psychopharmacol , vol.121 , pp. 231-241
    • Sunderland, T.1    Esposito, G.2    Molchan, S.E.3
  • 22
    • 5944231668 scopus 로고
    • Radioiodination of a 3-quinuclidinyl benzilate using no-carrier-added concentration of iodine-125/Nal
    • Lee KS, Gibson RE, Eckelman WC, Reba RC. Radioiodination of a 3-quinuclidinyl benzilate using no-carrier-added concentration of iodine-125/Nal [Abstract]. J Nucl Med 1986;27:(suppl)1045P.
    • (1986) J Nucl Med , vol.27 , Issue.SUPPL.
    • Lee, K.S.1    Gibson, R.E.2    Eckelman, W.C.3    Reba, R.C.4
  • 23
    • 0021364888 scopus 로고
    • Synthesis and evaluation of radioiodinated derivatives of 1-azabicyclo[2.2.2]oct-3-yl alpha-hydroxy-alpha-(4-iodophenyl)-alpha- Phenylacetate as potential radiopharmaceuticals
    • Rzeszotarski WJ, Eckelman WC, Francis BE, et al. Synthesis and evaluation of radioiodinated derivatives of 1-azabicyclo[2.2.2]oct-3-yl alpha-hydroxy-alpha-(4-iodophenyl)-alpha- phenylacetate as potential radiopharmaceuticals. J Med Chem 1984;27:156-160.
    • (1984) J Med Chem , vol.27 , pp. 156-160
    • Rzeszotarski, W.J.1    Eckelman, W.C.2    Francis, B.E.3
  • 26
    • 45249126362 scopus 로고
    • Synthesis of iodine-125-labeled 3-quinuclidinyl 4′-iodobenzilate
    • Kabalka GW, Gai YZ, Mathur S. Synthesis of iodine-125-labeled 3-quinuclidinyl 4′-iodobenzilate. Int J Rad Appl Instrum [b] 1989;16:359-360.
    • (1989) Int J Rad Appl Instrum [B] , vol.16 , pp. 359-360
    • Kabalka, G.W.1    Gai, Y.Z.2    Mathur, S.3


* 이 정보는 Elsevier사의 SCOPUS DB에서 KISTI가 분석하여 추출한 것입니다.