Endocrine mechanisms of suppressive effect of low dose estrogen-antiandrogen treatment on androgen-dependent organs of male rats

Journal of Endocrinological Investigation

Volumn 19, Issue 10, 1996, Pages 654-658

  Reznikov, A G ^a   Varga, S V ^a   Chaikovskaya, L V ^a   Tarasenko, L V ^a   Polyakova, L I ^a  

^a V P Komisarenko Institute of Endocrinology and Metabolism of the Ukraine Academy of Medical Sciences   (Ukraine)

Author keywords

5 reductase; Antiandrogen; Estrogen; LH; Testosterone; Ventral prostate

Indexed keywords

3BETA HYDROXY DELTA5 STEROID DEHYDROGENASE; ANDROGEN; ANTIANDROGEN; DNA; ESTROGEN; FLUTAMIDE; HEXESTROL; LUTEINIZING HORMONE; STEROID 5ALPHA REDUCTASE; TESTOSTERONE;

ACCESSORY SEX GLAND; ANIMAL EXPERIMENT; ANIMAL TISSUE; ARTICLE; CASTRATION; CELL HYPERPLASIA; CELL SECRETION; CONNECTIVE TISSUE CELL; CONTROLLED STUDY; DNA CONTENT; DRUG EFFECT; ENDOCRINE FUNCTION; ENZYME ACTIVITY; EPITHELIUM CELL; HISTOLOGY; LUTEINIZING HORMONE BLOOD LEVEL; MALE; NONHUMAN; ORAL DRUG ADMINISTRATION; ORGAN WEIGHT; PROSTATE VENTRAL LOBE; RAT; SEMINAL VESICLE; SMOOTH MUSCLE FIBER; SUBCUTANEOUS DRUG ADMINISTRATION; TESTOSTERONE BLOOD LEVEL;

EID: 0030469236     PISSN: 03914097     EISSN: None     Source Type: Journal    
DOI: 10.1007/BF03349034     Document Type: Article

References (18)

1. Labrie F., Dupont A., Cusan L., Gomes J., Emond J., Monfette G. Combination therapy with flutamide and medical (LHRH agonist) or surgical castration in advanced prostatic cancer: 7-year clinical experience. J. Steroid Biochem. Molec. Biol. 37: 943, 1990.
2. Crawford E.D., Allen J.A. Treatment of newly diagnosed stage D prostate cancer with leuprolide and flutamide or leuprolide alone, phase III, intergroup study 0036. J. Steroid Biochem. Molec Biol. 37: 961, 1990.
3. Ojasoo T. Nilutamide. Drugs Future 12: 763, 1987.
4. Namer M., Toubol J., Caty A., Couette J.E. A randomized double blind study evaluating anandron associated with orchiectomy in stage D prostate cancer. J. Steroid Biochem. Molec. Biol. 37: 909, 1990.
5. Sinitsyn P.V., Varga S.V., Reznikov A.G. Diethylstilboestrol-induced potentiation of antiandrogenic effects of niftolide in the prostate. Pharmakologia i Toxicologia 4: 75, 1988 (in Russian).
6. Reznikov A.G., Varga S.V. Experimental background for combined estrogenantiandrogen therapy of prostatic cancer. J. Endocrinol. Invest. 17(Suppl.): 57, 1994.
7. Rao B.R., Geldof A.A., van der Wilt C.L., de Voogt H.J. Efficacy and advantages in the use of low doses of anandron and estrogen combination in the treatment of prostate cancer. Prostate 13: 69, 1988.
8. Van Damme M.P., Robertson D.M., Diczfalusy E. An improved method for measuring luteinizing hormone (LH) activity using mouse Leydig cell preparations. Acta Endocrinol. (Copenh.) 77: 655, 1974.
9. Baraghini G.F., Celani M.F., Zaidi A.A., Cavani D., Baraldi E., Seghedoni S., Bazzani M., Montanini V. Problems associated with the in vitro bioassay of serum luteinizing hormone (LH) on mouse Leydig cell preparations: methodological aspects. J. Endocrinol. Invest. 7(Suppl.): 23, 1984.
10. Burton K. A study of the conditions and mechanism of the diphenylamine reaction for the colorimetric estimation of deoxyribonucleic acid. Biochem. J. 62: 315, 1956.
11. English H.F., Santen R.J., Isaacs J.T. Response of glandular versus basal rat ventral prostatic epithelial cells to androgen withdrawal and replacement. Prostate 11: 229, 1987.
12. Reznikov A.G., Demchenko V.N., Nishchimenko O.V. Effect of antitesticular cytotoxic serum on formation of testosterone in rat testicles under normal conditions with hypogonadism induced by cadmium chloride. Fiziologichesky Zhurnal, 22: 616, 1976 (in Russian).
13. Södersten P., Gray G., Damasa D.A., Smith E.R., Davidson J.M. Effects of a nonsteroidal antiandrogen on sexual behavior and pituitary-gonadal function in the male rat. Endocrinology 97: 1468, 1975.
14. Hellman L., Bradlow H.L., Freed S., Levin J., Rosenfeld R.S., Whitmore W.F., Zumoff B. The effect of flutamide on testosterone metabolism and the plasma levels of androgens and gonadotropins. J. Clin. Endocrinol. Metab. 45: 1224, 1997.
15. Reznikov A.G., Demchenko V.N., Varga S.V., Bozhok Yu.M. Hypothalamo-hypophyseal-gonadal system in male rats and guinea pigs treated with the antiandrogen 4′-nitro-3-trifluoromethyl-isobutyranilide. Endokrinologie 72: 276, 1978.
16. Hsueh A.Y.W., Dufau M.L., Catt K.Y. Direct inhibitory effect of estrogen on Leydig cell function of hypophysectomized rats. Endocrinology 103: 1096, 1978.
17. Moger W.H. Direct effect of estrogens on the endocrine function of the mammalian testis. Can. J. Physiol. Pharmacol. 58: 1011, 1980.
18. 19-steroid metabolism. Endocrinology 89: 465, 1971.