-
1
-
-
0027208041
-
Antitumor agents. 3. Synthesis and biological activity of 4β-alkyl derivatives containing hydroxy, amino, and amido groups of 4′-O-demethyl-4-desoxypodophyllotoxin as antitumor agents
-
Terada, T., Fujimoto, K., Nomura, M., Yamashita, J., Wierzba, K., Yamazaki, R., Shibata, J., Sugimoto, Y., Yamada, Y. Antitumor agents. 3. Synthesis and biological activity of 4β-alkyl derivatives containing hydroxy, amino, and amido groups of 4′-O-demethyl-4-desoxypodophyllotoxin as antitumor agents. J Med Chem 1993, 36: 1689-99.
-
(1993)
J Med Chem
, vol.36
, pp. 1689-1699
-
-
Terada, T.1
Fujimoto, K.2
Nomura, M.3
Yamashita, J.4
Wierzba, K.5
Yamazaki, R.6
Shibata, J.7
Sugimoto, Y.8
Yamada, Y.9
-
2
-
-
3142625153
-
-
Taiho Pharm. Co., Ltd. 4-Desoxy-4-epipodophyllotoxin deriv. or pharmaceutically aceptable salt thereof. EP 522173, JP 93503298, WO 9212982
-
Terada, T., Fujimoto, K., Nomura, M., Yamashita, J., Takeda, S., Kobunai, T., Yamaguchi, H., Wierzba, K. (Taiho Pharm. Co., Ltd.). 4-Desoxy-4-epipodophyllotoxin deriv. or pharmaceutically aceptable salt thereof. EP 522173, JP 93503298, WO 9212982.
-
-
-
Terada, T.1
Fujimoto, K.2
Nomura, M.3
Yamashita, J.4
Takeda, S.5
Kobunai, T.6
Yamaguchi, H.7
Wierzba, K.8
-
3
-
-
0021891888
-
DNA topoisomerases
-
Wang, J.C. DNA topoisomerases. Annu Rev Biochem 1985, 54: 665-97.
-
(1985)
Annu Rev Biochem
, vol.54
, pp. 665-697
-
-
Wang, J.C.1
-
4
-
-
0024316466
-
DNA topoisomerase poisons as antitumor drugs
-
Liu, L. DNA topoisomerase poisons as antitumor drugs. Annu Rev Biochem 1989, 58: 351-75.
-
(1989)
Annu Rev Biochem
, vol.58
, pp. 351-375
-
-
Liu, L.1
-
5
-
-
0024853052
-
Topoisomerase-targeting antitumor drugs
-
D'Arpa, P., Liu, L. Topoisomerase-targeting antitumor drugs. Biochim Biophys Acta 1989, 989: 163-77.
-
(1989)
Biochim Biophys Acta
, vol.989
, pp. 163-177
-
-
D'Arpa, P.1
Liu, L.2
-
6
-
-
0028046036
-
Structure and function of type II DNA topoisomerases
-
Watt, P.M., Hickson, I.D. Structure and function of type II DNA topoisomerases. Biochem J 1994, 303: 681-95.
-
(1994)
Biochem J
, vol.303
, pp. 681-695
-
-
Watt, P.M.1
Hickson, I.D.2
-
7
-
-
0028985716
-
Topoisomerases IIalpha and beta as therapy targets in breast cancer
-
Isaacs, R.J., Davies, S.L., Wells, N.J., Harris, A.L. Topoisomerases IIalpha and beta as therapy targets in breast cancer. Anti-Cancer Drugs 1995, 6: 195-211.
-
(1995)
Anti-Cancer Drugs
, vol.6
, pp. 195-211
-
-
Isaacs, R.J.1
Davies, S.L.2
Wells, N.J.3
Harris, A.L.4
-
8
-
-
0027186443
-
DNA topoisomerase I is involved in both repression and activation of transcription
-
Merino, A., Madden, K.R., Lane, W.S., Champoux, J.J., Reinberg, D. DNA topoisomerase I is involved in both repression and activation of transcription. Nature 1993, 365: 227-32.
-
(1993)
Nature
, vol.365
, pp. 227-232
-
-
Merino, A.1
Madden, K.R.2
Lane, W.S.3
Champoux, J.J.4
Reinberg, D.5
-
9
-
-
0027138674
-
Identification of human DNA topoisomerase I as a cofactor for activator-dependent transcription by RNA polymerase II
-
Kretzschmar, M., Meisterernst, M., Roeder, R.G. Identification of human DNA topoisomerase I as a cofactor for activator-dependent transcription by RNA polymerase II. Proc Natl Acad Sci USA 1993, 90: 11508-12.
-
(1993)
Proc Natl Acad Sci USA
, vol.90
, pp. 11508-11512
-
-
Kretzschmar, M.1
Meisterernst, M.2
Roeder, R.G.3
-
10
-
-
0023792369
-
Topoisomerases as novel targets for cancer chemotherapy
-
Bodley, A., Liu, L. F. Topoisomerases as novel targets for cancer chemotherapy. Biotechnology 1988, 6: 1315-8.
-
(1988)
Biotechnology
, vol.6
, pp. 1315-1318
-
-
Bodley, A.1
Liu, L.F.2
-
11
-
-
0025653684
-
DNA topoisomerase as anticancer drug targets
-
Schneider, E., Hsiang, Y.-H., Liu, L.F. DNA topoisomerase as anticancer drug targets. Adv Pharmacol 1990, 21: 149-83.
-
(1990)
Adv Pharmacol
, vol.21
, pp. 149-183
-
-
Schneider, E.1
Hsiang, Y.-H.2
Liu, L.F.3
-
12
-
-
0028174984
-
DNA topoisomerases: Essential enzymes and lethal targets
-
Chen, A.Y., Liu, L.F. DNA topoisomerases: Essential enzymes and lethal targets. Annu Rev Pharmacol Toxicol 1994, 34: 191-218.
-
(1994)
Annu Rev Pharmacol Toxicol
, vol.34
, pp. 191-218
-
-
Chen, A.Y.1
Liu, L.F.2
-
13
-
-
0021151237
-
Adriamycin-induced DNA damage mediated by mammalian DNA topoisomerase II
-
Tewey, K.M., Rowe, T.C., Yang, L., Halligan, B.D., Liu, L.F. Adriamycin-induced DNA damage mediated by mammalian DNA topoisomerase II. Science 1984, 226: 466-8.
-
(1984)
Science
, vol.226
, pp. 466-468
-
-
Tewey, K.M.1
Rowe, T.C.2
Yang, L.3
Halligan, B.D.4
Liu, L.F.5
-
14
-
-
0003761717
-
-
Academic Press, New York
-
Issel, B.F., Muggia, F.M., Carter, S.K. Etoposide (VP-16) Current Status and New Developments, Academic Press, New York, 1984.
-
(1984)
Etoposide (VP-16) Current Status and New Developments
-
-
Issel, B.F.1
Muggia, F.M.2
Carter, S.K.3
-
15
-
-
3142513103
-
The investigation of new inhibitors of DNA topoisomerase II
-
(Oct 5-7, Sendai) Abst 2401
-
Kobunai, T., Yoshida, M., Saito, H., Nomura, N., Takeda, S., Wierzba, K., Terada, T., Yamazaki, R., Yamada, Y., Unemi, N. The investigation of new inhibitors of DNA topoisomerase II. 52nd Annu Meet Jpn Cancer Assoc (Oct 5-7, Sendai) 1993, Abst 2401.
-
(1993)
52nd Annu Meet Jpn Cancer Assoc
-
-
Kobunai, T.1
Yoshida, M.2
Saito, H.3
Nomura, N.4
Takeda, S.5
Wierzba, K.6
Terada, T.7
Yamazaki, R.8
Yamada, Y.9
Unemi, N.10
-
16
-
-
3142621641
-
Antitumor activity of novel podophyllotoxin derivative TOP-53 [I]
-
(Oct 5-7, Sendai) Abst 2400
-
Utsugi, T., Kobunai, T., Matsuo, K., Shibata, J., Sugimoto, Y., Wierzba, K., Yamada, Y., Tsuruo, T. Antitumor activity of novel podophyllotoxin derivative TOP-53 [I]. 52nd Annu Meet Jpn Cancer Assoc (Oct 5-7, Sendai) 1993, Abst 2400.
-
(1993)
52nd Annu Meet Jpn Cancer Assoc
-
-
Utsugi, T.1
Kobunai, T.2
Matsuo, K.3
Shibata, J.4
Sugimoto, Y.5
Wierzba, K.6
Yamada, Y.7
Tsuruo, T.8
-
17
-
-
3142554770
-
Antitumor activity of novel podophyllotoxin derivative, TOP-53 against various lung cancers
-
(Oct 19-21, Nagoya) Abst 2237
-
Saito, H., Yoshida, M., Nakano, K., Fujioka, A., Kobunai, T., Nomura, N., Takeda, S., Unemi, N. Antitumor activity of novel podophyllotoxin derivative, TOP-53 against various lung cancers. 53rd Annu Meet Jpn Cancer Assoc (Oct 19-21, Nagoya) 1994, Abst 2237.
-
(1994)
53rd Annu Meet Jpn Cancer Assoc
-
-
Saito, H.1
Yoshida, M.2
Nakano, K.3
Fujioka, A.4
Kobunai, T.5
Nomura, N.6
Takeda, S.7
Unemi, N.8
-
18
-
-
0001766983
-
In vitro and in vivo antitumor activity against lung cancer of TOP-53, a novel podophyllotoxin derivative
-
Abst 2154
-
Kobunai, T., Saito, H., Yoshida, M., Toko, T., Takeda, S., Unemi, N. In vitro and in vivo antitumor activity against lung cancer of TOP-53, a novel podophyllotoxin derivative. Proc Amer Assoc Cancer Res 1994, 35: Abst 2154.
-
(1994)
Proc Amer Assoc Cancer Res
, vol.35
-
-
Kobunai, T.1
Saito, H.2
Yoshida, M.3
Toko, T.4
Takeda, S.5
Unemi, N.6
-
19
-
-
3142551209
-
The mode of action of novel podophyllotoxin derivative, TOP-53
-
(Oct 19-21, Nagoya) Abst 2236
-
Kobunai, T., Yoshida, M., Saito, H., Nomura, N., Takeda, S., Unemi, N. The mode of action of novel podophyllotoxin derivative, TOP-53. 53rd Annu Meet Jpn Cancer Assoc (Oct 19-21, Nagoya) 1994, Abst 2236.
-
(1994)
53rd Annu Meet Jpn Cancer Assoc
-
-
Kobunai, T.1
Yoshida, M.2
Saito, H.3
Nomura, N.4
Takeda, S.5
Unemi, N.6
-
20
-
-
3142511389
-
Antitumor activity of TOP-53, a novel podophyllotoxin derivative, against several human lung cancer xenografts
-
(Oct 10-12, Yokohama) Abst 2373
-
Kobunai, T., Saito, H., Yoshida, M., Utsugi, T., Yamada, Y. Antitumor activity of TOP-53, a novel podophyllotoxin derivative, against several human lung cancer xenografts. 55th Annu Meet Jpn Cancer Assoc (Oct 10-12, Yokohama) 1996, Abst 2373.
-
(1996)
55th Annu Meet Jpn Cancer Assoc
-
-
Kobunai, T.1
Saito, H.2
Yoshida, M.3
Utsugi, T.4
Yamada, Y.5
-
21
-
-
0010640093
-
Antitumor activity of TOP-53, a novel podophyllotoxin derivative
-
Abst 2914
-
Kobunai, T., Saito, H., Yoshida, M., Utsugi, T., Terada, T., Yamada, Y. Antitumor activity of TOP-53, a novel podophyllotoxin derivative. Proc Amer Assoc Cancer Res 1996, 37: Abst 2914.
-
(1996)
Proc Amer Assoc Cancer Res
, vol.37
-
-
Kobunai, T.1
Saito, H.2
Yoshida, M.3
Utsugi, T.4
Terada, T.5
Yamada, Y.6
-
22
-
-
3142552987
-
Relationship between lung distribution of TOP-53 and its interaction with phospholipids
-
(Oct 10-12, Yokohama) Abst 2467
-
Yoshida, M., Kobunai, T., Utsugi, T., Wierzba, K., Yamada, Y. Relationship between lung distribution of TOP-53 and its interaction with phospholipids. 55th Annu Meet Jpn Cancer Assoc (Oct 10-12, Yokohama) 1996, Abst 2467.
-
(1996)
55th Annu Meet Jpn Cancer Assoc
-
-
Yoshida, M.1
Kobunai, T.2
Utsugi, T.3
Wierzba, K.4
Yamada, Y.5
-
23
-
-
8944259912
-
Antitumor activity of a novel podophyllotoxin derivative (TOP-53) against lung cancer and lung metastatic cancer
-
Utsugi, T., Shibata, J., Sugimoto, Y., Aoyagi, K., Wierzba, K., Kobunai, T., Terada, T., Oh-hara, T., Tsuruo, T., Yamada, Y. Antitumor activity of a novel podophyllotoxin derivative (TOP-53) against lung cancer and lung metastatic cancer. Cancer Res 1996, 56: 2809-14.
-
(1996)
Cancer Res
, vol.56
, pp. 2809-2814
-
-
Utsugi, T.1
Shibata, J.2
Sugimoto, Y.3
Aoyagi, K.4
Wierzba, K.5
Kobunai, T.6
Terada, T.7
Oh-hara, T.8
Tsuruo, T.9
Yamada, Y.10
|