T cell reactions in patients showing adverse immune reactions to drugs

Inflammation Research

Volumn 45, Issue SUPPL. 2, 1996, Pages

  Zanni, M P ^a   Von Greyerz, S ^a   Schnyder, B ^a   Mauri Hellweg, D ^a   Brander, C ^a   Kalbermatten, C ^a   Pichler, W J ^a  

^a UNIVERSITY OF BERN   (Switzerland)

Author keywords

Drug hypersensitivity; Hapten; Interleukin 5; Penicillin; T cell

Indexed keywords

AMOXICILLIN; AMPICILLIN; BUPIVACAINE; CD4 ANTIGEN; CD8 ANTIGEN; CYTOKINE; INTERLEUKIN 5; LIDOCAINE; MEPIVACAINE; PENICILLIN G; SULFAMETHOXAZOLE; TETANUS TOXOID;

ADULT; CELL PROLIFERATION; CLINICAL ARTICLE; CONFERENCE PAPER; CONTACT DERMATITIS; CONTROLLED STUDY; DIARRHEA; DNA SYNTHESIS; DRUG HYPERSENSITIVITY; EFFECTOR CELL; ENZYME LINKED IMMUNOSORBENT ASSAY; FEVER; HELPER CELL; HUMAN; HUMAN CELL; IMMUNE RESPONSE; IMMUNOFLUORESCENCE; MALAISE; MONONUCLEAR CELL; RASH; T LYMPHOCYTE;

ADULT; ANESTHETICS, LOCAL; ANTI-INFECTIVE AGENTS; CD4-POSITIVE T-LYMPHOCYTES; CD8-POSITIVE T-LYMPHOCYTES; CELL DIVISION; CELL LINE; DRUG HYPERSENSITIVITY; ENZYME-LINKED IMMUNOSORBENT ASSAY; HUMANS; INTERFERON TYPE II; INTERLEUKIN-5; ISOTOPE LABELING; LIDOCAINE; LYMPHOCYTE ACTIVATION; PENICILLIN G; PENICILLINS; SULFAMETHOXAZOLE; TRITIUM; UP-REGULATION;

EID: 0030468290     PISSN: 10233830     EISSN: None     Source Type: Journal    
DOI: None     Document Type: Conference Paper

References (26)

1. O'Donnell CA, Foster AL, Coleman JW. Penicillame and penicillin can generate antigenic determinants on rat peritoneal cells in vitro. Immunology 1991; 72:571-6.
2. de Weck AL. Drugs as allergens. J Allergy Clin Immunol 1976;78:1047-50.
3. Weiss ME, Adkinson NF. Immediate hypersensitivity reactions to penicillin and releated antibiotics. Clin Allergy 1988;18:515-40.
4. Blanca M, Mayorga C, Sanchez F, Vega JM, Fernandez J, Juarez C, et al. Differences in serum IgE antibody activity to benzylpenicillin and amoxicillin measured by RAST in a roup of penicillin allergic patients. Allergy 1991;46:632-8.
5. Coleman JW. Allergic reactions to drugs: current concepts and problems. Allergy 1990;20:79-85.
6. Koponen M, Pichler WJ, de Weck AL. T cell reactivity to penicillin: phenotypic analysis of in vitro activated cell subsets. J Allergy Clin Immunol 1986;78:645-52.
7. Martin S, Weltzien HU. T cell recognition of haptens, a molecular view. Int Arch Allergy Immunol 1994;104:10-7.
8. Park BK, Coleman JW, Kitteringham NR. Drug disposition and drug hypersensitivity. Biochem Pharmacol 1987;36:581-90.
9. Schneider CH, de Weck AL. Chemische Aspekte der Penicilin-Allergie: Die direkte Penicilloylierung von E-Aminogruppen durch Penicilline bei pH 7.4. Helv Chem Acta 1966;49:1695-701.
10. Masubuchi Y, Araki J, Narimatsu S, Suzuki T. Metabolic activation of lidocaine and covalent binding to rat liver microsomal protein. Biochem Pharmacol 1992;43:2551-7.
11. Cribb AE, Spielberg SP. Hepatic microsomal metabolism of sulfamethoxazole to the hydroxylamine. Drug Metab Dispos 1990;18:784-7.
12. Zakrevska JM, Ivanyi L. In vitro lymphocyte transformation by carbamazepine, carbamazepine-10, 11-epoxide, and oxcarbamazepine in the diagnosis of drug induced hypersensitivity. J Allergy Clin Immunol 1988;82:110-5.
13. Jiang X, Khursigara G, Rubin RL. Transformation of lupus-inducing drugs to cytotoxic products by activated neutrophils. Science 1994;266:810-3.
14. Rieder MJ, Krause R, Bird IA, Dekaban EA. Toxicity of sulfonamide-reactive metabolites in HIV-infected, HTLV-infected, and noninfected cells. J Acquir Immune Def Syndr 1995;8:134-40.
15. Cribb AE, Miller M, Leeder JS, Hill J, Spielberg SP. Reactions of the nitroso and hydroxylamine metabolites of sulfamethoxazole with reduced glutathione. Drug Metab Dispos 1991;19:900-6.
16. Batchelor JR, Welsh KL, Tinoco RM, Dollery CT, Hughes DRV, Bernstien R, et al. Hydralazin induced systemic lupus erythematosus: Influence of HLA-DR and sex on susceptibility. Lancet 1980;1:1107-9.
17. Romagnoli P, Spinas GA, Sinigaglia F. Gold specific T cells in rheumatoid arthritis patients treated with gold. J Clin Invest 1991;89:254-8.
18. Romagnoli P, Labhardt AM, Sinigaglia F. Selective interaction of Ni with a MHC-bound peptide. EMBO J 1991;10:1303-6.
19. Sotiini A, Imberli L, Gorla R, Cattaneo R, Primi D. Restricted expression of T cell receptor Vβ but not Vα genes in rheumatoid arthritis. Eur J Immunol 1991;21:461-6.
20. Kalish RS, LaPorte A, Wood JA, Johnson KL Sulfonamide-reactive lymphocyte detected at very low frequency in the peripheral blood of patients with drug-induced eruptions. . Allergy Clin Immunol 1994;94:465-72.
21. Brander C, Mauri-Hellweg D, Bettens F, Rolli H, Goldman M, Pichler WJ. Heterogeneous T cell responses to β-lactam-modified self structures are observed in penicillin-allergic individuals. J Immunol 1995;155:2670-8.
22. Hellweg-Mauri D, Bettens F, Mauri D, Brander C, Hunziker T, Pichler WJ. Activation of drug specific CD4+ and CD8+ T cells in individuals allergic to sulfamethoxazole, phenytoin and carbamazepine. J Immunol 1995;155:462-72.
23. Dent LA, Strath M, Mellor AL, Sanderson CJ. Eosinophilia in transgenic mice expressing interleukin 5. J Exp Med 1990;172:1425-31.
24. Morrison LA, Lukacher AE, Braciale VL, Fan DP, Brajiale TJ. Differences in the antigen presentation of MHC class I- and class II-restricted influenza virus-specific cytolytic T lymphocyte clones. J Exp Med 1986;163:903-11.
25. Cribb AE, Miller M, Tesero A, Spielberg SP. Peroxidase-dependent oxidation of sulfonamides by monocytes and neutrophils from humans and dogs. Mol Pharmacol 1990;38:744-9.
26. Kapsenberg ML, Wierenga EA, Bos JD, Jansen HM. Functional subsets of allergen-reactive human T cells. Immunol Today 1991;12:392-5.