Fetal peripheral blood mononuclear cell proliferative responses to mitogenic and allergenic stimuli during gestation

Pediatric Allergy and Immunology

Volumn 7, Issue 3, 1996, Pages 109-116

  Jones, A C ^a   Miles, E A ^a   Warner, J O ^a   Colwell, B M ^a   Bryant, T N ^a   Warner, J A ^a  

^a SOUTHAMPTON GENERAL HOSPITAL   (United Kingdom)

Author keywords

Allergen; Fetal; Immune responses; PBMC; Proliferation

Indexed keywords

ALLERGEN; BEE VENOM; BETA LACTOGLOBULIN; MELITTIN; OVALBUMIN; PHYTOHEMAGGLUTININ;

ALLERGIC REACTION; ARTICLE; DERMATOPHAGOIDES PTERONYSSINUS; FETUS; FETUS BLOOD; HUMAN; HUMAN CELL; IMMUNE SYSTEM; MAJOR CLINICAL STUDY; MITOGENESIS; MONONUCLEAR CELL; NEWBORN; POLLEN; PREGNANCY; PRENATAL EXPOSURE; PRIORITY JOURNAL;

EID: 0030467722     PISSN: 09056157     EISSN: None     Source Type: Journal    
DOI: 10.1111/j.1399-3038.1996.tb00117.x     Document Type: Article

References (21)

1. 1 Rawle, FC, Mitchell, EB, Platts‐Mills, TAE., T cell responses to the major allergen from the house dust mite Dermatophagoides pteronyssinus antigen P1: comparison of patients with asthma, atopic dermatitis, and perennial rhinitis. J Immunol 1984: 133: 195–201.
2. 2 Kondo, N, Hiroatsu, A, Fukutomi, O, Motoyoshi, F, Orh T. Lymphocyte responses to food allergens in patients with atopic dermatitis who are sensitive to foods. J Allergy Clin Immunol 1990: 86: 253–60.
3. 3 Piccinni, MP, Mecacci, F, Sampognaro, S, Manetti, R, Parronchi, P, Maggi, E, Romagnani, S., Aeroallergen sensitisation can occur during fetal life. Int Arch Allergy Immunol 1993: 102: 301–3.
4. 4 Holt, PG, O'Keeffe, P, Holt, BJ, et al. T cell ‘priming’ against environmental allergens in human neonates: sequential deletion of food antigen reactivity during infancy with concomitant expansion of responses to ubiquitous inhalant allergens. Pediatr Allergy Immunol 1995: 6: 85–90.
5. 5 Kondo, N, Kobayashi, Y, Shinoda, S, et al. Cord blood lymphocyte responses to food antigens for the prediction of allergic disorders. Arch Dis Child 1992: 67: 1003–7.
6. 6 Warner, JA, Miles, EA, Jones, AC, Quint, DJ, Colwell, BM, Warner, JO., Is deficiency of interferon gamma production by allergen triggered cord blood cells a predictor of atopic eczema Clin Exp Allergy 1994: 24: 423–30.
7. 7 Piastra, M, Stabile, A, Fioravanti, G, Castagnola, M, Pani, G, Ria, F., Cord blood mononuclear cell responsiveness to beta‐lactoglobulin: T‐cell activity in atopy prone and non‐atopy prone newborns. Int Arcb Allergy Immunol 1994: 104: 358–65.
8. 8 Hayward, AR., Development of lymphocyte responses in humans, the fetus and newbom. Immunol Rev 1981: 57: 43–61.
9. 9 Papadogiannakis, N, Johnsen, S‐A, Olding, LB., Monocyte‐regulated hyporesponsiveness of buman cord blood lymphocytes of OKT3‐monoclonal antibody‐induced mitogenesis. ScandJ Immunol 1986: 23: 91–9.
10. 10 Wilson, CB, Penix, L, Weaver, WM, Melvin, A, Lewis, DB., Ontogeny of T lymphocyte function in the neonates. Am J Reprod Immunol 1992: 28: 132–5.
11. 11 Holt, PG, Clough, JB, Holt, BJ, et al. Genetic risk for atopy is associated with delayed postnatal maturation of T‐cell competence. Clinical Exp Allergy 1992: 22: 1093–9.
12. 12 Miles, EA, Warner, JA, Lane, AC, Jones, AC, Colwell, BM, Warner, JO., Altered T lymphocyte phenotype at birth in babies born to atopic parents. Pediatr Allergy Immunol 1994: 5: 202–8.
13. 13 Schwarze, J, Bartmann, P., Influence of dexamelhasone on lymphocyte proliferation in whole blood cultures of neonates. Biol Neonate 1994: 65: 295–301.
14. 14 Vanto, T, Koivikko, A., Dog hyperscnsitivity in asthmatic children. Acta Paediatr Scand 1983: 72: 571–5.
15. 15 Bjorksten, B, Souniemi, I, Koski, V., Neonatal birch‐pollen contact and subsequent allergy to birch pollen. Clinical Allergy 1980: 10: 585–91.
16. 16 Holt, PG., Postnatal maturation of immune competence during infancy and childhood. Pediatr Allergy Immunol 1995: 6: 59–70.
17. 17 Hattevig, G, Kjellman, B, Bjorksten, B., Appearance of IgE antibodies to ingested and inhalant allergens during the first 12 years of life in atopic and non‐atopic children. Ped Allergy Immunol 1993: 4: 182–6.
18. 18 Mariani, F, Price, JF, Kemeny, DM., The IgG subclass antibody response to an inhalant antigen (Dermatophagoides pteronyssinus) during the first year of life: evidence for early stimulation of the immune system following natural exposure. Clin Exp Allergy 1992: 22: 29–33.
19. 19 Devey, ME, Bekman, S, Kemeny, DM., The functional affinities of antibodies of different IgG subclass to dietary antigens in mother and their babies. Clin Exp Immunol 1993: 94: 117–21.
20. 20 Hannet, I, Erkeller‐Yuksel, F, Lydyard, P, Deneys, V, Debruyere, M., Development and maiurational changes in human blood lymphocyte subpopulations. Immunology Today 1992: 13: 215–8.
21. 21 Sanders, ME, Malegapuru, W, Shaw, S., Human naive and memory T cells: reinterpretation of helper‐inducer and suppressor‐inducer subsets. Immunology Today 1988: 9: 195–9.