Regulated expression of the interferon-induced protein kinase p68 (PKR) by vaccinia virus recombinants inhibits the replication of vesicular stomatitis virus but not that of poliovirus

Journal of Interferon and Cytokine Research

Volumn 16, Issue 12, 1996, Pages 1073-1078

  Lee, Sean Bong ^a,c   Bablanian, Rostom ^a   Esteban, Mariano ^a,b  

^a SUNY DOWNSTATE MEDICAL CENTER   (United States)

^b CSIC   (Spain)

^c MASSACHUSETTS GENERAL HOSPITAL CANCER CENTER   (United States)

Author keywords

[No Author keywords available]

Indexed keywords

INTERFERON; PROTEIN KINASE;

ANTIVIRAL ACTIVITY; ARTICLE; ESCHERICHIA COLI; HUMAN; HUMAN CELL; IMMUNOBLOTTING; NONHUMAN; POLIOMYELITIS VIRUS; PRIORITY JOURNAL; PROTEIN EXPRESSION; VACCINIA VIRUS; VESICULAR STOMATITIS VIRUS; VIRUS INHIBITION; VIRUS REPLICATION;

ENCEPHALOMYOCARDITIS VIRUS; ESCHERICHIA COLI; POLIOVIRUS; RNA VIRUSES; VACCINIA; VACCINIA VIRUS; VESICULAR STOMATITIS VIRUS;

EID: 0030467465     PISSN: 10799907     EISSN: None     Source Type: Journal    
DOI: 10.1089/jir.1996.16.1073     Document Type: Article

References (14)

1. SAMUEL, C.E. (1991). Antiviral actions of interferon: interferon-regulated cellular proteins and their surprisingly selective antiviral activities. Virology 183, 1-11.
2. MEURS, E., WATANABE, Y., KADEREIT, S., BARBER, G., KATZE, M.G., CHONG, K., WILLIAMS, B.R.G., and HOVANESSIAN, A. (1992). Constitutive expression of human double-stranded RNA-activated p68 kinase in murine cells mediates phosphorylation of eukaryotic initiation factor 2 and partial resistance to encephalomyocarditis virus growth. J. Virol. 66, 5805-5814.
3. LEE, S.B., and ESTEBAN, M. (1993). The interferon-induced double-stranded RNA-activated human p68 protein kinase inhibits the replication of vaccinia virus. Virology 193, 1037-1041.
4. LEE, S.B., GREEN, S., MATHEWS, M.B., and ESTEBAN, M. (1994). Activation of the double-stranded (ds-RNA) activated human protein kinase in the absence of its ds-RNA binding domain. Proc. Natl. Acad. Sci. USA 91, 10551-10555.
5. RODRIGUEZ, J.F., and SMITH, G.L. (1990). Inducible gene expression from vaccinia vectors. Virology 177, 239-250.
6. JOKLIK, W.K. (1962). The purification of four stains of poxviruses. Virology 18, 9-18.
7. PAEZ, E., and ESTEBAN, M. (1984). Resistance of vaccinia virus to interferon is related to an interference phenomenon between the virus and the interferon system. Virology 134, 12-28.
8. BLACK, T., SAFER, B., HOVANESSIAN, A., and KATZE, M. (1989). The cellular 68,000 Mr protein kinase is highly autophosphorylated and activated yet significantly degraded during poliovirus infection: implications for translational regulation. J. Virol. 63, 2244-2252.
9. SMITH, G.L. (1993). Virus strategies for evasion of host response to infection. Trends Microbiol. 2, 81-88.
10. BEATTIE, E., TARTAGLIA, J., and PAOLETTI, E. (1991). Vaccinia virus encoded eIF-2a homolog abrogates the antiviral effect of interferon. Virology 183, 419-422.
11. DAVIES, M.V., ELROY-STEIN, O., JARGUS, R., MOSS, B., and KAUFMAN, R. (1992). The vaccinia virus K3L gene product potentiates translation by inhibiting double-stranded-RNA-activated protein kinase and phosphorylation of the alpha subunit of eukaryotic initiation factor 2. J. Virol. 66, 1943-1950.
12. CHANG, H.-W., WATSON, J.C., and JACOB, B.L. (1992). The E3L gene of vaccinia virus encodes an inhibitor of the interferon-induced double-stranded RNA-dependent protein kinase. Proc. Natl. Acad. Sci. USA 89, 4825-4829.
13. BARBER, T., WAMBACH, M., WONG, M.-L., DEVER, T.E., HINNEBUSCH, A.G., and KATZ, M. (1993). Translational regulation of the interferon-induced double-stranded RNA activated 68-kDa protein kinase. Proc. Natl. Acad. Sci. USA 90, 4621-4625.
14. LEE, S.B., and ESTEBAN, M. (1994). The interferon-induced double-stranded RNA-activated protein kinase induces apoptosis. Virology 199, 491-496.