Protocols for the treatment of human tumor xenografts with camptothecins

Annals of the New York Academy of Sciences

Volumn 803, Issue , 1996, Pages 181-187

  Giovanella, B C ^a   Natelson, E ^a   Harris, N ^a   Vardeman, D ^a   Stehlin, J S ^a  

^a St Joseph's Medical Center Houston   (United States)

Author keywords

[No Author keywords available]

Indexed keywords

ANTINEOPLASTIC ALKALOID; CAMPTOTHECIN;

CLINICAL PROTOCOL; CONFERENCE PAPER; EXPERIMENTAL NEOPLASM; HUMAN; NONHUMAN; TUMOR MODEL; TUMOR XENOGRAFT;

EID: 0030467156     PISSN: 00778923     EISSN: None     Source Type: Book Series    
DOI: 10.1111/j.1749-6632.1996.tb26387.x     Document Type: Conference Paper

References (15)

1. WALL, M. E., M. C. WANI, C. E. COOK, K. H. PALMER, A. T. MCPHAIL & G. A. SIM. 1966. Plant antitumor agents. I. The isolation and structure of camptothecin, a novel alkaloidal leukemia and tumor inhibitor from Camptotheca acuminata. J. Am. Chem. Soc 88: 3888-3890.
2. MUGGIA, F. M., P. J. CREAVEN, H. H. HANSEN, M. H. COHEN & O. S. SELAWRY. 1972. Phase I clinical trial of weekly and daily treatment with camptothecin (NSC-100880); correlation with preclinical studies. Cancer Chemother. Rep. 56: 515-521.
3. MOERTEL, C. G., A. J. SHUTT, R. J. REITEMEIER & R. G. HAHN. 1972. Phase II study of camptothecin (NSC-100880) in the treatment of advanced gastrointestinal cancer. Cancer Chemother. Rep. 56: 95-101.
4. GIOVANELLA, B. C., J. S. STEHLIN, M. E. WALL, M. C. WANI, A. W. NICHOLAS, L. F. LIU, R. SILBER & M. POTMESIL. 1989. DNA topoisomerase I-targeted chemotherapy of human colon cancer in xenografts. Science 246: 1046-1048.
5. GIOVANELLA, B. C., H. R. HINZ, A. J. KOZIELSKI, J. S. STEHLIN, JR., R. SILBER & M. POTMESIL. 1991. Complete growth inhibition of human cancer xenografts in nude mice by treatment with 20-(S)-camptothecin. Cancer Res. 51: 3052-3055.
6. KUNIMOTO, T., K. NITTA, T. TANAKA, N. UEHARA, H. BABA, M. TAKEUCHI, T. YOKOKURA, S. SAWADA, T. MIYASAKA & M. MUTAI. 1991. Antitumor activity of 7-ethyl-10-[4-(1-piperidino)-1-piperidino] carbonyloxy-camptothecin, a novel water-soluble derivative of camptothecin, against murine tumors. Cancer Res. 47: 5944-5947.
7. KINGSBURY, W. C., J. BOEHM, D. R. JAKAS, K. G. HOLDEN, S. M. HECHT, G. GALLAGHER, M. J. CARANFA, F. L. MCCABE, L. F. FAUCETTE, R. K. JOHNSON & R. P. HERTZBERG. 1991. Synthesis of water-soluble (aminoalkyl) camptothecin analogues: inhibition of topoisomerase I and antitumor activity. J. Med. Chem. 35: 98-107.
8. POTMESIL, M., B. C. GIOVANELLA, L. F. LIU, M. E. WALL, R. SILBER, J. S. STEHLIN, JR. Y-H., HSIANG & M. C. WANI. 1991. Preclinical studies of DNA topoisomerase I-targeted 9-amino and 10,11-methylendioxy camptothecins. In DNA Topoisomerases in Cancer. M. Potmesil & K. W. Kohn, Eds.: 299-311. Oxford University Press. New York.
9. POTMESIL, M., B. C. GIOVANELLA, M. E. WALL, L. F. LIU, R. SILBER, J. S. STEHLIN, M. C. WANI & H. HOCHSTER. 1993. Preclinical and clinical development of DNA topoisomerase In inhibitors in the United States. In Molecular Biology of DNA Topoisomerases and Its Application to Chemotherapy, Chap. 29, 301-311. T. Andoh, H. Ikeda & M. Oguro, Eds. CRC Press. Nagoya, Japan.
10. PANTAZIS, P., J. A. EARLY, A. J. KOZIELSKI, J. T. MENDOZA, H. R. HINZ & B. C. GIOVANELLA. 1993. Regression of human breast carcinoma tumors in immunodeficient mice treated with 9-nitrocamptothecin: Differential response of nontumorigenic and tumorigenic human breast cells in vitro. Cancer Res. 53: 1577-1582.
11. PANTAZIS, P., A. J. KOZIELSKI, J. T. MENDOZA, J. A. EARLY, H. R. HINZ & B. C. GIOVANELLA. 1993. Camptothecin derivatives induce regression of human ovarian carcinomas grown in nude mice and distinguish between non-tumorigenic and tumorigenic cells in vitro. Int. J. Cancer 53: 863-871.
12. PANTAZIS, P., J. A. EARLY, J. T. MENDOZA, A. R. DEJESUS & B. C. GIOVANELLA. 1994. Cytotoxic efficacy of 9-nitrocamptothecin in the treatment of human malignant melanoma cells in vitro. Cancer Res. 54: 771-776.
13. HINZ, H. R., N. J. HARRIS, E. A. NATELSON & B. C. GIOVANELLA. 1994. Pharmacokinetics of the in vivo and in vitro conversion of 9-nitro-20(S)-camptothecin to 9-amino-20(S)-camptothecin in humans, dogs and mice. Cancer Res. 52: 3096-3100.
14. MI, Z. & T. G. BURKE. 1994. Differential interactions of camptothecin lactone and carboxylate forms with human blood components. Biochemistry 33: 10325-10336.
15. MI, Z. & T. G. BURKE. 1994. Marked interspecies variations concerning interactions of camptothecin with serum albumin. Biochemistry 33: 12540-12545.