Conservation of function and expression of unc-119 from two Caenorhabditis species despite divergence of non-coding DNA

Gene

Volumn 183, Issue 1-2, 1996, Pages 77-85

  Maduro, Morris ^a   Pilgrim, David ^a  

^a UNIVERSITY OF ALBERTA   (Canada)

Author keywords

C. briggsae; Homologous gene; Neuronal promoter; Sequence comparison

Indexed keywords

COMPLEMENTARY DNA; DNA; NERVE PROTEIN;

ANIMAL TISSUE; ARTICLE; BINDING SITE; CAENORHABDITIS; CAENORHABDITIS ELEGANS; CONTROLLED STUDY; DNA FLANKING REGION; GENE EXPRESSION; GENE FUNCTION; GENE FUSION; GENE SEQUENCE; GENETIC CONSERVATION; INTRON; MOLECULAR CLONING; MUTANT; NONHUMAN; NUCLEOTIDE SEQUENCE; OPEN READING FRAME; PRIORITY JOURNAL; REPORTER GENE; SEQUENCE HOMOLOGY; TRANSCRIPTION REGULATION; TRANSGENIC ANIMAL;

AMINO ACID SEQUENCE; ANIMALS; ANIMALS, GENETICALLY MODIFIED; BASE SEQUENCE; BETA-GALACTOSIDASE; CAENORHABDITIS; CAENORHABDITIS ELEGANS; CAENORHABDITIS ELEGANS PROTEINS; CLONING, MOLECULAR; CONSERVED SEQUENCE; DNA, HELMINTH; EVOLUTION, MOLECULAR; GENE EXPRESSION REGULATION; GENES, HELMINTH; GENES, REPORTER; HELMINTH PROTEINS; INTRONS; MOLECULAR SEQUENCE DATA; NERVE TISSUE PROTEINS; OPEN READING FRAMES; PROMOTER REGIONS (GENETICS); REGULATORY SEQUENCES, NUCLEIC ACID; RESTRICTION MAPPING; SEQUENCE ANALYSIS, DNA; SEQUENCE HOMOLOGY, NUCLEIC ACID;

EID: 0030466944     PISSN: 03781119     EISSN: None     Source Type: Journal    
DOI: 10.1016/S0378-1119(96)00491-X     Document Type: Article

References (26)

1. Berks, M. and the C. elegans genome mapping and sequencing consortium (1995) The C. elegans genome sequencing project. Genome Res. 5, 99-104.
2. Burns, N., Grimwade, B., Ross-Macdonald, P.B., Choi, E.-Y., Finberg, K., Roeder, G.S. and Snyder, M. (1994) Large-scale analysis of gene expression, protein localization, and gene disruption in Saccharomyces cerevisiae. Genes Dev. 8, 1087-1105.
3. Chalfie, M., Tu, Y., Euskirchen, G., Ward, W.W. and Prasher, D.C. (1994) Green fluorescent protein as a marker for gene expression. Science 263, 802-805.
4. Fire, A., Harrison, S.W. and Dixon, D. (1990) A modular set of lacZ fusion vectors for studying gene expression in Caenorhabditis elegans. Gene 93, 189-198.
5. Frohman, M.A., Dush, M.K. and Martin, G.R. (1988) Rapid production of full-length cDNAs from rare transcripts: amplification using a single gene-specifc oligonucleotide primer. Proc. Natl. Acad. Sci. USA 85, 8998-9002.
6. Goodwin, E.B., Okkema, P.G., Evans, T.C. and Kimble, J. (1993) Translational regulation of tra-2 by its 3′ untranslated region controls sexual identity in C. elegans. Cell 75, 329-339.
7. Heschl, M.F.P. and Baillie, D.L. (1990) Functional elements and domains inferred from sequence comparisons of a heat shock gene in two nematodes. J. Mol. Evol. 31, 3-9.
8. Hodgkin J., Plasterk, R.H.A. and Waterston, R.H. (1995) The nematode Caenorhabditis elegans and its genome. Science 270, 410-414.
9. Jones, D. and Candido, E.P.M. (1993) Novel ubiquitin-like ribosomal protein fusion genes from the nematodes Caenorhabditis elegans and Caenorhabditis briggsae. J. Biol. Chem. 268, 19545-19551.
10. Kennedy, B.P., Aamodt, E.J., Allen, F.L., Chung, M.A., Heschl, M.F.P. and McGhee, J.D. (1993) The gut esterase gene (ges-1) from the nematodes Caenorhabditis elegans and Caenorhabditis briggsae. J. Mol. Biol. 229, 890-908.
11. Krause, M. (1995) Transcription and translation. Methods Cell Biol. 48, 483-512.
12. Krause, M., Harrison, S.W., Xu, S.-Q., Chen, L. and Fire, A. (1994) Elements regulating cell-and stage-specific expression of the C. elegans MyoD family homolog hlh-1. Dev. Biol. 166, 133-148.
13. Kuwabara, P.E. and Shah, S. (1994) Cloning by synteny: identifying C. briggsae homologues of C. elegans genes. Nucleic Acids Res. 22, 4414-4418.
14. Lee, Y.H., Huang, X.Y., Hirsh, D., Fox, G.E. and Hecht, R.M. (1992) Conservation of gene organization and trans-splicing in the glyceraldehyde-3-phosphate dehydrogenase-encoding genes of Caenorhabditis briggsae. Gene 121, 227-235.
15. MacMorris, M., Spieth, J., Madej, C., Lea, K. and Blumenthal, T. (1994) Analysis of the VPE sequences in the Caenorhabditis elegans vit-2 promoter with extrachromosomal tandem array-containing strains. Mol. Cell. Biol. 14, 484-491.
16. Maduro, M. and Pilgrim, D. (1995) Identification and cloning of unc-119, a gene expressed in the Caenorhabditis elegans nervous system. Genetics 141, 977-988.
17. Marck, C. (1988) 'DNA Strider': a 'C' program for the fast analysis of DNA and protein sequences on the Apple Macintosh family of computers. Nucleic Acids Res. 16, 1829-1836.
18. Mello, C.C., Kramer, J.M., Stinchcomb, D. and Ambros, V. (1991) Efficient gene transfer in C. elegans: extrachromosomal maintenance and integration of transforming sequences. EMBO J. 10, 3959-3970.
19. Pilgrim, D., McGregor, A., JŠckle, P., Johnson, T. and Hansen, D. (1995) The C. elegans sex determining gene fem-2 encodes a putative protein phosphatase. Mol. Biol. Cell 6, 1159-1171.
20. Prasad, S.S. and Baillie, D.L. (1989) Evolutionarily conserved coding sequences in the dpy-20-unc-22 region of Caenorhabditis elegans. Genomics 5, 185-198.
21. Sambrook, J., Fritsch, E.F. and Maniatis, T. (1989) Molecular Cloning. A Laboratory Manual. Cold Spring Harbor Laboratory Press, Cold Spring Harbor, NY.
22. Snutch, T.P. (1984) Ph.D. Thesis, Simon Fraser University, Burnaby, BC.
23. Southern, E. (1975) Detection of specific sequences among DNA fragments separated by gel electrophoresis. J. Mol. Biol. 98, 503-517.
24. Spieth, J., Denison, K., Kirtland, S., Cane, J. and Blumenthal, T. (1985) The C. elegans vitellogenin genes: short sequence repeats in the promoter regions and homology to the vertebrate genes. Nucleic Acids Res. 13, 5283-5295.
25. White, J.G., Southgate, E., Thomson, J.N. and Brenner, S. (1986) The structure of the nervous system of Caenorhabditis elegans. Phil. Trans. R. Soc. Lond. B Biol. Sci. 314, 1-340.
26. Zucker-Aprison, E. and Blumenthal, T. (1989) Potential regulatory element of nematode vitellogenin genes revealed by interspecies sequence comparison. J. Mol. Evol. 28, 487-496.