Activation of the protein phosphatase calcineurin during carbachol exposure decreases the extent of recovery from end-plate desensitization

Journal of Neurophysiology

Volumn 76, Issue 6, 1996, Pages 3609-3616

  Hardwick, Jean C ^a   Parsons, Rodney L ^a  

^a UNIVERSITY OF VERMONT   (United States)

Author keywords

[No Author keywords available]

Indexed keywords

ACETYLCHOLINE; CALCINEURIN; CALYCULIN A; CARBACHOL; DELTAMETHRIN; ION CHANNEL; MEMBRANE PROTEIN; OKADAIC ACID; PHOSPHOPROTEIN PHOSPHATASE; PROTEIN KINASE C; STAUROSPORINE;

ANIMAL TISSUE; ARTICLE; CALCIUM TRANSPORT; ELECTROPHYSIOLOGY; ENZYME ACTIVATION; ENZYME PHOSPHORYLATION; MINIATURE ENDPLATE POTENTIAL; NERVE ENDING; NONHUMAN; PATCH CLAMP; PRIORITY JOURNAL; SNAKE;

EID: 0030466334     PISSN: 00223077     EISSN: None     Source Type: Journal    
DOI: 10.1152/jn.1996.76.6.3609     Document Type: Article

References (33)

1. 2+-activated phosphatase in mammalian brain. Trends Neurosci. 12: 117-122, 1989.
2. BIALOJAN, C. AND TAKAI, A. Inhibitory effect of a marine-sponge toxin, okadaic acid, on protein phosphatases. Biochem. J. 256: 283-290, 1988.
3. + channel in rat peptidergic nerve terminals. J. Physiol. Lond. 475: 241-254, 1994.
4. CLAUDIO, T. Molecular genetics of acetylcholine receptors-channels. In: Frontiers in Molecular Biology: Molecular Biology, edited by D. M. Glover and B. D. Hames. Oxford, UK: IRL, 1989, p. 63-412.
5. COHEN, P. The structure and regulation of protein phosphatases. Annu. Rev. Biochem. 58: 453-508, 1989.
6. CONNOR, E. A., FIEKERS, J. F., NEEL, D. S., PARSONS, R. L., AND SCHNITZLER, R. M. Comparison of cholinergic activation and desensitization at snake twitch and slow muscle fibre end-plates. J. Physiol. Lond. 351: 657-674, 1984.
7. DANI, J. A. Structure, diversity, and ionic permeability of neuronal and muscle acetylcholine receptors. In: Structure, Diversity, and Ionic Permeability of Neuronal and Muscle Acetylcholine Receptors, edited by D. Siemen and J. Heschler. Basel: Birkhäuser, 1993, p. 47-59.
8. DIONNE, V. E. Two types of nicotinic acetylcholine receptor channels at slow fibre end-plates of the garter snake. J. Physiol. Lond. 409: 313-331, 1989.
9. ENAN, E. AND MATSUMURA, F. Specific inhibition of calcineurin by type II synthetic pyrethroid insecticides. Biochem. Pharmacol. 43: 1777-1784, 1992.
10. HALPAIN, S. AND GREENGARD, P. Activation of NMDA receptors induces rapid dephosphorylation of the cytoskeletal protein MAP2. Neuron 5: 237-246, 1990.
11. HAMILL, O. P., MARTY, A., NEHER, E., SAKMANN, B., AND SIGWORTH, F. Improved patch-clamp techniques for high resolution current recording from cells and cell-free membrane patches. Pfluegers Arch. 391: 85-100, 1981.
12. HARDWICK, J. C., CONIGLIO, L. M., AND PARSONS, R. L. Staurosporine inhibits the extent of acetylcholine receptor recovery from carbachol-induced desensitization at snake twitch fibres. Br. J. Pharmacol. 104: 879-886, 1991.
13. HARDWICK, J. C. AND PARSONS, R. L. Mechanism of staurosporine-induced decrease in acetylcholine receptor recovery from desensitization. Br. J. Pharmacol. 108: 741-748, 1993.
14. HARDWICK, J. C. AND PARSONS, R. L. Necessity of protein kinase C activity for maintenance of acetylcholine receptor function at snake twitch fibre end-plates. Br. J. Pharmacol. 114: 433-441, 1995a.
15. HARDWICK, J. C. AND PARSONS, R. L. Requirement of a colchicine-sensitive component of the cytoskeleton for acetylcholine receptor recovery. Br. J. Pharmacol. 114: 442-446, 1995b.
16. HOLMES, C. F. B., LUU, H. A., CARRIER, F., AND SCHMITZ, F. J. Inhibition of protein phosphatases-1 and -2A with acanthifolicin. FEBS Lett. 270: 216-218, 1990.
17. HUGANIR, R. L. Regulation of the nicotinic acetylcholine receptor channel by protein phosphorylation. Curr. Top. Membr. Transp. 33: 147-163, 1988.
18. LEVITAN, I. B. Modulation of ion channels by protein phosphorylation and dephosphorylation. Annu. Rev. Physiol. 56: 193-212, 1994.
19. 2+-dependent phosphatases. Nature Lond. 369: 235-239, 1994.
20. LIU, J., FARMER, J. D., JR., LANE, W. S., FRIEDMAN, J., WEISSMAN, I., AND SCHREIBER, S. L. Calcineurin is a common target of cyclophilincyclosporin A and FKBP-FK506 complexes. Cell 66: 807-815, 1991.
21. MANTHEY, A. A. Changes in Ca permeability of muscle fibers during desensitization to carbamylcholine. Am. J. Physiol. 226: 481-489, 1974.
22. MONTORO, R. J., DIAZ-NIDO, J., AVILA, J., AND LOPEZ-BARNEO, J. N-methyl-D-aspartate stimulates the dephosphorylation of the microtubule-associated protein 2 and potentiates excitatory synaptic pathways in the rat hippocampus. Neuroscience 54: 859-871, 1993.
23. MULKEY, R. M., ENDO, S., SHENOLIKAR, S., AND MALENKA, R. C. Involvement of a calcineurin/inhibitor-1 phosphatase cascade in hippocampal long-term depression. Nature Lond. 369: 486-488, 1994.
24. OCHOA, E. L. M., CHATTOPADHYAY, A., AND MCNAMEE, M. G. Desensitization of the nicotinic acetylcholine receptor: molecular mechanisms and effect of modulators. Cell. Mol. Neurobiol. 9: 141-178, 1989.
25. PARSONS, R. L. Role of calcium in desensitization at the motor end-plate of skeletal muscle. In: Role of Calcium in Desensitization at the Motor End-Plate of Skeletal Muscle, edited by G, B. Weiss. New York: Plenum, 1978, p. 289-313.
26. PARSONS, R. L. AND NASTUK, W. L. Activation of contractile system in depolarized skeletal muscle fibers. Am. J. Physiol. 217: 364-369, 1969.
27. RAMAN, I. M., TONG, G., AND JAHR, C. E. β-Adrenergic regulation of synaptic NMDA receptors by cAMP-dependent protein kinase. Neuron 16: 415-421, 1996.
28. RUFF, R. L. AND SPIEGEL, P. Calcium sensitivity and acetylcholine receptor currents of twitch and tonic snake muscle fibers. Am. J. Physiol. 259 (Cell Physiol. 28): C911-C919, 1990.
29. STELZER, A. AND SHI, H. Impairment of GABAA receptor function by N-methyl-D-aspartate-mediated calcium influx in isolated CA1 pyramidal cells. Neuroscience 62: 813-828, 1994.
30. TAKEUCHI, N. Effects of calcium on the conductance change of the end-plate membrane during the action of transmitter. J. Physiol. Lond. 167: 141-155, 1963.
31. TONG, G., SHEPHERD, D., AND JAHR, C. E. Synaptic desensitization of NMDA receptors by calcineurin. Science Wash. DC 267: 1510-1512, 1995.
32. 3 receptor ligand-gated ion channels. Recept. Channels 3: 7-12, 1995.
33. VERNINO, S., ROGERS, M., RADCLIFFE, K. A., AND DANI, J. A. Quantitative measurement of calcium flux through muscle and neuronal nicotinic acetylcholine receptors. J. Neurosci. 14: 5514-5524, 1994.