Zonal heterogeneity of peroxisome proliferation in rat liver

Annals of the New York Academy of Sciences

Volumn 804, Issue , 1996, Pages 341-361

  Fahimi, H D ^a   Beier, K ^a   Lindauer, M ^a   Schad, A ^a   Zhan, J ^a   Pill, J ^b   Rebel, W ^b   Volkl A ^a   Baumgart, E ^a  

^a UNIVERSITY OF HEIDELBERG   (Germany)

^b F HOFFMANN LA ROCHE LTD   (Switzerland)

Author keywords

[No Author keywords available]

Indexed keywords

2,2,13,13 TETRACHLOROTETRADECANE 1,14 DIOIC ACID; 5 (4 CHLOROPHENYL) 2 (4 METHYLPHENYLSULFONYL) 4 PENTYNOIC ACID; 5 (4 CHLORPHENYL) 2 (4 METHYLPHENYLSULFONYL) 4 PENTINIC ACID; ANTILIPEMIC AGENT; BEZAFIBRATE; BM 170249; FATTY ACID; MESSENGER RNA; NUCLEAR PROTEIN; PEROXISOME PROLIFERATOR; UNCLASSIFIED DRUG; XENOBIOTIC AGENT;

ANIMAL EXPERIMENT; ANIMAL TISSUE; CELL DIFFERENTIATION; CELL ULTRASTRUCTURE; CONFERENCE PAPER; CONTROLLED STUDY; FATTY ACID OXIDATION; IMMUNOELECTRON MICROSCOPY; IN SITU HYBRIDIZATION; LIVER CELL; MORPHOMETRICS; NONHUMAN; NORTHERN BLOTTING; PEROXISOME; RAT; SMOOTH ENDOPLASMIC RETICULUM;

ANIMALIA;

EID: 0030466177     PISSN: 00778923     EISSN: None     Source Type: Book Series    
DOI: 10.1111/j.1749-6632.1996.tb18627.x     Document Type: Conference Paper

References (55)

1. RAPPAPORT, A.M. 1958. The structural and functional unit of the human liver (liver acinus). Anat. Rec. 130: 637-686.
2. GUMUCIO, J.J. 1989. Hepatocyte heterogeneity: The coming of age from the description of a biological curiosity to a partial understanding of its physiological meaning and regulation. Hepatology 9: 154-160.
3. GUMUCIO, J.J. & L.L. CHIANALE. 1988. Liver cell heterogeneity and liver function. In The Liver: Biology and Pathobiology, 2nd ed. I.M. ARIAS, W.B. JAKOBY, H. POPPER, D. SCHACHTER & D.A. SHAFRITZ, Eds.: 931-947. Raven Press. New York.
4. JUNGERMAN, K. & N. KATZ. 1989. Functional specialization of different hepatocyte populations. Physiol. Rev. 69: 708-764.
5. GEBHARD, R. 1992. Metabolic zonation of the liver: Regulation and implications for liver function. Pharmacol. Ther. 53: 275-354.
6. BASS, N.M. 1989. Organization and zonation of hepatic lipid metabolism. Cell. Biol. Rev. 19: 61-86.
7. KATZ, N. 1986. Metabolism of lipids. In Regulation of Hepatic Metabolism: Intra and Intercellular Compartmentation. R.G. THURMAN, F.C. KAUFMAN & K. JUNGERMAN, Eds.: 237-252. Plenum Press. New York.
8. GUZMAN, M. & J. CASTRO. 1990. Zonation of fatty acid metabolism in rat liver. Biochem. J. 264: 107-113.
9. FAHIMI, H.D. 1969. Cytochemical localization of peroxidatic activity of catalase in rat hepatic microbodies (peroxisomes). J. Cell Biol. 43: 275-288.
10. LOUD, A.V. 1968. A quantitative stereological description of the ultrastructure of normal rat liver parenchymal cells. J. Cell Biol. 37: 27-46.
11. SCHMUCKER, D.L., J.S. MOONEY & A.L. JONES. 1978. Stereological analysis of hepatic fine structure in the Fischer 344 rat. J. Cell Biol. 78: 319-337.
12. VAN DEN BOSCH, H., R.B.H. SCHUTGENS, R.J.A. WANDERS & J.M. TAGER. 1992. Biochemistry of Peroxisomes. Annu. Rev. Biochem. 61: 157-197.
13. MANNAERTS, G.P. & P.P. VAN VELDHOVEN. 1993. Metabolic pathways in mammalian peroxisomes. Biochimie 75: 147-158.
14. LE HIR, M. & U.C. DUBACH. 1980. The activities of peroxisomal oxidases in periportal and perivenous zones of the rat liver acinus. Histochemistry 69: 95-99.
15. ANGERMÜLLER, S. & H.D. FAHIMI. 1988. Heterogenous staining of D-amino acid oxidase in peroxisomes of rat liver and kidney. Histochemistry 88: 277-285.
16. BEIER, K., A. VÖLKL & H.D. FAHIMI. 1992. Suppression of peroxisomal lipid β-oxidation enzymes by TNF-α. FEBS Lett. 310: 273-276.
17. BEIER, K., A. VÖLKL & H.D. FAHIMI. 1993. The impact of aging on enzyme proteins of rat liver peroxisomes: Quantitative analysis by immunoblotting and immunoelectron microscopy. Virchows Archiv B Cell Pathol. 63: 139-146.
18. LINDAUER, M., K. BEIER, A. VÖLKL & H.D. FAHIMI. 1994. Zonal heterogeneity of peroxisomal enzymes in rat liver: Differential induction by three divergent hypolipidemic drugs. Hepatology 20: 475-486.
19. SCHAD, A., H.D. FAHIMI, A. VÖLKL & E. BAUMGART. 1995. Nonradioactive in situ hybridization for catalase- and urate oxidase-mRNAs in rat liver and kidney. Eur. J. Cell Biol. 66 (Supplement ECBO Meeting 1995): 70 (abstract).
20. HESS, R., W. STÄUBLI & W. RIES. 1965. Nature of the hepatomegalic effect produced by ethyl-chlorophenoxy-isobutyrate in the rat. Nature 208: 856-858.
21. MOODY, D.E. & J.K. REDDY. 1976. Morphometric analysis of the ultrastructural changes in rat liver induced by the peroxisome proliferator SaH 42-348. J. Cell Biol. 71: 768-780.
22. BAUMGART, E., K. STEGMEIER, F.H. SCHMIDT & H.D. FAHIMI. 1987. Proliferation of peroxisomes in pericentral hepatocytes of rat liver after administration of a new hypocholesterolemic agent (BM 15766). Lab. Invest. 56: 554-564.
23. GORGAS, K. & S.K. KRISANS. 1989. Zonal heterogeneity of peroxisome proliferation and morphology in rat liver after gemfibrozil treatment. J. Lipid Res. 30: 1859-1875.
24. JUST, W.W., K. GORGAS, F.U. HARTL, P. HEINEMANN, M. SALZER & H. SCHIMASSEK. 1989. Biochemical effects and zonal heterogeneity of peroxisome proliferation induced by perfluorocarboxylic acids in rat liver. Hepatology 9: 570-581.
25. BELL, D.A., R.G. BARS, G.G. GIBSON & C.R. ELCOMBE. 1991. Localization and differential induction of cytochrome P450IV A and acyl-CoA oxidase in rat liver. Biochem. J. 275: 247-252.
26. BARS, R.G., D.R. BELL & C.R. ELCOMBE. 1993. Induction of cytochrome P450 and peroxisomal enzymes by clofibric acid in vivo and in vitro. Biochem. Pharmacol. 45: 2045-2053.
27. BOUT, A., P.A.J. DE BOER, J.M. TAGER, R. BENNE & A.F.M. MOORMAN. 1990. Zonal distribution of peroxisomal 3-oxoacyl-CoA thiolase messenger RNA in liver from rats treated with di-(2-ethylhexyl) phthalate. Biochim. Biophys. Acta 1055: 240-242.
28. HUANG, Q., A.V. YELDANDI, K. ALVARES, H. IDE, J.K. REDDY & M.S. RAO. 1995. Localization of peroxisome proliferator-activated receptor in mouse and rat tissues and demonstration of its nuclear translocation in transfected CV-1 cells. Int. J. Oncol. 6: 307-312.
29. TOSH, D., K.G. ALBERTI & L. AGIUS. 1989. Clofibrate induces carnitine acyltransferases in periportal and perivenous zones of rat liver and does not disturb the acinar zonation of gluconeogenesis. Biochim. Biophys. Acta 992: 245-250.
30. GERONDAES, P., K.G. ALBERTI & L. AGIUS. 1988. Fatty acid metabolism in hepatocytes cultured with hypolipidemic drugs. Biochem. J. 253: 161-167.
31. BEIER, K. & H.D. FAHIMI. 1987. Application of automatic image analysis for morphometric studies of peroxisomes stained cytochemically for catalase. II. Light-microscopic application. Cell Tissue Res. 247: 179-185.
32. BEIER, K. & H.D. FAHIMI. 1992. Application of automatic image analysis for quantitative morphological studies of peroxisomes in rat liver in conjunction with cytochemical staining with 3-3′ diaminobenzidine and immunocytochemistry. Microsc. Res. Technique 21: 271-282.
33. BEIER, K., A. VÖLKL, T. HASHIMOTO & H.D. FAHIMI. 1988. Selective induction of peroxisomal enzymes by the hypolipidemic drug bezafibrate: Detection of modulations by automatic image analysis in conjunction with immunoelectron microscopy and immunoblotting. Eur. J. Cell Biol. 46: 383-393.
34. HERTZ, R., J. BAR TANA, M. SUJATTA, J. PILL, F.H. SCHMIDT & H.D. FAHIMI. 1988. The induction of liver peroxisomal proliferation by β,β′-methyl-substituted hexadecanedioic acid (MEDICA 16). Biochem. Pharmacol. 37: 3571-3577.
35. LINDROS, K.O. & K.E. PENTTILÄ. 1985. Digitonin-collagenase perfusion for efficient separation of periportal or perivenous hepatocytes. Biochem. J. 228: 757-760.
36. ZHAN, J., A. VÖLKL & H.D. FAHIMI. 1995. Investigation of the heterogeneity of peroxisomal enzymes at the protein and RNA level in periportal and pericentral rat hepatocytes. Eur. J. Cell Biol. 66 (Supplement ECBO Meeting 1995): 71 (abstract).
37. ISSEMANN, I. & S. GREEN. 1990. Activation of a member of the steroid hormone receptor superfamily by peroxisome proliferators. Nature 347: 645-650.
38. GÖTTLICHER, M., E. WIDMARK, Q. LI & J.A. GUSTAFSSON. 1992. Fatty acids activate a chimera of the clofibric acid-activated receptor and the glucocorticoid receptor. Proc. Natl. Acad. Sci. USA 89: 4653-4657.
39. SHER, T., H.F. YI, O.W. MCBRIDE & F.J. GONZALEZ. 1993. CDNA cloning, chromosomal mapping, and functional characterization of the human peroxisome proliferator activated receptor. Biochemistry 32: 5598-5604.
40. DREYER, C., H. KELLER, A. MAHFOUDI, V. LAUDET, G. KREY & W. WAHLI. 1993. Positive regulation of the peroxisomal beta-oxidation pathway by fatty acids through activation of peroxisome proliferator-activated receptors (PPAR). Biol. Cell. 77: 67-76.
41. OSUMI, T., J.K., WEN & T. HASHIMOTO. 1991. Two cis-acting regulatory sequences in the peroxisome proliferator-responsive enhancer region of rat acyl-CoA oxidase gene. Biochem. Biophys. Res. Commun. 175: 866-871.
42. KLIEWER, S.A., K. UMESONO, D.J. NOONAN, R.A. HEYMAN & R.M. EVANS. 1992. Convergence of 9-cis-retinoic acid and peroxisome proliferator signalling pathways through heterodimer formation of their receptors. Nature 358: 771-774.
43. ZHANG, B.W., S.L. MARCUS, F.G. SAJJADI, K. ALVARES, J.K. REDDY, S. SUBRAMANI, R.A. RACHUBINSKI & J.P. CAPONE. 1992. Identification of a peroxisome proliferator-responsive element upstream of the gene encoding rat peroxisomal enoyl-CoA hydratase/3-hydroxyacyl-CoA dehydrogenase. Proc. Natl. Acad. Sci. USA 89: 7541-7545.
44. ARBER, N., G. ZAJICEK & I. ARIEL. 1988. The streaming liver II. Hepatocyte life history. Liver 8: 80-87.
45. REID, L.M. 1990. Stem cell biology, hormone/matrix synergies and liver differentiation. Curr. Opin. Cell Biol. 2: 121-130.
46. SIGAL, S.H., S. BRILL, A.S. FIORINO & L.M. REID. 1992. The liver as a stem cell and lineage system. Am. J. Physiol. 263: G139-G148.
47. ITABASHI, M., Y. MOCHIZUKI & H. TSUKADA. 1977. Changes in peroxisomes in preneoplastic liver of rats induced by 3′-methyl-4-dimethylaminoazobenzene. Cancer Res. 37: 1035-1043.
48. YOSHIHITO, Y., S. TSUCHIDA, I. HATAYAMA, K. SATOH, T. NARITA, M.S. RAO, J.K. REDDY, J. YAMADA, T. SUGA & K. SATO. 1992. Loss of peroxisomal enzyme expression in preneoplastic and neoplastic lesions induced by peroxisome proliferators in rat liver. Carcinogenesis 13: 265-269.
49. YAMAMOTO, K. & H.D. FAHIMI. 1987. Biogensis of peroxisomes in regenerating rat liver. I. Sequential changes of catalase and urate oxidase detected by ultrastructural cytochemistry. Eur. J. Cell Biol. 43: 293-300.
50. SAWADA, N., K. FURUKAWA, M. GOTHOH, Y. MOCHIZUKI & H. TSUKUDA. 1982. Primary culture of preneoplastic hepatocytes from rats treated with 2-acetylaminofluorene and clofibrate: Relationship between resistance to dimethylnitrosamine and responsiveness of peroxisomes. Gann. 73: 1-6.
51. LÜERS, G., T. HASHIMOTO, H.D. FAHIMI & A. VÖLKL. 1993. Biogenesis of peroxisomes: Isolation and characterization of two distinct peroxisomal populations from normal and regenerating rat liver. J. Cell Biol. 121: 1271-1280.
52. FAHIMI, H.D., E. BAUMGART & A. VÖLKL. 1993. Ultrastructural aspects of the biogenesis of peroxisomes in rat liver. Biochimie 75: 201-208.
53. SCHRADER, M., E. BAUMGART, A. VÖLKL & H.D. FAHIMI. 1994. Heterogeneity of peroxisomes in human hepatoblastoma cell line HepG2: Evidence of distinct subpopulations. Eur. J. Cell Biol. 64: 281-294.
54. YAMAMOTO, K. & H.D. FAHIMI. 1987. Three-dimensional reconstruction of a peroxisomal reticulum in regenerating rat liver: Evidence of interconnections between heterogeneous segments. J. Cell Biol. 105: 713-722.
55. SCHRADER, M., J. K. BURKHARDT, E. BAUMGART, G. LÜERS, H. SPRING, A. VÖLKL & H. D. FAHIMI. 1996. Interaction of microtubules with peroxisomes. Tubular and spherical peroxisomes in HepG2 cells and their alterations induced by microtubule-active drugs. Eur. J. Cell Biol. 69: 24-35.