Selective impairment of nitric oxide dependent vasodilation in young adults with hypercholesterolemia

European Journal of Cardiovascular Prevention & Rehabilitation

Volumn 3, Issue 5, 1996, Pages 465-471

  Preik, Michael ^a   Kelm, Malte ^a   Schoebel, Frank ^a   Schottenfeld, Yvonne ^a   Leschke, Matthias ^a   Strauer, Bodo E ^a  

^a HEINRICH HEINE UNIVERSITY   (Germany)

Author keywords

endothelial dysfunction; hypercholesterolaemia; nitric oxide; vascular smooth muscle

Indexed keywords

ACETYLCHOLINE; ADENOSINE; BRADYKININ; NITRIC OXIDE; NITROPRUSSIDE SODIUM; VASODILATOR AGENT;

ARTICLE; BLOOD VESSEL INJURY; CLINICAL ARTICLE; CONTROLLED STUDY; FOREARM BLOOD FLOW; HUMAN; HYPERCHOLESTEROLEMIA; INTRAARTERIAL DRUG ADMINISTRATION; PRIORITY JOURNAL; VASCULAR ENDOTHELIUM; VASCULAR RESISTANCE; VASODILATATION;

ACETYLCHOLINE; ADULT; ARTERIES; BRADYKININ; FOREARM; HUMANS; HYPERCHOLESTEROLEMIA; MATCHED-PAIR ANALYSIS; MUSCLE, SMOOTH, VASCULAR; NITRIC OXIDE; NITROPRUSSIDE; VASODILATION;

EID: 0030464944     PISSN: 17418267     EISSN: 17418275     Source Type: Journal    
DOI: 10.1177/174182679600300509     Document Type: Article

References (31)

1. Moncada S, Higgs A: The L-arginine-nitric oxide pathway N Engl J Med 1993, 329: 2002–2012.
2. Garg U, Hassid A: Nitric oxide-generating vasodilators and 8-bromocyclic guanosine monophosphate inhibit mitogenesis and proliferation of cultured rat vascular smooth muscle cells J Clin Invest 1989, 83: 1774–1777.
3. Ignarro LJ: Biological actions and properties of endothelium-derived nitric oxide formed and released from artery and veins Circ Res 1989, 65: 1–21.
4. Vallance P, Collier J, Moncada S: Effects of endothelium-derived nitric oxide on peripheral arteriolar tone in man Lancet 1989, 28: 997–999.
5. Bath P, Hasall D, Gladwin A, Palmer RMJ, Martin J: Nitric oxide and prostacyclin. Divergence of inhibitor effects of monocyte chemotaxis and adhesion to endothelium in vitro Arterioscler Thromb 1991, 11: 254–260.
6. Furchott R, Vanhoutte PM: Endothelium-derived relaxing and contracting factors FASEB J 1989, 3: 2007–2018.
7. Moncada S, Martin J, Higgs A: Symposium on regression of atherosclerosis Eur J Clin Invest 1993, 23: 385–398.
8. Moore S: Dietary atherosclerosis and arterial wall injury Lab Invest 1989, 60: 733–736.
9. Ross R: The pathogenesis of atherosclerosis - an update N Engl J Med 1986, 314: 488–500.
10. Gotto AM: Lipid lowering, regression, and coronary events. A review of the Interdisciplinary Council on Lipids and Cardiovascular Risk Intervention, seventh council meeting Circulation 1995, 92: 646–656.
11. Flavahan N: Atherosclerosis on lipoprotein-induced endothelial dysfunction Circulation 1992, 85: 1927–1938.
12. Chowienczyk PJ, Watts GF, Cockcroft Jr., Ritter JM: Impaired endothelium-dependent vasodilation of forearm resistance vessels in hypercholesterolemia Lancet 1992, 340: 1430–1432.
13. Creager MA, Cooke JP, Mendelsohn ME, Gallagher SJ, Coleman SM, Loscalzo J etal: Impaired vasodilation of forearm resistance vessels in hypercholesterolemic humans J Clin Invest 1990, 86: 228–234.
14. Freiman P, Mitchell G, Heistad D, Armstrong M, Harrison MG: Atherosclerosis impairs endothelium-dependent vascular relaxation to acetylcholine and thrombin in primates Circ Res 1986, 58: 783–789.
15. Jayakody L, Senaratne M, Thomson A, Kappgoda T: Endothelium-dependent relaxation in experimental atherosclerosis in rabbit Circ Res 1987, 60: 251–264.
16. Casino PR, Kilcoyne CM, Quyyumi AA, Hoeg JM, Panza JA: The role of nitric oxide in endothelium-dependent vasodilation of hypercholesterolemic patients Circulation 1993, 88: 2541–2547.
17. Celermajer DS, Sorensen KE, Gooch VM, Spiegelthaler DJ, Miller OI, Sullivan ID etal: Non-invasive detection of endothelial dysfunction in children and adults at risk of atherosclerosis Lancet 1992, 340: 1111–1115.
18. Gilligan DM, Guetta V, Panza J, Garcia CE, Quyyumi AA, Cannon RO: Selective loss of microvascular endothelial function in human hypercholesterolemia Circulation 1994, 90: 35–41.
19. Grundy SM: National Cholesterol Education Program: Second report of the Expert Panel on Detection, Evaluation, and Treatment of High Blood Cholesterol in Adults Circulation 1994, 89: 1329–1445.
20. Kerslake D: The effects of the application of an arterial occlusion cuff to the wrist on the blood flow in the human forearm J Physiol 1949, 108: 451–457.
21. Heavey DJ, Barrow S, Hickling N, Ritter JM: Aspirin causes short-lived inhibition of bradykinin-stimulated prostacyclin production in man Nature 1985, 318: 186–188.
22. Collis MG: The vasodilator role of adenosine Pharmacol Ther 1989, 41: 143–162.
23. Smits P, Williams SB, Lipson DE, Banitt P, Rongen GA, Creager MA: Endothelial release of nitric oxide contributes to the vasodilator effect of adenosine in humans Circulation 1995, 92: 2135–2141.
24. Patterson GC, Whelan RF: Reactive hyperemia in the human forearm Clin Sci 1955, 14: 197–211.
25. Tagawa T, Imaizumi T, Endo T, Shiramoto M, Harasawa Y, Takeshita A: The role of nitric oxide in reactive hyperemia in human forearm resistance vessels Circulation 1994, 90: 2285–2290.
26. Carlsson I, Sollevi A, Wennmalm A: The role of myogenic relaxation, adenosine and prostaglandins in human forearm reactive hyperemia J Physiol 1987, 389: 147–161.
27. Creager MA, Girerd X, Gallagher SJ, Coleman SM, Dzau VJ, Cooke JP: L-arginine improves endothelium-dependent vasodilation in hypercholesterolemic humans J Clin Invest 1992, 90: 1168–1172.
28. Bruning TA, Hendriks MGC, Chang PC, Kuypers EAR, van Zwieten PA: In vivo characterization of vasodilating muscarinic-receptor subtypes in humans Circ Res 1994, 74: 912–919.
29. Simon BC, Cunningham L, Cohen R: Oxidized low density lipoproteins cause contraction and inhibit endothelium-dependent relaxation in pig coronary artery J Clin Invest 1990, 86: 75–79.
30. Chin J, Azhar S, Hoffmann B: Inactivation of endothelial derived relaxing factor by oxidized lipoproteins J Clin Invest 1992, 89: 10–18.
31. Woditsch I, Schrör K: Reduced endothelium-dependent relaxation at enhanced NO release in hearts of hypercholesterolemic rabbits Br J Pharmacol 1994, 111: 1035–1040.