The first direct experimental determination of strain in neutral and protonated 2-azetidinone

Journal of the American Chemical Society

Volumn 118, Issue 50, 1996, Pages 12735-12737

  Roux, M V ^a   Jimenez P ^a   Davalos J Z ^a   Castano O ^b   Molina, M T ^c   Notario, R ^a   Herreros, M ^a   Abboud, J L M ^a  

^a INSTITUTO DE QUÍMICA FÍSICA ROCASOLANO   (Spain)

^b UNIVERSITY OF ALCALÁ   (Spain)

^c INSTITUTO DE QUÍMICA MÉDICA   (Spain)

Author keywords

[No Author keywords available]

Indexed keywords

2 AZETIDINONE; AZETIDINE DERIVATIVE; UNCLASSIFIED DRUG;

ARTICLE; DRUG STRUCTURE; MOLECULAR DYNAMICS; THEORY; THERMODYNAMICS;

EID: 0030464715     PISSN: 00027863     EISSN: None     Source Type: Journal    
DOI: 10.1021/ja962792w     Document Type: Article

References (30)

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2. For recent reviews on the chemistry and biology of β-lactam antibiotics see, e.g.: (a) The Organic Chemistry of β-lactams, Georg, G. I., Ed.; VCH Publishers: New York, 1993. (b) Newall, C. E.; Hallam, P. D. In Comprehensive Medicinal Chemistry; Hansch C., Ed.; Pergamon Press: New York, 1990; Vol. 2, p 609. (c) Dürckheimer, W.; Adam, F.; Fischer, G.; Kirrstetter, R. Adv. Drug Res. 1988, 17, 61-234.
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18. This structure would be that of a six-membered ring.
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21. +(g).
22. 15
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