Cardiorespiratory and renal responses to arterial chemoreceptor stimulation by hypoxia or almitrine in men

Clinical and Experimental Pharmacology and Physiology

Volumn 23, Issue 12, 1996, Pages 1021-1027

  Brauer, H ^a   Gens, A ^a   Ledderhos, C ^a   Sanchez, R ^a,b   Schuster, R ^a   Quies, W ^a,b   Honig, A ^a  

^a UNIVERSITY OF GREIFSWALD   (Germany)

^b Texaco 3c ^*  (Germany)

Author keywords

Almitrine bismesylate; Arterial chemoreceptors; Heart rate; Hypoxic hypoxia; Renal haemodynamics; Renal tubular function; Ventilation

Indexed keywords

ALMITRINE; ALMITRINE DIMESILATE;

ADULT; ARTICLE; CHEMORECEPTOR; CONTROLLED STUDY; HEART RATE; HUMAN; HUMAN EXPERIMENT; HYPOXIA; KIDNEY FUNCTION; MALE; NORMAL HUMAN; ORAL DRUG ADMINISTRATION; RESPIRATION CONTROL;

EID: 0030464155     PISSN: 03051870     EISSN: None     Source Type: Journal    
DOI: 10.1111/j.1440-1681.1996.tb01162.x     Document Type: Article

References (37)

1. Honig A. Peripheral arterial chemoreceptors and reflex control of sodium and water homeostasis. Am. J. Physiol. 1989; 257: R1282-302.
2. Hoyt RW, Honig A. Body fluid volumes and energy metabolism at high altitude. In: Blatteis CM, Fregly MF (eds). American Handbook of Physiology, Section 4: Environmental Physiology. Oxford University Press, New York. 1996; 1277-89.
3. Heyes MP, Farber MO, Manfredi F et al. Acute effects of hypoxia on renal and endocrine function in normal humans. Am. J. Physiol. 1982; 243: R265-70.
4. Pauli HG, Truniger B, Larsen JK, Mulhausen RO. Renal function during prolonged exposure to hypoxia and carbon monoxide. I. Glomerular filtration rate and plasma flow. Scand. J. Clin. Lab. Invest. 1968; 22 (Suppl. 103); 55-60.
5. Pauli HG, Truniger B, Larsen JK, Mulhausen RO. Renal function during prolonged exposure to hypoxia and carbon monoxide. II. Electrolyte handling. Scand. J. Clin. Lab. Invest. 1968; 22 (Suppl. 103): 61-7.
6. Swenson ER, Duncan TB, Goldberg SV, Ramirez G, Ahmad S, Schoene RB. Diuretic effect of acute hypoxia in humans: Relationship to hypoxic ventilatory responsiveness and renal hormones. J. Appl. Physiol. 1996; 78: 377-83.
7. Koller EA, Schopen M, Keller M, Lang RE, Valloton MB. Ventilatory, circulatory, endocrine and renal effects of almitrine infusion in man: A contribution to high-altitude physiology. Eur. J. Appl. Physiol. 1989; 58: 419-25.
8. Honig A, Schmidt M, Freyse EJ. Influence of unilateral renal nerve section on the kidney effects of carotid chemoreceptor stimulation. Acta. Biol. Med. Germ. 1979; 38: 1647-50.
9. Karim F, Poucher SM, Summerill RA. The effects of stimulating carotid chemoreceptors on renal hemodynamics and function in dogs. J. Physiol. 1987; 392: 451-62.
10. Karim F, Al-Obaidi M. Modification of carotid chemoreceptor-induced changes in renal hemodynamics and function by carotid baroreflex in dogs. J. Physiol. 1993; 466: 599-610.
11. Schmidt M, Ledderhos C, Honig A. Kidney function during arterial chemoreceptor stimulation. I. Influence of unilateral renal nerve section, bilateral cervical vagotomy, constant artificial ventilation, and carotid body chemoreceptor inactivation. Biomed. Biochim. Acta 1985; 44: 695-709.
12. Bardsley PA, Suggett AJ. The carotid body and natriuresis: Effect of almitrine bismesylate. Biomed. Biochim. Acta 1987; 46: 1017-22.
13. Bardsley PA, Johnson BF, Stewart AG, Barer GB. Natriuresis secondary to carotid chemoreceptor stimulation with almitrine bismesylate in the rat: The effect on kidney function and the response to renal denervation and deficiency of antidiuretic hormone. Biomed. Biochim. Acta 1991; 50: 175-82.
14. Honig A, Wedler B, Zingler C, Ledderhos C, Schmidt M. Kidney function during arterial chemoreceptor stimulation. III. Long-lasting inhibition of renal tubular sodium reabsorption due to pharmacological stimulation of the peripheral arterial chemoreceptors with almitrine bismesylate. Biomed. Biochim. Acta 1985; 44: 1659-72.
15. Schmidt M, Kretschmann B, Schuster R, Honig A. Influence of sorbitol and mannitol on the reactions of kidney excretory function evoked by arterial chemoreceptor stimulation with almitrine in anaesthetized and artificially ventilated cats. Biomed. Biochim. Acta 1990; 49: 1067-80.
16. Ledderhos C, Quies W, Schuster R, Peters R. Renal hemodynamics and excretory function of healthy young men during stimulation of their peripheral arterial chemoreceptors by almitrine bismesylate. Biomed. Biochim. Acta 1987; 46: 1035-42.
17. Ledderhos C, Sanchez R, Quies W, Schuster R. Does the stimulation of the peripheral arterial chemoreceptors in humans by almitrine bismesylate inhibit proximal tubular sodium reabsorption? In: Acker H, Trzebski A, O'Regan RG (eds). Chemoreceptors and Chemoreceptor Reflexes. Plenum Press, New York. 1990; 293-302.
18. Wiersbitzky M, Landgraf R, Gruska S et al. Hormonal and renal responses to arterial chemoreceptor stimulation by almitrine in healthy and normotensive men. Biomed. Biochim. Acta 1990; 49: 1155-63.
19. Fuehr J. Aerztliches Labor. 1958; 4: 79.
20. DeBacker W, Vermeire P, Bogaert E, Janssens E, Van Maele R. Almitrine has no effect on gas exchange after bilateral carotid body resection in severe chronic airflow obstruction. Bull. Eur. Physiopath. Resp. 1985; 21: 427-32.
21. Anderson RJ, Pluss RG, Berns AS et al. Mechanism of effect of hypoxia on renal water excretion, J. Clin. Invest. 1978; 62: 769-77.
22. Dhillon DP, Barer GR. Respiratory stimulation by almitrine during acute or chronic hypoxia/hypercapnia in rats. Bull. Eur. Physiopath. Resp. 1982; 18: 751-64.
23. Laubie M, Schmitt H. Long-lasting hyperventilation induced by almitrine: Evidence for a specic effect on carotid and thoracic chemoreceptors. Eur. J. Pharmacol. 1980; 61: 125-36.
24. de Burgh Daly M, Scott MJ. An analysis of the primary reflex effects of stimulation of carotid body chemoreceptors in the dog. J. Physiol. 1962; 162: 555-73.
25. Drysdale DB, Strange-Petersen E. Arterial chemoreceptors, ventilation and heart rate in man. J. Physiol. 1977; 273: 109-20.
26. Gross PM, Whipp BJ, Davidson JT, Koyal SN, Wasserman K. Role of the carotid bodies in the heart rate response to breath holding in man. J. Appl. Physiol. 1976; 41: 336-40.
27. Marshall, JM. Peripheral chemoreceptors and cardiovascular regulation. Physiol. Rev. 1994; 74: 543-94.
28. Becker EL, Schilling JA, Harvey RB. Renal function in man acclimatized to high altitude. J. Appl. Physiol. 1957; 10: 79-80.
29. Monge C, Lozano CR, Marchena C, Whittembury J, Torres C. Kidney function in the high-altitude native. Fed. Proc. 1969; 28: 1199-203.
30. Ou LC, Silverstein J, Edwards BR. Renal function in rats chronically exposed to high altitude. Am. J. Physiol. 1984; 247: F45-9.
31. Abildgaard U, Holstein-Rathlou N-H, Leyssac PP. Effect of renal nerve activity on tubular sodium and water reabsorption in dog kidneys as determined by the lithium clearance method. Acta Physiol. Scand. 1986; 126: 251-7.
32. Koomans HA, Boer WH, Mees EJD. Evaluation of lithium clearance as a marker of proximal tubule sodium handling. Kidney Int. 1989; 36: 2-12.
33. Seldin DW, Eknoyan G, Suki WN, Rector FC. Localization of diuretic action from the pattern of water and electrolyte excretion. Ann. N.Y. Acad. Sci. 1966; 139: 328-43.
34. Thomson K. Lithium clearance: A new method for determining proximal and distal reabsorption of sodium and water. Nephron 1984; 37: 217-23.
35. Spitzer A, Windhager E. Effect of peritubular oncotic pressure changes on proximal fluid reabsorption. Am. J. Physiol. 1970; 218: 1188-93.
36. Kopp UC, DiBona GF. The neural control of renal function. In: Seldin DW, Giebisch G (eds). The Kidney. Physiology and Pathophysiology. Raven Press, New York. 1992; 1157-204.
37. Olsen NV, Kanstrup I-L, Richalet J-P, Hansen JM, Plazen G, Galen F-X. Effects of acute hypoxia on renal and endocrine function at rest and during graded exercise in hydrated subjects. J. Appl. Physiol. 1992; 73: 2036-43.