Evidence that ursodeoxycholic acid prevents steroid-resistant rejection in adult liver transplantation

Clinical Transplantation

Volumn 10, Issue 6 II, 1996, Pages 658-662

  Clavien, Pierre A ^a   Sharara, Ala I ^a   Camargo Jr , Carlos A ^a   Harland, Robert C ^a   Fitz, J Gregory ^a  

^a DUKE UNIVERSITY MEDICAL CENTER   (United States)

Author keywords

Cost; Liver transplantation; Pilot study; Prophylaxis; Rejection; Ursodeoxycholic acid

Indexed keywords

IMMUNOSUPPRESSIVE AGENT; METHYLPREDNISOLONE; URSODEOXYCHOLIC ACID;

ADULT; ARTICLE; CHOLESTASIS; CLINICAL ARTICLE; CLINICAL TRIAL; FEMALE; GRAFT REJECTION; HUMAN; IMMUNOSUPPRESSIVE TREATMENT; INTRAVENOUS DRUG ADMINISTRATION; LIVER TRANSPLANTATION; MALE; ORAL DRUG ADMINISTRATION; PRIORITY JOURNAL;

ADOLESCENT; ADULT; ANTI-INFLAMMATORY AGENTS; CHOLAGOGUES AND CHOLERETICS; CHOLESTASIS; DRUG RESISTANCE; FEMALE; FOLLOW-UP STUDIES; GRAFT REJECTION; HUMANS; LIVER TRANSPLANTATION; MALE; MIDDLE AGED; PILOT PROJECTS; RECURRENCE; URSODEOXYCHOLIC ACID;

EID: 0030463870     PISSN: 09020063     EISSN: None     Source Type: Journal    
DOI: None     Document Type: Article

References (18)

1. CALNE R. Immunosuppression in liver transplantation. N Engl J Med 1994: 331: 1154.
2. BEUERS U SPENGLER U, KRUIS W, AYDEMIR U, WIEBECKE B. Ursodeoxicholic acid for treatment of primary sclerosing cholangitis: a placebo control trial. Hepatology 1992: 16: 707.
3. POUPON R, POUPON R, BALKAU B. THE UDCA-PBC STUDY GROUP. Ursodiol for the long-term treatment of primary biliary cirrhosis. N Engl J Med 1994: 330: 1342.
4. + exchange inhibitors Am J Physiol 1988: 254: G232.
5. BEUERS U, NATHANSON M, ISALES C. BOYER J. Tauroursodeoxycholic acid stimulates hepatocellular exocytosis and mobilizes extracellular calcium mechanisms defective in cholestasis. J Clin Invest 1993: 92: 2984.
6. BOUSCAREL B. FROMM H. NUSSBAUM R. Ursodeoxycholate mobilizes intracellular calcium and activates phophorylase a in isolated hepatocytes. Am J Physiol 1993: 264: G243.
7. LACAILLE F. PARADIS K. The immunosuppressive effect of ursodeoxycholic acid: a comparative in vitro study on human peripheral blood mononuclear cells. Hepatology 1993. 18: 165.
8. FRIMAN S, MJORNSTEDT L, PERSSON H, KARLBER I. OLAUSSON M. Ursodeoxycholic acid reduces acute rejection in heart allografted rats. Transpl Proc 1992: 24: 344.
9. SAMA C. MAZZIOTTI A, GRIGIONI W. et al. Ursodeoxycholic acid administration does not prevent rejection after OLT. J Hepatol 1991: 13. A263.
10. FRIMAN S, PERSSON H. SCHERTSEN T, SVANIK J, KARLBER I. Adjuvant treatment with ursodeoxycholic acid reduces acute rejection after liver transplantation. Transpl Proc 1992: 389: 389.
11. FROMM H, ROAT JW, GONZALEZ V, SARVA RP, FARIVAR S. Comparative efficacy and side effects of ursodeoxycholic acid in dissolving gallstones: a double blind controlled study. Gastroenterology 1983: 85: 1257.
12. EUROPEAN FK506 MULTICENTRE LIVER STUDY GROUP. Randomized trial comparing tacrolimus (FK506) and cyclosporin in prevention of allograft rejection. Lancet 1994: 344: 473.
13. THE US MULTICENTER FK506 LIVER STUDY GROUP. A comparison of Tacrolimus (FK506) and cyclosporine for immunosuppression in liver transplantation. N Engl J Med 1994: 331: 1110.
14. DEMETRIS A. QIAN S, SUN H, FUNG J. Liver allograft rejection: an overview of morphologic findings. Am J Pathol 1990;14 (Suppl 1): 49.
15. CALMUS Y, GANE P, ROUGER P, POUPON R. Hepatic expression of class I and class II major histocompatibility complex molecules in primary biliary cirrhosis: effect of ursodeoxycholic acid. Hepatology 1990: 11: 12.
16. BARNES D, TALENTI D, GOORMASTIC M. et al. Ursodeoxycholic acid reduces hepatic allograft rejection after orthotopic liver transplantation A prospective, randomized, placebo-controlled, double-blind trial. Hepatology 1995: 22: A170.
17. PAGEAUX G, BALNC P, PERRIGAULT P, et al. Failure of ursodeoxycholic acid to prevent acute cellular rejection after liver transplantation. J Hepatol 1995: 23: 119.
18. CLAVIEN P-A, CAMARGO C JR, CROXFORD R, LANGER B, LEVY G, GREIG P. Definition and classification of negative outcomes in organ transplantation. Application in liver transplantation. Ann Surg 1994: 220: 109.