Effect of a single injection of high-dose FK506 on lung transplantation in rats

Surgery Today

Volumn 26, Issue 12, 1996, Pages 999-1005

  Sano, Yoshifumi ^a   Maruyama, Shuichiro ^a   Aoe, Motoi ^a   Date, Hiroshi ^a   Shimizu, Nobuyoshi ^a  

^a OKAYAMA UNIVERSITY MEDICAL SCHOOL   (Japan)

Author keywords

FK506; flow cytometry; IL 2 receptor; lung transplantation; MHC class II antigen

Indexed keywords

INTERLEUKIN 2 RECEPTOR; MAJOR HISTOCOMPATIBILITY ANTIGEN CLASS 2; MONOCLONAL ANTIBODY; TACROLIMUS;

ANIMAL EXPERIMENT; ANIMAL MODEL; ANIMAL TISSUE; ANOREXIA; ARTICLE; CONTROLLED STUDY; DIARRHEA; DRUG EFFECT; GRAFT REJECTION; GRAFT SURVIVAL; HISTOPATHOLOGY; INTRAMUSCULAR DRUG ADMINISTRATION; LUNG TRANSPLANTATION; MALE; NONHUMAN; RAT; SPLEEN; THYMUS; WEIGHT REDUCTION;

ANIMALS; FLOW CYTOMETRY; HISTOCOMPATIBILITY ANTIGENS CLASS II; IMMUNOSUPPRESSIVE AGENTS; INJECTIONS, INTRAMUSCULAR; LUNG TRANSPLANTATION; MALE; RATS; RATS, INBRED BN; RATS, INBRED LEW; RECEPTORS, INTERLEUKIN-2; TACROLIMUS;

EID: 0030463622     PISSN: 09411291     EISSN: None     Source Type: Journal    
DOI: 10.1007/BF00309961     Document Type: Article

References (50)

1. Kino T, Hatanaka U, Hashimoto M, Nishiyama M, Goto T, Okuhara M, Kohsaka M, Aoki H, Imanaka H (1987) FK-506, a novel immunosuppressant isolated from a Streptomyces. I. Fermentation, isolation and physico-chemical and biological characteristics. J Antibiot (Tokyo) 40:1244-1255
2. Kino T, Hatanaka H, Miyata S, Inamura N, Nishiyama M, Yajima T, Goto T, Okuhara M, Kohsaka M, Aoki H, Ochiai T (1987) FK-506, a novel immunosuppressant isolated from a Streptomyces. II. Immunosuppressive effect of FK-506 in vitro. J Antibiol (Tokyo) 40:1256-1265
3. Zeevi A, Duquesnoy R, Eiras G, Rabinowich H, Todo S, Makowka L, Starzl TE (1987) Immunosuppressive effect of FK-506 on in vitro lymphocyte alloactivation: synergism with cyclosporin A. Transplant Proc 19:40-44
4. Tocci MJ, Matkovich DA, Collier KA, Kwok P, Dumont F, Lin S, Degudicibus S, Siekierka JJ, Chin J, Hutchinson NI (1989) The immunosuppressant FK-506 selectively inhibits expression of early T cell activation genes. J Immunol 143:718-726
5. Sawada S, Suzuki G, Kawase Y, Takaku F (1987) Novel immunosuppressive agent, FK-506. In vitro effects on the cloned T cell activation. J Immunol 139:1797-1803
6. Beck Y, Akiyama N (1989) Effect of FK-506 and cyclosporine on human lymphocyte responses in vitro. Transplant Proc 21:3464-3467
7. Ochiai T, Nakajima K, Nagata M, Suzuki T, Asano T, Uematsu T, Goto T, Hori S, Kenmochi T, Nakagoori T, Isono K (1987) Effect of a new immunosuppressive agent, FK506, on heterotopic cardiac allotransplantation in the rat. Transplant Proc 19:1284-1286
8. Lee P, Murase N, Todo S, Makowka L, Starzl T (1987) The immunosuppressive effects of FR 900506 in rats receiving heterotopic cardiac allogralts. Surg Res Commun 1:325-331
9. Murase N, Todo S, Lee PH, Lai H-S, Chapman F, Nalesnik MA, Makowka L, Starzl TE (1987) Heterotopic heart transplantation in the rat receiving FK506 alone or with cyclosporine. Transplant Proc 19:71-75
10. Ochiai T, Nakajima K, Nagata M, Hori S, Asano I, Isono K (1987) Studies of the induction and maintenance of long term graft acceptance by treatment with FK-506 in heterotopic cardiac allotransplantation in rats. Transplantation 44:734-738
11. Lim SML, Thiru S, White DJG (1987) Heterotopic heart transplantation in the rat receiving FK-506. Transplant Proc 19:68-70
12. Todo S, Demetris AJ, Ueda Y, Inventarza O, Okuda K, Casavilla A, Cemaj S, Ghalab A, Mazzaferro V, Rhoe BS, Tonghna Y, Makowka L, Starzl TE (1987) Canine kidney transplantation with FK-506 alone or in combination with cyclosporine and steroids. Transplant Proc 19:57-61
13. Todo S, Podesta L, ChapChap P, Kahn D, Pan C-E, Ueda Y, Okuda K, Inventarza O, Casavilla A, Demetris AJ, Makowka L, Starzl TE (1987) Orthotopic liver transplantation in dogs receiving FK-506. Transplant Proc 19:64-67
14. Ochiai T, Nagata M, Nakajima K, Suzuki T, Sakamoto K, Enomoto K, Gunji Y, Uematsu T, Goto T, Hori S, Kenmochi T, Nakagouri T, Asano T, Isono K, Hamaguchi K, Tsuchida H, Nakahara K, Inamura N, Goto T (1987) Studies of the effects of FK-506 on renal allografting in the beagle dog. Transplantation 44:729-733
15. Todo S, Ueda Y, Demetris JA, Imventarza O, Nalesnik M, Venkataramanan R, Makowka L, Starzl TE (1988) Immunosuppression of canine, monkey, and baboon allografts by FK506 with special reference to synergism with other drugs and to tolerance induction. Surgery 104:239-249
16. Todo S, Demetris A, Ueda Y, Imventarza O, Cadoff E, Zeevi A, Starzl TE (1989) Renal transplantation in baboons under FK506. Surgery 106:444-451
17. Starzl TE, Todo S, Fung J, Demetris AJ, Venkataramanan R, Jain A (1989) FK 506 for liver, kidney, and pancreas transplantation. Lancet 2:1000-1004
18. Murase N, Kim D, Todo S, Cramer DV, Fung JJ, Starzl TE (1990) Suppression of allograft rejection with FK506. I. Prolonged cardiac and liver survival in rats following short-course therapy. Transplantation 50:186-189
19. Murase N, Kim D, Todo S, Cramer DV, Fung J, Starzl TE (1990) FK506 suppression of heart and liver allograft rejection. II. The induction of graft acceptance in rats. Transplantation 50:739-744
20. Hoffman AL, Makowka L, Banner B, Cai X, Cramer DV, Pascualone A, Todo S, Starzl TE (1990) The use of FK-506 for small intestine allotransplantation. Inhibition of acute rejection and prevention of fatal graft-versus-host disease. Transplantation 49:483-490
21. Iga C, Okajima K, Takeda Y, Tezuka K (1990) Prolonged survival of small intestinal allograft in the rat with cyclosporine A, FK506, and 15-Deoxyspergualin. Transplant Proc 22:1658
22. Langrehr JM, Hoffman RA, Demetris AJ, Lee KKW, Neuhaus P, Wren SM, Ildstad ST, Schraut WH (1992) Evidence that indefinite survival of small bowel allografts achieved by a brief course of Cyclosporine or FK506 is not due to systemic hyporesponsiveness. Transplantation 54:505-510
23. Santiago SF, Fukuzawa M, Azuma T, Okada A (1992) Effect of short-term immunosuppressive therapy with FK 506 or CyA on the donor in small intestine allotransplantation in rats. Transplant Proc 24:1189
24. Ohtsuka S, Hayashi S, Sato E, Tanaka Y, Hachisuka T, Haba T, Taira N, Orihata A, Uchida K, Kano T, Yokoyama I, Takagi H (1991) The effect of short-term FK 506 therapy on pancreas transplantation in rats. Transplant Proc 23:3217-3218
25. Gotoh M, Fukuzaki T, Dono K, Wada H, Kanai T, Monden M, Mori T (1992) FK-506 and islet transplantation: A potential protocol for inducing tolerance. Diab Nutr Metab 5:125-128
26. Katayama Y, Yada I, Namikawa S, Kusagawa M (1991) Immunosuppressive effects of FK 506 in rat lung transplantation. Transplant Proc 23:3300-3301
27. Hirai T, Waddel TK, Puskas JD, Wada H, Hitomi S, Gorczynski RM, Slutsky AS, Patterson GA (1992) Prolonged lung allograft survival with a short course of FK 506. J Thorac Cardiovasc Surg 105:1-8
28. Maruyama S, Sano Y, Date H, Shimizu N, Teramoto S (1993) Diagnosis of rejection in the allografted rat lung: Using monoclonal antibodies to T cell subsets for immunologic monitoring. Acta Med Okayama 47:399-406
29. Mizuta T, Kawaguchi A, Nakahara K, Kawashima Y (1989) Simplified rat lung transplantation using a cuff technique. J Thorac Cardiovasc Surg 97:578-581
30. Prop J, Tazelaar HD, Billingham ME (1987) Rejection of combined heart-lung transplants in rats: Function and pathology. Am J Pathol 127:97-105
31. Tazelaar HD, Prop J, Nieuwenhuis P, Billingham ME, Wildevuur CRH (1988) Airway pathology in the transplanted rat lung. Transplantation 45:864-869
32. Sendecor GW, Cochran (1971) Statistical methods. Iowa State University Press
33. The Toronto Lung Transplantation Group (1988) Experienee with single-lung transplantation for pulmonary fibrosis. JAMA 259:2258-2262
34. Patterson GA, Cooper JD, Goldman B, Weisel RD, Pearson FG, Waters PF, Todd TR, Scully H, Goldberg M, Ginsberg RJ (1988) Techniques of successful clinical double lung transplantation. Ann Thorac Surg 45:626-633
35. Cooper JD (1989) Lung transplantation. Ann Thorac Surg 47:28-44
36. Nalesnik MA, Todo S, Murase N, Gryzan S, Lee P-H, Makowka L, Starzl TE (1987) Toxicology of FK-506 in the Lewis rat. Transplant Proc 19:89-92
37. Gotoh M, Monden M, Kanai T, Umeshita K, Wang K, Ukei T, Dono K, Tono T, Murata M, Tanimoto J, Hashimoto M, Okamura J, Mori T (1991) Tolerance induction by liver grafting and FK 506 treatment in nonhuman primates. Transplant Proc 23:3265-3268
38. Stephen M, Woo J, Hasan NU, Whiting PH, Thomson AW (1989) Immunosuppressive activity, lymphocyte subset analysis, and acute toxicity of FK-506 in the rat. A comparative and combination study with cyclosporine. Transplantation 47:60-65
39. Takai K, Tsuchida M, Konishi M, Tokuda N, Fujikura Y, Jojima K, Fukumoto T (1991) Immunosuppressive effects of FK506 on rat lymphoid organs. Transplant Proc 23:2964-2966
40. Takai K, Tokuda N, Sawada T, Fujikura Y, Jojima K, Sakatoku J, Fukumoto T (1992) Effects of FK506 on rat thymic epithelial cells: immunohistochemical study. Thymus 19:207-217
41. Chen MF, Suzuki H, Maruyama M, Yano S (1991) The influence of FK-506 on the thymus and spleen in normal C3H/He mice: flow cytometric analysis of lymphocyte subpopulations. Immunol Lett 29:255-260
42. Seddik M, Seemayer TA, Lapp WS (1984) The graft-versus-host reaction and immune function: I. T-helper cell immunodeficiency associated with graft-versus-host induced thymic epithelial cell damage. Transplantation 37:281-286
43. Kruisbeek AM, Mond JJ, Fowlkes BJ, Carmen JA, Bridges S, Longo DL (1985) Absence of the Lyt2-, L3T4- lineage treated neonatally with anti-I-A antibody correlates with absence of intrathymic I-A-bearing antigen-presenting cell function. J Exp Med 82:1029-1047
44. Blue M-L, Daley JF, Levine H, Schlossman SF (1985) Class II major histocompatibility complex molecules regulate the development of the T4 + T8-inducer phenotype of cultured human thymocytes. Proc Natl Acad Sci USA 82:8178-8182
45. Wekerle H, Ketelsen U-P (1980) Thymic nurse cells: Ia-bearing epithelium involved in T-lymphocyte differentiation? Nature 283:402-404
46. Schwartz RH (1989) Acquisition of immunologic self-tolerance. Cell 57:1073-1081
47. Farr AG, Anderson SK, Marrack P, Kappler J (1985) Expression of antigen-specific, major histocompalibility complex-restricted receptors by cortical and medullary thymocytes in situ. Cell 43:543-550
48. Sprent J, Lo D, Gao E-K, Ron Y (1988) T cell-selection in the thymus. Immunol Rev 101:173-190
49. Woo J, Sewell HF, Thomson AW (1990) Effects of FK506 and low concentration cyclosporine on human lymphocyte activation antigen expression: a flow cytometric analysis. Transplant Proc 22:1645-1646
50. Takaori K, Nio Y, Inoue K, Tun T, Fukumoto M, Hashida T, Yasuhara M, Hori R, Tobe T (1992) A comparative study on Immunosuppressive effects of cyclosporin A and FK506 on peripheral blood lymphocytes in dogs. Biotherapy 4:129-137