Tyrosinase-mediated cytotoxicity of 4-substituted phenols: Use of QSAR to forecast reactivities of thiols towards the derived ortho-quinones

Quantitative Structure-Activity Relationships

Volumn 15, Issue 6, 1996, Pages 498-503

  Cooksey, Christopher J ^a   Land, Edward J ^b   Rushton, Francis A P ^b   Ramsden, Christopher A ^c   Riley, Patrick A ^d  

^a UNIVERSITY COLLEGE LONDON   (United Kingdom)

^b CHRISTIE HOSPITAL   (United Kingdom)

^c KEELE UNIVERSITY   (United Kingdom)

^d ROYAL FREE AND UNIVERSITY COLLEGE MEDICAL SCHOOL   (United Kingdom)

Author keywords

4 substituted phenols; Hammett constants; Malignant melanoma; O quinones; QSAR; Thiols; Tyrosinase mediated cytotoxicity

Indexed keywords

AMINO ACIDS; CYTOTOXICITY; ONCOLOGY; PHENOLS; RADIATION CHEMISTRY; RATE CONSTANTS; REGRESSION ANALYSIS;

4-SUBSTITUTED PHENOLS; CATALYZED OXIDATION; HAMMETT'S CONSTANT; MALIGNANT MELANOMA; MELANOGENESIS; O-QUINONES; QUANTITATIVE STRUCTURE ACTIVITY RELATIONSHIP; THIOL; TYROSINASE-MEDIATED CYTOTOXICITY; TYROSINE ANALOGUES;

CHEMOTHERAPY;

ANTINEOPLASTIC AGENT; BENZOQUINONE; CATECHOL DERIVATIVE; CYSTEINE; GLUTATHIONE; MONOPHENOL MONOOXYGENASE; PHENOL DERIVATIVE; QUINONE DERIVATIVE; THIOL;

ARTICLE; CYTOTOXICITY; DRUG DESIGN; ELECTRON; MELANOGENESIS; MELANOMA; MULTIVARIATE ANALYSIS; OXIDATION; PREDICTION; PRIORITY JOURNAL; PULSE RADIOLYSIS; QUANTITATIVE STRUCTURE ACTIVITY RELATION; REGRESSION ANALYSIS;

EID: 0030462560     PISSN: 09318771     EISSN: None     Source Type: Journal    
DOI: 10.1002/qsar.19960150606     Document Type: Article

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