Increased microvascular permeability induced by prolonged interleukin-2 administration is attenuated by the oxygen-free-radical scavenger dimethylthiourea

Cancer Immunology Immunotherapy

Volumn 43, Issue 4, 1996, Pages 240-244

  Gutman, Mordechai ^a   Laufer, Ruth ^b   Eisenthal, Avi ^b   Goldman, Gideon ^a   Ravid, Anat ^b   Inbar, Moshe ^b   Klausner, Joseph M ^a  

^a TEL AVIV SOURASKY MEDICAL CENTER   (Israel)

^b TEL AVIV UNIVERSITY   (Israel)

Author keywords

[No Author keywords available]

Indexed keywords

DIMETHYLTHIOUREA; INTERLEUKIN 2;

ANIMAL EXPERIMENT; ANIMAL MODEL; ARTICLE; BLOOD VESSEL PERMEABILITY; CONTROLLED STUDY; CYTOTOXICITY; FEMALE; INTRAPERITONEAL DRUG ADMINISTRATION; LUNG; MOUSE; NONHUMAN; PRIORITY JOURNAL; SPLEEN;

ANIMALS; CAPILLARY PERMEABILITY; DRUG INTERACTIONS; EDEMA; FEMALE; FREE RADICAL SCAVENGERS; IMMUNOTHERAPY, ADOPTIVE; INTERLEUKIN-2; KILLER CELLS, LYMPHOKINE-ACTIVATED; LEUKOCYTES, MONONUCLEAR; MELANOMA, EXPERIMENTAL; MICE; MICE, INBRED BALB C; PERITONEAL CAVITY; REACTIVE OXYGEN SPECIES; SPLEEN; THIOUREA;

EID: 0030462478     PISSN: 03407004     EISSN: None     Source Type: Journal    
DOI: 10.1007/s002620050328     Document Type: Article

References (39)

1. Bass DA, Ponce JW, Cechatelet LR, Szejda C, Seed MC, Thomas M (1983) Flow cytometric studies of oxidative product formation by neutrophils: a graded response to membrane stimulation. J Immunol 130:1910
2. Damle NK, Doyle LV, Bender JA, Bradely EC (1987) Interleukin-2 activated human lymphocytes exhibit enhanced adhesion to normal vascular endothelial cells and cause their lysis. J Immunol 138:1779
3. DeJoy SQ, Jeyaseelan R, Torley LW, Schow SR, Wick MM (1995) Attenuation of interleukin-2-induced pulmonary vascular leak syndrome by low doses of oral methotrexate. Cancer Res 55:4929
4. Del Maestro RE, Bjork FJ, Afres KE (1981) Increase in microvascular permeability induced by enzymatically generated free radicals. Microvasc Res 22:25
5. Dubinett SM, Huang M, Lichtenstein A, McBride WH, Wang J, Markovitz G, Kelley D, Grody WW, Mintz LE, Dhanani S (1994) Tumor necrosis factor-α plays a central role in interleukin-2-induced pulmonary vascular leak and lymphocyte accumulation. Cell Immunol 157:170
6. Edwards MJ, Schuschke DA, Abney DL, Miller FN (1991) Interleukin-2 acutely induces protein leakage from the circulation. J Surg Res 50:609
7. Ettinghaussen SE, Puri RK, Rosenberg SA (1988) Increased vascular permeability in organs mediated by the systemic administration of lymphokine-activated killer cells and recombinant interleukin-2 in mice. J Natl Cancer Inst 80:177
8. Fox RB (1984) Prevention of granulocyte-mediated oxidant lung injury in rats by a hydroxyl radical scavenger, dimethylthiourea, J Clin Invest 74:1456
9. Fraker DL, Langstein HN, Norton JA (1989) Passive immunization against tumor necrosis factor partially abrogates interleukin-2 toxicity. J Exp Med 170:1015
10. Fyfe G, Fisher RI, Rosenberg SA, Sznol M, Parkinson DR, Louie AC (1995) Results of treatment of 255 patients with metastatic renal cell carcinoma. J Clin Oncol 13:688
11. Gately AK, Anderson TD, Hayes TJ (1989) Role of asialo-GM positive lymphoid cells in mediating the toxic effects of IL-2 in mice. J Immunol 141:189
12. Gutman M, Singh RK, Yooh S, Xie K, Bucana CD, Fidler IJ (1994) Leukocyte induced angiogenesis and subcutaneous growth of B16 melanoma. Cancer Biother 9:163
13. Heniford BT, Edwards MJ, Wilson MA, Klar EA, Doak KW, Miller FN (1994) Interleukin-8 suppresses the toxicity and antitumor effect of interleukin-2. J Surg Res 56:82
14. Klausner JM, Morel N, Paterson IS, Kobzik L, Valeri CR, Eberlein TJ, Shepro D, Hechtman HB (1989) The rapid induction by interleukin-2 of pulmonary microvascular permeability. Ann Surg 209:119
15. Klausner JM, Paterson IS, Goldman G, Kobzik L, Lelcuk S, Skornick Y, Eberlein T, Valeri RC, Shepro D, Hechtman HB (1991) Interleukin-2 induced lung injury is mediated by oxygen free radicals. Surgery 109:169
16. Klausner JM, Abu-Abid S, Alexander JS, Hanschke-Mineau R, Goldman G, Morel N, Valeri CR, Shepro D, Hechtman HB (1994) Thromboxane modulates endothelial permeability. Mediat Inflamm 3:149
17. Lotze MT, Matory YL, Raynor AA, Ettinghaussen SE, Seipp CA, Rosenberg SA (1986) Clinical effects and toxicity of IL-2 in patients with cancer. Cancer 58:2764
18. Matsubara T, Ziff M (1986) Increased superoxide anion release from human endothelial cells in response to cytokines. J Immunol 137:3295
19. McCord JM (1985) Oxygen derived free radicals in post-ischemic tissue injury. N Engl J Med 312:159
20. Nathan CF (1987) Neutrophil activation on biological surfaces. Massive secretion of hydrogen peroxide in response to products of macrophages and lymphocytes. J Clin Invest 80:1550
21. Olson NC, Anderson DL, Grizzle MK (1987) Dimethylthiourea attenuates endotoxin-induced acute respiratory failure in pigs. J Appl Physiol 63:2426
22. Palder SB, Wong C, Hood I, Wenger H, Mannick JA, Demerling RA (1985) Chemotactic activity of plasma and lung lymph in sheep with endotoxemia: effect of hydroxyl radical scavengers. J Surg Res 38:162
23. Papa MZ, Vetto JT, Ettinghausen SE, Mule JJ, Rosenberg SA (1986) Effect of corticosteroids on the antitumor activity of lymphokine activated killer cells and interleukin-2 in mice. Cancer Res 46:5618
24. Parks DA, Shah AK, Granger DN (1984) Oxygen radicals: effects on intestinal vascular permeability. Am J Physiol 247:G167
25. Puri RK, Travis WT, Rosenberg SA (1989) Decrease in interleukin-2-induced vascular leakage in the lungs of mice by the administration of interleukin 1α in vivo. Cancer Res 49:969
26. Rabinovici R, Sofronski MD, Renz JF, Hillegas LM, Esser KM, Vernick J, Feuerstein G (1992) Platelet activating factor mediates interleukin-2 induced lung injury in the rat. J Clin Invest 89:1669
27. Rabinovici R, Sofronski MD, Borboroglu P, Spirig AM, Hillegas LM, Levine J, Vernick J, Scesney SM, Feuerstein N, Feuerstein G (1994) Interleukin-2 induced lung injury: the role of complement. Circ Res 74:329
28. Rosenberg SA (1992) The immunotherapy and gene therapy of cancer. J Clin Oncol 10:180
29. Rosenstein M, Ettinghaussen EC, Rosenberg SA (1986) Extravasation of intravascular fluid mediated by the systemic administration of interleukin-2. J Immunol 137:1735
30. Seigel JP, Puri RK (1992) Interleukin-2 toxicity. J Clin Oncol 9:694
31. Staub NC (1988) Pulmonary intravascular macrophages. Chest 93:845
32. Tate RM, Morris HG, Schroeder WR, Repine JE (1984) Oxygen metabolites stimulate thromboxane production and vasoconstriction in isolated saline-perfused rabbit lungs. J Clin Invest 74:608
33. Thijs LG, Hack CE, Strack Van Schijndel RJM, Nuijens JH, Wolbink GJ, Eerenberg-Belmer AK, Van der Vall H, Wagstaff J (1990) Activation of the complement system during immunotherapy with IL-2. Relation to the development of side effects. J Immunol 144:2419
34. Thom AK, Fraker DL, Norton JA. IL-1 receptor antagonist (IL-Ira) augments IL-2 induced pulmonary vascular leak. J Surg Res 54:336
35. Vetto JT, Papa MZ, Lotze MT (1987) Reduction of toxicity of IL-2 and lymphokine activated killer cells in humans by the administration of corticosteroids. J Clin Oncol 5:496
36. Ward PA, Till GO, Hatherill JR, Annesley TM, Kunkel RG (1985) Systemic complement activation, lung injury, and products of lipid peroxidation. J Clin Invest 76:517
37. Ward PA, Johnson KJ, Till GO (1986) Oxygen radicals and microvascular injury of lungs and kidney. Acta Physiol Scand [Suppl] 548:79
38. Weiss SJ, Young J, Lo Buglio AF, Slivka A (1981) Role of hydrogen peroxide in neutrophil-mediated destruction of cultured endothelial cells. J Clin Invest 68:714
39. Welbourn R, Goldman G, Kobzik L, Paterson IS, Shepro D, Hechtman HB (1991) Interleukin-2 induces early multisystem organ edema mediated by neutrophils. Ann Surg 214:181