Chapter 1. The polymodal receptor: Bio-warning and defense system

Progress in Brain Research

Volumn 113, Issue C, 1996, Pages 3-18

  Kumazawa, Takao ^a  

^a NAGOYA UNIVERSITY   (Japan)

Author keywords

[No Author keywords available]

Indexed keywords

NEUROPEPTIDE;

ANIMAL EXPERIMENT; ELECTROSTIMULATION; MALE; NERVE CELL PLASTICITY; NOCICEPTION; NONHUMAN; PAIN RECEPTOR; PRIORITY JOURNAL; REVIEW; TESTIS; VERTEBRATE;

EID: 0030462426     PISSN: 00796123     EISSN: 18757855     Source Type: Book Series    
DOI: 10.1016/S0079-6123(08)61078-X     Document Type: Article

References (99)

1. Baker, D.G., Coleridge, H.M., Coleridge, J.C.G., Nerdrum, T., Search for a cardiac nociceptor: stimulation by bradykinin of sympathetic afferent nerve endings in the heart of the cat. J. Physiol. (Lond.) 306 (1980), 519-536.
2. Beck, P.W., Handwerker, H.O., Zimmermann, M., Nervous outflow from the cat's foot during noxious radiant heat stimulation. Brain Res. 67 (1974), 373-386.
3. Beitel, R.E., Dubner, R., Response of unmeylinated (C) polymodal nociceptors to thermal stimuli applied to monkey's face. J. Neurophysiol. 39 (1976), 1160-1175.
4. Belmonte, C., Gallar, J., Pozo, M.A., Rebollo, I., Excitation by irritant chemical substances of sensory afferent units in the cat's cornea. J. Physiol. (Lond.) 437 (1991), 709-725.
5. Bernard, J.F., Huang, G.F., Besson, J.M., The parabrachial area: electrophysiological evidence for an involvement in visceral nociceptive processes. J. Neurophysiol. 71 (1994), 1646-1660.
6. Bertrand, F., Hugelin, A., Respiratory synchronizing function of nucleus parabrachialis medialis: pneumotaxic mechanisms. J. Neurophysiol. 34 (1971), 189-207.
7. Bessou, P., Perl, E.R., Response of cutaneous sensory units with unmyelinated fibers to noxious stimuli. J. Neurophysiol. 32 (1969), 1025-1043.
8. Brimijoin, S., Lundberg, J.M., Brodin, E., Hokfelt, T., Nilsson, G., Axonal transport of substance P in the vagus and sciatic nerves of the guinea pig. Brain Res. 191 (1980), 443-457.
9. Burgess, P.R., Perl, E.R., Myelinated afferent fibres responding specifically to noxious stimulation of the skin. J. Physiol. (Lond.) 190 (1967), 541-562.
10. Burgess, P.R., Perl, E.R., Cutaneous mechanoreceptors and nociceptors. Iggo, A., (eds.) Handbook of Sensory Physiology., Vol. 2, Somatosensory System, 1973, Springer, Berlin, 29-78.
11. Cechetto, D.F., Standaert, D.G., Saper, C.B., Spinal and trigeminal dorsal horn projections to the parabrachial nucleus in the rat. J. Comp. Neurol. 240 (1985), 153-160.
12. Cevero, F., Sharkey, K.A., An electrophysiological and anatomical study of intestinal afferent fibres in the rat. J. Physiol. (Lond.) 401 (1988), 381-397.
13. Cohen, R.H., Perl, E.R., Contributions of arachidonic acid derivatives and substance P to the sensitization of cutaneous nociceptors. J. Neurophysiol. 64 (1990), 457-464.
14. Croze, S., Duclaux, R., Kenshalo, D.R., The thermal sensitivity of the polymodal nociceptors in the monkey. J. Physiol. (Lond.) 263 (1976), 539-562.
15. Dahl, J.B., Neuronal plasticity and pre-emptive analgesia: implications for the management of postoperative pain. Dan. Med. Bull. 41 (1994), 434-442.
16. Dickenson, A.H., Spinal cord pharmacology of pain. Br. J. Anaesth. 75 (1995), 193-200.
17. Dray, A., Bettaney, J., Forster, P., Perkins, M.N., Bradykinin-induced stimulation of afferent fibres is mediated through protein kinase C. Neurosci. Lett. 91 (1988), 301-307.
18. Dray, A., Urban, L., Dickenson, A., Pharmacology of chronic pain. Trends Pharmacol Sci. 15 (1994), 190-197.
19. Duclaux, R., Mei, N., Ranieri, F., Conduction velocity along the afferent vagal dendrites: a new type of fibre. J. Physiol. (Lond.) 260 (1976), 487-495.
20. Eguchi, K., Tadaki, E., Simbulan, D. Jr., Kumazawa, T., Respiratory depression caused by either morphine microinjection or repetitive electrical stimulation in the region of the nucleus parabrachialis of cats. Pflügers Arch. 409 (1987), 367-373.
21. Fleischer, E., Handwerker, H.O., Joukhadar, S., Unmyelinated nociceptive units in two skin areas of the rat. Brain Res. 267 (1983), 81-92.
22. Floyd, K., Hick, V.E., Morrison, J.F.B., Mechanosensitive afferent units in the hypogastric nerve of the cat. J. Physiol. (Lond.) 259 (1976), 457-471.
23. 2-adrenergic receptors. J. Neurochem. 57 (1991), 1145-1150.
24. Grimmelikhuijzen, C.J.P., Balfe, A., Emson, P.C., Powell, D., Sundler, F., Substance P-like immunoreactivity in the nervous system of hydra. Histochemistry 71 (1981), 325-333.
25. Halin, R.G., Torebjörk, H.E., Wiesenfeld, Z., Nociceptors and warm receptors innervated by C fibres in human skin. J. Neurol. Neurosurg. Psychiatry 45 (1982), 313-319.
26. Haupt, P., Jänig, W., Kohler, W., Response pattern of visceral afferent fibres, supplying the colon, upon chemical and mechanical stimuli. Pflügers Arch. 398 (1983), 41-47.
27. Hirano, T., Simbulan, D., Kumazawa, T., Effects of kainic acid in the parabrachial region for ongoing respiratory activity and reflexive respiratory suppression. Brain Res. 665 (1994), 54-62.
28. Hylden, J.K., Hayashi, H., Bennett, G.J., Dubner, R., Spinal lamina I neurons projecting to the parabrachial area of the cat midbrain. Brain Res. 336 (1985), 195-198.
29. Iggo, A., The electrophysiological identification of single nerve fibres, with particular reference to the slowest-conducting vagal afferent fibres in the cat. J. Physiol. (Lond.) 142 (1958), 110-126.
30. Iggo, A., Cutaneous heat and cold receptors with slowly conducting (C) afferent fibres. Quart. J. Exp. Physiol. 44 (1959), 362-370.
31. Kanaka, R., Schaible, H.-G., Schmidt, R.F., Activation of fine articular afferent units by bradykinin. Brain Res. 372 (1985), 81-90.
32. Katz, J., Clairoux, M., Kavanagh, B.P., Roger, S., Nierenberg, H., Redahan, C., Sandler, A.N., Pre-emptive lumar epidural anaesthesia reduces postoperative pain and patient-controlled morphine consumption after lower abdominal surgery. Pain 59 (1994), 395-403.
33. Kaufman, M.P., Iwamoto, G.A., Longhurst, J.C., Mitchell, J.H., Effects of capsaicin and bradykinin on afferent fibers with endings in skeletal muscle. Circ. Res. 50 (1982), 133-139.
34. Kenins, P., Identification of the unmyelinated sensory nerves which evoke extravasation in response to antidromic stimulation. Neurosci. Lett. 25 (1981), 137-141.
35. 1 receptor mediated excitation and facilitation of the heat response by histamine in canine visceral polymodal receptors studied in vitro. J. Neurophysiol., 1996 in press.
36. Kruger, L., Morphological features of thin sensory afferent fibers: a new interpretation of ‘nociceptor’ function. Hamann, W., Iggo, A., (eds.) Progress in Brain Research, Vol. 74, Transduction and Cellular Mechanisms in Sensory Receptors, 1988, Elsevier, Amsterdam, 253-257.
37. Kruger, L., Kumazawa, T., Mizumura, K., Sato, J., Yeh, Y., Observations on electrophysiologically characterized receptive fields of thin testicular afferent axons: a preliminary note on the analysis of fine structural specializations of polymodal receptors. Somatosens. Res. 5 (1988), 373-380.
38. Kumazawa, T., Nociceptors and autonomic nervous control. Asian Med. J. 24 (1981), 632-656.
39. Kumazawa, T., Sensory innervation of reproductive organs. Cervero, F., Morrison, J.F.B., (eds.) Progress in Brain Research, Vol 67. Visceral Sensation, 1986, Elsevier, Amsterdam, 115-131.
40. Kumazawa, T., Functions of the nociceptive primary neurons. Jpn. J. Physiol. 40 (1990), 1-14.
41. Kumazawa, T., Sensitization of polymodal receptors. Belmonte, C., Cervero, F., (eds.) Neurobiology of Nociceptors, 1996, Oxford Univ. Press, Oxford in press.
42. Kumazawa, T., Mizumura, K., The polymodal C-fiberreceptor in the muscle of the dog. Brain Res. 101 (1976), 589-593.
43. Kumazawa, T., Mizumura, K., Thin-fibre receptors responding to mechanical, chemical, and thermal stimulation in the skeletal muscle of the dog. J. Physiol. (Lond.) 273 (1977), 179-194.
44. Kumazawa, T., Mizumura, K., The polymodal receptors in the testis of dog. Brain Res. 136 (1977), 553-558.
45. Kumazawa, T., Mizumura, K., Chemical responses of polymodal receptors of the scrotal contents in dogs. J. Physiol (Lond.) 299 (1980), 219-231.
46. Kumuzawa, T., Mizumura, K., Mechanical and thermal responses of polymodal receptors recorded from the superior spermatic nerve of dogs. J. Physiol. (Lond.) 299 (1980), 233-245.
47. Kumazawa, T., Perl, E.R., Primate cutaneous sensory units with unmyelinated (C) afferent fibers. J. Neurophysiol. 40 (1977), 1325-1338.
48. Kumazawa, T., Tadaki, E., Two different inhibitory effects on respiration by thin-fiber muscular afferents in cats. Brain Res. 272 (1983), 364-367.
49. Kumazawa, T., Tadaki, E., Mizumura, K., Kim, K., Post-stimulus fascilitatory and inhibitory effects on respiration induced by chemical and electrical stimulation of thin-fiber muscular afferents in dogs. Neurosci. Lett. 35 (1983), 283-287.
50. Kumazawa, T., Eguchi, K., Tadaki, E., Naloxone-reversible respiratory inhibition induced by muscular thin-fiber afferents in decerebrated cats. Neurosci. Lett. 53 (1985), 81-85.
51. Kumazawa, T., Mizumura, K., Sato, J., Modulations of testicular polymodal receptor activity: implication of receptors in inflammatory pain. Schmidt, R.F., Schaible, H.-G., Vahle-Hinz, C., (eds.) Fine Afferent Nerve Fibers and Pain, 1987, VCH Verlagsgesellschaft, Weinheim, 147-157.
52. Kumazawa, T., Mizumura, K., Sato, J., Response properties of polymodal receptors studied using in vitro testis superior spermatic nerve preparations of dogs. J. Neurophysiol. 57 (1987), 702-711.
53. Kumazawa, T., Mizumura, K., Minagawa, M., Tsujii, Y., Sensitizing effects of bradykinin on the heat responses of the visceral nociceptor. J. Neurophysiol. 66 (1991), 1819-1824.
54. Kumazawa, T., Mizumura, K., Minagawa, M., Koda, H., Tsujii, Y., Sato, J., Differences in the response of the polymodal receptor to heat stimulation and to bradykinin. Inoki, R., Shigenaga, Y., Tohyama, M., (eds.) Processing and Inhibition of Nociceptive Information, 1992, Elsevier, Amsterdam, 3-8.
55. 2-induced sensitization of polymodal receptors in response to bradykinin and heat. J. Neurophysiol. 75 (1996), 2361-2368.
56. Kuntz, A., Innervation of the sex organs. The Autonomic Nervous System, 1947, Les and Febiger, Phidadelphia, 304-323.
57. Leng, S., Mizumura, K., Koda, H., Kumazawa, T., Excitation and sensitization of the heat response induced by a phorbal ester in canine visceral polymodal receptors studied in vitro. Neurosci. Lett. 206 (1996), 13-16.
58. Levins, J.D., Taiwo, Y.O., Collins, S.D., Tam, J.K., Noradrenaline hyperalgesia is mediated through interaction with sympathetic postganglionic neurone terminals rather than activation of primary afferent nociceptors. Nature 323 (1986), 158-160.
59. Light, A.R., Casale, E., Sedivec, M., The physiology and anatomy of spinal laminae I and II neurons antidromically activated by stimulation in the parabrachial region of the midbrain and pons. Schmidt, R.F., Schaible, H.-G., Vahle-Hinz, C., (eds.) Fine Afferent Nerve Fibers and Pain, 1987, VCH Verlagsgesellschaft, Weinheim, 347-356.
60. Lynn, B., The heat sensitization of polymodal nociceptors in the rabbit and its independence of the local blood flow. J. Physiol. (Lond.) 287 (1979), 493-507.
61. Lynn, B., Carpenter, S.E., Primary afferent units from the hairy skin of the rat hind limb. Brain Res. 238 (1982), 29-43.
62. 2. Brain Res. 225 (1981), 95-105.
63. Mense, S., Schmidt, R.F., Activation of group IV afferent units from muscle by algesic agents. Brain Res. 72 (1974), 305-310.
64. Mizumura, K., Kumazawa, T., Reflex respiratory response induced by chemical stimulation of muscle afferents. Brain Res. 109 (1976), 402-406.
65. Mizumara, K., Sato, J., Kumazawa, T., Effects of prostaglandins and other putative chemical intermediaries on the activity of canine testicular polymodal receptors studied in vitro. Pflugers Arch. 408 (1987), 565-572.
66. Mizumura, K., Minagawa, M., Tsujii, Y., Kumazawa, T., The effects of bradykinin agonists and antagonists on visceral polymodal receptor activities. Pain 40 (1990), 221-227.
67. 2 on testicular nociceptor activities studied in vitro. Naunyn Schmiedebergs Arch. Pharmacol. 344 (1991), 368-376.
68. Mizumura, K., Sato, J., Kumazawa, T., Strong heat stimulation sensitizes the heat response as well as the bradykinin response of visceral polymodal receptors. J. Neurophysiol. 68 (1992), 1209-1215.
69. 2-induced sensitization of the heat response of canine visceral polymodal receptors in vitro. Neurosci. Lett. 161 (1993), 117-119.
70. Mizumura, K., Sugiura, Y., Kumazawa, T., Spinal termination patterns of canine identified A-delta and C-spermatic polymodal receptors traced by intracellular labeling with Phaseolus-vulgaris-leucoagglutinin. J. Comp. Neurol. 335 (1993), 460-468.
71. Mizumura, K., Sato, J., Minagawa, M., Kumazawa, T., Incomplete suppressive effects of acetylsalicylic acid on the heat sensitization of canine testicular polymodal receptor activity. J. Neurophysiol. 72 (1994), 2729-2736.
72. Mizumura, K., Koda, H., Kumazawa, T., Opposite effects of increased intracellular cyclic AMP on the heat and bradykinin responses of canine visceral polymodal receptors in vitro. Neurosci. Res., 1996 in press.
73. Molander, C., Ygge, J., Dalsgaard, C.-J., Substance P-, somatostatin- and calcitonin gene-related peptide-like immunoreactivity and fluoride resistant acid phosphatase-activity in relation to retrogradely labeled cutaneous, muscular and visceral primary sensory neurons in the rat. Neurosci. Lett. 74 (1987), 37-42.
74. 1 on cardiac pressor reflex and sympathetic afferents. Am. J. Physiol. 250 (1986), R815–R822.
75. Nishi, K., Sakanashi, M., Takenaka, F., Activation of afferent cardiac sympathetic nerve fibers of cats by pain producing substances and by noxious heat. Pflügers Arch. 372 (1977), 53-61.
76. O'Brien, C., Woolf, C.J., Fitzgerald, M., Lindsay, R.M., Molander, C., Differences in the chemical expression of rat primary afferent neurons which innervate skin, muscle or joint. Neuroscience 32 (1989), 493-502.
77. Otsuka, M., Yoshioka, K., Neurotransmitter functions of mammalian tachykinins. Physiol. Rev. 73 (1993), 229-308.
78. 8]-BK and HOE 140, in two models of persistent hyperalgesia in the rat. Pain 53 (1993), 191-197.
79. Reeh, P.W., Sensory receptors in mammalian skin in an in vitro preparation. Neurosci. Lett. 66 (1986), 141-146.
80. Sato, J., Perl, E.R., Adrenergic excitation of cutaneous pain receptors induced by peripheral nerve injury. Science 251 (1991), 1608-1610.
81. Sato, J., Mizumura, K., Kumazawa, T., Effects of ionic calcium on the responses of canine testicular polymodal receptors to algesic substances. J. Neurophysiol. 62 (1989), 119-125.
82. Sato, J., Suzuki, S., Iseki, T., Kumazawa, T., Adrenergic excitation of cutaneous nociceptors in chronically inflamed rats. Neurosci. Lett. 164 (1993), 225-228.
83. Sato, J., Suzuki, S., Tamura, R., Kumazawa, T., Norepinephrine excitation of cutaneous nociceptors in adjuvant-induced inflamed rats does not depend on sympathetic neurons. Neurosci. Lett. 177 (1994), 135-138.
84. Schaible, H.-G., Schmidt, R.F., Mechanosensibility of joint receptors with fine afferent fibers. Exp. Brain Res., 1984, 284-297 Suppl. 9.
85. 2. J. Physiol. (Lond.) 403 (1988), 91-104.
86. Sengupta, J.N., Gebhart, G.F., Mechanosensitive properties of pelvic nerve afferent fibers innervating the urinary bladder of the rat. J. Neurophysiol. 72 (1994), 2420-2430.
87. Slugg, R.M., Light, A.R., Spinal cord and trigeminal projections to the pontine parabrachial region in the rat as demonstrated with Phaseolus vulgaris leucoagglutinin. J. Comp. Neurol. 339 (1994), 49-61.
88. Standaert, D.G., Watson, S.J., Houghten, R.A., Saper, C.B., Opioid peptide immunoreactivity in spinal and trigeminal dorsal horn neurons projecting to the parabrachial nucleus in the rat. J. Neurosci. 6 (1986), 1220-1226.
89. Stanton-Hicks, M., Jänig, W., Hassenbusch, S., Haddox, J.D., Boas, R., Wilson, P., Reflex sympathetic dystrophy: Changing concepts and taxonomy. Pain 63 (1995), 127-133.
90. Sugiura, Y., Lee, C.L., Perl, E.R., Central projections of identified, unmyelinated (C) afferent fibers innervating mammalian skin. Science 234 (1986), 358-361.
91. Tamura, R., Mizumura, K., Sato, J., Kitoh, J., Kumazawa, T., Segmental distribution of afferent neurons innervating the canine testis. J. Auton. Nerv. Syst. 58 (1996), 101-107.
92. Tamura, R., Mizumura, K., Kumazawa, T., Coexistence of calcitonin gene-related peptide- and substance P-like immunoreactivity in retrogradely labeled superior spermatic neurons in the dog. Neurosci. Res. 25 (1996), 293-299.
93. Torebjörk, H.E., Hallin, R.G., Identification of afferent C units in intact human skin nerves. Brain Res. 67 (1974), 387-403.
94. Tsujii, Y., Koeda, T., Sato, J., Suzuki, S., Kumazawa, T., Sympathetically induced paradoxical increases of the cutaneous blood flow in chronically inflamed rats. J. Auton. Nerv. Syst. 59 (1996), 103-112.
95. Uchida, Y., Murao, S., Bradykinin-induced excitation of afferent cardiac sympathetic nerve fibers. Jpn. Heart J. 15 (1974), 84-91.
96. Uchida, Y., Murao, S., Acid-induced excitation of afferent cardiac sympathetic nerve fibers. Am. J. Physiol. 228 (1975), 27-33.
97. Witt, I., Griffin, J.P., Afferent cutaneous C-fibre activity to repeated thermal stimuli. Nature 194 (1962), 776-777.
98. Woolf, C.J., Evidence for a central component of postinjury pain hypersensitivity. Nature 306 (1983), 686-688.
99. Yamashita, K., Histological study on innervation of human testis and epididymis (Japanese). Manshu–Igaku-Zasshi 30 (1939), 367-394.