Unique and efficient synthesis of [2S-(2R*,3S*,4R*)]-2-amino-1-cyclohexyl-6-methyl-3,4- heptanediol, a popular C-terminal component of many renin inhibitors

Journal of Organic Chemistry

Volumn 61, Issue 26, 1996, Pages 9564-9568

  Schwindt, Mark A ^a   Belmont, Daniel T ^a   Carlson, Mark ^a   Franklin, Lloyd C ^a   Hendrickson, Valerie S ^a   Karrick, Gregory L ^a   Poe, Russell W ^a   Sobieray, Denis M ^a   Van De Vusse, Jim ^a  

^a PFIZER INC   (United States)

Author keywords

[No Author keywords available]

Indexed keywords

2 AMINO 1 CYCLOHEXYL 6 METHYL 3,4 HEPTANEDIOL; ALKANEDIOL DERIVATIVE; RENIN INHIBITOR; UNCLASSIFIED DRUG;

ARTICLE; DRUG SYNTHESIS; REACTION ANALYSIS;

EID: 0030462372     PISSN: 00223263     EISSN: None     Source Type: Journal    
DOI: 10.1021/jo960694n     Document Type: Article

References (37)

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36. The aldehyde 3 could be stored for several days packed in dry ice without a change in optical purity measured by optical rotation.
37. 7