Proteins expressed by DNA vaccines induce both local and systemic immune responses

Annals of the New York Academy of Sciences

Volumn 797, Issue , 1996, Pages 196-206

  Whitton, J Lindsay ^a   Yokoyama, Masayuki ^a  

^a SCRIPPS RESEARCH INSTITUTE   (United States)

Author keywords

[No Author keywords available]

Indexed keywords

DNA VACCINE; INACTIVATED VACCINE; LIVE VACCINE; MAJOR HISTOCOMPATIBILITY ANTIGEN CLASS 1; VIRUS VACCINE;

ANIMAL CELL; ANIMAL EXPERIMENT; CONFERENCE PAPER; CONTROLLED STUDY; DRUG COST; DRUG DELIVERY SYSTEM; DRUG EFFICACY; DRUG SAFETY; IMMUNE RESPONSE; IMMUNOGENICITY; INTRAMUSCULAR DRUG ADMINISTRATION; INTRAPERITONEAL DRUG ADMINISTRATION; INTRAVENOUS DRUG ADMINISTRATION; MALE; MOUSE; NONHUMAN; PROTEIN EXPRESSION; VACCINATION; VACCINE PRODUCTION;

ANIMALIA;

EID: 0030462279     PISSN: 00778923     EISSN: None     Source Type: Book Series    
DOI: 10.1111/j.1749-6632.1996.tb52961.x     Document Type: Conference Paper

References (33)

1. CONNER, M. E., D. O. MATSON & M. K. ESTES. 1994. Rotavirus vaccines and vaccination potential. Curr. Top. Microbiol. Immunol. 185: 285-337.
2. FREED, E. R., R. J. DUMA & M. R. ESCOBAR. 1972. Vaccinia necrosum and its relationship to impaired immunologic responsiveness. Am. J. Med. 52: 411-420.
3. EVANS, D. M., G. DUNN, P. D. MINOR, et al. 1985. Increased neurovirulence associated with a single nucleotide change in a noncoding region of the Sabin type 3 poliovaccine genome. Nature 314: 548-550.
4. NKOWANE, B. M., S. G. WASSILAK, W. A. ORENSTEIN et al. 1987. Vaccine-associated paralytic poliomyelitis. United States: 1973 through 1984. JAMA 257: 1335-1340.
5. NATHANSON, N. & A. D. LANGMUIR. 1995. The Cutter incident. Poliomyeliltis following formaldehyde-inactivated poliovirus vaccination in the United States during the spring of 1955. II. Relationship of poliomyelitis to Cutter vaccine. 1963 [classical article]. Am. J. Epidemiol. 142: 109-140; discussion 107-108.
6. LANZAVECCHIA, A. 1987. Antigen uptake and accumulation in antigen-specific B cells. Immunol. Rev. 99: 39-51.
7. ULMER, J. B., J. J. DONNELLY, S. E. PARKER, et al. 1993. Heterologous protection against influenza by injection of DNA encoding a viral protein. Science 259: 1745-1749.
8. ROBINSON, H. L., L. A. HUNT & R. G. WEBSTER. 1993. Protection against a lethal influenza virus challenge by immunization with a haemagglutinin-expressing plasmid DNA. Vaccine 11: 957-960.
9. FYNAN, E. F., R. G. WEBSTER, D. H. FULLER, J. R. HAYNES, J. C. SANTORO & H. L. ROBINSON. 1993. DNA vaccines: Protective immunizations by parenteral, mucosal, and gene-gun inoculations. Proc. Natl. Acad. Sci. USA 90: 11478-11482.
10. COX, G. J. M., T. J. ZAMB & L. A. BABIUK. 1993. Bovine herpesvirus 1: Immune responses in mice and cattle injected with plasmid DNA. J. Virol. 67: 5664-5667.
11. PEDROZA MARTINS, L., L. L. LAU, M. S. ASANO & R. AHMED. 1995. DNA vaccination against persistent viral infection. J. Virol. 69: 2574-2582.
12. WHITTON, J. L., M. YOKOYAMA & J. ZHANG. 1995. DNA immunization in an arenavirus model. In Antiviral Immunity. M. Eibl & H. H. Peter, Eds.: 151-164. Springer-Verlag. New York.
13. ZAROZINSKI, C. C., E. F. FYNAN, L. K. SELIN, H. L. ROBINSON & R. M. WELSH. 1995. Protective CTL-dependent immunity and enhanced immunopathology in mice immunized by particle bombardment with DNA encoding an internal virion protein. J. Immunol. 154: 4010-4017.
14. XIANG, Z. Q., S. SPITALNIK, M. TRAN, W. H. WUNNER, J. CHENG & H. C. ERTL. 1994. Vaccination with a plasmid vector carrying the rabies virus glycoprotein gene induces protective immunity against rabies virus. Virology 199: 132-140.
15. WHITTON, J. L., N. SHENG, M. B. A. OLDSTONE & T. A. MCKEE. 1993. A "string-of-beads" vaccine, comprising linked minigenes, confers protection from lethal-dose virus challenge. J. Virol. 67: 348-352.
16. WHITTON, J. L. 1990. Lymphocytic choriomeningitis virus CTL. Sem. Virol. 1: 257-262.
17. KLAVINSKIS, L. S., M. B. A. OLDSTONE & J. L. WHITTON. 1989. Designing vaccines to induce cytotoxic T lymphocytes: Protection from lethal viral infection. In Vaccines 89. Modern Approaches to New Vaccines Including Prevention of AIDS. F. Brown, R. Chanock, H. Ginsberg & R. Lender, Eds.: 485-489. Cold Spring Harbor Laboratory. Cold Spring Harbor.
18. SCHULZ, M., R. M. ZINKERNAGEL & H. HENGARTNER. 1991. Peptide-induced antiviral protection by cytotoxic T cells. Proc. Natl Acad. Sci. USA 88: 991-993.
19. HANY, M., S. OEHEN, M. SCHULZ, et al. 1988. Anti-viral protection and prevention of lymphocytic choriomeningitis or of the local footpad swelling reaction in mice by immunization with vaccinia recombinant virus expressing LCMV-we nucleoprotein or glycoprotein. Eur. J. Immunol. 19: 417-424.
20. AHMED, R., B. D. JAMIESON & D. D. PORTER. 1987. Immune therapy of a persistent and disseminated viral infection. J. Virol. 61: 3920-3929.
21. SCHEEPERS, K. & H. BECHT. 1994. Protection of mice against an influenza virus infection by oral vaccination with viral nucleoprotein incorporated into immunostimulating complexes. Med. Microbiol. Immunol. (Berl.) 183: 265-278.
22. KULKARNI, A. B., P. L. COLLINS, I. BACIK, et al. 1995. Cytotoxic T cells specific for a single peptide on the M2 protein of respiratory syncytial virus are the sole mediators of resistance induced by immunization with M2 encoded by a recombinant vaccinia virus. J. Virol. 69: 1261-1264.
23. DEL VAL, M., H. J. SCHLICHT, H. VOLKMER, M. MESSERLE, M. J. REDDEHASE & U. H. KOSZINOWSKI. 1991. Protection against lethal cytomegalovirus infection by a recombinant vaccine containing a single nonameric T-cell epitope. J. Virol. 65: 3641-3646.
24. BACHMANN, M. F., T. M. KUNDIG, G. FREER, et al. 1994. Induction of protective cytotoxic T cells with viral proteins. Eur. J. Immunol. 24: 2228-2236.
25. WOLFF, J. A., R. W. MALONE, P. WILLIAMS, et al. 1990. Direct gene transfer into mouse muscle in vivo. Science 247: 1465-1468.
26. RAZ, E., D. A. CARSON, S. E. PARKER, et al. 1994. Intradermal gene immunization: The possible role of DNA uptake in the induction of cellular immunity to viruses. Proc. Natl. Acad. Sci. USA 91: 9519-9523.
27. TANG, D. C., M. DEVIT & S. A. JOHNSTON. 1992. Genetic immunization is a simple method for eliciting an immune response. Nature 356: 152-154.
28. AHMED, R. 1992. Immunological memory against viruses. Semin. Immunol. 4: 105-109.
29. YOKOYAMA, M., J. ZHANG & J. L. WHITTON. 1995. DNA immunization confers protection against lethal lymphocytic choriomeningitis virus infection. J. Virol. 69: 2684-2688.
30. LI, L. & R. M. HOFFMAN. 1995. The feasibility of targeted selective gene therapy of the hair follicle. Nature Med 1: 705-706.
31. + T lymphocytes in coxsackie virus B3-induced myocarditis. J. Virol. 69: 6720-6728.
32. + T helper cell and IL-2 independent in BALB/c mice. Am. J. Pathol. 127: 335-341.
33. KUNDIG, T. M., M. F. BACHMANN, C. DEPAOLO, et al. 1995. Fibroblasts as efficient antigen-presenting cells in lymphoid organs. Science 268: 1343-1347.