Method development in liquid chromatography with a charged cyclodextrin additive for chiral resolution of rac-amlodipine utilising a central composite design

Chirality

Volumn 8, Issue 7, 1996, Pages 466-476

  Owens, Paul K ^a   Fell, Anthony F ^a   Coleman, Michael W ^b   Berridge, John C ^b  

^a UNIVERSITY OF BRADFORD   (United Kingdom)

^b PFIZER GLOBAL RESEARCH AND DEVELOPMENT   (United Kingdom)

Author keywords

amlodipine; central composite design; charged cyclodextrin; chiral; experimental design; liquid chromatography; mobile phase additive; optimisation; rac amlodipine

Indexed keywords

AMLODIPINE;

ARTICLE; CHIRALITY; DRUG CONFORMATION; DRUG DETERMINATION; ENANTIOMER; PRIORITY JOURNAL; REPRODUCIBILITY; REVERSED PHASE HIGH PERFORMANCE LIQUID CHROMATOGRAPHY;

AMLODIPINE; BETA-CYCLODEXTRINS; CALCIUM CHANNEL BLOCKERS; CARBOHYDRATE SEQUENCE; CHROMATOGRAPHY, HIGH PRESSURE LIQUID; CYCLODEXTRINS; DATA INTERPRETATION, STATISTICAL; ELECTROCHEMISTRY; MODELS, CHEMICAL; MOLECULAR SEQUENCE DATA; STEREOISOMERISM;

EID: 0030462252     PISSN: 08990042     EISSN: None     Source Type: Journal    
DOI: 10.1002/(SICI)1520-636X(1996)8:7<466::AID-CHIR2>3.0.CO;2-9     Document Type: Article

References (20)

1. Almquist, S.R., Petersson, P., Walther, W., Markides, K.E. Direct and indirect approaches to enantiomeric separation of benzodiazepines using micro column techniques. J. Chromatogr. A 679:139-146, 1994.
2. Donnecke, J., König, W.A, Gyllenhaal, O., Vessman, J., Schulze, C. Enantiomer separation by capillary SFC and GC on immobilised octakis (2,6-di-O-methyl-3-O-pentyl)-gamma-cyclodextrin. J. High Res. Chromatogr. 17:779-783, 1994.
3. Armstrong, D.W., Demond, W. Cyclodextrin bonded phases for the liquid-chromatographic separation of optical, geometrical and structural isomers. J. Chromatogr. Sci. 22:411-415, 1984.
4. Debowski, J., Sybilska, D., Jurczak, J. β-Cyclodextrin as a chiral component of the mobile phase for separation of mandelic acid into enantiomers in reversed-phase systems of high-performance liquid chromatography. J. Chromatogr. 237:303-306, 1982.
5. Nishi, H., Nakamura, K., Kakai, H., Terabe, S. Enantiomeric separation of trimetoquinol, denopamine and trimepidium by capillary electrophoresis and HPLC and the application of capillary electrophoresis to the optical purity testing of the drugs. Chromatographia 40:638-644, 1995.
6. Tait, R.J., Skanchy, D.J., Thompson, D.P., Chetwyn, N.C., Dunshee, D.A, Rajewski, R.A, Stella, V.J., Stobaugh, J.F. Characterization of sulphoalkyl ether derivatives of β-cyclodextrin by capillary electrophoresis with indirect UV detection. J. Pharm. Biomed. Anal. 10:615-622, 1992.
7. Chankvetadze, B., Endresz, G., Blaschke, G. About some aspects of the use of charged cyclodextrins for capillary electrophoresis enantioseparation. Electrophoresis 15:804-807, 1994.
8. Roussel, C., Favrou, A. Cationic β-cyclodextrin: A new versatile chiral additive for separation of drug enantiomers by high-performance liquid chromatography. J. Chromatogr. A 704:67-74, 1995.
9. Lindner, W., LePage, J., Davies, G., Seitz, D., Karger, B.L. Reversed-phase separation of optical isomers of DNS-amino acids and peptides using chiral metal chelate additives. J. Chromatogr. 185:323-344, 1979.
10. Pettersson, C., Schill, G. Separation of enantiomeric amines by ion-pair chromatography. J. Chromatogr. 204:179-183, 1981.
11. Kristulovic, A.M. Chiral Separations by HPLC, Applications to Pharmaceutical Compounds. Chichester: Wiley, Ternary complexation 1989:107-172.
12. Berridge, J.C. Techniques for the Automated Optimisation of HPLC Separations. Chichester Wiley, Factorial design 1985:62-70.
13. Abushoffa, A.M., Clark, B.J. Resolution of the enantiomers of oxamniquine by capillary electrophoresis and high-performance liquid chromatography with cyclodextrins and heparin as chiral selectors. J. Chromatogr. A 700:51-58, 1995.
14. Tucker, R.P., Fell, A.F., Berridge, J.C., Coleman, M.W. Computer-aided models for optimization of eluent parameters in chiral liquid chromatography. Chirality 4:316-322, 1992.
15. Small, T.S., Fell, A.F., Coleman, M.W., Berridge, J.C. Central composite design for the rapid optimisation of ruggedness and chiral separation of amlodipine in capillary electrophoresis. Chirality 7:226-234, 1995.
16. Box, G.E.P., Wilson, K.B. On the experimental attainment of optimum conditions. J. R Stat Soc. B 13:1-45, 1951.
17. Morgan, E.D. Chemometrics: Experimental Design, Acol Analytical Chemistry by Open Learning. Chichester: Wiley, Response surface methodology 1991:238-258.
18. Kaiser, R.E. Gas Chromatographie. Leipzig: Geest and Portig, 1960.
19. Berridge, J.C. Techniques for the Automated Optimisation of HPLC Separations. Chichester: Wiley, Instrumental requirements and optimization criteria 1985:22.
20. Zukowski, J., Sybilska, D., Bojarski, J. Application of α- and β-cyclodextrin and heptakis(2,6-di-o-methyl)-β-cyclodextrin as mobile phase components for the separation of some chiral barbiturates into enantiomers by reversedphase high-performance liquid chromatography. J. Chromatogr. 364:225-232, 1986.