Glycans derived from porcine stomach mucin are effective inhibitors of natural anti-α-galactosyl antibodies in vitro and after intravenous infusion in baboons

Transplantation

Volumn 62, Issue 9, 1996, Pages 1324-1331

  Li, S F ^a   Neethling, F A ^a   Taniguchi, S ^a   Yeh, J C ^b   Kobayashi, T ^a   Ye, Y ^a   Koren, E ^c   Cummings, R D ^b   Cooper, D K C ^a,d  

^a INTEGRIS Nazih Zuhdi Transplant Institute   (United States)

^b UNIVERSITY OF OKLAHOMA HEALTH SCIENCES CENTER   (United States)

^c OKLAHOMA MEDICAL RESEARCH FOUNDATION   (United States)

^d MASSACHUSETTS GENERAL HOSPITAL   (United States)

Author keywords

[No Author keywords available]

Indexed keywords

ANTIBODY; EPITOPE; GALACTOSE; GLYCAN; OLIGOSACCHARIDE;

ANIMAL CELL; ANIMAL EXPERIMENT; ANIMAL MODEL; ANTIBODY AFFINITY; ANTIBODY TITER; ANTIGEN ANTIBODY REACTION; ARTICLE; CYTOTOXICITY; GRAFT REJECTION; IMMUNOAFFINITY CHROMATOGRAPHY; NONHUMAN; PRIORITY JOURNAL; SWINE; VASCULAR ENDOTHELIUM; XENOTRANSPLANTATION;

ANIMALS; ANTIBODIES; CELLS, CULTURED; CYTOTOXICITY, IMMUNOLOGIC; GASTRIC MUCIN; HUMANS; INFUSIONS, INTRAVENOUS; KIDNEY; OLIGOSACCHARIDES; PAPIO; SWINE; TRISACCHARIDES;

EID: 0030461539     PISSN: 00411337     EISSN: None     Source Type: Journal    
DOI: 10.1097/00007890-199611150-00026     Document Type: Article

References (26)

1. Cooper DKC, Ye Y, Rolf LL Jr, Zuhdi N. The pig as potential organ donor for man. In: Cooper DKC, et al., eds. Xenotransplantation. Heidelberg: Springer, 1991: 481.
2. Lexer G, Cooper DKC, Rose AG, et al. Hyperacute rejection in a discordant (pig-to-baboon) cardiac xenograft model. J Heart Transplant 1986; 5: 411.
3. Platt JL, Vercellotti G, Dalmasso AP, et al. Transplantation of discordant xenografts: a review of progress. Immunol Today 1990; 11: 450.
4. Platt JL. Immunopathology of hyperacute xenograft rejection in a swine-to-primate model. Transplantation 1991; 52: 214.
5. Fischel RJ, Matas AJ, Platt JL, et al. Cardiac xenografting in the pig-to-rhesus monkey model: manipulation of antiendothelial antibody prolongs survival. J Heart Lung Transplant 1992; 11: 965.
6. Good AH, Cooper DKC, Malcolm AJ, et al. Identification of carbohydrate structures that bind human anti-pig antibodies: implications for discordant xenografting in humans. Transplant Proc 1992; 24: 559.
7. Cooper DKC, Good AH, Koren E, et al. Identification of α-galactosyl and other carbohydrate epitopes that are bound by human anti-pig antibodies: relevance to discordant xenografting in man. Transpl Immunol 1993; 1: 198.
8. Cooper DKC, Koren E, Oriol R. Oligosaccharides and discordant xenotransplantation. Immunol Rev 1994; 141: 31.
9. Bach FH, Robson SC, Winkler H, et al. Barriers to xenotransplantation. Nat Med 1995; 1: 869.
10. Neethling FA, Koren E, Ye Y, et al. Protection of pig kidney (PK15) cells from the cytotoxic effect of anti-pig antibodies by α-galactosyl oligosaccharides. Transplantation 1994; 57: 959.
11. Ye Y, Neethling FA, Niekrasz M, et al. Evidence that intravenously administered α-galactosyl carbohydrates reduce baboon serum cytotoxicity to pig kidney cells (PK15) and transplanted pig heart. Transplantation 1994; 58: 330.
12. Zhao Z, Michalski JC, Chereau C, et al. An approach to the structure of carbohydrate epitopes recognized by human natural antibodies on porcine endothelial cells [Abstract 110]. Presented at the Second International Congress on Xenotransplantation, 1993.
13. Li S, Yeh J-C, Cooper DKC, Cummings RD. Inhibition of human anti-αGal IgG by oligosaccharides derived from porcine stomach mucin. Xenotransplantation 1995; 2: 279.
14. Dubois M, Giles KA, Hamilton JK, Rebens PA, Smith F. Colorimetric method for determination of sugars and related substances. Anal Chem 1956; 28: 350.
15. Koren E, Neethling FA, Koscec M, et al. In vitro model for hyperacute rejection of xenogeneic cells. Transplant Proc 1994; 26: 1166.
16. Cooper DKC, Ye Y, Niekrasz M. Heart transplantation in primates. In: Makowka L, Cramer DV, Sher L, eds. Experimental techniques in transplantation. Boca Raton, FL: CRC Press, 1994: 173.
17. Koren E, Neethling FA, Ye Y, et al. Heterogeneity of preformed human anti-pig xenogeneic antibodies. Transplant Proc 1992; 24: 598.
18. Koren E, Neethling FA, Richards S, et al. Binding and specificity of major immunoglobulin classes of human anti-pig heart antibodies. Transpl Int 1993; 6: 351.
19. Kujundzic M, Koren E, Neethling FA, et al. Variability of anti-αGal antibodies in human serum and their relation to serum cytotoxicity against pig cells. Xenotransplantation 1994; 1: 58.
20. Rieben R, von Allmen E, Korchagina EY, et al. Detection, immunoadsorption, and inhibition of cytotoxic activity of anti-αGal antibodies using newly developed substances with synthetic Galα1-3Gal disaccharide epitopes. Xenotransplantation 1995; 2: 98.
21. Galili U, Shohet SB, Kobrin E, Stults CLM, Macher BA. Man, apes and Old World monkeys differ from other mammals in the expression of α-galactosyl epitopes on nucleated cells. J Biol Chem 1988; 263: 17755.
22. Oriol R, Ye Y, Koren E, Cooper DKC. Carbohydrate antigens of pig tissue reacting with human natural antibodies as potential targets for hyperacute vascular rejection in pig-to-man organ xenotransplantation. Transplantation 1993; 56: 1433.
23. Oriol R, Barthod F, Bergemer A-M, et al. Monomorphic and polymorphic carbohydrate antigens on pig tissues: implications for organ xenotransplantation in the pig-to-man model. Transpl Int 1994; 7: 405.
24. Glenister DA, Salamon KE, Smith K, Beighton D, Keevil CW. Enhanced growth of complex communities of dental plaque bacteria in mucin-limited continuous culture. Microbial Ecol Health Dis 1988; 1: 31.
25. Taniguchi S, Neethling FA, Bovin N, et al. In vivo immunoadsorption of anti-pig antibodies in baboons using a specific αGal1-3Gal column. Transplantation (in press).
26. Cooper DKC, Cairns TDH, Taube DH. Extracorporeal immunoadsorption of anti-pig antibody in baboons using αGal oligosaccharide immunoaffinity columns. Xeno. (in press).